Drug & supplement interaction

Saccharomyces Boulardii + Terbinafine

Terbinafine brand name: Lamisil.

Minor Interaction
Medically reviewed by · Updated September 2026
The bottom line Minor

Saccharomyces Boulardii has a minor interaction with Terbinafine. Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.

Read the full interaction report
SeverityMinor
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Saccharomyces Boulardii and Terbinafine

Here is the interaction we found between these two, with the evidence behind it.

Minor

ANTIFUNGALS

Why this applies to Terbinafine

Terbinafine falls under ANTIFUNGALS — the group Saccharomyces Boulardii interacts with.

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.
Severity Minor Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the thing to keep in mind with this pair: Saccharomyces boulardii is a live, beneficial yeast, and terbinafine (Lamisil) is an antifungal designed to stop fungi from growing. So in theory, the medicine that fights fungus could also knock down some of the helpful yeast in your probiotic, making it work less well. This goes one direction only, it doesn't change how terbinafine treats your nail or scalp infection.

I'll be honest, this is a theoretical concern based on how the drugs work, not solid human studies, so I wouldn't lose sleep over it. If you want the probiotic to do its job, a common-sense move is to space them apart during the day. Run your specific plan by your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Saccharomyces Boulardii Also Interacts With Other Medications

Saccharomyces Boulardii has 39 minor known drug interactions in our database — the Terbinafine one above is one of them. If you take anything else, check it against the full list below.

Minor 39 No known interaction 2,791 (incl. Terbinafine)
Taking anything else?

Check Another of Your Medications Against Saccharomyces Boulardii

Covers the 2,830 medications we’ve checked against Saccharomyces Boulardii. Pick one to open its full report.

From our Q&A

Questions About Saccharomyces Boulardii or Terbinafine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Saccharomyces Boulardii or Terbinafine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Terbinafine

This page covers Saccharomyces Boulardii only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Terbinafine page lists 72 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Ashwagandha (moderate).

By severity: 4 major · 45 moderate · 23 minor.

From our pharmacist’s overview on the Terbinafine page

“Liver strain is the risk that dominates this list. Terbinafine (Lamisil), the antifungal most people take for months to clear a nail infection, can injure the liver in rare cases on its own, and 38 of the 72 supplements catalogued here carry liver risks that could stack on top of that.”

Reviewed by 2 · Jul 18, 2026

Open the Terbinafine interaction page

One more smart check

Taking Saccharomyces Boulardii as Part of a Dietary Supplement Product? Check It for Interactions

We hold 608 real supplement products containing Saccharomyces Boulardii, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Saccharomyces Boulardii. Your product may carry other ingredients that interact with Terbinafine too, on top of Saccharomyces Boulardii — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Saccharomyces Boulardii and Terbinafine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Saccharomyces Boulardii
Top 25%

#268 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Terbinafine
Top half

#1,170 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Saccharomyces Boulardii

What is Saccharomyces Boulardii?

Saccharomyces Boulardii
  • Acute diarrhea
  • Antibiotic-associated diarrhea
  • Traveler's diarrhea
  • Preventing C. difficile recurrence
  • General gut health

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea. It is generally well tolerated in healthy people, but those who are seriously ill or have weakened immune systems should avoid it because of rare but serious bloodstream infections. Talk with your pharmacist or doctor before starting it.

Read the full Saccharomyces Boulardii monograph & all interactions
Medication

About Terbinafine

What Is Terbinafine Used For?

Brand name: Lamisil

Terbinafine tablets treat fungal infections of the toenails or fingernails caused by dermatophytes (onychomycosis, also called tinea unguium). Nail samples should be tested first to confirm the diagnosis.

Topical terbinafine products, such as Lamisil AT cream and spray, cure most athlete’s foot (tinea pedis), jock itch (tinea cruris) and ringworm (tinea corporis). They also relieve itching, burning, cracking and scaling. A CVS cream is labeled for jock itch only. A Toenail Fungus Treatment liquid is labeled for nail fungus, discoloration, thickening, splitting, crumbling and brittleness.

See full Terbinafine drug information
Keep checking

Other Drugs & Saccharomyces Boulardii

Browse every other medication we’ve checked against Saccharomyces Boulardii — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
39Minor
2,790No known interaction
39 Minor 2,790 No interaction
Minor

39 interactions

No interaction 2,790 drugs checked — show the list

We also checked Saccharomyces Boulardii against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,790 medications checked with no known interaction — see the full Saccharomyces Boulardii list.

See the full Saccharomyces Boulardii interactions page
See every supplement checked against Terbinafine, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Saccharomyces Boulardii monograph › Uses, safety, and every drug interaction in one place Terbinafine supplement interactions › Every supplement checked against Terbinafine, ranked by severity Terbinafine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Saccharomyces Boulardii and Terbinafine Together: Common Questions

Can you take Saccharomyces Boulardii with Terbinafine?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Saccharomyces Boulardii and Terbinafine interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Terbinafine and Saccharomyces Boulardii?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.