Major interaction on record — check this product against your medications before combining. Based on 7 of 8 ingredients. Check your meds →
Dietary supplement

3-Day Colon Cleanse Ingredients & Drug Interactions

by BIOHM

3-Day Colon Cleanse label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking 3-Day Colon Cleanse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

3-Day Colon Cleanse is a dietary supplement by BIOHM with 8 active ingredients. Its ingredients are commonly taken for constipation, bowel cleansing before procedures, hemorrhoids.Based on those ingredients, 2,189 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Charcoal, Activated, Cascara sagrada Bark Extract, Plus SD. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against 3-Day Colon Cleanse by BIOHM

Ask about any prescription or over-the-counter medication and we check it for interactions with 3-Day Colon Cleanse by BIOHM — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of 3-Day Colon Cleanse by BIOHM

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 8 active ingredients.
  • “BIOHM FX Probiotic Blend” is a proprietary blend — the label gives one combined amount (22 mg) without saying how much of each component you get.

This 8-ingredient product combines two classes of active ingredients: bowel movers and gut-friendly bacteria. Cascara sagrada bark extract and aloe (in the Plus SD ingredient) are stimulant laxatives—they work by triggering intestinal muscle contractions to promote bowel movements.

Activated charcoal is a processed form of carbon that binds to substances in your digestive tract. The four probiotic strains—Lactobacillus acidophilus, Saccharomyces boulardii, Lacticaseibacillus rhamnosus, and Bifidobacterium breve—are live microorganisms thought to support healthy gut bacteria.

Amylase is an enzyme. The product also contains inactive ingredients: cellulose and stearic acid.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: colon detoxification and gut health support.
  • We looked for evidence on: Abdominal pain, Antibiotic-associated diarrhea, Bowel preparation, Clostridioides difficile infection, Colic, Constipation — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Aloe is rated "Possibly Effective" for Constipation.

The evidence for this product's ingredients is mixed. Cascara sagrada has insufficient evidence to rate for constipation, and is rated possibly ineffective for bowel preparation.

Aloe is rated possibly effective for constipation. Activated charcoal is rated possibly effective for poisoning but has insufficient evidence for other uses like dyspepsia or wound healing.

The probiotics show the strongest evidence: Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, antibiotic-associated diarrhea, and bacterial vaginosis. Saccharomyces boulardii is possibly effective for travelers' diarrhea, antibiotic-associated diarrhea, and Clostridioides difficile infection.

Lacticaseibacillus rhamnosus is possibly effective for atopic dermatitis and antibiotic-associated diarrhea. Bifidobacterium breve has insufficient evidence for most uses.

Overall, the bowel-cleansing claims rest on limited evidence.

The evidence, ingredient by ingredient Cascara Sagrada Activated Charcoal Lactobacillus Acidophilus Saccharomyces Boulardii Lacticaseibacillus Rhamnosus Bifidobacterium Breve Aloe

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Cascara sagrada is generally well tolerated for short-term use, causing only mild abdominal cramps and discomfort in most people. However, long-term use carries real risks: it can lead to potassium loss (hypokalemia), muscle weakness, weight loss, and kidney damage (albuminuria and hematuria).

The safety data advises against use during pregnancy and breastfeeding because active compounds pass into breast milk. Activated charcoal is generally well tolerated short-term but can cause constipation, black stools, bloating, and gas; rare serious effects include bowel obstruction.

It is not well studied in pregnancy, so use only under medical guidance. The probiotics are generally well tolerated in healthy adults and can cause uncommon gas, bloating, or mild abdominal discomfort.

However, in critically ill or severely immunocompromised patients, these live organisms have rarely caused serious infections. Aloe latex (oral) can cause abdominal pain, cramps, and diarrhea; long-term use risks the same potassium loss and organ damage as cascara.

Avoid aloe by mouth during pregnancy and breastfeeding.

