Itraconazole

Generic name: Pronounced as (it'' ra kon' a zole)
Brand names
  • Onmel®
  • Sporanox®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 11/15/2017

Itraconazole can cause heart failure (condition in which the heart cannot pump enough blood through the body). Tell your doctor if you have or have ever had heart failure. Your doctor may tell you not to take itraconazole. Also tell your doctor if you have or have ever had a heart attack; an irregular heartbeat; or any other type of heart, lung , liver or kidney disease. If you experience any of the following symptoms, stop taking itraconazole and call your doctor immediately: shortness of breath; coughing up white or pink phlegm; weakness; excessive tiredness; fast heartbeat; swelling of the feet, ankles, or legs; waking up at night; and sudden weight gain.

Do not take cisapride (Propulsid) (not available in the U.S.), disopyramide (Norpace), dofetilide (Tikosyn), dronedarone (Multaq), eplerenone (Inspra), ergot-type medications such as dihydroergotamine (D.H.E, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), methylergometrine (Methergine); felodipine (Plendil), irinotecan (Camptosar), ivabradine (Corlanor), levomethadyl acetate (Orlaam) (not available in the U.S.),lovastatin (Altoprev, in Advicor), lurasidone (Latuda), methadone (Dolophine, Methadose), midazolam (taken by mouth), nisoldipine (Sular), pimozide (Orap), quinidine (in Nuedexta), ranolazine (Ranexa), simvastatin (Zocor, in Simcor, in Vytorin), ticagrelor (Brilinta), and triazolam (Halcion) while taking itraconazole and for 2 weeks afterward. Tell your doctor if you have kidney or liver disease and are taking any of the following medication: colchicine (Colcrys, Mitigare), fesoterodine (Toviaz), solifenacin (Vesicare), or telithromycin (Ketek). Taking these medications with itraconazole can cause serious heart problems including QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death).

Talk to your doctor about the risks of taking itraconazole.

Itraconazole capsules are used to treat fungal infections in the lungs that can spread throughout the body. Itraconazole capsules are also used to treat fungal infections of the fingernails. Itraconazole tablets and capsules are used to treat fungal infections of the toenails. Itraconazole oral solution (liquid) is used to treat yeast infections of the mouth and throat or of the esophagus (tube that connects the throat to the stomach). Itraconazole is in a class of antifungals called triazoles. It works by slowing the growth of fungi that cause infection.

Itraconazole comes as a capsule, a tablet, and a solution (liquid) to take by mouth. If you are taking itraconazole to treat fungal infections in the lungs, the capsules are usually taken during or right after a full meal one or two times a day for at least 3 months. However, if you are taking itraconazole to treat a serious fungal infection in the lungs, the capsules may be taken with a meal three times a day for the first 3 days of treatment and then taken once or twice a day with a meal for at least 3 months. If you are taking itraconazole to treat fungal infections of the toenails (including or without fingernail infections), the capsules or tablets are usually taken once a day with a full meal for 12 weeks. If you are taking itraconazole to treat fungal infections of the fingernails only, the capsules are usually taken twice a day with a full meal for 1 week, skipped for 3 weeks, and then taken twice a day with a meal for a week. Itraconazole oral solution is usually taken on an empty stomach once or twice a day for 1 to 4 weeks or sometimes longer. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take itraconazole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow itraconazole capsules whole; do not open, chew, or crush them.

Your doctor may tell you to take itraconazole capsules with a cola soft drink if you have certain medical conditions or are taking any of the following medications: cimetidine; famotidine (Pepcid); nizatidine (Axid); proton-pump inhibitors such as esomeprazole (Nexium, in Vimovo), lansoprazole (Prevacid, in Prevpac), omeprazole (Prilosec, in Zegerid), pantoprazole (Protonix), rabeprazole (AcipHex), or ranitidine (Zantac). Follow these directions carefully.

To take itraconazole oral solution for fungal infections of the mouth or throat, swish 10 milliliters (about 2 teaspoons) of the solution in your mouth for several seconds and swallow. Repeat if necessary to take your entire dose.

Itraconazole capsules and oral solution are absorbed into the body in different ways and work to treat different conditions. Do not substitute the capsules for the liquid or the liquid for the capsules. Be sure that your pharmacist gives you the itraconazole product that your doctor prescribed.

If you are taking itraconazole to treat a nail infection, your nails will probably not look healthier until new nails grow. It can take up to 6 months to grow a new fingernail and up to 12 months to grow a new toenail, so you should not expect to see improvement during your treatment or for several months afterward. Continue to take itraconazole even if you do not see any improvement.

Continue to take itraconazole until your doctor tells you to stop even if you feel well. Do not stop taking itraconazole without talking to your doctor. If you stop taking itraconazole too soon, your infection may come back after a short time.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Itraconazole is also sometimes used to treat other types of fungal infections and to prevent fungal infections in people who have human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS). Talk to your doctor about the possible risks of using this drug for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking itraconazole,

  • tell your doctor and pharmacist if you are allergic to itraconazole; other antifungal medications such as fluconazole (Diflucan), ketoconazole (Nizoral), or voriconazole (Vfend); any other medications, or any of the ingredients in itraconazole products. If you are taking itraconazole oral solution, tell your doctor if you are allergic to saccharin or sulfa medications. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist if you are taking the following medications or took them in the last 2 weeks before starting treatment with itraconazole: carbamazepine (Epitol, Tegretol, Teril, others); efavirenz (Sustiva, in Atripla); isoniazid (Laniazid, in Rifamate, in Rifater); rifabutin (Mycobutin); rifampicin; nevirapine (Viramune); phenobarbital; and phenytoin (Dilantin, Phenytek).

