FDA-filed SPL labeling · retrieved through openFDA

Econazole Topical

Econazole is a topical antifungal used to treat fungal skin infections such as athlete's foot (tinea pedis).

Brand names SpectazoleEcozaEconazole NitrateEconavixZolpak
Drug class ⓘ Azole Antifungal
Rx Forms 2 Route Topical
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 13 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

At a glance
Linked label effectiveOct 31, 2025
Clinical labels in scope ⓘ13
AvailabilityRx
Earliest approval/marketing year ⓘ1982
FDA-listed product records ⓘ33
Boxed warningNone found in compared labels
How we combine label and product data →
✓No current FDA shortage listed · checked Sep 22, 2026
⭐ Econazole Topical at a glance The quick version — the full detail is in the Patient Information Guide below.
💊
HelloPharmacist Editorial Team Bottom Line
Econazole is a well-established topical antifungal used to treat athlete's foot and related fungal skin infections in people 12 and older. Apply it as directed and finish the full course, even if your skin starts looking better sooner. If you take warfarin, be sure your prescriber knows you're using this medication.
How we write & review this content — our editorial policy →

📖 Econazole Topical: Patient Information Guide

A plain-language walkthrough of Econazole Topical — what it treats, how it works, how it’s taken, side effects, warnings and interactions. Tap any section to expand it.

🎯What it's used for▾

Econazole nitrate is a topical antifungal that treats several types of fungal and yeast skin infections. Approved uses vary by product form:

  • Interdigital tinea pedis (athlete's foot between the toes) — supported by both the econazole nitrate cream and the Ecoza topical foam, in patients 12 years and older
  • Tinea cruris (jock itch) — econazole nitrate cream
  • Tinea corporis (ringworm of the body) — econazole nitrate cream
  • Tinea versicolor (patchy skin discoloration from a yeast overgrowth) — econazole nitrate cream
  • Cutaneous candidiasis (skin infection caused by Candida yeast) — econazole nitrate cream
⚙️How it works▾

Econazole is an azole antifungal. It works by blocking a specific fungal enzyme called 14 alpha-lanosterol demethylase — essentially a key tool fungi need to build ergosterol, a crucial component of their cell walls. When ergosterol can't be made, the cell wall breaks down and the fungus can't survive or reproduce. This action is described as fungistatic, meaning it stops fungi from growing rather than instantly killing them, which is why completing the full course of treatment matters.

Econazole has been shown to work against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum — the most common fungi responsible for athlete's foot and related infections.

💊How it's taken▾

Econazole is applied directly to the affected skin. The frequency and length of treatment depend on the type of infection and the product form used:

  • Ecoza foam: applied once daily
  • Econazole nitrate cream: once daily for tinea pedis, tinea cruris, tinea corporis, and tinea versicolor; twice daily (morning and evening) for cutaneous candidiasis

It's important to use econazole for the full prescribed period, even if your skin looks better early on — stopping too soon can allow the infection to come back. Follow your prescriber's instructions closely.

🤒Side effects — in detail▾

Most people tolerate econazole well. The most commonly reported side effects are mild and occur at the site of application:

  • Burning or stinging sensation on the skin
  • Itching at the application site
  • Redness or irritation where it's applied

These reactions were reported in less than 1% of people in clinical trials. If you develop signs of an allergic reaction — such as severe rash, swelling, or trouble breathing — stop using econazole and get medical help right away.

⚠️Warnings & precautions▾
  • Flammable foam: The Ecoza topical foam is flammable. Do not use it near open flames, heat sources, or while smoking. This includes immediately after applying it. Do not puncture or incinerate the canister — even when empty — and store it below 120°F (49°C), away from direct sunlight.
  • Not for eye use: Econazole nitrate cream must not be applied in or around the eyes.
  • Increased absorption with large-area or covered use: Applying econazole to large areas of skin, in the genital region, or under an occlusive dressing (a bandage that seals in moisture) can increase how much of the drug enters your bloodstream. This raises the risk of a drug interaction, particularly with warfarin.
  • No improvement after treatment: If your skin does not get better after completing the full treatment period, contact your doctor — the diagnosis may need to be re-evaluated.
🔀What it interacts with▾

Econazole has one key drug interaction to be aware of:

  • Warfarin (Coumadin): Using econazole at the same time as warfarin — especially on large areas of skin, in the genital area, or under an occlusive dressing — can increase warfarin's blood-thinning effect. This raises the risk of bleeding. If you take warfarin, your doctor may want to check your INR (a blood-clotting measurement) more frequently.

