Metaxalone

Generic name: Pronounced as (me tax' a lone)
Brand names
  • Skelaxin®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 10/15/2018

Metaxalone, a muscle relaxant, is used with rest, physical therapy, and other measures to relax muscles and relieve pain and discomfort caused by strains, sprains, and other muscle injuries.

Metaxalone comes as a tablet to take by mouth. It usually is taken three or four times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metaxalone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking metaxalone,

  • tell your doctor and pharmacist if you are allergic to metaxalone, any other medications, or any of the ingredients in metaxalone tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially medications for seizures, allergies, colds, or coughs; pain medications; sedatives; tranquilizers; and vitamins.

  • tell your doctor if you have or have ever had kidney disease, liver disease, seizures, or a blood disorder.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking metaxalone, call your doctor immediately.

  • talk to your doctor about the risks and benefits of taking metaxalone if you are 65 years of age or older. Older adults should not usually take metaxalone because it is not as safe or effective as other medications that can be used to treat the same condition.

  • you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how metaxalone affects you.

  • remember that alcohol can add to the drowsiness caused by this drug.

Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Metaxalone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • drowsiness

    • dizziness

    • upset stomach

    • vomiting

    • headache

    • nervousness

  • If you experience any of the following symptoms, call your doctor immediately:

    • severe skin rash

    • difficulty breathing

    • yellowing of the skin or eyes

    • unusual bruising or bleeding

    • unusual tiredness or weakness

    • seizures

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor.