  • tell your doctor or pharmacist if you are taking the following medications: aliskiren (Tekturna, in Amturnide, Tekamlo, and Tekturna HCT), apixaban (Eliquis), axitinib (Inlyta), colchicine (Colcrys, Mitigare), dabrafemob (Taflinar), darifenacin (Enablex), dasatinib (Sprycel), everolimus (Afinitor, Zortress), ibrutinib (Imbruvica), nilotinib (Tasigna), rivaroxaban (Xarelto), salmeterol (Serevent), sildenafil (only Revatio brand used for lung disease), simeprevir (Olysio), sunitinib (Sutent), tamsulosin (Flomax, in Jalyn), temsirolimus (Torisel), trabectedin (Yondelis), and vardenafil (Staxyn, Levitra). Your doctor may tell you not to take these medications during your treatment and for 2 weeks after your treatment with itraconazole.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antibiotic medications such as ciprofloxacin (Cipro), clarithromycin (Biaxin, in PrevPac), erythromycin (E.E.S. Ery-Tab, others), and telithromycin (Ketek); anticoagulant (''blood thinner'') such as warfarin (Coumadin, Jantoven); alprazolam (Xanax); aprepitant (Emend); aripiprazole (Abilify); atorvastatin (Lipitor, in Caduet, in Liptruzet); bortezomib (Velcade); bosentan (Tracleer); budesonide (Entocort EC, Pulmicort, Uceris); buprenorphine (Buprenex, Butrans, in Bunavail; others); buspirone; ciclesonide (Alvesco, Omnaris, Zetonna); cilostazol (Pletal); cinacalcet (Sensipar); cyclosporine (Gengraf, Neoral, Sandimmune); dabigatran (Pradaxa); dexamethasone; diazepam (Valium); digoxin (Lanoxin); docetaxel (Docefrez, Taxotere); eletriptan (Relpax); erlotinib (Tarceva); fentanyl (Actiq, Duragesic, Fentora, Subsys, others); fesoterodine (Toviaz); fluticasone (Flovent, in Advair); gefitinib (Iressa); haloperidol (Haldol); HIV protease inhibitors including indinavir (Crixivan), darunavir (Prezista) taken with ritonavir, fosamprenavir (Lexiva) taken with ritonavir, and saquinavir (Invirase); imatinib (Gleevac); ixabepilone (Ixempra Kit); lapatinib (Tykerb); maraviroc (Selzentry); meloxicam (Mobic); methylprednisolone (Medrol); nadolol (Corgard, in Corzide); oxybutynin (Ditropan XL, Oxytrol); oxycodone (Oxaydo, Oxycontin, in Percodan; others); ponatinib (Iclusig); praziquantel (Biltricide); quetiapine (Seroquel); ramelteon (Rozerem); repaglinide (Prandin, in Prandimet); riociguat (Adempas); risperidone (Risperdal); saxagliptin (Kombiglyze XR, Onglyza); sirolimus (Rapamune); solifenacin (Vesicare); tacrolimus (Astagraf, Prograf); tadalafil (Adcirca, Cialis); tolterodine (Detrol); vardenafil (Levitra, Staxyn); verapamil (Calan, Covera, Verelan PM, in Tarka), vinblastine, vincristine (Marqibo Kit), and vinorelbine (Navelbine). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with itraconazole, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on these lists.

  • if you are taking an antacid, take it 1 hour before or 2 hours after you take itraconazole.

  • tell your doctor if you have or have ever had the conditions mentioned in the IMPORTANT WARNING section,, cystic fibrosis (an inborn disease that causes problems with breathing, digestion, and reproduction), any condition that decreases the amount of acid in your stomach, or HIV.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. You should not take itraconazole to treat nail fungus if you are pregnant or could become pregnant. You may start to take itraconazole to treat nail fungus only on the second or third day of your menstrual period when you are sure you are not pregnant. You must use effective birth control during your treatment and for 2 months afterward. If you become pregnant while taking itraconazole to treat any condition, call your doctor.

  • you should know that itraconazole may make you dizzy or cause blurred or double vision. Do not drive a car or operate machinery until you know how this medication affects you.

Talk to your doctor about drinking grapefruit juice while taking this medication.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Itraconazole may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • diarrhea

    • constipation

    • gas or bloating

    • heartburn

    • unpleasant taste

    • sore or bleeding gums

    • headache

    • dizziness

    • sweating

    • muscle pain or weakness

    • joint pain

    • decreased sexual desire or ability

    • nervousness

    • depression

    • runny nose and other cold symptoms

    • fever

    • hair loss

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • blurred vision or double vision

    • ringing in the ears

    • inability to control urination or urinating more than usual

  • If you experience any of the following symptoms or those listed in the IMPORTANT WARNING section, stop taking itraconazole and call your doctor immediately or get emergency medical treatment:

    • excessive tiredness

    • loss of appetite

    • nausea

    • stomach pain

    • vomiting

    • yellowing of the skin or eyes

    • dark urine

    • pale stools

    • feelings of numbness, tingling, pricking, burning, or creeping on the skin

    • hearing loss

    • increased sensitivity to light

    • severe skin disorder

    • hearing loss

    • rash

    • hives

    • itching

    • swelling of the face, throat, tongue, lips, eyes, hands, ankles, or lower legs

    • hoarseness

    • difficulty breathing or swallowing

  • One of the ingredients in itraconazole oral solution caused cancer in some types of laboratory animals. It is not known whether people who take itraconazole solution have an increased risk of developing cancer. Talk to your doctor about the risks of taking itraconazole solution.

  • Itraconazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat, light, and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to itraconazole.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. If you still have symptoms of infection after you finish the itraconazole, call your doctor.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Moxifloxacin Moxifloxacin The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Moxifloxacin.
Nevirapine Nevirapine The serum concentration of Itraconazole can be decreased when it is combined with Nevirapine.
Atorvastatin Atorvastatin The serum concentration of Atorvastatin can be increased when it is combined with Itraconazole.
Dolasetron Dolasetron The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Dolasetron.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Itraconazole.
Anagrelide Anagrelide The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Anagrelide.
Calcium Carbonate Calcium Carbonate Calcium carbonate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Candesartan Candesartan The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Candesartan.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Itraconazole.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Itraconazole.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be decreased when combined with Itraconazole.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Itraconazole.
Guanfacine Guanfacine The metabolism of Guanfacine can be decreased when combined with Itraconazole.
Magnesium Hydroxide Magnesium Hydroxide Magnesium hydroxide can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Magnesium Oxide Magnesium Oxide Magnesium oxide can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Olsalazine Olsalazine The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Olsalazine.
Paregoric Paregoric The serum concentration of Morphine can be increased when it is combined with Itraconazole.
Penbutolol Penbutolol The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Acebutolol.
Potassium Potassium Potassium may increase the hyperkalemic activities of Itraconazole.
Prednisone Prednisone The metabolism of Prednisone can be decreased when combined with Itraconazole.
Ranitidine Ranitidine Ranitidine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Itraconazole.
Tizanidine Tizanidine The risk or severity of QTc prolongation can be increased when Tizanidine is combined with Itraconazole.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be decreased when combined with Itraconazole.
Famotidine Injection Famotidine Injection Famotidine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Fluconazole Injection Fluconazole Injection The risk or severity of QTc prolongation can be increased when Fluconazole is combined with Itraconazole.
Foscarnet Injection Foscarnet Injection The risk or severity of QTc prolongation can be increased when Foscarnet is combined with Itraconazole.
Levofloxacin Injection Levofloxacin Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Levofloxacin.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Itraconazole.
Methylprednisolone Injection Methylprednisolone Injection The metabolism of Methylprednisolone can be decreased when combined with Itraconazole.
Metoclopramide Injection Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Metoclopramide.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Itraconazole.
Morphine Injection Morphine Injection The serum concentration of Morphine can be increased when it is combined with Itraconazole.
Cyclosporine Cyclosporine The serum concentration of Cyclosporine can be increased when it is combined with Itraconazole.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Itraconazole.
Enoxaparin Injection Enoxaparin Injection The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Enoxaparin.
Granisetron Granisetron The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Granisetron.
Olanzapine Olanzapine Olanzapine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Itraconazole.
Eprosartan Eprosartan The risk or severity of hyperkalemia can be increased when Eprosartan is combined with Itraconazole.
Hydroxychloroquine Hydroxychloroquine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Hydroxychloroquine.
Meloxicam Meloxicam The serum concentration of Meloxicam can be decreased when it is combined with Itraconazole.
Pantoprazole Pantoprazole Itraconazole can cause a decrease in the absorption of Pantoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan The risk or severity of hyperkalemia can be increased when Telmisartan is combined with Itraconazole.
Zaleplon Zaleplon The metabolism of Zaleplon can be decreased when combined with Itraconazole.
Desloratadine Desloratadine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Desloratadine.
Trimipramine Trimipramine The serum concentration of Itraconazole can be increased when it is combined with Trimipramine.
Perindopril Perindopril The risk or severity of hyperkalemia can be increased when Perindopril is combined with Itraconazole.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Choline magnesium trisalicylate.
Sirolimus Sirolimus The serum concentration of the active metabolites of Sirolimus can be increased when Sirolimus is used in combination with Itraconazole.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Itraconazole.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Itraconazole.
Escitalopram Escitalopram The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Escitalopram.
Olmesartan Olmesartan The risk or severity of hyperkalemia can be increased when Olmesartan is combined with Itraconazole.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Itraconazole.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Itraconazole.
Atomoxetine Atomoxetine The risk or severity of QTc prolongation can be increased when Atomoxetine is combined with Itraconazole.
Atazanavir Atazanavir The metabolism of Itraconazole can be decreased when combined with Atazanavir.
Almotriptan Almotriptan The metabolism of Almotriptan can be decreased when combined with Itraconazole.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Itraconazole.
Mefloquine Mefloquine The risk or severity of QTc prolongation can be increased when Mefloquine is combined with Itraconazole.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Itraconazole.
Vardenafil Vardenafil The serum concentration of Vardenafil can be increased when it is combined with Itraconazole.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Itraconazole.
Aprepitant Aprepitant The metabolism of Aprepitant can be decreased when combined with Itraconazole.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Itraconazole.
Tadalafil Tadalafil The metabolism of Tadalafil can be decreased when combined with Itraconazole.
Fosamprenavir Fosamprenavir The serum concentration of Itraconazole can be increased when it is combined with Fosamprenavir.
Gemifloxacin Gemifloxacin The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Gemifloxacin.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Itraconazole.
Apomorphine Injection Apomorphine Injection The metabolism of Itraconazole can be decreased when combined with Apomorphine.
Protriptyline Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Itraconazole.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Itraconazole.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Itraconazole.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Itraconazole.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Itraconazole.
Eszopiclone Eszopiclone The serum concentration of Eszopiclone can be increased when it is combined with Itraconazole.
