Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Propadrol EP Ingredients & Drug Interactions

by EST

Propadrol EP label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Propadrol EP against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Propadrol EP is a dietary supplement by EST with 4 active ingredients. Its ingredients are commonly taken for chronic venous insufficiency, hemorrhoids, leg swelling and heaviness.Based on those ingredients, 888 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are 3,5,7-Trihydroxy-4 Methoxyflavone, 7-Methoxy-2-Phenyl-4H-Chromen-One. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Propadrol EP by EST

Ask about any prescription or over-the-counter medication and we check it for interactions with Propadrol EP by EST — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Propadrol EP by EST

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 4 active ingredients.
  • “Proprietary Propadrol Blend” is a proprietary blend — the label gives one combined amount (200 mg) without saying how much of each component you get.
  • “Methyl-2A” is listed as a grouped ingredient — the label gives one combined amount (3 Gram(s)) without saying how much of each component you get.

Propadrol EP contains 4 active ingredients. The main one is diosmin (also called 3,5,7-Trihydroxy-4 Methoxyflavone), a plant compound used to support vein and circulatory health.

The other actives are 7-methoxyflavone, D-Aspartic Acid, and N-Methyl-D-Asparate. The product also contains inactive ingredients — magnesium stearate, gelatin, FD&C Blue #1, and titanium dioxide — which serve as binders, capsule material, and colorants.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed

This product doesn't appear to be marketed for a specific use, so we graded its ingredients' overall clinical evidence instead.

Moderate

Some clinical evidence supports its ingredients for:

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.
  • Since the label doesn't commit to one use, we graded the ingredients' overall clinical evidence instead.
  • On file: Chronic venous insufficiency (CVI) — rated "Possibly Effective" (Diosmin) (Natural Medicines).
  • On file: Hemorrhoids — rated "Possibly Effective" (Diosmin) (Natural Medicines).
  • On file: Venous leg ulcers — rated "Possibly Effective" (Diosmin) (Natural Medicines).

Diosmin is possibly effective for chronic venous insufficiency (poor blood flow in the veins of the legs), venous leg ulcers, and hemorrhoids, based on clinical evidence. The evidence for back pain and diabetic nerve pain (diabetic neuropathy) is insufficient — we don't have enough reliable data to say whether it works for those.

The effectiveness of 7-methoxyflavone, D-Aspartic Acid, and N-Methyl-D-Asparate has not been established in the data we hold.

The evidence, ingredient by ingredient Diosmin 7-methoxyflavone

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 1 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diosmin is generally well tolerated in short-term use, though long-term safety is less well studied. The most common side effects are abdominal pain, diarrhea, dizziness, gastritis, nausea, and skin inflammation or redness.

Rare serious effects include cardiac arrhythmias (irregular heartbeat) and hemolytic anemia (breakdown of red blood cells). 7-Methoxyflavone has very limited human safety data — it cannot be called clearly safe, and it may have hormonal effects, so it should be avoided pending more research.

No adverse-effect data are on file for D-Aspartic Acid or N-Methyl-D-Asparate.

Side effects, ingredient by ingredient Diosmin 7-methoxyflavone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Diosmin, 7-methoxyflavone.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 889 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before starting Propadrol EP, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (like warfarin, aspirin, clopidogrel) — diosmin may raise bleeding risk. Also double-check nonsteroidal anti-inflammatory drugs (NSAIDs like diclofenac), muscle relaxants like chlorzoxazone, seizure medications like carbamazepine, testosterone therapy, or aromatase inhibitors (used for breast cancer).

The product may increase levels or effects of these drugs.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence behind its ingredients' uses. Moderate medication interactions have been identified, and some safety-information gaps remain.

This product is mainly diosmin, which has solid evidence for circulatory and vein conditions. However, its moderate interactions with blood thinners, common pain relievers, seizure drugs, and hormone therapies make it important to review your exact medications before starting.

The 7-methoxyflavone ingredient lacks safety data and may affect hormones. Talk with your doctor or pharmacist before taking Propadrol EP if you're on any regular medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Propadrol EP, straight from the product label.

