Colesevelam
Colesevelam is a bile acid sequestrant used with diet and exercise to lower LDL (“bad”) cholesterol in adults and some teens, and, in certain products, to improve blood sugar control in adults with type 2 diabetes.
🧬 Where this information comes from Click to expand
The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 31 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →
Colesevelam (Welchol) is a cholesterol medicine that stays in the gut and binds bile acids, so the liver pulls more LDL (“bad”) cholesterol from the blood to make new ones; on the market since about 2000 and available as a generic, it is usually added to a statin or used when one is not tolerated, and some products also help control type 2 diabetes. Because it is not absorbed, it is generally well tolerated, though constipation, indigestion and nausea are common. Stop it and get medical help for severe belly pain or severe constipation (possible pancreatitis, an inflamed pancreas, or a bowel blockage), or a tablet that feels stuck in your throat.
Clinical pearls
- Take levothyroxine, phenytoin, glipizide, birth control pills, vitamins and other interacting medicines at least 4 hours before colesevelam.
- Take it with a meal, and if the large tablets are hard to swallow, the stir-in powder packets are an alternative.
- Expect a triglyceride (blood fat) test before you start and from time to time after, since colesevelam can raise triglycerides.
- On warfarin, expect frequent INR (blood clotting test) checks when starting, because colesevelam has been shown to lower INR.
Patient information guide A plain-language walkthrough of Colesevelam, written from its FDA label.
What Colesevelam is used for
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Colesevelam is used for these conditions, depending on the product:
- Lowering LDL cholesterol in adults with primary hyperlipidemia, along with diet and exercise.
- Lowering LDL cholesterol in boys and postmenarchal girls ages 10 to 17 with heterozygous familial hypercholesterolemia who haven’t reached target levels with diet and lifestyle changes.
- Improving blood sugar control in adults with type 2 diabetes, along with diet and exercise. This applies to Welchol and to other colesevelam products whose labels include this use, not to all of them.
- It should not be used for type 1 diabetes or diabetic ketoacidosis.
How Colesevelam works
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Colesevelam is a non-absorbed polymer that binds bile acids in your intestine so they can’t be reabsorbed. Your liver responds by turning more cholesterol into bile acids and adding more LDL receptors, which clear LDL cholesterol from your blood. Triglycerides may rise or stay the same. The way it improves blood sugar is unknown.
Colesevelam dosage
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Colesevelam is taken by mouth with a meal. Tablets are taken with a liquid, either once daily or split into two daily doses. The oral suspension is mixed with water, fruit juice, or diet soft drink and drunk right away. Your triglycerides and cholesterol are checked before you start. Follow your prescriber’s directions and your product label.
Dosing details from the FDA-approved label
From the Colesevelam prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.
- Primary hyperlipidemia in adults and in boys and postmenarchal girls aged 10 to 17 years
- 3.75 grams daily
- Tablets: take 6 tablets once daily or 3 tablets twice daily with a meal and liquid
- For oral suspension: take one 3.75 grams packet once daily or one 1.875 grams packet twice daily with a meal (some labels: one packet once daily)
- Due to tablet size, for oral suspension is recommended for the pediatric population; can be dosed at the same time as a statin or apart; monitor lipid levels within 4 to 6 weeks after initiation
- Type 2 diabetes mellitus in adults
- 3.75 grams daily
- Tablets: take 6 tablets once daily or 3 tablets twice daily with a meal and liquid
- For oral suspension: take one 3.75 grams packet once daily or one 1.875 grams packet twice daily with a meal (some labels: one packet once daily)
- Take with a meal; for oral suspension mix the packet in 1/2 to 1 cup (4 to 8 ounces) or 1 cup (8 ounces) of water, fruit juice, or diet soft drinks
Read the label’s full dosing text
