Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Florastor Ingredients & Drug Interactions

by Biocodex

Florastor label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Florastor against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Florastor is a dietary supplement by Biocodex with 2 active ingredients. Its ingredients are commonly taken for acute diarrhea, antibiotic-associated diarrhea, traveler's diarrhea.Based on those ingredients, 40 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Saccharomyces boulardii CNCM 1-745. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Florastor by Biocodex

Ask about any prescription or over-the-counter medication and we check it for interactions with Florastor by Biocodex — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Florastor by Biocodex

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Florastor contains 2 active ingredients: Saccharomyces boulardii CNCM 1-745, a live yeast probiotic, and lactose. The probiotic is the main player here—it's meant to restore helpful microbes in your gut.

The product also includes magnesium stearate and hydroxypropyl methylcellulose as inactive ingredients (binders and capsule material).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: supports immune response and digestive balance.
  • We looked for evidence on: Antibiotic-associated diarrhea, Clostridioides difficile infection, Travelers' diarrhea, Rotaviral diarrhea, Irritable bowel syndrome (IBS), Crohn disease — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Saccharomyces Boulardii is rated "Insufficient Reliable Evidence To Rate" for HIV/AIDS-related diarrhea, Constipation, Crohn disease.

Saccharomyces boulardii in Florastor is rated possibly effective for several types of diarrhea: rotaviral diarrhea, travelers' diarrhea, and diarrhea caused by antibiotics. It's also rated possibly effective for necrotizing enterocolitis (a serious intestinal condition in newborns), Clostridioides difficile infection, and Helicobacter pylori.

These are based on available evidence, though for most of these uses the data isn't yet definitive.

The evidence, ingredient by ingredient Saccharomyces Boulardii

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Saccharomyces boulardii is generally well tolerated in healthy adults, but it should be avoided if you're critically ill or have a weakened immune system—there's a rare risk of the yeast itself entering the bloodstream in those situations, especially if you have a central venous catheter or are on broad-spectrum antibiotics. A small number of people have reported mild gastrointestinal side effects like stomach cramps, gas, nausea, or loss of appetite.

There isn't enough reliable safety data for pregnancy and lactation, so talk with your doctor before using it if you're pregnant or nursing.

Side effects, ingredient by ingredient Saccharomyces Boulardii

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Saccharomyces Boulardii.
  • The most serious interaction on file is rated Minor.
  • For scale: 40 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before taking Florastor if you're on antifungal medications (like fluconazole, terbinafine, or others)—they can reduce the effectiveness of the probiotic by killing the beneficial yeast. No other medication interactions are documented for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.

Florastor is a probiotic option if you're dealing with diarrhea from antibiotics, travel, or certain infections and you're otherwise healthy with a working immune system. Steer clear if you're critically ill or immunocompromised.

If you take antifungal medications, check with your doctor or pharmacist about timing. And if you're pregnant, nursing, or have any other health concerns, confirm it's right for you first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 16, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Florastor, straight from the product label.

Brand Biocodex
Barcode (UPC) 704142000071
Net contents 50 Vegetable Capsule(s)
Market status On market
Date entered into DSLD Jun 16, 2022
DSLD ID 270390
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Florastor by Biocodex, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
50
UPC/BARCODE
704142000071
IngredientAmount% DV
Lactose32.5 mg--
Saccharomyces boulardii CNCM 1-745250 mg--

Other ingredients: Magnesium Stearate, Hydroxypropyl Methylcellulose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Statement of Identity

Daily Probiotic Supplement

Formulation

Unique strain with larger, stronger cells than other probiotics

Supports a immune response Strengthen digestive balance Complements your active lifestyle

100% titanium dioxide free clear capsules

Gluten-free

Vegetarian

Non-GMO

Appropriate for lactose intolerance Be Biotic bi-ot-ic,/bi atik/ Adjective Proactive about health Driven, confident, and strong

Biocodex|USA

Formula

Saccharomyces boulardii lyo CNCM- 1-745

100% titanium dioxide free clear capsules

For men and women

Storage

Do not refrigerate.