Brand EST
Barcode (UPC) 895524000625
Net contents 120 Capsule(s)
Market status On market
Date entered into DSLD Nov 25, 2011
DSLD ID 1965
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Propadrol EP by EST, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Capsule(s)
Maximum serving Sizes:
4 Capsule(s)
Servings per container
30
UPC/BARCODE
895524000625
IngredientAmount% DV
D-Aspartic Acid0 NP--
3,5,7-Trihydroxy-4 Methoxyflavone0 NP--
Proprietary Propadrol Blend200 mg--
7-Methoxy-2-Phenyl-4H-Chromen-One0 NP--
Methyl-2A3 Gram(s)--
N-Methyl-D-Asparate0 NP--

Other ingredients: Magnesium Stearate, Gelatin, FD&C Blue #1, Ti02

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Do not exceed recommended dose.

Suggested Use: Take four (4) capsules once daily. DO NOT exceed recommended dose. Use only for a period of 30 days. Wait 90 days prior to using the product again.

Use only as directed.

Precautions

Keep out of reach of children.

Warning: Do not use if you are pregnant or nursing, or at risk for high blood pressure, liver, prostate, diabetes, or psychiatric disease.

Do not purchase if seal is broken

Do not use this product if under the age of 18.

If you have any medical condition, seek professional medical advice before taking this or any supplement.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

Protect from heat, light and moisture.

Store at 15º-30ºC(59º-86º F)

General Statements

3.2 g

5 Alpha Reductase Inhibitor

Anti-Aromatase/Testosterone Inducer

ENGINEERED SPORTS TECHNOLOGY

Fortified with Methyl-2a

Pharmacokinectically designed to Induce Free Testosterone Promotes 5 Alpha Reductase Inhibitation Promotes Sexual Vigor Fortified with Methyl-2a for Enhanced Optimization

There are no typical results with use of this product.

General

Product Code: 305

Brand IP Statement(s)

Elite Performance Series(TM)

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Propadrol EP by EST label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Propadrol EP label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Propadrol EP by EST

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Propadrol Blend

200 mg per serving

Methyl-2A

3 Gram(s) per serving
  • › D-Aspartic Acid
  • › N-Methyl-D-Asparate

Other (inactive) ingredients: Magnesium Stearate, Gelatin, FD&C Blue #1, Ti02. These complete the product’s ingredient list but are not active constituents.

Interaction report

Propadrol EP by EST Drug Interactions

Want to check YOUR meds against Propadrol EP?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
888Drugs
888 Moderate

Ingredients driving the most interactions

3,5,7-Trihydroxy-4 Methoxyflavone 884
7-Methoxy-2-Phenyl-4H-Chromen-One 12

Individual Drug Interactions

The ingredients in Propadrol EP interact with 888 drugs. Click any drug to see the details.

2 of the 4 ingredients in Propadrol EP interact with drugs. Each result below shows which ingredient is responsible. 3,5,7-Trihydroxy-4 Methoxyflavone 7-Methoxy-2-Phenyl-4H-Chromen-One

Each ingredient & the kinds of drugs it affects

For each ingredient in Propadrol EP with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

3,5,7-Trihydroxy-4 Methoxyflavone9 drug types · 884 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, diosmin may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
A case of spontaneous intraventricular hemorrhage has been reported for a 77-year-old female after 6 weeks of warfarin therapy, despite an international normalized ratio (INR) of only 1.8. The patient had also been taking aspirin and diosmin for several years. Experts speculate that chronic intake of diosmin predisposed the patient to spontaneous intraventricular hemorrhage by inducing chronic microcirculatory hypertension and inhibiting platelet aggregation. The presence of aspirin was also thought to play a role in this event.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, diosmin might reduce the effects of carbamazepine and increase the risk for convulsions.
A pharmacokinetic study in humans shows that taking diosmin (Venex) 500 mg daily for 10 days prior to oral administration of carbamazepine 200 mg increases blood levels of carbamazepine by approximately 58% and decreases carbamazepine clearance by 42%. It also decreases the formation of carbamazepine's active metabolite. It is speculated that diosmin reduces the metabolism of carbamazepine by inhibiting cytochrome P450 3A4 (CYP3A4).

Likelihood Probable Evidence B
Chlorzoxazone (Parafon Forte, Paraflex)

Theoretically, diosmin might increase the levels and clinical effects of chlorzoxazone.
A pharmacokinetic study in humans shows that taking diosmin (Venex 500) 500 mg daily for 9 days prior to oral administration of chlorzoxazone 250 mg increases blood levels of chlorzoxazone by 53% and decreases chlorzoxazone clearance by 40%. It is speculated that diosmin reduces the metabolism of chlorzoxazone by inhibiting cytochrome P450 2E1 (CYP2E1).