2 DOSAGE AND ADMINISTRATION • Obtain lipid parameters, including serum triglyceride (TG) levels, before starting colesevelam hydrochloride for oral suspension ( 2.1 ). • The recommended dosage for adults and for boys and postmenarchal girls aged 10 to 17 years with primary hyperlipidemia is 3.75 grams daily or one 1.875 grams packet twice daily. The recommended dosage for adults with type 2 diabetes mellitus is 3.75 grams daily or one 1.875 grams packet twice daily. Colesevelam hydrochloride for oral suspension should be taken as follows ( 2.2 , 2.4 ): For Oral Suspension Take one 3.75 grams packet once daily or one 1.875 grams packet twice daily with a meal. To prepare, empty the entire contents of one packet into the glass or cup. Add ½ cup to 1 cup of water, fruit juice, or diet soft drinks. Stir well and drink. 2.1 Testing Prior to Initiation of Colesevelam Hydrochloride for Oral Suspension Obtain lipid parameters, including triglyceride (TG) levels, before starting colesevelam hydrochloride for oral suspension. Colesevelam hydrochloride for oral suspension is contraindicated in patients with TG levels >500 mg/dL [see Contraindications ( 4 ) and Warnings and Precautions ( 5.1 )] . 2.2 Recommended Dosage in Primary Hyperlipidemia and Type 2 Diabetes Mellitus The recommended dosage of colesevelam hydrochloride for oral suspension for adults and for boys and postmenarchal girls aged 10 to 17 years with primary hyperlipidemia is 3.75 grams daily or one 1.875 grams packet twice daily. The recommended dosage of colesevelam hydrochloride for oral suspension for adults with type 2 diabetes mellitus is 3.75 grams daily or one 1.875 grams packet twice daily. Colesevelam hydrochloride for oral suspension should be taken as follows: For Oral Suspension 1.875 gm – Take one packet twice daily 3.75 gm - Take one packet once daily. 2.3 Important Dosing Information for Primary Hyperlipidemia Colesevelam hydrochloride for oral suspension can be dosed at the same time as a statin, or colesevelam hydrochloride for oral suspension and the statin can be dosed apart . Monitor lipid levels within 4 to 6 weeks after initiation of colesevelam hydrochloride for oral suspension. 2.4 Administration Instructions For Oral Suspension To prepare, empty the entire contents of one packet into a glass or cup. Add ½ to 1 cup (4 to 8 ounces) of water, fruit juice, or diet soft drinks.
Excerpted — the section continues on the label. Read the full Dosage and Administration section on DailyMed →
Colesevelam side effects
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The most common side effects in studies were:
Common side effects
- Constipation
- Indigestion (dyspepsia)
- Nausea
- Weakness (asthenia)
- Sore throat or runny nose
- Muscle aches
- Back pain (in diabetes studies)
- Headache and vomiting (in teens)
When to get medical help
- Severe belly pain, with or without nausea and vomiting, could be pancreatitis (inflammation of the pancreas). Stop colesevelam and get medical help promptly.
- Severe belly pain or severe constipation may signal a bowel blockage. Stop colesevelam and get medical attention.
- Trouble swallowing tablets or a feeling of something stuck can mean a throat (esophageal) blockage. Get medical help.
- A body rash with mouth blistering after starting the medicine may be an allergic reaction. Call your doctor.
Colesevelam warnings and precautions
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- High triglycerides and pancreatitis: colesevelam can raise triglycerides. Stop it and get prompt help for severe belly pain with or without nausea and vomiting.
- Bowel obstruction: not recommended with gastroparesis, other gut motility problems, or major gut surgery.
- Swallowing problems: tablets can cause trouble swallowing or throat blockage.
- Vitamin deficiency: it may lower absorption of vitamins A, D, E, and K.
Colesevelam interactions
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Colesevelam can reduce absorption of other drugs, so timing matters.
- Cyclosporine: levels can drop.
- Phenytoin: seizure activity or lower levels reported.
- Levothyroxine and other thyroid replacement: lower exposure, higher TSH.
- Warfarin: INR can drop, so it needs monitoring.
- Birth control pills with ethinyl estradiol and norethindrone: may be less effective.
- Olmesartan and sulfonylureas: lower exposure.
- Metformin extended release: exposure rises, so watch blood sugar.
- Vitamins: take at least 4 hours before colesevelam.