Do not let anyone else take your medications. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Dolasetron Dolasetron The risk or severity of adverse effects can be increased when Metaxalone is combined with Dolasetron.
Cilostazol Cilostazol Metaxalone may decrease the excretion rate of Cilostazol which could result in a higher serum level.
Diphenoxylate Diphenoxylate The risk or severity of respiratory depression can be increased when Diphenoxylate is combined with Metaxalone.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Fenofibrate Fenofibrate Metaxalone may decrease the excretion rate of Fenofibrate which could result in a higher serum level.
Guanfacine Guanfacine The risk or severity of adverse effects can be increased when Metaxalone is combined with Guanfacine.
Magnesium Hydroxide Magnesium Hydroxide Metaxalone may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Mycophenolate Mycophenolate Metaxalone may decrease the excretion rate of Mycophenolic acid which could result in a higher serum level.
Naratriptan Naratriptan The risk or severity of adverse effects can be increased when Metaxalone is combined with Naratriptan.
Olsalazine Olsalazine Olsalazine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Paregoric Paregoric The risk or severity of respiratory depression can be increased when Morphine is combined with Metaxalone.
Pentazocine Pentazocine The risk or severity of respiratory depression can be increased when Pentazocine is combined with Metaxalone.
Potassium Potassium Potassium may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Ranitidine Ranitidine Metaxalone may decrease the excretion rate of Ranitidine which could result in a higher serum level.
Reserpine Reserpine The risk or severity of adverse effects can be increased when Reserpine is combined with Metaxalone.
Rizatriptan Rizatriptan The risk or severity of adverse effects can be increased when Metaxalone is combined with Rizatriptan.
Sumatriptan Sumatriptan The risk or severity of adverse effects can be increased when Metaxalone is combined with Sumatriptan.
Tacrolimus Tacrolimus Tacrolimus may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Metaxalone is combined with Tizanidine.
Zolmitriptan Zolmitriptan The risk or severity of adverse effects can be increased when Zolmitriptan is combined with Metaxalone.
Ampicillin Injection Ampicillin Injection Ampicillin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Doxycycline Injection Doxycycline Injection Doxycycline may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Fluconazole Injection Fluconazole Injection Fluconazole may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection The risk or severity of respiratory depression can be increased when Hydromorphone is combined with Metaxalone.
Levofloxacin Injection Levofloxacin Injection Metaxalone may decrease the excretion rate of Levofloxacin which could result in a higher serum level.
Meperidine Injection Meperidine Injection The risk or severity of adverse effects can be increased when Meperidine is combined with Metaxalone.
Metoclopramide Injection Metoclopramide Injection The risk or severity of sedation can be increased when Metaxalone is combined with Metoclopramide.
Morphine Injection Morphine Injection The risk or severity of respiratory depression can be increased when Morphine is combined with Metaxalone.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Metaxalone may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Metaxalone.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cyclosporine Cyclosporine Cyclosporine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Ondansetron Ondansetron The risk or severity of adverse effects can be increased when Metaxalone is combined with Ondansetron.
Granisetron Granisetron The risk or severity of adverse effects can be increased when Metaxalone is combined with Granisetron.
Torsemide Torsemide Torasemide may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine The risk or severity of adverse effects can be increased when Olanzapine is combined with Metaxalone.
Alosetron Alosetron The risk or severity of adverse effects can be increased when Metaxalone is combined with Alosetron.
Entacapone Entacapone The risk or severity of adverse effects can be increased when Entacapone is combined with Metaxalone.
Meloxicam Meloxicam Meloxicam may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Oxcarbazepine Oxcarbazepine The risk or severity of adverse effects can be increased when Metaxalone is combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Temozolomide Temozolomide Metaxalone may decrease the excretion rate of Temozolomide which could result in a higher serum level.
Zaleplon Zaleplon The risk or severity of adverse effects can be increased when Metaxalone is combined with Zaleplon.
Desloratadine Desloratadine The risk or severity of adverse effects can be increased when Metaxalone is combined with Desloratadine.
Linezolid Linezolid The risk or severity of serotonin syndrome can be increased when Linezolid is combined with Metaxalone.
Trimipramine Trimipramine The risk or severity of adverse effects can be increased when Metaxalone is combined with Trimipramine.
Glycopyrrolate Glycopyrrolate Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Glycopyrronium.
Perindopril Perindopril Metaxalone may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Eplerenone Eplerenone Eplerenone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Escitalopram.
Zonisamide Zonisamide The risk or severity of adverse effects can be increased when Metaxalone is combined with Zonisamide.
Aripiprazole Aripiprazole The risk or severity of adverse effects can be increased when Metaxalone is combined with Aripiprazole.
Atomoxetine Atomoxetine The risk or severity of adverse effects can be increased when Atomoxetine is combined with Metaxalone.
Dexmethylphenidate Dexmethylphenidate The risk or severity of adverse effects can be increased when Metaxalone is combined with Dexmethylphenidate.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Almotriptan Almotriptan The risk or severity of adverse effects can be increased when Metaxalone is combined with Almotriptan.
Eletriptan Eletriptan The risk or severity of adverse effects can be increased when Eletriptan is combined with Metaxalone.
Emtricitabine Emtricitabine Metaxalone may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Memantine Memantine Metaxalone may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod Tegaserod The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Tegaserod.
Tadalafil Tadalafil Metaxalone may decrease the excretion rate of Tadalafil which could result in a higher serum level.
Frovatriptan Frovatriptan The risk or severity of adverse effects can be increased when Metaxalone is combined with Frovatriptan.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Metaxalone is combined with Apomorphine.