Precautions

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Suggested use: 2 capsules 1-2 times daily

General Statements

I strive to be healthy and push myself to hike new heights every day... I am Biotic

1. Swidsinski A, Loening-Baucke V, Verstraelen H, Osowska S, Doerffel Y (2008) Biostructure of fecal microbiota in healthy subjects and patients with chronic idiopathic diarrhea. Gastroenterology: 135(2):568-579. 2. Martins FS, Silva AA, Vieira AT, Barbosa FH, Arantes RM, et al. (2009) Comparative study of Bifidobacterium animalis, Escherichia coli, Lactobacillus casei and Saccharomyces boulardii probiotic properties. Arch Microbiol 191:623-630. 3. Klein SM, Elmer GW, McFarland LV, Surawicz CM, Levy RH (1993) Recovery and elimination of the biotherapeutic agent, Saccharomyces boulardii, in healthy human volunteers. Pharm Res 10:1615-1619. 4. Schneider SM, Girard-Pipau F, Filippi J, Hebuterne X, Moyse D, et al. (2005) Effects of Saccharomyces boulardii on fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition. World J Gastroenterol 11:6165-6169. 5. Buts JP, Bernasconi P, Van Craynest MP, Maldague P, De Meyer R (1986) Response of human and rat small intestinal mucosa to oral administration of Saccharomyces boulardii. Pediatr Res 20:192-196.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Florastor by Biocodex label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Florastor label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Florastor by Biocodex

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lactose

32.5 mg per serving

Saccharomyces boulardii CNCM 1-745

Interacts with
40 drugs
250 mg per serving

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea,...

Saccharomyces boulardii CNCM 1-745 monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Hydroxypropyl Methylcellulose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Florastor by Biocodex Drug Interactions

Want to check YOUR meds against Florastor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
40Drugs
40 Minor

Ingredients driving the most interactions

Saccharomyces boulardii CNCM 1-745 40

Individual Drug Interactions

The ingredients in Florastor interact with 40 drugs. Click any drug to see the details.

1 of the 2 ingredients in Florastor interact with drugs. Each result below shows which ingredient is responsible. Saccharomyces boulardii CNCM 1-745

Each ingredient & the kinds of drugs it affects

For each ingredient in Florastor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Saccharomyces boulardii CNCM 1-7451 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii CNCM 1-745 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Florastor, from the product label.

Biocodex

See all Biocodex products
Name
Biocodex
City
Beauvais
Pharmacist Counseling Corner

Florastor by Biocodex: Common Questions

Does Florastor by Biocodex interact with any medications?
Yes. Based on its ingredients, Florastor has a known interaction with 40 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Florastor contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will Florastor help my antibiotic-associated diarrhea?
Saccharomyces boulardii is rated possibly effective for diarrhea caused by antibiotics. That means the available evidence suggests it may help, though the research isn't definitive yet. Talk to your doctor about whether it's a good fit for your situation.
Can I take Florastor if I'm on an antifungal medication?
You can, but timing matters. Antifungals may reduce how well the probiotic works by killing the yeast organisms. Check with your pharmacist or doctor about the best schedule—they may suggest taking them at different times of day.
Is Florastor safe if I have a weak immune system?
No—it should be avoided if you're critically ill or immunocompromised. There's a rare risk that the yeast could enter your bloodstream in those situations, especially if you have a central line or are on broad-spectrum antibiotics. Talk with your doctor first if you fall into that category.
What side effects might I get from Florastor?
Most people tolerate it well. Rarely, some people report mild stomach upset like cramps, gas, nausea, or loss of appetite. If any of these bother you, stop and let your doctor know.
Is it safe to take Florastor while pregnant or breastfeeding?
There isn't enough reliable safety data to say. Talk with your doctor or pharmacist before taking it if you're pregnant or nursing—they can help you weigh the pros and cons for your situation.
What exactly is Saccharomyces boulardii?
It's a live yeast probiotic—a beneficial microorganism meant to help restore healthy bacteria and yeast balance in your gut. Unlike most probiotics, it's a yeast rather than a bacteria.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Florastor label
Go deeper

The Full Monographs Behind Florastor’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph →
Sources