Interactions listed in the FDA-approved label
From the Colesevelam prescribing information (“Drug Interactions”): what the manufacturer studied or reported to the FDA.
- Drugs with a narrow therapeutic index (e.g., cyclosporine): Concomitant use may decrease the exposure of the narrow therapeutic index drug; a decrease in cyclosporine exposure was shown in vivo. Administer at least 4 hours prior to colesevelam hydrochloride. Monitor drug levels when appropriate.
- Phenytoin: Postmarketing reports of increased seizure activity or decreased phenytoin levels. Administer phenytoin 4 hours prior to colesevelam hydrochloride.
- Thyroid hormone replacement therapy: Decreased exposure of levothyroxine in vivo; postmarketing reports of elevated TSH. Administer thyroid hormone replacement therapy 4 hours prior to colesevelam hydrochloride.
- Warfarin: Postmarketing reports of reduced INR in patients receiving warfarin therapy. Monitor INR frequently during colesevelam hydrochloride initiation then periodically thereafter.
- Oral contraceptives containing ethinyl estradiol and norethindrone: Decreased exposure of ethinyl estradiol and norethindrone in vivo. Administer oral contraceptives 4 hours prior to colesevelam hydrochloride.
- Olmesartan medoxomil: Decrease in olmesartan medoxomil exposure in vivo. Administer olmesartan medoxomil 4 hours prior to colesevelam hydrochloride.
- Sulfonylureas (glimepiride, glipizide, glyburide): Decrease in sulfonylureas in vivo when coadministered. Administer sulfonylureas 4 hours prior to colesevelam hydrochloride.
- Oral vitamin supplements: Colesevelam hydrochloride may decrease the absorption of fat-soluble vitamins A, D, E, and K. Take vitamins at least 4 hours prior to colesevelam hydrochloride.
- Metformin extended release: Increase in metformin extended release exposure in vivo when coadministered. Monitor patients' glycemic control.
- Other drugs not tested for interaction, especially those with a narrow therapeutic index: Potential for decreased absorption of other drugs. Consider administering at least 4 hours prior to colesevelam hydrochloride.
Read the label’s full interactions text
5.4 Drug Interactions Colesevelam hydrochloride reduces gastrointestinal absorption of some drugs. Administer drugs with a known interaction at least 4 hours prior to colesevelam hydrochloride [see Drug Interactions ( 7 )] . Due to the potential for decreased absorption of other drugs that have not been tested for interaction, especially those with a narrow therapeutic index, consider administering at least 4 hours prior to colesevelam hydrochloride [see Clinical Pharmacology ( 12.3 )] .
7 DRUG INTERACTIONS Concomitant use with colesevelam hydrochloride may decrease the exposure of the following drugs: Drugs with a narrow therapeutic index (e.g., cyclosporine), phenytoin, thyroid hormone replacement therapy, warfarin, oral contraceptives containing ethinyl estradiol and norethindrone, olmesartan medoxomil, and sulfonylureas (glimepiride, glipizide, glyburide). Administer these drugs 4 hours prior to colesevelam hydrochloride. For patients on warfarin, monitor International Normalized Ratio (INR) frequently during initiation then periodically ( 7.1 ). Concomitant use with colesevelam hydrochloride may increase the exposure of the following drugs: Metformin extended release. Monitor patients' glycemic control ( 7.2 ). 7.1 Colesevelam Hydrochloride Drug Interactions that Decrease the Exposure of the Concomitant Medication Table 4 includes a list of drugs that decrease exposure of the concomitant medication when administered concomitantly with colesevelam hydrochloride and instructions for preventing or managing them. Table 4 Colesevelam Hydrochloride Drug Interactions that Decrease the Exposure of the Concomitant Medication Drugs with a Narrow Therapeutic Index Clinical Impact Concomitant use with colesevelam hydrochloride may decrease the exposure of the narrow therapeutic index drug. In vivo drug interactions studies showed a decrease in exposure of cyclosporine when coadministered with colesevelam hydrochloride [see Clinical Pharmacology ( 12.3 )] .
Excerpted — the section continues on the label. Read the full Drug Interactions section on DailyMed →
Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.