Side effects, ingredient by ingredient Cascara Sagrada Activated Charcoal Lactobacillus Acidophilus Saccharomyces Boulardii Lacticaseibacillus Rhamnosus Bifidobacterium Breve Aloe

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Activated Charcoal, Saccharomyces Boulardii, Aloe, Cascara Sagrada, Lactobacillus Acidophilus, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications.
  • For scale: 2,190 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your pharmacist if you use any of these: digoxin or other heart medications (especially high risk), blood thinners like warfarin, corticosteroids, water pills (diuretics), other laxatives, blood sugar medications, oral contraceptives, antibiotics, antifungal drugs, or other oral medications in general. Activated charcoal can interfere with the absorption of many drugs, so time matters—separate doses by at least 2 hours.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product combines laxatives, charcoal, and probiotics for short-term bowel support, but it's not a quick fix and carries real risks with long-term use—especially potassium loss and interactions with common heart and blood-pressure medications. If you take any prescription drugs, warfarin, digoxin, water pills, steroids, antibiotics, antifungals, or blood sugar medications, talk to your pharmacist before starting it.

Healthy adults using it briefly and carefully may tolerate it, but it's not appropriate for pregnant or nursing people, the critically ill, or anyone on interacting medications.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about 3-Day Colon Cleanse, straight from the product label.

Brand BIOHM
Barcode (UPC) 852131008499
Net contents 6 Capsule(s)
Market status On market
Date entered into DSLD Dec 21, 2024
DSLD ID 319943
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for 3-Day Colon Cleanse by BIOHM, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
3
UPC/BARCODE
852131008499
IngredientAmount% DV
Cascara sagrada Bark Extract400 mg--
Charcoal, Activated500 mg--
Lactobacillus acidophilus 16axg0 NP--
Saccharomyces boulardii 16mxg0 NP--
Lacticaseibacillus rhamnosus 18fx0 NP--
Bifidobacterium breve 19bx0 NP--
BIOHM FX Probiotic Blend22 mg--
Amylase0 NP--
Plus SD5 mg--

Other ingredients: Cellulose, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

3 Cleansers + 1 billion CFUs of probiotics

3 powerful natural cleansers 1 Billion CFUs of patented probiotics

Formulation

Our unique formulation of natural plant powders supports gentle colon detoxification.

BIOHM FX probiotics allow you to start seeding your gut with the good guys from the start.

Non-GMO Gluten free Made without soy

Vegetarian

Cleanse Restore Support Supports: Improved regularity Reduced bloating Bowel Function Occasional Constipation Digestive Discomfort Microflora Blanace Breaks down Gut Biofilms Improved Digestion Immune Function

Supports Waste & toxin elimination + regularity + reduced bloating

0 harsh or artificial laxatives

Suggested/Recommended/Usage/Directions

Directions for use Take two (2) capsules once per day with a full 8 oz. glass of water.

Precautions

Do not exceed recommended dose. For short term use only; do not take continuously for more than 7 days.

Warnings For adults only.

This product contains cascara. Do not use this product if you have abdominal pain, diarrhea or chronic constipation.

Consult your healthcare provider if pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if any part of this package is torn, open, or damaged.

General Statements

Results may vary.

BIOHM was co-founded by Dr. Ghannoum, one of the world's foremost gut health scientists. 47+ years of research 500+ published science papers 30,000+ Citations Dr. Mahmoud Ghannoum, the scientist who is now known as the leading microbiome researcher in the world. - The Washington Post

From the world's leading microbiome scientist (meet Dr. Ghannoum on side panel)

Storage

Store at room temperature. No refrigeration necessary.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

BIOHM FX is covered by the following U.S. patent number: US 11,304,985 B2.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

3-Day Colon Cleanse by BIOHM label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

3-Day Colon Cleanse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in 3-Day Colon Cleanse by BIOHM

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container3 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Cascara sagrada Bark Extract

Interacts with
745 drugs
400 mg per serving

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Becaus...

Cascara sagrada Bark Extract monograph & interactions

Charcoal, Activated

Interacts with
2,027 drugs
500 mg per serving Form: Coconut

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings...

Charcoal, Activated monograph & interactions

Plus SD

Interacts with
461 drugs
5 mg per serving Form: Aloe, Powder

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...

