Drug & supplement interaction

7-methoxyflavone + Metaxalone

Metaxalone brand name: Skelaxin.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between 7-methoxyflavone and Metaxalone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

7-methoxyflavone and Metaxalone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Metaxalone and 7-methoxyflavone in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

7-methoxyflavone safety at a glance

7-methoxyflavone overall Not established Human safety data are very limited, so it cannot be called clearly safe.
Pregnancy Avoid Avoid because of unknown safety and possible effects on hormones.
Breastfeeding Avoid Avoid due to lack of safety data and potential hormonal activity.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Metaxalone and 7-methoxyflavone? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Metaxalone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Metaxalone is filed under 2 classifications — skeletal muscle relaxants, oral drugs. 7-methoxyflavone has documented interactions with 2 drug classes — the most serious being aromatase inhibitors (moderate) and testosterone (moderate) — and none of Metaxalone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

7-methoxyflavone Does Interact With Other Medications

7-methoxyflavone has 12 moderate known drug interactions in our database — Metaxalone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 12 No known interaction 2,818 (incl. Metaxalone)
Taking anything else?

Check Another of Your Medications Against 7-methoxyflavone

Covers the 2,830 medications we’ve checked against 7-methoxyflavone. Pick one to open its full report.

What to actually watch for

What Metaxalone’s Own FDA Label Lists

This is not an interaction — none of it involves 7-methoxyflavone. These are the most notable effects listed in the ADVERSE REACTIONS section of Metaxalone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 5 of them are worth acting on rather than waiting out — marked below.

  • Serotonin syndrome Worth acting on
  • Yellowing of the skin or eyes Worth acting on
  • Anemia Worth acting on
  • A severe allergic reaction Worth acting on
  • An allergic reaction Worth acting on
  • Mood changes or irritability
  • Drowsiness
  • Anxiety or restlessness
  • Stomach upset
  • Itching

Showing the 10 most notable of 15 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Metaxalone. Read the label on DailyMed › Where a percentage is shown, it is the share of 3,328 voluntary FDA FAERS reports for Metaxalone that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. 7-methoxyflavone’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no 7-methoxyflavone side to compare — that is a limit of the record, not a statement that 7-methoxyflavone has no side effects.

From our Q&A

Questions About 7-methoxyflavone or Metaxalone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers 7-methoxyflavone or Metaxalone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Metaxalone

This page covers 7-methoxyflavone only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Metaxalone page lists 20 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Procaine (major), Coffee Charcoal (moderate), European Mandrake (moderate) and Glucomannan (moderate).

By severity: 2 major · 9 moderate · 9 minor.

From our pharmacist’s overview on the Metaxalone page

“Most of what interacts with metaxalone (Skelaxin), a muscle relaxant prescribed for painful muscle spasms, works by getting between the pill and your bloodstream. Fiber gums, mucilage herbs like slippery elm, and above all activated charcoal can bind or slow the drug in the gut, leaving you with less relief than your dose should deliver.”

Reviewed by 2 · Jul 18, 2026

Open the Metaxalone interaction page

One more smart check

Taking 7-methoxyflavone as Part of a Dietary Supplement Product? Check It for Interactions

We hold 20 real supplement products containing 7-methoxyflavone, each one broken down to its full ingredient list — and combination products often carry several ingredients besides 7-methoxyflavone. Even though 7-methoxyflavone itself has no known interaction with Metaxalone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where 7-methoxyflavone and Metaxalone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement 7-methoxyflavone
Steady interest

#1,122 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Metaxalone
Steady interest

#2,728 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every 7-methoxyflavone reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The 7-methoxyflavone and Metaxalone records this page draws on were last updated June 20, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About 7-methoxyflavone

What is 7-methoxyflavone?

  • Boosting testosterone
  • Reducing estrogen (aromatase inhibition)
  • Athletic and bodybuilding performance
  • Muscle building support

7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that it blocks the aromatase enzyme. However, solid human evidence that it raises testosterone, improves performance, or builds muscle is essentially lacking, and its long-term safety has not been well studied. Talk to your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Isolated flavonoid compound (synthesized or extracted from plants) · Capsules, tablets, powders (often in combination supplements)

An interaction check asks whether these two react with each other — it does not ask whether 7-methoxyflavone is a good idea for someone in your situation. Here is what our 7-methoxyflavone record says about it on its own.

7-methoxyflavone: dosing

There is no established, science-based dose for 7-methoxyflavone. It has not been studied enough in people to know a safe and effective amount.Most products that contain it provide it as part of a blend, and amounts vary widely from brand to brand. They can help you weigh whether the product makes sense for you and check for any concerns based on your health and other medicines.

From our 7-methoxyflavone monograph — the full record covers uses, side effects and every documented interaction.

Read the full 7-methoxyflavone monograph & all interactions
Medication

About Metaxalone

What Is Metaxalone Used For?

Brand name: Skelaxin

Metaxalone tablets are used to help relieve discomfort caused by acute (short-term), painful musculoskeletal conditions — things like muscle strains, sprains, and similar injuries. It is meant to be used together with rest, physical therapy, and other treatments, not as a stand-alone fix.

This use applies to adults and adolescents 13 years of age and older. Metaxalone tablets are available as the branded product Skelaxin and as a generic.

Most-Reported Side Effects for Metaxalone

From FAERS, the FDA’s public side-effect reporting system (3,328 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Completed suicide 261 reports
Nausea 198 reports
Fatigue 196 reports
Headache 172 reports
Toxicity to various agents 164 reports
See full Metaxalone drug information
Keep checking

Other Drugs & 7-methoxyflavone

Browse every other medication we’ve checked against 7-methoxyflavone — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
12Moderate
0Minor
2,817No known interaction
12 Moderate 2,817 No interaction
Moderate

12 interactions

No interaction 2,817 drugs checked — show the list

We also checked 7-methoxyflavone against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,817 medications checked with no known interaction — see the full 7-methoxyflavone list.

See the full 7-methoxyflavone interactions page
See every supplement checked against Metaxalone, ranked by severity
Evidence & sources

7-methoxyflavone References

The 1 references that drive our 7-methoxyflavone monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Ta N, Walle T. Aromatase inhibition by bioavailable flavones. J Steroid Biochem Mol Biol 2007;107(1-2):127-9.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking 7-methoxyflavone and Metaxalone Together: Common Questions

Is it safe to take 7-methoxyflavone with Metaxalone?
We do not list a known interaction between 7-methoxyflavone and Metaxalone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the 7-methoxyflavone and Metaxalone combination checked?
Interactions in our licensed database are recorded against drug classes. Metaxalone is filed under 2 classifications, and 7-methoxyflavone has documented interactions with 2 drug classes — none of Metaxalone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does 7-methoxyflavone interact with any other medications?
Yes. 7-methoxyflavone has 12 documented drug interactions in our database — Metaxalone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Metaxalone interact with any supplements?
Yes. Metaxalone has documented interactions with 20 supplements in our database — 7-methoxyflavone is not one of them. The Metaxalone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

7-methoxyflavone monograph Uses, safety profile, and every drug interaction in one place Metaxalone drug information The full plain-English guide to this medication Metaxalone supplement interactions Every supplement checked against Metaxalone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Metaxalone and 7-methoxyflavone?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.