Herb & supplement monograph

Saccharomyces Boulardii Drug Interactions, Uses, Effectiveness, Safety & More

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS ·Updated July 2026

What is this page for?

First and foremost: how Saccharomyces Boulardii interacts with medications. The heart of this page is the interaction list — every drug Saccharomyces Boulardii is known to interact with, and how serious each one is.

But these pages have grown well beyond that into a full monograph — what Saccharomyces Boulardii is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy

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Saccharomyces Boulardii Drug Interactions: The Bottom Line

From the HelloPharmacist Editorial Team · Updated July 2026

Based on the available evidence, the overall risk of a clinically significant Saccharomyces Boulardii drug interaction appears low for most people. Every interaction on record is rated minor, with none rated moderate or major.

Interactions deserving the most attention

The only concern that stands out involves antifungal medications. Because Saccharomyces boulardii is itself a live yeast, taking an antifungal at the same time could kill many of the probiotic organisms and weaken its benefit. This is a theoretical concern, not one proven in people, and importantly the risk runs toward the supplement losing effect rather than the medication causing harm. Nothing in this profile points to problems with closely monitored medicines like blood thinners or diabetes drugs.

What the rest of the list means

Although a few dozen medications appear on the interaction list, they all fall under this single antifungal concern, and none of them are expected to become more dangerous or less effective because of the probiotic. In short, the long list reflects one theoretical issue applied to many drugs, not many separate risks.

Check your medications against Saccharomyces Boulardii

Based on HelloPharmacist’s Saccharomyces Boulardii interaction data and reviewed under our editorial standards.

Interaction report

Drugs that interact with Saccharomyces Boulardii

40 medications have a known interaction with Saccharomyces Boulardii, graded by severity. Select any drug for the full evidence-based detail.

Don’t want to scroll the list? Just ask.

Tell us the medications you take and we’ll check each one against Saccharomyces Boulardii using our pharmacist-reviewed interaction data.

AI summaries are generated from our Saccharomyces Boulardii interaction data for education only — always confirm with your pharmacist. How we use AI

2,830 drugs

Amphotericin BAbelcet, AmBisome, Amphocil, Amphocin, Fungizone IV

Minor Antifungals