Plus SD monograph & interactions

Other (inactive) ingredients: Cellulose, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

3-Day Colon Cleanse by BIOHM Drug Interactions

Want to check YOUR meds against 3-Day Colon Cleanse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,189Drugs
2,022 Major 114 Moderate 53 Minor

Ingredients driving the most interactions

Charcoal, Activated 2,027
Cascara sagrada Bark Extract 745
Plus SD 461
Lactobacillus acidophilus 16axg 182
Lacticaseibacillus rhamnosus 18fx 182

Individual Drug Interactions

The ingredients in 3-Day Colon Cleanse interact with 2,189 drugs. Click any drug to see the details.

7 of the 8 ingredients in 3-Day Colon Cleanse interact with drugs. Each result below shows which ingredient is responsible. Charcoal, Activated Cascara sagrada Bark Extract Plus SD Lactobacillus acidophilus 16axg Lacticaseibacillus rhamnosus 18fx Bifidobacterium breve 19bx Saccharomyces boulardii 16mxg

Each ingredient & the kinds of drugs it affects

For each ingredient in 3-Day Colon Cleanse with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Charcoal, Activated3 drug types · 2,027 drugs

Oral Drugs

Activated charcoal reduces systemic exposure to many drugs, including those that undergo enterohepatic recirculation, regardless of the route of administration.
Activated charcoal adsorbs various drugs and may reduce their absorption and/or half-life. Examples of affected drugs include acetaminophen, aminophylline, amiodarone, atenolol, carbamazepine, dapsone, digoxin, disopyramide, fluoxetine, indomethacin, moxifloxacin, nadolol, phenytoin, phenobarbital, piroxicam, quinine, sotalol, theophylline, tricyclic antidepressants, valproate, and verapamil. Avoid co-administration, except after drug overdose.

Likelihood Probable Evidence B
Alcohol (Ethanol)

The binding action of activated charcoal may be reduced by alcohol.
Alcohol may lower the adsorptive capacity of activated charcoal.

Likelihood Probable Evidence D
Contraceptive Drugs

Activated charcoal may reduce the clinical effects of oral contraceptives.
Activated charcoal, taken in a dose of 5 grams four times daily for 3 days, may bind to, and reduce the absorption of, oral contraceptives, thereby limiting their effectiveness and increasing the risk of contraceptive failure. However, some clinical research shows that the risk for this interaction is minimal when activated charcoal is taken either 3 hours after or at least 12 hours before oral contraceptives.

Likelihood Possible Evidence B
Charcoal, Activated full monograph & interactions

Cascara sagrada Bark Extract6 drug types · 745 drugs

Corticosteroids

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Cascara sagrada Bark Extract full monograph & interactions

Plus SD7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Plus SD full monograph & interactions

Lactobacillus acidophilus 16axg1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus 16axg full monograph & interactions

Lacticaseibacillus rhamnosus 18fx1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lacticaseibacillus rhamnosus with antibiotic drugs might decrease the effectiveness of L. rhamnosus.
L. rhamnosus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. rhamnosus preparations by at least two hours.

Likelihood Probable Evidence D
Lacticaseibacillus rhamnosus 18fx full monograph & interactions

Bifidobacterium breve 19bx1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve 19bx full monograph & interactions

Saccharomyces boulardii 16mxg1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Saccharomyces boulardii 16mxg full monograph & interactions
The maker

Brand information

Manufacturer and brand details for 3-Day Colon Cleanse, from the product label.

