Dapsone

15 interactions 253 cited references
Also sold as: Aczone Dapsone
About Dapsone

Dapsone is used to treat leprosy and skin infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Read the full Dapsone drug information page →

Dr. Brian Staiger, PharmD, BCPS
Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Articaine Lidocaine Methotrexate Rifabutin Rifampin Warfarin
8 Major 7 Moderate
All (15) Major (8) Moderate (7)

Major

Dapsone Articaine An increased risk of methemoglobinemia Details Dapsone Lidocaine Akten An increased risk of methemoglobinemia Details Dapsone Methotrexate Jylamvo Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details Dapsone Rifabutin Mycobutin Reduced dapsone exposure Details Dapsone Rifampin Rifadin Reduced dapsone exposure, reduced efficacy of dapsone, an increased hydroxylamine metabolite of dapsone and an increased the risk... Details Dapsone Warfarin Coumadin Increased International Normalized Ratio (INR) Details Dapsone Zidovudine Retrovir Hematologic toxicity (neutropenia) Details Dapsone Methotrexate Injection Abitrexate® Increased methotrexate exposure, an increased risk of methotrexate-related severe adverse reactions, reduced active metabolite for... Details

Moderate

Dapsone Amprenavir An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, lethargy, weakness) Details Dapsone Atazanavir Reyataz An increased risk of hemolytic anemia and symptomatic hyperbilirubinemia Details Dapsone Bacillus Of Calmette And Guerin Vaccine, Live Reduced efficacy of intravesical treatment or vaccination Details Dapsone Fosamprenavir Lexiva An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, lethargy, weakness) Details Dapsone Probenecid An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, lethargy, weakness) Details Dapsone Rifapentine Priftin Decreased dapsone effectiveness Details Dapsone Trimethoprim Primsol An increased risk of dapsone toxicity (hemolytic anemia, methemoglobinemia, peripheral neuropathy) or trimethoprim toxicity (bone... Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.