Likelihood Probable Evidence B
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, diosmin might inhibit the metabolism of CYP2C9 substrates.
Diclofenac is metabolized by CYP2C9 enzymes. Clinical and laboratory research shows that diosmin inhibits the metabolism of diclofenac. A pharmacokinetic study in humans shows that taking diosmin (Venex 500) 500 mg daily for 9 days prior to oral administration of diclofenac 100 mg increases blood levels of diclofenac and decreases diclofenac clearance.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, diosmin might inhibit the metabolism of CYP2E1 substrates.
Chlorzoxazone is metabolized by CYP2E1 enzymes. A pharmacokinetic study in humans shows that taking diosmin (Venex 500) 500 mg daily for 9 days prior to oral administration of chlorzoxazone (Paraflex 250) 250 mg increases blood levels of chlorzoxazone by 34% and decreases chlorzoxazone clearance by 40%. It is speculated that diosmin reduces the metabolism of chlorzoxazone by inhibiting CYP2E1.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, diosmin might inhibit the metabolism of CYP3A4 substrates.
Laboratory research is conflicting with respect to the effects of diosmin on CYP3A4. Some research suggests that diosmin does not affect CYP3A4 activity. However, other research suggests that diosmin alters the metabolism of carbamazepine, a CYP3A4 substrate. Laboratory and animal research show that oral administration of diosmin for 7 days prior to oral administration of carbamazepine increases plasma concentrations of carbamazepine, decreases the clearance of carbamazepine, and decreases the formation of carbamazepine's active metabolite. Additionally, pharmacokinetic research in healthy male subjects shows that taking diosmin (Venex) 500 mg daily for 10 days prior to oral administration of carbamazepine 200 mg increases blood levels of carbamazepine by approximately 58% and decreases carbamazepine clearance by 42%. It is speculated that diosmin reduces the metabolism of carbamazepine by inhibiting CYP3A4. Diosmetin, a metabolite of diosmin, may also inhibit CYP3A4.

Likelihood Possible Evidence B
Diclofenac (Voltaren, Others)

Theoretically, diosmin might increase the levels and clinical effects of diclofenac.
Clinical and laboratory research shows that diosmin inhibits the metabolism of diclofenac. A pharmacokinetic study in humans shows that taking diosmin (Venex 500) 500 mg daily for 9 days prior to oral administration of diclofenac 100 mg increases blood levels of diclofenac and decreases diclofenac clearance. It is speculated that diosmin reduces the metabolism of diclofenac by inhibiting cytochrome P450 2C9 (CYP2C9).

Likelihood Probable Evidence B
Fexofenadine (Allegra)

Theoretically, diosmin might increase the levels and clinical effects of fexofenadine.
A pharmacokinetic study in humans shows that taking diosmin (Venex) 500 mg daily for 10 days prior to oral administration of fexofenadine 120 mg increases blood levels of fexofenadine by approximately 49% and decreases the apparent oral clearance of fexofenadine by 41%. The time taken to reach maximum plasma concentration, the half-life, and the apparent renal clearance of fexofenadine are not affected. For this reason, it is speculated that diosmin alters the pharmacokinetics of fexofenadine via inhibition of P-glycoprotein in the intestine, but not in the kidney or liver.

Likelihood Probable Evidence B
P-Glycoprotein Substrates

Theoretically, diosmin might increase levels of drugs that are substrates of P-glycoprotein (P-gp).
Preliminary laboratory research suggests that diosmin inhibits P-gp. Additionally, pharmacokinetic research in healthy male subjects shows that taking diosmin (Venex) 500 mg daily for 10 days prior to oral administration of fexofenadine 120 mg increases blood levels of fexofenadine, a P-gp substrate, by approximately 49% and decreases the apparent oral clearance of fexofenadine by 41%. The time taken to reach maximum plasma concentration, the half-life, and the apparent renal clearance of fexofenadine are not affected. For this reason, it is speculated that diosmin inhibits P-gp in the intestine, but not in the kidney or liver.