Solifenacin Solifenacin The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Solifenacin.
Voriconazole Voriconazole The risk or severity of QTc prolongation can be increased when Voriconazole is combined with Itraconazole.
Ibandronate Ibandronate The risk or severity of QTc prolongation can be increased when Ibandronate is combined with Itraconazole.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Itraconazole.
Pregabalin Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Itraconazole.
Tipranavir Tipranavir The metabolism of Itraconazole can be increased when combined with Tipranavir.
Felbamate Felbamate The metabolism of Felbamate can be decreased when combined with Itraconazole.
Ranolazine Ranolazine The metabolism of Itraconazole can be decreased when combined with Ranolazine.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Itraconazole.
Sitagliptin Sitagliptin The serum concentration of Sitagliptin can be increased when it is combined with Itraconazole.
Gefitinib Gefitinib The metabolism of Itraconazole can be decreased when combined with Gefitinib.
Albuterol Albuterol The risk or severity of QTc prolongation can be increased when Salbutamol is combined with Itraconazole.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Itraconazole.
Bortezomib Bortezomib The metabolism of Itraconazole can be decreased when combined with Bortezomib.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Oxaliplatin.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Itraconazole.
Primaquine Primaquine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Primaquine.
Aliskiren Aliskiren The serum concentration of Aliskiren can be increased when it is combined with Itraconazole.
Darunavir Darunavir The metabolism of Itraconazole can be decreased when combined with Darunavir.
Dimenhydrinate Dimenhydrinate The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Dimenhydrinate.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Itraconazole.
Vorinostat Vorinostat The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Vorinostat.
Sorafenib Sorafenib The metabolism of Sorafenib can be decreased when combined with Itraconazole.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Itraconazole.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Itraconazole.
Levocetirizine Levocetirizine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Levocetirizine.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Itraconazole.
Mexiletine Mexiletine The metabolism of Mexiletine can be decreased when combined with Itraconazole.
Temsirolimus Temsirolimus The serum concentration of the active metabolites of Temsirolimus can be increased when Temsirolimus is used in combination with Itraconazole.
Maraviroc Maraviroc The metabolism of Maraviroc can be decreased when combined with Itraconazole.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Itraconazole.
Toremifene Toremifene The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Toremifene.
Budesonide Budesonide The metabolism of Budesonide can be decreased when combined with Itraconazole.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Arsenic trioxide.
Nebivolol Nebivolol The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Nebivolol.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Itraconazole.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Itraconazole.
Flecainide Flecainide The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Flecainide.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Itraconazole.
Irinotecan Injection Irinotecan Injection The serum concentration of SN-38, an active metabolite of Irinotecan, can be increased when used in combination with Itraconazole.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Itraconazole.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Itraconazole.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Itraconazole.
Midazolam Midazolam The metabolism of Midazolam can be decreased when combined with Itraconazole.
Milnacipran Milnacipran The metabolism of Milnacipran can be decreased when combined with Itraconazole.
Dexlansoprazole Dexlansoprazole Itraconazole can cause a decrease in the absorption of Dexlansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sodium Phosphate Sodium Phosphate Sodium phosphate, monobasic may increase the hyperkalemic activities of Itraconazole.
Fesoterodine Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Itraconazole.
Degarelix Injection Degarelix Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Degarelix.
Betaxolol Betaxolol The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Betaxolol.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Itraconazole.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Itraconazole.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Itraconazole.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Itraconazole.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Itraconazole.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Itraconazole.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Itraconazole.
Telavancin Injection Telavancin Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Telavancin.
Romidepsin Injection Romidepsin Injection The serum concentration of Romidepsin can be increased when it is combined with Itraconazole.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Itraconazole.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Itraconazole.
Asenapine Asenapine Asenapine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Itraconazole.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Itraconazole.
Fingolimod Fingolimod The metabolism of Fingolimod can be decreased when combined with Itraconazole.
Eribulin Injection Eribulin Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Itraconazole.
Lurasidone Lurasidone The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Lurasidone.
Acetaminophen Injection Acetaminophen Injection Itraconazole may increase the hepatotoxic activities of Acetaminophen.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Itraconazole.
Terbutaline Injection Terbutaline Injection The risk or severity of QTc prolongation can be increased when Terbutaline is combined with Itraconazole.
Azilsartan Azilsartan The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Azilsartan medoxomil.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Itraconazole.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Itraconazole.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Itraconazole.
Rilpivirine Rilpivirine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Rilpivirine.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Itraconazole.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the hyperkalemic activities of Itraconazole.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Itraconazole.
Triptorelin Injection Triptorelin Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Triptorelin.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Itraconazole.
Ticagrelor Ticagrelor The serum concentration of Ticagrelor can be increased when it is combined with Itraconazole.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Itraconazole.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Itraconazole.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Itraconazole.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Itraconazole.
Vemurafenib Vemurafenib The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Vemurafenib.
Ivacaftor Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Itraconazole.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Itraconazole.