Before taking Colesevelam
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- Not for triglycerides above 500 mg/dL, past pancreatitis from high triglycerides, or past bowel obstruction.
- Tell your doctor about swallowing trouble, gastroparesis, or major gut surgery.
- Pregnancy and breastfeeding: not absorbed, so exposure to the baby isn’t expected. Tell your doctor if you become pregnant.
- Children: studied ages 10 to 17 with HeFH only. The oral suspension is recommended.
- Older adults: no overall differences, but some may be more sensitive.
- Mild to moderate kidney impairment showed no overall differences in diabetes studies.
Colesevelam overdose
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Colesevelam is not absorbed, so the risk of whole-body toxicity is low. Too much may cause stronger stomach and bowel effects, such as constipation. Contact a doctor or poison control if you take too much.
What Colesevelam does in the body
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The maximum cholesterol-lowering effect was reached within 2 weeks and held up with long-term use. In diabetes studies, HbA1c (a 2–3 month blood sugar measure) began to fall after 4 to 6 weeks. It reached its maximal or near-maximal effect after 12 to 18 weeks.
How your body processes Colesevelam
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Colesevelam is not absorbed and stays in the digestive tract. It is not broken down by digestive enzymes or metabolized in the body, and it does not interfere with cytochrome P450 enzymes. Only a tiny amount (about 0.05% of radioactivity) was found in urine.
How to store Colesevelam
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Store at 25°C (77°F); excursions permitted to 15°C to 30°C (59°F to 86°F) . Protect from moisture.
Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
Supplements & herbs that interact with Colesevelam
17 supplements and herbal products have documented interactions with Colesevelam in the licensed clinical database we use. Most are manageable — but your pharmacist should know about everything you take, including vitamins and herbals.
- Major · 1
- Moderate · 7
- Minor · 9
Educational information from a licensed clinical database (Natural Medicines) — see our data sources & update cadence. Not medical advice: an interaction being documented does not mean it will happen to you; do not start or stop medications or supplements without professional guidance.
Colesevelam: pharmacist answers to common questions
Quick, plain-English answers to the questions patients ask most about Colesevelam — the kind of thing our pharmacy team would talk through with you at the counter.
What is colesevelam for?
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How should I take it?
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What side effects should I expect?
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Can I take my other medicines with it?
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Is it safe in pregnancy?
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I have trouble swallowing pills. Is there another option?
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Is Colesevelam available over the counter?
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When was Colesevelam first available?
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Who makes Colesevelam?
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Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →
More about Colesevelam on HelloPharmacist
Colesevelam forms and strengths (how it comes)
Colesevelam is available in 2 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.
Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Colesevelam inactive ingredients by manufacturer.
Tablet
How this form is used
- Colesevelam hydrochloride tablets are used with diet and exercise to lower LDL cholesterol in adults with primary hyperlipidemia.
- Colesevelam hydrochloride tablets are used to lower LDL cholesterol in boys and postmenarchal girls ages 10 to 17 with HeFH.
- Welchol tablets are also used to improve blood sugar control in adults with type 2 diabetes.
- Welchol tablets are taken once daily or divided into two daily doses, with a meal and liquid.
- Colesevelam hydrochloride tablets can cause swallowing trouble or throat blockage because of their size.
Oral suspension
How this form is used
- Colesevelam hydrochloride for oral suspension is used with diet and exercise to lower LDL cholesterol in adults with primary hyperlipidemia.
- Colesevelam hydrochloride for oral suspension is used to lower LDL cholesterol in boys and postmenarchal girls ages 10 to 17 with HeFH.
- Welchol for oral suspension is also used to improve blood sugar control in adults with type 2 diabetes.
- Welchol oral suspension is taken as a packet once daily with a meal.
- Empty the packet into a glass or cup, add water, fruit juice, or diet soft drink, stir well, and drink.
- Colesevelam hydrochloride for oral suspension is recommended for children because of tablet size.
Colesevelam on the U.S. market: products, makers and brands
How Colesevelam appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.
