Drug & supplement interaction

Irvingia Gabonensis + Testosterone Enanthate

Testosterone Enanthate brand name: Xyosted.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Irvingia Gabonensis has a moderate interaction with Testosterone Enanthate. Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Irvingia Gabonensis and Testosterone Enanthate

Here is the interaction we found between these two, with the evidence behind it.

Moderate

TESTOSTERONE

Theoretically, taking Irvingia gabonensis with testosterone products drugs might cause additive effects in some patients.
Animal research suggests that Irvingia gabonensis increases testosterone levels. The mechanism of action is unclear. Until more is known, advise patients taking testosterone to avoid using or use Irvingia gabonensis cautiously.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the short version on combining African mango (Irvingia gabonensis) with your testosterone enanthate (Xyosted). In some animal studies, this seed extract seemed to nudge testosterone levels upward, though nobody really knows how it works. The worry is simply that the two might stack on top of each other, giving you a bit more testosterone effect than your injection alone would.

I want to be honest with you: this is theoretical and based only on lab and animal research, so I'm not losing sleep over it. If there were any added effect, it could look like more acne, oily skin, mood swings, or a higher red blood cell count over time. Since your doctor already tracks your levels with bloodwork, just mention the supplement at your next visit so they can keep an eye on things. Don't start or stop anything on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Wolfe OA, Ijeoma UF. Effects of aqueous extracts of Irvingia gabonensis seeds on the hormonal parameters of male guinea pigs. Asian Pacific Journal of Tropical Medicine. 2010;3(3):200-204. DOI

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Irvingia Gabonensis Also Interacts With Other Medications

Irvingia Gabonensis has 93 moderate known drug interactions in our database — the Testosterone Enanthate one above is one of them. If you take anything else, check it against the full list below.

Moderate 93 No known interaction 2,737 (incl. Testosterone Enanthate)
Taking anything else?

Check Another of Your Medications Against Irvingia Gabonensis

Covers the 2,830 medications we’ve checked against Irvingia Gabonensis. Pick one to open its full report.

From our Q&A

Questions About Irvingia Gabonensis or Testosterone Enanthate

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Irvingia Gabonensis or Testosterone Enanthate, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Testosterone Enanthate

This page covers Irvingia Gabonensis only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Testosterone Enanthate page lists 184 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Grapefruit (major), Siberian Cocklebur (major) and St. John's Wort (major).

By severity: 6 major · 134 moderate · 44 minor.

From our pharmacist’s overview on the Testosterone Enanthate page

“Beer and wine both carry major ratings on this list, because heavy alcohol use can compound the strain testosterone enanthate (Xyosted) already places on the liver. That liver theme runs through 38 of the 184 ingredients on file, Siberian cocklebur among them, and with six interactions rated major overall, this page deserves genuine ca…”

Reviewed by 2 · Jul 18, 2026

Open the Testosterone Enanthate interaction page

One more smart check

Taking Irvingia Gabonensis as Part of a Dietary Supplement Product? Check It for Interactions

We hold 406 real supplement products containing Irvingia Gabonensis, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Irvingia Gabonensis. Your product may carry other ingredients that interact with Testosterone Enanthate too, on top of Irvingia Gabonensis — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Irvingia Gabonensis and Testosterone Enanthate Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Irvingia Gabonensis
Top 25%

#252 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Testosterone Enanthate
Top half

#1,044 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Irvingia Gabonensis

What is Irvingia Gabonensis?

Irvingia Gabonensis
  • Weight loss
  • Appetite control
  • Cholesterol support
  • Blood sugar support
  • Metabolism support

Irvingia gabonensis (African mango) is a seed extract marketed mainly for weight loss and metabolic health. A few small studies suggest possible benefits, but the research is limited and low-quality, so the true effect is uncertain. Talk with your pharmacist or doctor before using it, and do not rely on it in place of proven diet and lifestyle changes.

Read the full Irvingia Gabonensis monograph & all interactions
Medication

About Testosterone Injection

What Is Testosterone Injection Used For?

Brand name: Xyosted

Testosterone injection is primarily used in men whose bodies do not produce enough testosterone on their own — a condition called hypogonadism. This includes primary hypogonadism (a problem with the testicles themselves, such as from injury, infection, or surgery) and hypogonadotropic hypogonadism (caused by problems in the brain's hormone signaling from the hypothalamus or pituitary gland). It is also used to stimulate puberty in carefully selected adolescent males with clearly delayed puberty who have not responded to other support.

Testosterone Enanthate Injection is also approved for use in women with advanced, inoperable metastatic breast cancer (specifically skeletal metastases) who are one to five years past menopause, or in premenopausal women with hormone-responsive breast cancer who have had their ovaries removed. This use should be directed by an oncologist. Aveed (testosterone undecanoate) is specifically approved for male hypogonadism only.

See full Testosterone Injection drug information
Keep checking

Other Drugs & Irvingia Gabonensis

Browse every other medication we’ve checked against Irvingia Gabonensis — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
93Moderate
0Minor
2,736No known interaction
93 Moderate 2,736 No interaction
Moderate

93 interactions

Showing 60 of 93 moderate interactions — see all 93 on the Irvingia Gabonensis page.

No interaction 2,736 drugs checked — show the list

We also checked Irvingia Gabonensis against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,736 medications checked with no known interaction — see the full Irvingia Gabonensis list.

See the full Irvingia Gabonensis interactions page
See every supplement checked against Testosterone Enanthate, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Irvingia Gabonensis monograph › Uses, safety, and every drug interaction in one place Testosterone Enanthate supplement interactions › Every supplement checked against Testosterone Enanthate, ranked by severity Testosterone Injection drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Irvingia Gabonensis and Testosterone Enanthate Together: Common Questions

Can you take Irvingia Gabonensis with Testosterone Enanthate?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Irvingia Gabonensis and Testosterone Enanthate interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.