Crizotinib Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Itraconazole.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Itraconazole.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Itraconazole.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Itraconazole.
Enzalutamide Enzalutamide The metabolism of Itraconazole can be decreased when combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Itraconazole.
Regorafenib Regorafenib The serum concentration of Regorafenib can be increased when it is combined with Itraconazole.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Itraconazole.
Corticotropin, Repository Injection Corticotropin, Repository Injection The metabolism of Corticotropin can be decreased when combined with Itraconazole.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Itraconazole.
Bedaquiline Bedaquiline The metabolism of Bedaquiline can be decreased when combined with Itraconazole.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Itraconazole.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Itraconazole.
Pomalidomide Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Itraconazole.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Itraconazole.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Itraconazole.
Canagliflozin Canagliflozin The serum concentration of Canagliflozin can be increased when it is combined with Itraconazole.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Itraconazole.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Itraconazole.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Itraconazole.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Itraconazole.
Levomilnacipran Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Itraconazole.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Itraconazole.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Itraconazole.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Itraconazole.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Itraconazole.
Ketorolac Injection Ketorolac Injection The risk or severity of hyperkalemia can be increased when Ketorolac is combined with Itraconazole.
Simeprevir Simeprevir The serum concentration of Simeprevir can be increased when it is combined with Itraconazole.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Itraconazole.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Itraconazole.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Itraconazole.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Itraconazole.
Testosterone Injection Testosterone Injection The metabolism of Itraconazole can be decreased when combined with Testosterone.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Itraconazole.
Hydrocodone Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Itraconazole.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Itraconazole.
Edoxaban Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Itraconazole.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Itraconazole.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Itraconazole.
Riociguat Riociguat The serum concentration of Riociguat can be increased when it is combined with Itraconazole.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Itraconazole.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Itraconazole.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Itraconazole.
Lenvatinib Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Itraconazole.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Itraconazole.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Itraconazole.
Haloperidol Injection Haloperidol Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Haloperidol.
Ivabradine Ivabradine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Ivabradine.
Amiloride Amiloride The risk or severity of hyperkalemia can be increased when Amiloride is combined with Itraconazole.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Isavuconazonium can be increased when it is combined with Itraconazole.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Itraconazole.
Flibanserin Flibanserin The metabolism of Flibanserin can be decreased when combined with Itraconazole.
Prednisolone Prednisolone The metabolism of Prednisolone can be decreased when combined with Itraconazole.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Itraconazole.
Brexpiprazole Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Itraconazole.
Ziprasidone Injection Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Ziprasidone.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Itraconazole.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Itraconazole.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Itraconazole.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Itraconazole.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Itraconazole.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Itraconazole.
Dexamethasone Injection Dexamethasone Injection The metabolism of Dexamethasone can be decreased when combined with Itraconazole.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Itraconazole.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Itraconazole.
Cobicistat Cobicistat The metabolism of Cobicistat can be decreased when combined with Itraconazole.
Selexipag Selexipag The serum concentration of Selexipag can be increased when it is combined with Itraconazole.
Diphenhydramine Injection Diphenhydramine Injection The risk or severity of QTc prolongation can be increased when Diphenhydramine is combined with Itraconazole.
Rucaparib Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Itraconazole.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Itraconazole.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Itraconazole.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Itraconazole.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Itraconazole.
Deflazacort Deflazacort The serum concentration of Deflazacort can be increased when it is combined with Itraconazole.
Midostaurin Midostaurin The metabolism of Midostaurin can be decreased when combined with Itraconazole.
Neratinib Neratinib The serum concentration of Neratinib can be increased when it is combined with Itraconazole.
Enasidenib Enasidenib The metabolism of Itraconazole can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Itraconazole.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Itraconazole.
Copanlisib Injection Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Itraconazole.
Delafloxacin Delafloxacin The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Delafloxacin.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Itraconazole.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Itraconazole.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Itraconazole.
Tetrabenazine Tetrabenazine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Tetrabenazine.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Itraconazole.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Itraconazole.
Apalutamide Apalutamide The metabolism of Apalutamide can be decreased when combined with Itraconazole.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Itraconazole.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Itraconazole.
Sodium Zirconium Cyclosilicate Sodium Zirconium Cyclosilicate Sodium zirconium cyclosilicate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Lofexidine Lofexidine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Lofexidine.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Itraconazole.