BIOHM

See all BIOHM products
Name
BIOHM Health Inc.
Street Address
425 Literary Road, Suite 100
City
Cleveland
State
OH
ZipCode
44113
Web Address
BIOHMHEALTH.COM
Pharmacist Counseling Corner

3-Day Colon Cleanse by BIOHM: Common Questions

Does 3-Day Colon Cleanse by BIOHM interact with any medications?
Yes. Based on its ingredients, 3-Day Colon Cleanse has a known interaction with 2,189 medications, including 2022 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
3-Day Colon Cleanse contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on antibiotics?
No, not at the same time. The antibiotics will kill the live probiotic bacteria in this product, making them ineffective. If you're on antibiotics, talk to your pharmacist about timing—you may need to take the probiotics several hours before or after your antibiotic dose.
Will this help with my constipation?
Cascara sagrada has insufficient evidence for treating constipation, and aloe is rated possibly effective. The evidence isn't strong, and this product is really designed as a short-term cleanse, not a long-term constipation solution. Probiotics are more geared toward diarrhea and gut health.
Is it safe to take this while pregnant?
No. Stimulant laxatives like cascara and aloe are generally not recommended during pregnancy because they may stimulate the uterus and act as strong laxatives. Avoid this product if you're pregnant.
What does activated charcoal do in this product?
Activated charcoal binds to substances in your digestive tract. However, it can also bind to medications you take by mouth, reducing how much your body absorbs—which is why it can interfere with birth control and other drugs.
Can I use this long-term?
Not safely. Long-term use of cascara sagrada and aloe latex can cause potassium loss, muscle weakness, kidney damage, and other serious problems. This product is labeled as a 3-day cleanse for a reason.
What are the probiotics supposed to do?
They're live beneficial bacteria meant to support healthy gut flora. The evidence is strongest for antibiotic-associated diarrhea, travelers' diarrhea, and some digestive conditions—not primarily for 'cleansing.'

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

3-Day Colon Cleanse label
Go deeper

The Full Monographs Behind 3-Day Colon Cleanse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Cascara Sagrada

Interacts with 745 drugs

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...

Read the full Cascara Sagrada monograph → Herb & supplement monograph

Activated Charcoal

Interacts with 2,027 drugs

Activated charcoal is a highly porous form of carbon that can bind certain substances in the gut, and it is used in hospitals to treat some poisonings and overdoses. For everyday uses like g...

Read the full Activated Charcoal monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph → Herb & supplement monograph

Lacticaseibacillus Rhamnosus

Interacts with 182 drugs

Lacticaseibacillus rhamnosus (often labeled L. rhamnosus GG) is a well-studied probiotic bacterium used mainly for diarrhea and general gut health. It is considered safe for most healthy peo...

Read the full Lacticaseibacillus Rhamnosus monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph →
Sources

Sources & How We Checked

3-Day Colon Cleanse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 148 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Cascara Sagrada 9 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  3. Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
  4. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  5. Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
  6. Nadir A, Reddy D, Van Thiel DH. Cascara-sagrada induced intrahepatic cholestasis causing portal hypertension: case report and review of herbal hepatotoxicity. Am J Gastroenterol 2000;95:3634-7. PubMed
  7. Nakasone ES, Tokeshi J. A serendipitous find: a case of cholangiocarcinoma identified incidentally after acute liver injury due to cascara sagrada ingestion. Hawaii J Med Public Health 2015;74(6):200-2.
  8. Cirillo C, Capasso R. Constipation and botanical medicines: an overview. Phytother Res 2015;29(10):1488-93. PubMed
  9. Mazzari ALDA, Lacerda MG, Milton FA, et al. In vitro effects of European and Latin-American medicinal plants in CYP3A4 gene expression, glutathione levels, and P-glycoprotein activity. Front Pharmacol 2022;13:826395. PubMed

See these in context on the Cascara Sagrada monograph →

Activated Charcoal 14 references
  1. Kaaja RJ, Kontula KK, Raiha A, Laatikainen T. Treatment of cholestasis of pregnancy with peroral activated charcoal. A preliminary study. Scand J Gastroenterol 1994;29:178-81.
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Lactobacillus Acidophilus 15 references
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Lacticaseibacillus Rhamnosus 34 references
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  38. Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978. DOI
  39. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
  40. Sabbaghzadegan S, Soltani MH, Kamalinejad M, Bahrami M, Kabir A, Dadmehr M. The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.
  41. Lewis ED, Crowley DC, Guthrie N, Evans M. Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial. PubMed

See these in context on the Aloe monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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