14 companies list 29 Colesevelam product records with the FDA, mostly as tablet, oral suspension; the earliest marketing or approval year on record is 2000. Brand names on the directory include Welchol; the rest are generics.
FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
Also listed with the FDA, not a patient dose form: Powder (6) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.
Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.
How widely Colesevelam is used (Medicaid data)
A general measure of how commonly Colesevelam is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1–Q4 2025, summed across every form and brand of the drug.
Think of this as a proxy for how widely Colesevelam is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.
How commonly is Colesevelam prescribed? Of the 1,601 medications we measure, Colesevelam ranks #827 by Medicaid prescriptions — more than 48% of them.
Utilization by Colesevelam product
Pick a product to see its own Medicaid numbers. Each chip is one clinical product — a specific strength & dosage form as defined by RxNorm — with brand-name and generic versions combined.
colesevelam hydrochloride 625 MG Oral Tablet Most dispensed
Summed across the 8 of 45 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 866910
colesevelam hydrochloride 3750 MG Powder for Oral Suspension
Summed across the 2 of 9 listed NDC products with Medicaid activity — every brand and generic of this exact strength & form. RxNorm 866905
Shares are of the Medicaid prescriptions shown here. Product grouping follows RxNorm (the National Library of Medicine’s drug terminology), so “one product” means one strength & dosage form regardless of manufacturer. Dollar figures are gross Medicaid reimbursement before mandatory rebates — rebates (often large, especially for brand-name drugs) are confidential, so actual net cost to Medicaid is lower than shown.
Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Colesevelam, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 10 of 54 listed Colesevelam NDCs with Medicaid activity.
Compare Colesevelam products
A representative set of FDA-listed product records for Colesevelam — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)
| Strength | Route | Manufacturer / Labeler | Category ⓘ | Details |
|---|---|---|---|---|
| 💊Oral suspension | ||||
| 3.75 g | Oral | Amneal Pharmaceuticals of New York LLC | ANDA | View NDC → |
| 3.75 g | Oral | Ascend Laboratories, LLC | ANDA | View NDC → |
| 3.75 g | Oral | Bryant Ranch Prepack × 2 listings | ANDA | View NDC → |
| 3.75 g | Oral | Glenmark Pharmaceuticals Inc.,USA | ANDA | View NDC → |
| 💊Tablet | ||||
| 625 mg | Oral | A-S Medication Solutions × 6 listings | ANDA | View NDC → |
| 625 mg | Oral | A-S Medication Solutions × 2 listings | NDA | View NDC → |
| 625 mg | Oral | American Health Packaging | ANDA | View NDC → |
| 625 mg | Oral | Amneal Pharmaceuticals of New York LLC | ANDA | View NDC → |
| 625 mg | Oral | Ascend Laboratories, LLC | ANDA | View NDC → |
| 625 mg | Oral | Bionpharma Inc. × 2 listings | ANDA | View NDC → |
| 625 mg | Oral | Bryant Ranch Prepack × 3 listings | ANDA | View NDC → |
| 625 mg | Oral | Cranbury Pharmaceuticals, LLC | ANDA | View NDC → |
| 625 mg | Oral | Dr.Reddys Laboratories Inc | ANDA | View NDC → |
| 625 mg | Oral | Glenmark Pharmaceuticals Inc., USA | ANDA | View NDC → |
| 625 mg | Oral | Golden State Medical Supply, Inc. | ANDA | View NDC → |
| 625 mg | Oral | Macleods Pharmaceuticals Limited | ANDA | View NDC → |
| 625 mg | Oral | PD-Rx Pharmaceuticals, Inc. | ANDA | View NDC → |
| 625 mg | Oral | Zydus Lifesciences Limited | ANDA | View NDC → |
| 625 mg | Oral | Zydus Pharmaceuticals USA Inc. | ANDA | View NDC → |
Showing 29 of 29 products — FDA National Drug Code Directory. See every product, package size and price: browse all 29 Colesevelam NDCs →
Colesevelam side effects reported to the FDA (FAERS)
After a medicine reaches the market, patients, doctors and drugmakers can send the FDA reports of problems they think may be linked to it. Here’s what’s been reported for Colesevelam — a signal of what to watch for, not proof the drug caused it.