Encorafenib Encorafenib The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Encorafenib.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Itraconazole.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Itraconazole.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Itraconazole.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Itraconazole.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Itraconazole.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Itraconazole.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Itraconazole.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Itraconazole.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Itraconazole.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Itraconazole.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Itraconazole.
Glasdegib Glasdegib The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Glasdegib.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Itraconazole.
Larotrectinib Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Itraconazole.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Itraconazole.
Rifamycin Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Itraconazole.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Itraconazole.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Itraconazole is combined with Siponimod.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Itraconazole.
Esomeprazole Injection Esomeprazole Injection Itraconazole can cause a decrease in the absorption of Esomeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Alpelisib Alpelisib The metabolism of Alpelisib can be decreased when combined with Itraconazole.
Polatuzumab vedotin-piiq Injection Polatuzumab vedotin-piiq Injection The risk or severity of adverse effects can be increased when Itraconazole is combined with Polatuzumab vedotin.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Itraconazole.
Triclabendazole Triclabendazole The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Triclabendazole.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Itraconazole.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Itraconazole.
Upadacitinib Upadacitinib The metabolism of Upadacitinib can be decreased when combined with Itraconazole.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Itraconazole.
Pitolisant Pitolisant The serum concentration of Pitolisant can be decreased when it is combined with Itraconazole.
Pretomanid Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Itraconazole.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Itraconazole.
Lefamulin Lefamulin Itraconazole may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection Phenytoin Injection The serum concentration of Phenytoin can be decreased when it is combined with Itraconazole.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Itraconazole.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Itraconazole.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Itraconazole.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Itraconazole.
Lumateperone Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Itraconazole.
Lasmiditan Lasmiditan The serum concentration of Lasmiditan can be increased when it is combined with Itraconazole.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Itraconazole.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Itraconazole.
Cenobamate Cenobamate The serum concentration of Cenobamate can be decreased when it is combined with Itraconazole.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Itraconazole.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Itraconazole.
Rimegepant Rimegepant The metabolism of Rimegepant can be decreased when combined with Itraconazole.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Itraconazole.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Itraconazole.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Itraconazole.
Selpercatinib Selpercatinib The serum concentration of Selpercatinib can be increased when it is combined with Itraconazole.
Capmatinib Capmatinib The serum concentration of Capmatinib can be increased when it is combined with Itraconazole.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Itraconazole.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Itraconazole.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Itraconazole.
Octreotide Octreotide The risk or severity of QTc prolongation can be increased when Octreotide is combined with Itraconazole.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Itraconazole.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Itraconazole.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Itraconazole can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Itraconazole.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Itraconazole.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Itraconazole.
Fenoprofen Fenoprofen The risk or severity of hyperkalemia can be increased when Fenoprofen is combined with Itraconazole.
Indomethacin Indomethacin The risk or severity of hyperkalemia can be increased when Indomethacin is combined with Itraconazole.
Mefenamic Acid Mefenamic Acid The risk or severity of hyperkalemia can be increased when Mefenamic acid is combined with Itraconazole.
Naproxen Naproxen The risk or severity of hyperkalemia can be increased when Naproxen is combined with Itraconazole.
Tolmetin Tolmetin The risk or severity of hyperkalemia can be increased when Tolmetin is combined with Itraconazole.
Sulindac Sulindac The risk or severity of hyperkalemia can be increased when Sulindac is combined with Itraconazole.
Trazodone Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Itraconazole.
Sucralfate Sucralfate Sucralfate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Sodium Bicarbonate Sodium Bicarbonate Sodium bicarbonate can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Itraconazole.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Itraconazole.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Itraconazole.
Methsuximide Methsuximide The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Methsuximide.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Itraconazole.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Itraconazole.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Itraconazole.
Amantadine Amantadine The risk or severity of QTc prolongation can be increased when Amantadine is combined with Itraconazole.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Itraconazole.
Thioridazine Thioridazine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Thioridazine.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Itraconazole.
Oxycodone Oxycodone The metabolism of Oxycodone can be decreased when combined with Itraconazole.
Methadone Methadone The serum concentration of Methadone can be increased when it is combined with Itraconazole.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Itraconazole.
Benztropine Benztropine The risk or severity of QTc prolongation can be increased when Benzatropine is combined with Itraconazole.
Maprotiline Maprotiline The risk or severity of QTc prolongation can be increased when Maprotiline is combined with Itraconazole.
Ibuprofen Ibuprofen The risk or severity of hyperkalemia can be increased when Ibuprofen is combined with Itraconazole.
Orphenadrine Orphenadrine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Orphenadrine.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Itraconazole.
Amoxapine Amoxapine The risk or severity of QTc prolongation can be increased when Amoxapine is combined with Itraconazole.