This is not a complete list of interactions. Always talk with your doctor or pharmacist before starting, stopping, or changing any medication.

📋Before taking it▾
  • Allergy: Do not use econazole nitrate cream if you have ever had an allergic reaction to it or any of its ingredients.
  • Pregnancy: There are no well-controlled studies in pregnant women. Use only if your doctor decides the benefit outweighs the potential risk to the baby.
  • Breastfeeding: It is not known if econazole passes into human breast milk. Talk to your doctor before using it while nursing.
  • Children under 12: Econazole has not been established as safe or effective in patients younger than 12 years.
  • Warfarin users: Tell your prescriber you are using econazole, especially if you apply it to large skin areas or in sensitive areas.
  • Older adults: No overall differences in safety or effectiveness were seen between older adults (65+) and younger adults in clinical trials.
🚑If you take too much▾

No cases of econazole overdose in humans have been reported. Because this medication is applied to the skin rather than swallowed, the risk of overdose is very low. If you have concerns about accidental ingestion or overuse, contact Poison Control or your healthcare provider.

🔬Pharmacokinetics — how your body processes it▾

Even though econazole is applied to the skin, small amounts can be absorbed into the bloodstream. In adult studies, people applying econazole nitrate foam once daily for about a month had low but measurable levels in their blood, with peak levels reached roughly 7 hours after application. In teens (ages 12–17) studied for 4 weeks, blood levels were similarly low. The amount absorbed is generally small when the product is used as directed on a limited area of skin.

📦How to store it▾

Store at controlled room temperature 20°C to 25°C (68°F to 77°F) with excursions permitted between 15°C and 30°C (59°F and 86°F). Do not refrigerate or freeze. Avoid heat, flame, and smoking during and immediately following application.

📄 Written from Econazole Topical’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Every point is grounded in that labeling — nothing is invented. How we use AI →

20

Supplements & herbs that interact with Econazole Topical

20 supplements and herbal products have documented interactions with Econazole Topical in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.

Severity mix
  • Major · 1
  • Moderate · 7
  • Minor · 12
ACTIVATED CHARCOAL Major COFFEE CHARCOAL Moderate EUROPEAN MANDRAKE Moderate GLUCOMANNAN Moderate GUAR GUM Moderate GUM ARABIC Moderate SLIPPERY ELM Moderate TRAGACANTH Moderate +12 more
Every supplement checked against Econazole Topical — ranked by severity The full interaction hub: 1 major · 7 moderate · 12 minor · every one linked to its full report. Check Econazole Topical against your exact supplements

Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.

🩺 Pharmacist Counseling Corner

Quick, plain-English answers to the questions patients ask most about Econazole Topical — the kind of thing our pharmacy team would talk through with you at the counter.

What exactly is this medication for? ▾
Econazole is an antifungal cream or foam that you apply to your skin to clear up fungal infections. Depending on which form you have, it can treat athlete's foot (the kind between your toes), jock itch, ringworm, a patchy skin condition called tinea versicolor, or yeast infections of the skin. It's for ages 12 and up.
How long does it take to work, and how long do I need to use it? ▾
Many people notice some relief fairly soon after starting treatment. That said, it's really important to keep going for the full course your doctor recommends — even if your skin looks better earlier. Stopping too soon can allow the infection to bounce back. Depending on the infection, that might mean a couple of weeks or up to a month.
Are there any side effects I should watch for? ▾
Econazole is generally very well tolerated. The most common side effects are mild — a little burning, itching, or redness right where you apply it. Those were reported in less than 1% of people in studies. If you have a more intense reaction like severe skin irritation or swelling, stop using it and call your doctor.
I take warfarin for my heart — is it safe to use econazole at the same time? ▾
This is a good question to flag. Econazole can increase how strong warfarin's blood-thinning effect is, which could raise your risk of bleeding. This is most likely to be a concern if you're applying econazole to a large area of skin or covering it with a bandage. Make sure your prescriber knows you're using econazole, and they may want to check your INR levels more closely while you're using it.
I have the foam version — is there anything special I need to know? ▾
Yes — the foam is flammable, so be careful around open flames, candles, or cigarettes while applying it and for a little while afterward. Store the canister away from heat and out of direct sunlight, and don't puncture or throw it in the trash near a fire, even when it's empty.
Can I use econazole if I'm pregnant or breastfeeding? ▾
There aren't strong safety studies in pregnant women, so your doctor needs to weigh whether the benefit is worth any potential risk. For breastfeeding, it's not known whether econazole passes into breast milk. Either way, have a conversation with your doctor first so you can make the best decision for your situation.
Is Econazole Topical available over the counter? ▾
Econazole Topical is dispensed by prescription according to its FDA labeling, so it isn't sold over the counter. Your prescriber and pharmacist will determine if it's appropriate for you.
When was Econazole Topical first available? ▾
Econazole Topical has been available in the United States since at least 1982, based on FDA approval history (Drugs@FDA) and product marketing records.
Who makes Econazole Topical? ▾
Econazole Topical is supplied by 15 manufacturers listed in the FDA NDC Directory, including Bryant Ranch Prepack, Preferred Pharmaceuticals Inc., Padagis Israel Pharmaceuticals Ltd.