Sources & How We Checked

Florastor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 26 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
  7. Hennequin C, Thierry A, Richard GF, et al. Microsatellite typing as a new tool for identification of Saccharomyces cerevisiae strains. J Clin Microbiol 2001;39:551-9.
  8. Plein K, Hotz J. Therapeutic effects of Saccharomyces boulardii on mild residual symptoms in a stable phase of Crohn's disease with special respect to chronic diarrhea - a pilot study. Z Gastroenterol 1993;31:129-34.
  9. Borriello SP, Hammes WP, Holzapfel W, et al. Safety of probiotics that contain lactobacilli or bifidobacteria. Clin Infect Dis 2003;36:775-80. PubMed
  10. Marteau P, Seksik P. Tolerance of probiotics and prebiotics. J Clin Gastroenterol 2004;38:S67-9. PubMed
  11. Munoz P, Bouza E, Cuenca-Estrella M, et al. Saccharomyces cerevisiae fungemia: an emerging infectious disease. Clin Infect Dis 2005;40:1625-34. PubMed
  12. Lherm, T., Monet, C., Nougiere, B., Soulier, M., Larbi, D., Le Gall, C., Caen, D., and Malbrunot, C. Seven cases of fungemia with Saccharomyces boulardii in critically ill patients. Intensive Care Med 2002;28(6):797-801. PubMed
  13. Riquelme, A. J., Calvo, M. A., Guzman, A. M., Depix, M. S., Garcia, P., Perez, C., Arrese, M., and Labarca, J. A. Saccharomyces cerevisiae fungemia after Saccharomyces boulardii treatment in immunocompromised patients. J Clin.Gastroenterol. 2003;36(1):41- PubMed
  14. Cherifi, S., Robberecht, J., and Miendje, Y. Saccharomyces cerevisiae fungemia in an elderly patient with Clostridium difficile colitis. Acta Clin Belg. 2004;59(4):223-224. PubMed
  15. Ellouze O, Berthoud V, Mervant M, Parthiot JP, Girard C. Septic shock due to Sacccaromyces boulardii. Med Mal Infect. 2016;46(2):104-105.
  16. Appel-da-Silva MC, Narvaez GA, Perez LRR, Drehmer L, Lewgoy J. Saccharomyces cerevisiae var. boulardii fungemia following probiotic treatment. Med Mycol Case Rep. 2017;18:15-7. PubMed
  17. Atici S, Soysal A, Karadeniz Cerit K, et al. Catheter-related Saccharomyces cerevisiae Fungemia Following Saccharomyces boulardii Probiotic Treatment: In a child in intensive care unit and review of the literature. Med Mycol Case Rep. 2017;15:33-35. PubMed
  18. Martin IW, Tonner R, Trivedi J, et al. Saccharomyces boulardii probiotic-associated fungemia: questioning the safety of this preventive probiotic's use. Diagn Microbiol Infect Dis. 2017;87(3):286-8. PubMed
  19. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr 2017;35(3):361-4.
  20. Roy U, Jessani LG, Rudramurthy SM, et al. Seven cases of Saccharomyces fungaemia related to use of probiotics. Mycoses 2017;60(6):375-380.
  21. Romanio MR, Coraine LA, Maielo VP, Abramczyc ML, Souza RL, Oliveira NF. Saccharomyces cerevisiae fungemia in a pediatric patient after treatment with probiotics. Rev Paul Pediatr. 2017 Jul-Sep;35(3):361-364. doi: 10.1590/1984-0462/;2017;35;3;00014.
  22. Flatley EA, Wilde AM, Nailor MD. Saccharomyces boulardii for the prevention of hospital onset Clostridium difficile infection. J Gastrointestin Liver Dis. 2015;24(1):21-4. PubMed
  23. Ventoulis I, Sarmourli T, Amoiridou P, et al. Bloodstream infection by Saccharomyces cerevisiae in two COVID-19 patients after receiving supplementation of Saccharomyces in the ICU. J Fungi (Basel). 2020;6(3):98. PubMed
  24. Wombwell E, Bransteitter B, Gillen LR. Incidence of Saccharomyces cerevisiae fungemia in hospitalised patients administered Saccharomyces boulardii probiotic. Mycoses 2021;64(12):1521-1526.
  25. Rannikko J, Holmberg V, Karppelin M, et al. Fungemia and Other Fungal Infections Associated with Use of Saccharomyces boulardii Probiotic Supplements. Emerg Infect Dis 2021;27(8):2090-6.
  26. Awoyemi A, Mayerhofer C, Felix AS, et al. Rifaximin or Saccharomyces boulardii in heart failure with reduced ejection fraction: Results from the randomized GutHeart trial. EBioMedicine 2021;70:103511. PubMed

See these in context on the Saccharomyces Boulardii monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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