Sulfasalazine Sulfasalazine The risk or severity of hyperkalemia can be increased when Sulfasalazine is combined with Itraconazole.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Itraconazole.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Itraconazole.
Dactinomycin Dactinomycin The serum concentration of Itraconazole can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Itraconazole.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Itraconazole.
Cimetidine Cimetidine Cimetidine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Itraconazole.
Loperamide Loperamide The metabolism of Itraconazole can be decreased when combined with Loperamide.
Promethazine Promethazine Promethazine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Meclofenamate Meclofenamate The risk or severity of hyperkalemia can be increased when Meclofenamic acid is combined with Itraconazole.
Nitrofurantoin Nitrofurantoin The risk or severity of hyperkalemia can be increased when Nitrofurantoin is combined with Itraconazole.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Itraconazole.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Itraconazole.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Itraconazole.
Ethosuximide Ethosuximide The metabolism of Ethosuximide can be decreased when combined with Itraconazole.
Triamterene Triamterene The risk or severity of hyperkalemia can be increased when Triamterene is combined with Itraconazole.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Itraconazole.
Desipramine Desipramine The metabolism of Itraconazole can be decreased when combined with Desipramine.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Itraconazole.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Itraconazole.
Quinidine Quinidine The metabolism of Quinidine can be decreased when combined with Itraconazole.
Procainamide Procainamide The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Procainamide.
Isoniazid Isoniazid The serum concentration of Itraconazole can be decreased when it is combined with Isoniazid.
Disopyramide Disopyramide The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Disopyramide.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Itraconazole.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Itraconazole.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Itraconazole.
Doxylamine Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Itraconazole.
Cyproheptadine Cyproheptadine The risk or severity of QTc prolongation can be increased when Cyproheptadine is combined with Itraconazole.
Clemastine Clemastine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Clemastine.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Itraconazole.
Brompheniramine Brompheniramine The risk or severity of QTc prolongation can be increased when Dexbrompheniramine is combined with Itraconazole.
Hydrochlorothiazide Hydrochlorothiazide The risk or severity of QTc prolongation can be increased when Hydrochlorothiazide is combined with Itraconazole.
Dantrolene Dantrolene The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Dantrolene.
Chlorzoxazone Chlorzoxazone The metabolism of Chlorzoxazone can be decreased when combined with Itraconazole.
Disulfiram Disulfiram The metabolism of Disulfiram can be decreased when combined with Itraconazole.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The metabolism of Propranolol can be decreased when combined with Itraconazole.
Nortriptyline Nortriptyline The serum concentration of Itraconazole can be increased when it is combined with Nortriptyline.
Spironolactone Spironolactone The risk or severity of hyperkalemia can be increased when Spironolactone is combined with Itraconazole.
Amphotericin B Injection Amphotericin B Injection The therapeutic efficacy of Amphotericin B can be decreased when used in combination with Itraconazole.
Nadolol Nadolol The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Nadolol.
Oxytocin Injection Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Itraconazole.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Itraconazole.
Papaverine Papaverine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Papaverine.
Fluorouracil Injection Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Fluorouracil.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Itraconazole.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Itraconazole.
Ketoconazole Ketoconazole The risk or severity of QTc prolongation can be increased when Ketoconazole is combined with Itraconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Itraconazole.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Itraconazole.
Captopril Captopril The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Captopril.
Vinblastine Vinblastine The metabolism of Itraconazole can be decreased when combined with Vinblastine.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Itraconazole.
Hydroxyzine Hydroxyzine The risk or severity of QTc prolongation can be increased when Hydroxyzine is combined with Itraconazole.
Thiothixene Thiothixene The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Thiothixene.
Aspirin Aspirin The risk or severity of hyperkalemia can be increased when Acetylsalicylic acid is combined with Itraconazole.
Salsalate Salsalate The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Salsalate.
Alprazolam Alprazolam The serum concentration of Alprazolam can be increased when it is combined with Itraconazole.
Triazolam Triazolam The metabolism of Triazolam can be decreased when combined with Itraconazole.
Hyoscyamine Hyoscyamine The risk or severity of QTc prolongation can be increased when Hyoscyamine is combined with Itraconazole.
Trimethoprim Trimethoprim The risk or severity of hyperkalemia can be increased when Trimethoprim is combined with Itraconazole.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Itraconazole.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Itraconazole.
Timolol Timolol The risk or severity of QTc prolongation can be increased when Timolol is combined with Itraconazole.
Verapamil Verapamil The metabolism of Verapamil can be decreased when combined with Itraconazole.
Atenolol Atenolol The risk or severity of hyperkalemia can be increased when Atenolol is combined with Itraconazole.
Pindolol Pindolol The risk or severity of hyperkalemia can be increased when Pindolol is combined with Itraconazole.
Diflunisal Diflunisal The risk or severity of hyperkalemia can be increased when Diflunisal is combined with Itraconazole.
Piroxicam Piroxicam The risk or severity of hyperkalemia can be increased when Piroxicam is combined with Itraconazole.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Itraconazole.
Glyburide Glyburide The metabolism of Itraconazole can be decreased when combined with Glyburide.
Indapamide Indapamide The risk or severity of QTc prolongation can be increased when Indapamide is combined with Itraconazole.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Itraconazole.
Labetalol Labetalol The risk or severity of hyperkalemia can be increased when Labetalol is combined with Itraconazole.
Leuprolide Injection Leuprolide Injection The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Leuprolide.
Ketoprofen Ketoprofen The risk or severity of hyperkalemia can be increased when Ketoprofen is combined with Itraconazole.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Itraconazole.
Enalapril Enalapril The risk or severity of hyperkalemia can be increased when Enalapril is combined with Itraconazole.
Flurbiprofen Flurbiprofen The risk or severity of hyperkalemia can be increased when Flurbiprofen is combined with Itraconazole.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Itraconazole.