Protriptyline Protriptyline The risk or severity of adverse effects can be increased when Protriptyline is combined with Metaxalone.
Duloxetine Duloxetine The risk or severity of adverse effects can be increased when Metaxalone is combined with Duloxetine.
Tinidazole Tinidazole Metaxalone may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Trospium Trospium Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Trospium.
Cefditoren Cefditoren Cefdinir may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Eszopiclone Eszopiclone The risk or severity of CNS depression can be increased when Metaxalone is combined with Eszopiclone.
Ganciclovir Ganciclovir Metaxalone may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Ribavirin Ribavirin Metaxalone may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin Solifenacin Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Solifenacin.
Valganciclovir Valganciclovir Metaxalone may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Adefovir Adefovir Adefovir may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine The risk or severity of adverse effects can be increased when Amphetamine is combined with Metaxalone.
Sodium Oxybate Sodium Oxybate Sodium oxybate may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Isocarboxazid Isocarboxazid The risk or severity of adverse effects can be increased when Metaxalone is combined with Isocarboxazid.
Ramelteon Ramelteon The risk or severity of adverse effects can be increased when Metaxalone is combined with Ramelteon.
Darifenacin Darifenacin Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Darifenacin.
Fentanyl Fentanyl The risk or severity of adverse effects can be increased when Metaxalone is combined with Fentanyl.
Pregabalin Pregabalin The therapeutic efficacy of Metaxalone can be increased when used in combination with Pregabalin.
Felbamate Felbamate The risk or severity of adverse effects can be increased when Metaxalone is combined with Felbamate.
Ranolazine Ranolazine Ranolazine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Rasagiline Rasagiline The risk or severity of adverse effects can be increased when Metaxalone is combined with Rasagiline.
Sitagliptin Sitagliptin Metaxalone may decrease the excretion rate of Sitagliptin which could result in a higher serum level.
Varenicline Varenicline Metaxalone may decrease the excretion rate of Varenicline which could result in a higher serum level.
Albuterol Albuterol Metaxalone may decrease the excretion rate of Salbutamol which could result in a higher serum level.
Paliperidone Paliperidone The risk or severity of adverse effects can be increased when Metaxalone is combined with Paliperidone.
Clofarabine Injection Clofarabine Injection Clofarabine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Lubiprostone Lubiprostone Metaxalone may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Pemetrexed Injection Pemetrexed Injection Metaxalone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Dimenhydrinate Dimenhydrinate The risk or severity of adverse effects can be increased when Metaxalone is combined with Dimenhydrinate.
Lisdexamfetamine Lisdexamfetamine The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Lisdexamfetamine.
Nabilone Nabilone Nabilone may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Sorafenib Sorafenib Sorafenib may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Dronabinol Dronabinol Dronabinol may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Levocetirizine Levocetirizine The risk or severity of adverse effects can be increased when Metaxalone is combined with Levocetirizine.
Pegaptanib Injection Pegaptanib Injection Metaxalone may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Azacitidine Injection Azacitidine Injection Metaxalone may decrease the excretion rate of Azacitidine which could result in a higher serum level.
Lenalidomide Lenalidomide Lenalidomide may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Budesonide Budesonide Metaxalone may decrease the excretion rate of Budesonide which could result in a higher serum level.
Desmopressin Desmopressin Desmopressin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
OnabotulinumtoxinA Injection OnabotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Metaxalone.
RimabotulinumtoxinB Injection RimabotulinumtoxinB Injection The risk or severity of adverse effects can be increased when Botulinum Toxin Type B is combined with Metaxalone.
Doripenem Injection Doripenem Injection Metaxalone may decrease the excretion rate of Doripenem which could result in a higher serum level.
Arsenic Trioxide Injection Arsenic Trioxide Injection Metaxalone may decrease the excretion rate of Arsenic trioxide which could result in a higher serum level.
Desvenlafaxine Desvenlafaxine The risk or severity of adverse effects can be increased when Metaxalone is combined with Desvenlafaxine.
Cevimeline Cevimeline Cevimeline may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Certolizumab Injection Certolizumab Injection Metaxalone may decrease the excretion rate of Certolizumab pegol which could result in a higher serum level.
Daptomycin Injection Daptomycin Injection Daptomycin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methylnaltrexone Injection Methylnaltrexone Injection Metaxalone may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Rufinamide Rufinamide The risk or severity of adverse effects can be increased when Rufinamide is combined with Metaxalone.
Midazolam Midazolam The risk or severity of adverse effects can be increased when Metaxalone is combined with Midazolam.
Naltrexone Injection Naltrexone Injection The risk or severity of respiratory depression can be increased when Naltrexone is combined with Metaxalone.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Milnacipran Milnacipran The risk or severity of adverse effects can be increased when Metaxalone is combined with Milnacipran.
Plerixafor Injection Plerixafor Injection Metaxalone may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine Fesoterodine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Fesoterodine.
Iloperidone Iloperidone The risk or severity of adverse effects can be increased when Metaxalone is combined with Iloperidone.
Prasugrel Prasugrel Metaxalone may decrease the excretion rate of Prasugrel which could result in a higher serum level.
Lacosamide Lacosamide The risk or severity of adverse effects can be increased when Metaxalone is combined with Lacosamide.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
AbobotulinumtoxinA Injection AbobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Metaxalone.
Pralatrexate Injection Pralatrexate Injection Metaxalone may decrease the excretion rate of Pralatrexate which could result in a higher serum level.
Palonosetron Injection Palonosetron Injection The risk or severity of adverse effects can be increased when Palonosetron is combined with Metaxalone.