Likelihood Possible Evidence D
3,5,7-Trihydroxy-4 Methoxyflavone full monograph & interactions

7-Methoxy-2-Phenyl-4H-Chromen-One2 drug types · 12 drugs

Aromatase Inhibitors

In vitro evidence shows that 7-methoxyflavone inhibits aromatase. Theoretically, 7-methoxyflavone might have an additive effects when used with other aromatase inhibitors, potentially increasing the therapeutic effects and adverse effects associated with these drugs. Some aromatase inhibitors include anastrozole (Arimidex), exemestane (Aromasin), and letrozole (Femara).

Likelihood Possible Evidence D
Testosterone

In vitro evidence shows that 7-methoxyflavone inhbits aromatase. Inhibiting aromatase reduces the conversion of testosterone and other androgens to estrogens. Theoretically, use of 7-methoxyflavone with testosterone might increase the effects and side effects of testosterone therapy.

Likelihood Possible Evidence D
7-Methoxy-2-Phenyl-4H-Chromen-One full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Propadrol EP, from the product label.

EST

See all EST products
Phone Number
866.GET.EST.1
Pharmacist Counseling Corner

Propadrol EP by EST: Common Questions

Does Propadrol EP by EST interact with any medications?
Yes. Based on its ingredients, Propadrol EP has a known interaction with 888 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Propadrol EP contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is Propadrol EP safe to take long-term?
Diosmin, the main ingredient, is generally well tolerated short-term, but long-term safety hasn't been well studied. The product also contains 7-methoxyflavone, which has very limited human safety data and should be avoided. Talk with your doctor about how long you should take this product.
What are the most common side effects?
The most common side effects from diosmin are abdominal pain, diarrhea, dizziness, gastritis, nausea, and skin redness or inflammation. Rare but serious effects include irregular heartbeat and breakdown of red blood cells. Stop and contact your doctor if you develop any of these.
Can I take this while pregnant or breastfeeding?
Diosmin is rated likely safe or possibly safe in pregnancy and lactation. We don't have safety data on file for the other active ingredients in this product, so talk with your doctor or pharmacist before taking it during pregnancy or while breastfeeding.
Does this product actually work for leg veins and circulation?
Yes — diosmin, the main ingredient, is possibly effective for chronic venous insufficiency, venous leg ulcers, and hemorrhoids. The evidence for back pain or diabetic nerve pain is not strong enough to say whether it works for those.
Why does this product interact with so many medications?
Diosmin slows down several enzyme systems in your liver that break down medications — including CYP2C9, CYP3A4, and CYP2E1. When your body clears drugs more slowly, their levels and effects can build up. Additionally, diosmin may block a protein (P-glycoprotein) that transports some drugs out of cells.
Is it safe to take this with NSAIDs like ibuprofen?
Diosmin may slow the breakdown of certain NSAIDs, particularly diclofenac, raising their levels and side effects. Check with your doctor or pharmacist about your specific pain reliever before starting this product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Propadrol EP label
Go deeper

The Full Monographs Behind Propadrol EP’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diosmin

Interacts with 884 drugs

Diosmin is a citrus-derived flavonoid most often used for vein-related problems such as chronic venous insufficiency and hemorrhoids, and it is usually combined with a related flavonoid call...

Read the full Diosmin monograph → Herb & supplement monograph

7-methoxyflavone

Interacts with 12 drugs

7-Methoxyflavone is a lab-made or plant-derived flavonoid marketed mainly in testosterone-boosting and bodybuilding supplements based on the idea that it blocks the aromatase enzyme. However...