Buspirone Buspirone The serum concentration of Buspirone can be increased when it is combined with Itraconazole.
Lovastatin Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Itraconazole.
Ciprofloxacin Ciprofloxacin The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Ciprofloxacin.
Mesalamine Mesalamine The risk or severity of hyperkalemia can be increased when Mesalazine is combined with Itraconazole.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Itraconazole.
Fluoxetine Fluoxetine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Fluoxetine.
Nimodipine Nimodipine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Nimodipine.
Clozapine Clozapine The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Clozapine.
Ofloxacin Ofloxacin The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Ofloxacin.
Didanosine Didanosine Didanosine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clarithromycin Clarithromycin The metabolism of Clarithromycin can be decreased when combined with Itraconazole.
Benazepril Benazepril The risk or severity of hyperkalemia can be increased when Benazepril is combined with Itraconazole.
Etodolac Etodolac The risk or severity of hyperkalemia can be increased when Etodolac is combined with Itraconazole.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Itraconazole.
Fosinopril Fosinopril The risk or severity of hyperkalemia can be increased when Fosinopril is combined with Itraconazole.
Nabumetone Nabumetone The risk or severity of hyperkalemia can be increased when Nabumetone is combined with Itraconazole.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Itraconazole.
Quinapril Quinapril The risk or severity of hyperkalemia can be increased when Quinapril is combined with Itraconazole.
Ramipril Ramipril The risk or severity of hyperkalemia can be increased when Ramipril is combined with Itraconazole.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Itraconazole.
Amlodipine Amlodipine The metabolism of Amlodipine can be decreased when combined with Itraconazole.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Itraconazole.
Lisinopril Lisinopril The risk or severity of hyperkalemia can be increased when Lisinopril is combined with Itraconazole.
Oxaprozin Oxaprozin The risk or severity of hyperkalemia can be increased when Oxaprozin is combined with Itraconazole.
Sotalol Sotalol The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Sotalol.
Bisoprolol Bisoprolol The serum concentration of Itraconazole can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Itraconazole.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Itraconazole.
Isradipine Isradipine The risk or severity of QTc prolongation can be increased when Isradipine is combined with Itraconazole.
Omeprazole Omeprazole Itraconazole can cause a decrease in the absorption of Omeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Itraconazole.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Itraconazole.
Venlafaxine Venlafaxine The risk or severity of QTc prolongation can be increased when Venlafaxine is combined with Itraconazole.
Nizatidine Nizatidine Nizatidine can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Itraconazole.
Lamotrigine Lamotrigine The risk or severity of QTc prolongation can be increased when Lamotrigine is combined with Itraconazole.
Losartan Losartan The risk or severity of QTc prolongation can be increased when Losartan is combined with Itraconazole.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Itraconazole.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Itraconazole.
Moexipril Moexipril The risk or severity of QTc prolongation can be increased when Moexipril is combined with Itraconazole.
Lansoprazole Lansoprazole Itraconazole can cause a decrease in the absorption of Lansoprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Itraconazole.
Nicardipine Nicardipine The risk or severity of QTc prolongation can be increased when Nicardipine is combined with Itraconazole.
Bupropion Bupropion The serum concentration of Bupropion can be increased when it is combined with Itraconazole.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Itraconazole.
Saquinavir Saquinavir The serum concentration of Saquinavir can be increased when it is combined with Itraconazole.
Dalteparin Injection Dalteparin Injection The risk or severity of hyperkalemia can be increased when Itraconazole is combined with Dalteparin.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Itraconazole.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Itraconazole.
Indinavir Indinavir The metabolism of Indinavir can be decreased when combined with Itraconazole.
Ritonavir Ritonavir The serum concentration of Itraconazole can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Itraconazole.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Itraconazole.
Zafirlukast Zafirlukast The metabolism of Itraconazole can be decreased when combined with Zafirlukast.
Mirtazapine Mirtazapine The risk or severity of QTc prolongation can be increased when Mirtazapine is combined with Itraconazole.
Trandolapril Trandolapril The risk or severity of hyperkalemia can be increased when Trandolapril is combined with Itraconazole.
Valsartan Valsartan The risk or severity of hyperkalemia can be increased when Valsartan is combined with Itraconazole.
Nelfinavir Nelfinavir The risk or severity of QTc prolongation can be increased when Nelfinavir is combined with Itraconazole.
Fexofenadine Fexofenadine The serum concentration of Itraconazole can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Itraconazole.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Itraconazole.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Itraconazole.
Selegiline Selegiline The metabolism of Itraconazole can be decreased when combined with Selegiline.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Itraconazole.
Propafenone Propafenone The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Propafenone.
Irbesartan Irbesartan The risk or severity of hyperkalemia can be increased when Irbesartan is combined with Itraconazole.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Itraconazole.
Quetiapine Quetiapine The serum concentration of Quetiapine can be increased when it is combined with Itraconazole.
Cetirizine Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Itraconazole.
Citalopram Citalopram The risk or severity of QTc prolongation can be increased when Itraconazole is combined with Citalopram.
Efavirenz Efavirenz The metabolism of Efavirenz can be decreased when combined with Itraconazole.
Sildenafil Sildenafil The serum concentration of Sildenafil can be increased when it is combined with Itraconazole.
Celecoxib Celecoxib The risk or severity of hyperkalemia can be increased when Celecoxib is combined with Itraconazole.
Tolterodine Tolterodine The serum concentration of Tolterodine can be increased when it is combined with Itraconazole.
Aluminum Hydroxide Aluminum Hydroxide Aluminum hydroxide can cause a decrease in the absorption of Itraconazole resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The risk or severity of hyperkalemia can be increased when Balsalazide is combined with Itraconazole.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Itraconazole.
Galantamine Galantamine The risk or severity of QTc prolongation can be increased when Galantamine is combined with Itraconazole.
Rabeprazole Rabeprazole Itraconazole can cause a decrease in the absorption of Rabeprazole resulting in a reduced serum concentration and potentially a decrease in efficacy.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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