Saxagliptin Saxagliptin Metaxalone may decrease the excretion rate of Saxagliptin which could result in a higher serum level.
Telavancin Injection Telavancin Injection Metaxalone may decrease the excretion rate of Telavancin which could result in a higher serum level.
Tapentadol Tapentadol Tapentadol may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Topotecan Topotecan Metaxalone may decrease the excretion rate of Topotecan which could result in a higher serum level.
Asenapine Asenapine The risk or severity of adverse effects can be increased when Metaxalone is combined with Asenapine.
Vigabatrin Vigabatrin The risk or severity of adverse effects can be increased when Metaxalone is combined with Vigabatrin.
Oxymorphone Oxymorphone The risk or severity of respiratory depression can be increased when Oxymorphone is combined with Metaxalone.
Dalfampridine Dalfampridine Metaxalone may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
IncobotulinumtoxinA Injection IncobotulinumtoxinA Injection The risk or severity of adverse effects can be increased when Botulinum toxin type A is combined with Metaxalone.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Lurasidone Lurasidone The risk or severity of adverse effects can be increased when Metaxalone is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Vilazodone Vilazodone The risk or severity of adverse effects can be increased when Metaxalone is combined with Vilazodone.
Ipilimumab Injection Ipilimumab Injection Metaxalone may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Terbutaline Injection Terbutaline Injection Metaxalone may decrease the excretion rate of Terbutaline which could result in a higher serum level.
Roflumilast Roflumilast Metaxalone may decrease the excretion rate of Roflumilast which could result in a higher serum level.
Rivaroxaban Rivaroxaban Metaxalone may decrease the excretion rate of Rivaroxaban which could result in a higher serum level.
Ruxolitinib Ruxolitinib Metaxalone may decrease the excretion rate of Ruxolitinib which could result in a higher serum level.
Clobazam Clobazam The risk or severity of adverse effects can be increased when Clobazam is combined with Metaxalone.
Deferiprone Deferiprone Metaxalone may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Cabergoline Cabergoline The risk or severity of adverse effects can be increased when Cabergoline is combined with Metaxalone.
Naloxone Injection Naloxone Injection Metaxalone may decrease the excretion rate of Naloxone which could result in a higher serum level.
Fondaparinux Injection Fondaparinux Injection Fondaparinux may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Ezogabine Ezogabine The risk or severity of adverse effects can be increased when Metaxalone is combined with Tiagabine.
Enzalutamide Enzalutamide Metaxalone may decrease the excretion rate of Enzalutamide which could result in a higher serum level.
Mirabegron Mirabegron Metaxalone may decrease the excretion rate of Mirabegron which could result in a higher serum level.
Teduglutide Injection Teduglutide Injection Metaxalone may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Alogliptin Alogliptin Metaxalone may decrease the excretion rate of Alogliptin which could result in a higher serum level.
Pomalidomide Pomalidomide The risk or severity of adverse effects can be increased when Metaxalone is combined with Pomalidomide.
Canagliflozin Canagliflozin Metaxalone may increase the excretion rate of Canagliflozin which could result in a lower serum level and potentially a reduction in efficacy.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib Trametinib Metaxalone may decrease the excretion rate of Trametinib which could result in a higher serum level.
Levomilnacipran Levomilnacipran The risk or severity of adverse effects can be increased when Metaxalone is combined with Levomilnacipran.
Ertapenem Injection Ertapenem Injection Ertapenem may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Vortioxetine Vortioxetine The risk or severity of adverse effects can be increased when Metaxalone is combined with Vortioxetine.
Perampanel Perampanel Perampanel may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Ketorolac Injection Ketorolac Injection Ketorolac may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Sofosbuvir Sofosbuvir Metaxalone may decrease the excretion rate of Sofosbuvir which could result in a higher serum level.
Dapagliflozin Dapagliflozin Dapagliflozin may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Apremilast Apremilast Metaxalone may decrease the excretion rate of Apremilast which could result in a higher serum level.
Droxidopa Droxidopa Metaxalone may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Eslicarbazepine Eslicarbazepine The risk or severity of adverse effects can be increased when Metaxalone is combined with Eslicarbazepine.
Testosterone Injection Testosterone Injection Testosterone may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Hydrocodone Hydrocodone Hydrocodone may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Suvorexant Suvorexant Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Suvorexant.
Edoxaban Edoxaban Metaxalone may decrease the excretion rate of Edoxaban which could result in a higher serum level.
Methamphetamine Methamphetamine The risk or severity of adverse effects can be increased when Metaxalone is combined with Metamfetamine.
Tasimelteon Tasimelteon The risk or severity of adverse effects can be increased when Metaxalone is combined with Tasimelteon.
Risperidone Injection Risperidone Injection The risk or severity of adverse effects can be increased when Metaxalone is combined with Risperidone.
Haloperidol Injection Haloperidol Injection The risk or severity of CNS depression can be increased when Haloperidol is combined with Metaxalone.
Amiloride Amiloride Amiloride may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Metaxalone may decrease the excretion rate of Macitentan which could result in a higher serum level.
Flibanserin Flibanserin The risk or severity of adverse effects can be increased when Metaxalone is combined with Flibanserin.
Brexpiprazole Brexpiprazole The risk or severity of adverse effects can be increased when Metaxalone is combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of adverse effects can be increased when Ziprasidone is combined with Metaxalone.
Cariprazine Cariprazine The risk or severity of adverse effects can be increased when Metaxalone is combined with Cariprazine.
Penicillin G Procaine Injection Penicillin G Procaine Injection Metaxalone may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline Eluxadoline The risk or severity of respiratory depression can be increased when Eluxadoline is combined with Metaxalone.
Ixazomib Ixazomib Metaxalone may decrease the excretion rate of Ixazomib which could result in a higher serum level.