Read the full 7-methoxyflavone monograph →
Sources

Sources & How We Checked

Propadrol EP's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diosmin 20 references
  1. Misra MC, Parshad R. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. Br J Surgery 2000;87:868-72. PubMed
  2. Thanapongsathorn W, Vajrabukka T. Clinical trial of oral diosmin (Daflon) in the treatment of hemorrhoids. Dis Colon Rectum 1992;35:1085-8. PubMed
  3. Cospite M. Double-blind, placebo-controlled evaluation of clinical activity and safety of Daflon 500 mg in the treatment of acute hemorrhoids. Angiology 1994;45:566-73.
  4. Guilhou JJ, Dereure O, Marzin L, et al. Efficacy of Daflon 500 mg in venous leg ulcer healing: a double-blind, randomized, controlled versus placebo trial in 107 patients. Angiology 1997;48:77-85.. PubMed
  5. Cospite, M. and Dominici, A. Double blind study of the pharmacodynamic and clinical activities of 5682 SE in venous insufficiency. Advantages of the new micronized form. Int Angiol. 1989;8(4 Suppl):61-65.
  6. Buckshee, K., Takkar, D., and Aggarwal, N. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. Int J Gynaecol Obstet 1997;57(2):145-151. PubMed
  7. Kumar RM, Van Gompel JJ, Bower R, Rabinstein AA. Spontaneous intraventricular hemorrhage associated with prolonged diosmin therapy. Neurocrit Care. 2011 Jun;14(3):438-40. PubMed
  8. Milano G, Leone S, Fucile C, Zuccoli ML, Stimamiglio A, Martelli A, Mattioli F. Uncommon serum creatine phosphokinase and lactic dehydrogenase increase during diosmin therapy: two case reports. J Med Case Rep. 2014 Jun 16;8:194. PubMed
  9. Rajnarayana K, Venkatesham A, Krishna DR. Bioavailability of diclofenac sodium after pretreatment with diosmin in healthy volunteers. Drug Metabol Drug Interact. 2007;22(2-3):165-74. PubMed
  10. Rajnarayana K, Venkatesham A, Nagulu M, Srinivas M, Krishna DR. Influence of diosmin pretreatment on the pharmacokinetics of chlorzoxazone in healthy male volunteers. Drug Metabol Drug Interact. 2008;23(3-4):311-21. PubMed
  11. Yoo HH, Lee M, Chung HJ, Lee SK, Kim DH. Effects of diosmin, a flavonoid glycoside in citrus fruits, on P-glycoprotein-mediated drug efflux in human intestinal Caco-2 cells. J Agric Food Chem. 2007 Sep 5;55(18):7620-5. PubMed
  12. Bedada SK, Neerati P. Modulation of CYP3A enzyme activity by diosmin and its consequence on carbamazepine pharmacokinetics in rats. Naunyn Schmiedebergs Arch Pharmacol. 2018;391(2):115-21. PubMed
  13. Burkina V, Zlabek V, Halsne R, Ropstad E, Zamaratskaia G. In vitro effects of the citrus flavonoids diosmin, naringenin and naringin on the hepatic drug-metabolizing CYP3A enzyme in human, pig, mouse and fish. Biochem Pharmacol. 2016;110-111:109-16 PubMed
  14. Bedada SK, Boga PK. Influence of diosmin on the metabolism and disposition of carbamazepine in healthy subjects. Xenobiotica. 2017;47(10):879-84. PubMed
  15. Bedada SK, Boga PK, Kotakonda HK. The effect of diosmin on the pharmacokinetics of fexofenadine in healthy human volunteers. Xenobiotica. 2017;47(3):230-35. PubMed
  16. Poór M, Boda G, Mohos V, et al. Pharmacokinetic interaction of diosmetin and silibinin with other drugs: Inhibition of CYP2C9-mediated biotransformation and displacement from serum albumin. Biomed Pharmacother. 2018;102:912-921. PubMed
  17. Gavrilov SG, Karalkin AV, Moskalenko YP, Grishenkova AS. Efficacy of two micronized purified flavonoid fraction dosing regimens in the pelvic venous pain relief. Int Angiol. 2021;40(3):180-186. PubMed
  18. Steinbruch M, Nunes C, Gama R, et al. Is nonmicronized diosmin 600?mg as effective as micronized diosmin 900?mg plus hesperidin 100?mg on chronic venous disease symptoms? Results of a noninferiority study. Int J Vasc Med. 2020;2020:4237204. PubMed
  19. Schastlivtsev I, Lobastov K, Barinov V, Kanzafarova I. Diosmin 600 in adjunction to rivaroxaban reduces the risk of post-thrombotic syndrome after femoropopliteal deep vein thrombosis: results of the RIDILOTT DVT study. Int Angiol. 2020;39(5):361-371. PubMed
  20. Mansilha A, Caldevilla H, Puskás A, Lucien A, Roby L, Kirienko A. MPFF 1000 mg chewable once daily vs. MPFF 500 mg twice daily in chronic venous disease: the double-blind, randomized, non-inferiority CHEWY trial. Int Angiol 2022;41(6):464-475. PubMed

See these in context on the Diosmin monograph →

7-methoxyflavone 1 reference
  1. Ta N, Walle T. Aromatase inhibition by bioavailable flavones. J Steroid Biochem Mol Biol 2007;107(1-2):127-9.

See these in context on the 7-methoxyflavone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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