💬 Answers drafted from Econazole Topical’s FDA-approved label information, summarized in plain language with AI, and reviewed by our pharmacy team before publication. Grounded in that labeling — nothing is made up. How we use AI →

🧰 Keep exploring

📊Econazole Topical supplement interactions20 checked — ranked by severity 🌿Drug & Supplement CheckerEconazole Topical vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Econazole Topical NDCs & costs 🅰️Browse Drugs A–ZLook up any medication

💊 How Econazole Topical comes

Econazole Topical is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

Topical cream, ointment or gel

On the skin
Brands Econazole Nitrate
How this form is used
What it may be used for
  • Econazole Nitrate cream is used to treat tinea pedis (athlete's foot), tinea cruris (jock itch), tinea corporis (ringworm), and tinea versicolor.
  • Econazole Nitrate cream is also used for cutaneous candidiasis (a skin yeast infection caused by Candida).
Important instructions
  • Econazole Nitrate cream is applied once daily for tinea pedis, tinea cruris, tinea corporis, and tinea versicolor.
  • Econazole Nitrate cream is applied twice daily (morning and evening) for cutaneous candidiasis.
  • Econazole Nitrate cream should not be applied in or around the eyes.
  • Follow your prescriber's recommended treatment length — stopping early increases the risk that the infection returns.
Available strengths 1 strength
10 mg/g
28 FDA-listed product records ⓘ

Inhaler

On the skin
Brands Econazole Nitrate Ecoza
How this form is used
What it may be used for
  • Ecoza (econazole nitrate topical foam, 1%) is indicated for interdigital tinea pedis (athlete's foot between the toes) caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum in patients 12 years and older.
Important instructions
  • Ecoza foam is applied topically once daily to the affected area.
  • Ecoza foam is flammable — avoid heat, open flame, and smoking during and right after application.
  • Do not puncture or incinerate the Ecoza canister; store away from heat above 120°F and out of direct sunlight.
  • Follow your prescriber's instructions for how long to continue treatment to reduce the chance of the infection returning.
Available strengths 1 strength
10 mg/g
3 FDA-listed product records ⓘ

📊 Econazole Topical across the U.S. market

How Econazole Topical appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

2
Dose forms ⓘ
15
Manufacturers
4
Brand names
33
FDA-listed product records ⓘ
1982
First marketed ⓘ

FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

Also listed with the FDA, not a patient dose form: Kit (2) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

Bryant Ranch Prepack33%
Preferred Pharmaceuticals Inc.24%
Padagis Israel Pharmaceuticals Ltd6%
Aurobindo Pharma Limited3%
Encube Ethicals, Inc.3%
Exeltis USA Dermatology, LLC3%
Other makers27%

Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

📈 How widely Econazole Topical is used

A general measure of how commonly Econazole Topical is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.

Think of this as a proxy for how widely Econazole Topical is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

31,736
Medicaid prescriptions filled (Q1–Q4 2025)
$759,121 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

How commonly is Econazole Topical prescribed? Of the 1,596 medications we measure, Econazole Topical ranks #727 by Medicaid prescriptions — more than 54% of them.

Where Econazole Topical ranks among the drugs we measure · Q1–Q4 2025 · neighbors ±5
Total prescriptions — #727 of 1,596
#722 Certolizumab Injection 32,049 Rx #723 Penicillin G Benzathin... 31,924 Rx #724 Filgrastim Injection 31,849 Rx #725 Guselkumab Injection 31,774 Rx #726 Loxapine 31,747 Rx #727 Econazole Topical 31,736 Rx #728 Iloperidone 31,677 Rx #729 Tapinarof Topical 31,509 Rx #730 Halcinonide Topical 31,482 Rx #731 Tazarotene Topical 31,374 Rx #732 Atovaquone and Proguan... 31,273 Rx

Utilization by Econazole Topical product

Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.

econazole nitrate 10 MG/ML Topical Cream

31,736 Medicaid prescriptions (Q1–Q4 2025) 100% of Econazole Topical prescriptions shown $759,121 gross reimbursement (before rebates) ≈ $24 per prescription (gross)

Summed across the 6 of 37 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 857366

Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.

Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Econazole Topical, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 6 of 37 listed Econazole Topical NDCs with Medicaid activity.

🔍 Compare Econazole Topical products

A representative set of FDA-listed product records for Econazole Topical — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

Showing 33 of 33 products — FDA National Drug Code Directory. See every product, package size and price: browse all 33 Econazole Topical NDCs →

RxNorm Concept Web — From Ingredient to Every Form and Strength

This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.

Ingredient (IN) Econazole Topical RxCUI 3743 4 dose forms · 4 strengths
  1. Dose form (SCDF) Ophthalmic Solution RxCUI 377425 No current FDA listing
    Clinical drug / strength (SCD) 10 MG/ML RxCUI 107453
  2. Dose form (SCDF) Topical Cream RxCUI 385105 In current FDA listings
    Clinical drug / strength (SCD) nitrate 10 MG/ML RxCUI 857366
  3. Dose form (SCDF) Topical Foam RxCUI 1442584 In current FDA listings
    Clinical drug / strength (SCD) nitrate 10 MG/ML RxCUI 1442585
  4. Dose form (SCDF) Topical Powder RxCUI 376499 No current FDA listing
    Clinical drug / strength (SCD) nitrate 0.01 MG/MG RxCUI 857473

Look up RxCUI 3743 in the RxCUI Atlas →

RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.

🏷️ Sold under these brand names

Spectazole Ecoza Econazole Nitrate Econavix Zolpak

🏭 Manufacturers & labelers

Bryant Ranch Prepack 11 Preferred Pharmaceuticals Inc. 8 Padagis Israel Pharmaceuticals Ltd 2 Aurobindo Pharma Limited 1 Encube Ethicals, Inc. 1 Exeltis USA Dermatology, LLC 1 McKesson Corporation 1 Primary Pharmaceuticals, Inc. 1 PureTek Corporation 1 Resilia Pharmaceuticals, Inc. 1 SOLA Pharmaceuticals 1 Sun Pharmaceutical Industries, Inc. 1 Taro Pharmaceuticals U.S.A., Inc. 1 Teligent Pharma, Inc. 1 Trifluent Pharma, LLC 1

RxNorm drug class

Econazole Topical belongs to the Azole Antifungal class.

Pharmacologic class Azole Antifungal
Drug family (ATC) Imidazole and triazole derivatives, Imidazole derivatives

Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

🔬 Where this comes from

Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

📄
FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Oct 31, 2025
🏭
Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Econazole Topical.
📈
Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
🚨
Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
🧾 Clinical label set — FDA-filed SPL labels retained for Econazole Topical after exact ingredient or ingredient-combination matching and applicable route/form matching
Clinical labels in scope
13
NDC products indexed
33
Distinct labelers/manufacturers represented
15
Linked representative label ⓘ
Trifluent Pharma, LLC
Linked label effective
Oct 31, 2025
Composite sections available
25
Linked SPL Set ID
3eb40c94-f369-ce4b-e063-6294a90abed4
Linked SPL Document ID
42777ef5-48c3-181e-e063-6394a90abce3
Open the linked representative label on DailyMed ↗
NDC package records associated with this linked SPL 1

How we combine label and product data

HelloPharmacist combines public FDA and NLM records; we don’t author the underlying clinical facts. We identified 13 FDA-filed SPL label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. The representative label is the starting point for the displayed reference monograph; the 12 largest stored in-scope SPL records, which may include that representative, are compared section by section, and the longest available version of each section is retained. Forms, routes, brands, labelers, product-listed strengths, and product-record counts are aggregated separately from ingredient-matched FDA NDC Directory records; package records listed above are associated with the linked SPL; and the normalized concept hierarchy comes from NLM RxNorm.

Where a section is identified as AI-written, its plain-language text is generated from bounded label evidence. New draft drug pages remain in the admin review queue before first publication. Trifluent Pharma, LLC is the representative DailyMed label linked for verification and dates; it is not the sole source used for the page.

This is general education, not medical advice — always consult your doctor or pharmacist about your medications and any medical condition. For the exact wording of the linked representative label, view that label on DailyMed; some displayed composite sections may come from other in-scope SPL labels. Learn how we use AI and our data sources & update cadence.