Lesinurad Lesinurad Metaxalone may decrease the excretion rate of Lesinurad which could result in a higher serum level.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Brivaracetam Injection Brivaracetam Injection The risk or severity of adverse effects can be increased when Metaxalone is combined with Brivaracetam.
Pimavanserin Pimavanserin The risk or severity of adverse effects can be increased when Metaxalone is combined with Pimavanserin.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of adverse effects can be increased when Metaxalone is combined with Diphenhydramine.
Furosemide Injection Furosemide Injection Metaxalone may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Lixisenatide Injection Lixisenatide Injection Metaxalone may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Doxepin (Insomnia) Doxepin (Insomnia) Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Doxepin.
Deutetrabenazine Deutetrabenazine Metaxalone may decrease the excretion rate of Deutetrabenazine which could result in a higher serum level.
Valbenazine Valbenazine Metaxalone may decrease the excretion rate of Valbenazine which could result in a higher serum level.
Safinamide Safinamide The risk or severity of adverse effects can be increased when Metaxalone is combined with Safinamide.
Naldemedine Naldemedine Metaxalone may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Benznidazole Benznidazole Metaxalone may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Delafloxacin Delafloxacin Metaxalone may decrease the excretion rate of Delafloxacin which could result in a higher serum level.
Ertugliflozin Ertugliflozin Ertugliflozin may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Buprenorphine Injection Buprenorphine Injection Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Buprenorphine.
Apalutamide Apalutamide Metaxalone may decrease the excretion rate of Apalutamide which could result in a higher serum level.
Baricitinib Baricitinib Metaxalone may decrease the excretion rate of Baricitinib which could result in a higher serum level.
Lofexidine Lofexidine The therapeutic efficacy of Metaxalone can be increased when used in combination with Lofexidine.
Plazomicin Injection Plazomicin Injection Metaxalone may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol Cannabidiol The risk or severity of adverse effects can be increased when Cannabidiol is combined with Metaxalone.
Stiripentol Stiripentol The risk or severity of adverse effects can be increased when Metaxalone is combined with Stiripentol.
Prucalopride Prucalopride Metaxalone may decrease the excretion rate of Prucalopride which could result in a higher serum level.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Brexanolone Injection Brexanolone Injection The risk or severity of adverse effects can be increased when Metaxalone is combined with Brexanolone.
Solriamfetol Solriamfetol The risk or severity of adverse effects can be increased when Metaxalone is combined with Solriamfetol.
Pitolisant Pitolisant Metaxalone may decrease the excretion rate of Pitolisant which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The risk or severity of adverse effects can be increased when Phenytoin is combined with Metaxalone.
Fosphenytoin Injection Fosphenytoin Injection The risk or severity of adverse effects can be increased when Metaxalone is combined with Fosphenytoin.
Lumateperone Lumateperone The risk or severity of adverse effects can be increased when Metaxalone is combined with Lumateperone.
Lasmiditan Lasmiditan The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Lasmiditan.
Lemborexant Lemborexant The risk or severity of adverse effects can be increased when Metaxalone is combined with Lemborexant.
Fenfluramine Fenfluramine The risk or severity of serotonin syndrome can be increased when Fenfluramine is combined with Metaxalone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine The risk or severity of adverse effects can be increased when Metaxalone is combined with Viloxazine.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Fenoprofen Fenoprofen Fenoprofen may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid Mefenamic acid may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Naproxen Naproxen Naproxen may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Tolmetin Tolmetin Tolmetin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Sulindac Sulindac Sulindac may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Trazodone Trazodone The risk or severity of serotonin syndrome can be increased when Trazodone is combined with Metaxalone.
Isotretinoin Isotretinoin Metaxalone may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate Sucralfate Sucralfate may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Floxuridine Floxuridine Floxuridine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Phenobarbital Phenobarbital The risk or severity of adverse effects can be increased when Metaxalone is combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection Methotrexate may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Levorphanol Levorphanol The risk or severity of respiratory depression can be increased when Levorphanol is combined with Metaxalone.
Primidone Primidone The risk or severity of adverse effects can be increased when Metaxalone is combined with Primidone.
Methsuximide Methsuximide The risk or severity of adverse effects can be increased when Metaxalone is combined with Methsuximide.
Diethylpropion Diethylpropion The risk or severity of adverse effects can be increased when Metaxalone is combined with Diethylpropion.
Chlorpromazine Chlorpromazine Chlorpromazine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Diazepam Diazepam The risk or severity of adverse effects can be increased when Metaxalone is combined with Diazepam.
Oxazepam Oxazepam The risk or severity of adverse effects can be increased when Metaxalone is combined with Oxazepam.
Flurazepam Flurazepam The risk or severity of adverse effects can be increased when Metaxalone is combined with Flurazepam.
Clorazepate Clorazepate The risk or severity of adverse effects can be increased when Clorazepic acid is combined with Metaxalone.
Lorazepam Lorazepam The risk or severity of adverse effects can be increased when Lorazepam is combined with Metaxalone.
Carmustine Carmustine Carmustine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Amantadine Amantadine The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Amantadine.
Codeine Codeine The risk or severity of adverse effects can be increased when Codeine is combined with Metaxalone.
Meprobamate Meprobamate The risk or severity of adverse effects can be increased when Meprobamate is combined with Metaxalone.
Chlordiazepoxide Chlordiazepoxide The risk or severity of adverse effects can be increased when Chlordiazepoxide is combined with Metaxalone.
Bromocriptine Bromocriptine The risk or severity of adverse effects can be increased when Metaxalone is combined with Bromocriptine.
Tranylcypromine Tranylcypromine The risk or severity of adverse effects can be increased when Metaxalone is combined with Tranylcypromine.
Phenelzine Phenelzine The risk or severity of adverse effects can be increased when Metaxalone is combined with Phenelzine.
Procarbazine Procarbazine The risk or severity of adverse effects can be increased when Metaxalone is combined with Procarbazine.
Ergoloid Mesylates Ergoloid Mesylates The risk or severity of adverse effects can be increased when Metaxalone is combined with Ergoloid mesylate.
Tetracycline Tetracycline Metaxalone may decrease the excretion rate of Tetracycline which could result in a higher serum level.
Minocycline Minocycline Minocycline may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Prochlorperazine Prochlorperazine The risk or severity of adverse effects can be increased when Prochlorperazine is combined with Metaxalone.
Thioridazine Thioridazine The risk or severity of adverse effects can be increased when Metaxalone is combined with Thioridazine.
Trifluoperazine Trifluoperazine The risk or severity of adverse effects can be increased when Metaxalone is combined with Trifluoperazine.
Bleomycin Bleomycin Bleomycin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Sulfadiazine Sulfadiazine Sulfadiazine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Oxycodone Oxycodone The risk or severity of respiratory depression can be increased when Oxycodone is combined with Metaxalone.
Methadone Methadone The risk or severity of adverse effects can be increased when Methadone is combined with Metaxalone.
Oxybutynin Oxybutynin Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Oxybutynin.
Benztropine Benztropine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Benzatropine.
Maprotiline Maprotiline Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Maprotiline.
Ibuprofen Ibuprofen Ibuprofen may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Trihexyphenidyl Trihexyphenidyl Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Trihexyphenidyl.
Orphenadrine Orphenadrine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Orphenadrine.
Perphenazine Perphenazine The risk or severity of adverse effects can be increased when Metaxalone is combined with Perphenazine.
Azathioprine Azathioprine Metaxalone may decrease the excretion rate of Azathioprine which could result in a higher serum level.
Fluphenazine Fluphenazine The risk or severity of adverse effects can be increased when Fluphenazine is combined with Metaxalone.
Phentermine Phentermine The risk or severity of serotonin syndrome can be increased when Phentermine is combined with Metaxalone.
Methylphenidate Methylphenidate Methylphenidate may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Amoxapine Amoxapine The risk or severity of adverse effects can be increased when Amoxapine is combined with Metaxalone.
Sulfasalazine Sulfasalazine Sulfasalazine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Carbamazepine Carbamazepine Metaxalone may decrease the excretion rate of Carbamazepine which could result in a higher serum level.
Molindone Molindone The risk or severity of adverse effects can be increased when Metaxalone is combined with Molindone.
Methyldopa Methyldopa Metaxalone may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine Clonidine The risk or severity of sedation can be increased when Clonidine is combined with Metaxalone.
Hydralazine Hydralazine Metaxalone may decrease the excretion rate of Hydralazine which could result in a higher serum level.
Cimetidine Cimetidine Cimetidine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Warfarin Warfarin Metaxalone may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam The risk or severity of adverse effects can be increased when Metaxalone is combined with Clonazepam.
Promethazine Promethazine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Promethazine.
Meclofenamate Meclofenamate Meclofenamic acid may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Nitrofurantoin Nitrofurantoin Metaxalone may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Digoxin Digoxin Metaxalone may decrease the excretion rate of Digoxin which could result in a higher serum level.
Loxapine Loxapine The risk or severity of adverse effects can be increased when Loxapine is combined with Metaxalone.
Chloroquine Chloroquine Chloroquine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Quinine Quinine The risk or severity of adverse effects can be increased when Quinine is combined with Metaxalone.
Ethosuximide Ethosuximide The risk or severity of adverse effects can be increased when Ethosuximide is combined with Metaxalone.
Triamterene Triamterene Triamterene may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Chlorothiazide Chlorothiazide Chlorothiazide may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone Metolazone Metolazone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The risk or severity of adverse effects can be increased when Secobarbital is combined with Metaxalone.
Desipramine Desipramine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Desipramine.
Amitriptyline Amitriptyline Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Amitriptyline.
Imipramine Imipramine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Imipramine.
Probenecid Probenecid Metaxalone may decrease the excretion rate of Probenecid which could result in a higher serum level.
Quinidine Quinidine Metaxalone may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Metaxalone may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Isoniazid.
Pyrazinamide Pyrazinamide Pyrazinamide may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Disopyramide Disopyramide Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Disopyramide.
Valproic Acid Valproic Acid The risk or severity of adverse effects can be increased when Valproic acid is combined with Metaxalone.
Butabarbital Butabarbital The risk or severity of adverse effects can be increased when Butabarbital is combined with Metaxalone.
Liothyronine Liothyronine Liothyronine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methimazole Methimazole Metaxalone may decrease the excretion rate of Methimazole which could result in a higher serum level.
Chlorpropamide Chlorpropamide Metaxalone may decrease the excretion rate of Chlorpropamide which could result in a higher serum level.
Tolbutamide Tolbutamide Metaxalone may decrease the excretion rate of Tolbutamide which could result in a higher serum level.
Tolazamide Tolazamide Metaxalone may decrease the excretion rate of Tolazamide which could result in a higher serum level.
Dextromethorphan Dextromethorphan The risk or severity of adverse effects can be increased when Dextromethorphan is combined with Metaxalone.
Cyclobenzaprine Cyclobenzaprine The risk or severity of CNS depression can be increased when Metaxalone is combined with Cyclobenzaprine.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Metaxalone.
Doxylamine Doxylamine Doxylamine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Cyproheptadine Cyproheptadine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Cyproheptadine.
Clemastine Clemastine The risk or severity of adverse effects can be increased when Clemastine is combined with Metaxalone.
Chlorpheniramine Chlorpheniramine The risk or severity of adverse effects can be increased when Metaxalone is combined with Chlorpheniramine.
Brompheniramine Brompheniramine The risk or severity of adverse effects can be increased when Dexbrompheniramine is combined with Metaxalone.
Meclizine Meclizine The risk or severity of adverse effects can be increased when Metaxalone is combined with Meclizine.
Ethambutol Ethambutol Ethambutol may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methyclothiazide Methyclothiazide Methyclothiazide may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Dantrolene Dantrolene The risk or severity of adverse effects can be increased when Metaxalone is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The risk or severity of adverse effects can be increased when Chlorzoxazone is combined with Metaxalone.
Carisoprodol Carisoprodol The risk or severity of adverse effects can be increased when Carisoprodol is combined with Metaxalone.
Methocarbamol Methocarbamol The risk or severity of adverse effects can be increased when Methocarbamol is combined with Metaxalone.
Pyridoxine Pyridoxine Pyridoxine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Folic Acid Folic Acid Folic acid may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Propranolol may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Pseudoephedrine Pseudoephedrine The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Pseudoephedrine.
Nortriptyline Nortriptyline The risk or severity of adverse effects can be increased when Nortriptyline is combined with Metaxalone.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Phytonadione Phytonadione Metaxalone may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Nadolol Nadolol Metaxalone may decrease the excretion rate of Nadolol which could result in a higher serum level.
Butorphanol Injection Butorphanol Injection The risk or severity of respiratory depression can be increased when Butorphanol is combined with Metaxalone.
Nalbuphine Injection Nalbuphine Injection The risk or severity of respiratory depression can be increased when Nalbuphine is combined with Metaxalone.
Allopurinol Allopurinol Allopurinol may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Trimethobenzamide Trimethobenzamide The risk or severity of adverse effects can be increased when Metaxalone is combined with Trimethobenzamide.
Flavoxate Flavoxate Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Flavoxate.
Colchicine Colchicine Metaxalone may decrease the excretion rate of Colchicine which could result in a higher serum level.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Dacarbazine Dacarbazine Metaxalone may decrease the excretion rate of Dacarbazine which could result in a higher serum level.
Acetazolamide Acetazolamide The risk or severity of adverse effects can be increased when Metaxalone is combined with Acetazolamide.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Pyrantel Pyrantel The risk or severity of adverse effects can be increased when Metaxalone is combined with Pyrantel.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Hydroxyzine Hydroxyzine Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Metaxalone.
Thiothixene Thiothixene The risk or severity of adverse effects can be increased when Metaxalone is combined with Thiothixene.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Salsalate Salsalate Salsalate may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Alprazolam Alprazolam The risk or severity of adverse effects can be increased when Alprazolam is combined with Metaxalone.
Temazepam Temazepam The risk or severity of adverse effects can be increased when Temazepam is combined with Metaxalone.
Triazolam Triazolam The risk or severity of adverse effects can be increased when Metaxalone is combined with Triazolam.
Dicyclomine Dicyclomine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Dicyclomine.
Hyoscyamine Hyoscyamine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Hyoscyamine.
Propantheline Propantheline Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Propantheline.
Trimethoprim Trimethoprim Trimethoprim may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Nifedipine Nifedipine Metaxalone may decrease the excretion rate of Nifedipine which could result in a higher serum level.
Timolol Timolol Timolol may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Verapamil Verapamil Metaxalone may decrease the excretion rate of Verapamil which could result in a higher serum level.
Pindolol Pindolol The risk or severity of adverse effects can be increased when Metaxalone is combined with Pindolol.
Cisplatin Injection Cisplatin Injection Metaxalone may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal Diflunisal may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Piroxicam Piroxicam Piroxicam may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Bumetanide Bumetanide Metaxalone may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Glipizide Glipizide Metaxalone may decrease the excretion rate of Glipizide which could result in a higher serum level.
Indapamide Indapamide Metaxalone may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin Amoxicillin Metaxalone may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Oxacillin Injection Oxacillin Injection Metaxalone may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline Pentoxifylline Metaxalone may decrease the excretion rate of Pentoxifylline which could result in a higher serum level.
Pentamidine Injection Pentamidine Injection Pentamidine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Labetalol Labetalol Labetalol may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Auranofin Auranofin Metaxalone may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection Leuprolide Injection Leuprolide may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Gemfibrozil Gemfibrozil Metaxalone may decrease the excretion rate of Gemfibrozil which could result in a higher serum level.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Ketoprofen Ketoprofen Ketoprofen may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Pimozide Pimozide The risk or severity of adverse effects can be increased when Metaxalone is combined with Pimozide.
Flurbiprofen Flurbiprofen Flurbiprofen may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Aztreonam Injection Aztreonam Injection Aztreonam may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Buspirone Buspirone The risk or severity of serotonin syndrome can be increased when Buspirone is combined with Metaxalone.
Ciprofloxacin Ciprofloxacin Ciprofloxacin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Mesalamine Mesalamine Mesalazine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Diclofenac Diclofenac Diclofenac may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Fluoxetine Fluoxetine The risk or severity of serotonin syndrome can be increased when Metaxalone is combined with Fluoxetine.
Clozapine Clozapine The risk or severity of adverse effects can be increased when Clozapine is combined with Metaxalone.
Estazolam Estazolam The risk or severity of adverse effects can be increased when Metaxalone is combined with Estazolam.
Didanosine Didanosine Metaxalone may decrease the excretion rate of Didanosine which could result in a higher serum level.
Pentostatin Injection Pentostatin Injection Pentostatin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Etodolac Etodolac Etodolac may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Fosinopril Fosinopril Fosinopril may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Nabumetone Nabumetone Nabumetone may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Lisinopril Lisinopril Metaxalone may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin Oxaprozin Oxaprozin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Bisoprolol Bisoprolol Bisoprolol may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Zolpidem Zolpidem Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Zolpidem.
Isradipine Isradipine Isradipine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cisapride Cisapride The risk or severity of adverse effects can be increased when Cisapride is combined with Metaxalone.
Gabapentin Gabapentin The risk or severity of adverse effects can be increased when Metaxalone is combined with Gabapentin.
Venlafaxine Venlafaxine The risk or severity of adverse effects can be increased when Venlafaxine is combined with Metaxalone.
Fluvoxamine Fluvoxamine The risk or severity of adverse effects can be increased when Metaxalone is combined with Fluvoxamine.
Nefazodone Nefazodone The risk or severity of adverse effects can be increased when Metaxalone is combined with Nefazodone.
Lamotrigine Lamotrigine The risk or severity of adverse effects can be increased when Lamotrigine is combined with Metaxalone.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Tramadol Tramadol The risk or severity of serotonin syndrome can be increased when Tramadol is combined with Metaxalone.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Ifosfamide Injection Ifosfamide Injection Metaxalone may decrease the excretion rate of Ifosfamide which could result in a higher serum level.
Nicardipine Nicardipine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Nicardipine.
Bupropion Bupropion The risk or severity of adverse effects can be increased when Metaxalone is combined with Bupropion.
Ticlopidine Ticlopidine Ticlopidine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Metformin Metformin Metformin may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Nisoldipine Nisoldipine Nisoldipine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Lamivudine Lamivudine Metaxalone may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole Riluzole The risk or severity of adverse effects can be increased when Metaxalone is combined with Riluzole.
Acarbose Acarbose Acarbose may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Meropenem Injection Meropenem Injection Metaxalone may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine Clomipramine The risk or severity of adverse effects can be increased when Metaxalone is combined with Clomipramine.
Fosfomycin Fosfomycin Metaxalone may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine Mirtazapine Metaxalone may increase the serotonergic activities of Mirtazapine.
Topiramate Topiramate The risk or severity of adverse effects can be increased when Topiramate is combined with Metaxalone.
Pramipexole Pramipexole Metaxalone may increase the sedative activities of Pramipexole.
Donepezil Donepezil The risk or severity of adverse effects can be increased when Metaxalone is combined with Donepezil.
Nilutamide Nilutamide Metaxalone may decrease the excretion rate of Nilutamide which could result in a higher serum level.
Flutamide Flutamide Flutamide may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Selegiline Selegiline The risk or severity of adverse effects can be increased when Metaxalone is combined with Selegiline.
Sertraline Sertraline The risk or severity of adverse effects can be increased when Metaxalone is combined with Sertraline.
Tamsulosin Tamsulosin Metaxalone may decrease the excretion rate of Tamsulosin which could result in a higher serum level.
Ropinirole Ropinirole Metaxalone may increase the sedative activities of Ropinirole.
Quetiapine Quetiapine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Cetirizine Cetirizine The risk or severity of adverse effects can be increased when Cetirizine is combined with Metaxalone.
Paroxetine Paroxetine The risk or severity of adverse effects can be increased when Metaxalone is combined with Paroxetine.
Tolcapone Tolcapone The risk or severity of adverse effects can be increased when Tolcapone is combined with Metaxalone.
Citalopram Citalopram The risk or severity of adverse effects can be increased when Metaxalone is combined with Citalopram.
Capecitabine Capecitabine Metaxalone may decrease the excretion rate of Capecitabine which could result in a higher serum level.
Efavirenz Efavirenz The risk or severity of adverse effects can be increased when Efavirenz is combined with Metaxalone.
Abacavir Abacavir Metaxalone may decrease the excretion rate of Abacavir which could result in a higher serum level.
Celecoxib Celecoxib Celecoxib may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Rosiglitazone Rosiglitazone Rosiglitazone may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Tolterodine Tolterodine Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Tolterodine.
Thalidomide Thalidomide Metaxalone may increase the central nervous system depressant (CNS depressant) activities of Thalidomide.
Oseltamivir Oseltamivir Oseltamivir may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Balsalazide Balsalazide Balsalazide may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Nateglinide Nateglinide Metaxalone may decrease the excretion rate of Nateglinide which could result in a higher serum level.
Levetiracetam Levetiracetam The risk or severity of adverse effects can be increased when Metaxalone is combined with Levetiracetam.
Rabeprazole Rabeprazole Metaxalone may decrease the excretion rate of Rabeprazole which could result in a higher serum level.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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