Source: openFDA, from the FDA Adverse Event Reporting System (FAERS). These are voluntary reports — they don’t prove the drug caused the effect, and counts reflect how often something was reported, not how often it actually happens. Reports also often name the very problem the medicine is taken for — a common reason to file one is that the drug didn’t help — so for a pain reliever you may see “pain” high on the list; that points to why the report was filed, not to the drug causing the symptom. This counts every report that lists Colesevelam in any role, so the total runs higher than the FDA’s official dashboard, which counts only cases where the drug is the suspect. For the authoritative figures, see the FDA FAERS Public Dashboard. Always talk to your pharmacist or doctor.
Colesevelam FDA approval history
How Colesevelam went from FDA review to the pharmacy shelf — the key milestones in its regulatory journey.
Source: Drugs@FDA.
Colesevelam recall history
A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.
The FDA’s enforcement reports list one Colesevelam recall since July 2021. It is still ongoing. A recall names specific lots from one company, so check the lot number on your own bottle rather than assuming every product is affected; your pharmacist can check whether your supply came from an affected lot.
- Colesvelam Hydrocholoride Tablets 625mg, 180-count bottle, Rx Only, Manufactured by: Glenmark Pharmaceuticals Limited, Pithampur, Madhya Pradesh 454775, India, Manufactured for: Glenmark Pharmaceutic… Lots: Lot # 17240669, exp. date Mar-26 17240876, exp. date Apr-26 17240883, exp. date May-26 17240909, exp. date May-26 17240914, exp. date May-26 17240927, exp. date May-26 FDA record D-0340-2025 →
Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.
RxNorm Concept Web — From Ingredient to Every Form and Strength
This page starts with one ingredient concept (IN). The branches below show its dose-form concepts (SCDF), then the available clinical drug and strength concepts (SCD). Combination products remain separate concepts with their own pages.
RxCUI 141626 2 dose forms · 3 strengths
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Dose form (SCDF) Oral Tablet RxCUI 374632In current FDA listingsClinical drug / strength (SCD) hydrochloride 625 MGRxCUI 866910 -
Dose form (SCDF) Powder for Oral Suspension RxCUI 1870338In current FDA listingsClinical drug / strength (SCD) hydrochloride 1875 MGRxCUI 866900hydrochloride 3750 MGRxCUI 866905
Look up RxCUI 141626 in the RxCUI Atlas →
RxNorm is the U.S. National Library of Medicine’s normalized drug vocabulary. Its concept hierarchy can include forms that are not currently marketed; the status on each branch compares that concept with current FDA listings. RxCUIs identify vocabulary concepts, not individual packages or manufacturers.
Colesevelam supply and shortage status
Whether Colesevelam is in short supply in the U.S. right now, plus any shortage history the FDA has on record. A shortage usually reflects a manufacturing or demand issue — not a safety problem with the drug.
Source: openFDA, from the FDA Drug Shortages database.
💵 What Colesevelam costs pharmacies (NADAC benchmark)
The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.
| Form | Strength | Pharmacy acquisition benchmark | |
|---|---|---|---|
| Tablet, Film Coated · Oral | 625 mg | $0.262 per tablet | NDC details & price history |
| Tablet · Oral | 625 mg | $0.262 per tablet | NDC details & price history |
| Tablet, Coated · Oral | 625 mg | $0.262 per tablet | NDC details & price history |
| For Suspension · Oral | 3.75 g | $3.57 each | NDC details & price history |
Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.
Colesevelam brand names
Colesevelam is sold under one brand name in the FDA directory — Welchol. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.
Who makes Colesevelam: manufacturers and labelers
14 companies list Colesevelam products with the FDA. By number of product records, the largest are A-S Medication Solutions, Bryant Ranch Prepack, Amneal Pharmaceuticals of New York LLC. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.
Colesevelam drug class (RxNorm)
Colesevelam belongs to the Bile Acid Sequestrant class.
Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.
Sources for this Colesevelam page
Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.
How this page is built
HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Zydus Pharmaceuticals USA Inc. is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →