Interactions on record — worth a quick check against your medications. Based on 3 of 13 ingredients. Check your meds →
Dietary supplement

Women's Balanced Probiotic Ingredients & Drug Interactions

by BIOHM

Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Women's Balanced Probiotic is a dietary supplement by BIOHM with 13 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 1,119 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pomegranate Hull Extract, Lactobacillus acidophilus, Bacillus subtilis DE-111. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Women's Balanced Probiotic by BIOHM

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 17 active ingredients.
  • “PreforPro” is listed as a grouped ingredient — the label gives one combined amount (15 mg) without saying how much of each component you get.
  • “Women's Proprietary Blend” is a proprietary blend — the label gives one combined amount (175 mg) without saying how much of each component you get.
  • “BIOHM FX Blend” is a proprietary blend — the label doesn't break down how much of each component you get.

This product contains 17 active ingredients: multiple live Lactobacillus strains (acidophilus, plantarum, casei, rhamnosus, reuteri), Bifidobacterium species (animalis lactis and breve), Bacillus subtilis, Saccharomyces boulardii (a beneficial yeast), Lacticaseibacillus rhamnosus, four bacteriophage strains, pomegranate hull extract, and Amylase (an enzyme). It also includes inactive ingredients like rice maltodextrin, hypromellose, pectin, water, rice, and medium chain triglyceride as fillers and capsule material.

The live organisms and yeast are meant to support gut health and digestion, while the pomegranate extract adds antioxidant polyphenols and the bacteriophages (viruses that target specific bacteria) round out the formula. Amylase helps break down carbohydrates.

These are grouped into a proprietary women's blend and a separate probiotic blend so you get a mix tailored to women's health.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support urinary vaginal digestive and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Colic, Constipation, Diarrhea, Flatulence — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea.
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea, Bacterial vaginosis.

The evidence for this product's ingredients is mixed. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome (IBS), antibiotic-associated diarrhea, bacterial vaginosis, and Helicobacter pylori infection, but possibly ineffective for atopic disease.

Bacillus subtilis is possibly effective for antibiotic-associated diarrhea. Saccharomyces boulardii is possibly effective for traveler's diarrhea, rotaviral diarrhea, antibiotic-associated diarrhea, and Clostridioides difficile (C. difficile) infection, as well as Helicobacter pylori.

Lacticaseibacillus rhamnosus is possibly effective for atopic dermatitis (eczema) and antibiotic-associated diarrhea. Pomegranate is possibly effective for high blood pressure but possibly ineffective for high cholesterol and diabetes.

For several conditions—athletic performance, constipation, eczema with Bacillus subtilis, and nonalcoholic fatty liver disease—the evidence isn't established in our data. Bifidobacterium breve has insufficient evidence for most conditions listed.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bacillus Subtilis Pomegranate

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 6 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus and related strains are generally well tolerated in healthy adults and children, though the data come with caveats: probiotics are often considered low risk but check with your doctor first. Gastrointestinal side effects like bloating, gas, abdominal pain, and diarrhea are uncommon but possible when taking multiple probiotics together.

In rare cases, live probiotic bacteria have caused serious infections (bacteremia, sepsis, endocarditis) mostly in people who are very ill or immunocompromised; most experts believe this happens when bacteria naturally present in the gut slip into the bloodstream rather than being introduced by the product. Bacillus subtilis and Saccharomyces boulardii carry similar cautions and should be avoided by people who are critically ill or immunocompromised.

Saccharomyces has rarely caused fungemia (yeast in the blood) in ICU patients. Pomegranate fruit and juice are generally safe as food, but concentrated extracts have limited safety data; at high doses, diarrhea, flatulence, nausea, and abdominal pain have occurred.

Pregnancy safety is listed as possibly safe for pomegranate and Lacticaseibacillus rhamnosus; for the other ingredients, pregnancy and lactation data are not on file, so talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bacillus Subtilis Pomegranate

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Saccharomyces Boulardii, Pomegranate, Lactobacillus Acidophilus, Bifidobacterium Breve, Lacticaseibacillus Rhamnosus, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 1,120 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications if you take antibiotic drugs—timing matters because antibiotics can kill the live probiotics. If you're on antihypertensive drugs (blood pressure medications), ACE inhibitors, or blood thinners like warfarin, the pomegranate extract needs your pharmacist's green light.

Also flag any drugs that are metabolized by the liver enzyme CYP2D6, and antifungal drugs if you're using them. Use the search tool below to verify your exact medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with certain types of diarrhea and gut issues, especially if you're taking antibiotics, but it's not right for everyone. If you take blood pressure drugs, heart medications, blood thinners like warfarin, statin cholesterol drugs, or have a weakened immune system, talk to your pharmacist or doctor before starting.

Always check your exact medications against the interaction tool on this page.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 17 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Women's Balanced Probiotic, straight from the product label.

Brand BIOHM
Barcode (UPC) 852131008178
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Nov 22, 2024
DSLD ID 319954
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult Female (18 - 50 Years), Seniors/Mature (>50 Years) - Women ONLY, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Women's Balanced Probiotic by BIOHM, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
UPC/BARCODE
852131008178
IngredientAmount% DV
Amylase0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus casei0 NP--
Bifidobacterium animalis lactis0 NP--
Lactobacillus rhamnosus0 NP--
PreforPro15 mg--
Lactobacillus reuteri0 NP--
Bacillus subtilis DE-1110 NP--
LH01-Myoviridae0 NP--
LL5-Siphoviridae0 NP--
T4D-Myoviridae0 NP--
LL12-Myoviridae0 NP--
Lactobacillus acidophilus 16axg0 NP--
Saccharomyces boulardii 16mxg0 NP--
Lacticaseibacillus rhamnosus 18fx0 NP--
Bifidobacterium breve 19bx0 NP--
Women's Proprietary Blend175 mg--
Pomegranate Hull Extract150 mg--
BIOHM FX Blend0 NP--

Other ingredients: Rice Maltodextrin, Hypromellose, Pectin, Water, Rice, Medium Chain Triglyceride

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

A probiotic formula designed to support four major areas of women's health: urinary, vaginal, digestive and immune health.

Non-GMO Made without soy Gluten-free

Vegetarian

Supports: Urinary, vaginal, digestive & immune health

Formula

Women's balanced probiotic Contains scientifically researched ingredients BIOHM FX and PreforPro. BIOHM FX is a groundbreaking probiotic blend that breaks down digestive plague while PreforPro stimulates the growth of beneficial bacteria in the gut.

9 powerful probiotic strains 30 Billion CFUs of probiotics 4 prebiotic phages + pomegranate

4-In-1 Women's care

Suggested/Recommended/Usage/Directions

Directions for use Take one (1) capsule daily with food.

Once daily

Precautions

Warnings Consult your healthcare provider if pregnant or nursing, taking medication, or have a medical condition.

Keep out of reach of children.

Do not use if any part of this package is torn, open, or damaged.

Storage

Store at room temperature. No refrigeration necessary.

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

DE111 & PreforPro are registered trademarks of Deerland Probiotics & Enzymes, Inc. BIOHM FX is covered by the following U.S. patent number: US 11,304,985 B2.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

See for yourself

Women's Balanced Probiotic by BIOHM label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Women's Balanced Probiotic by BIOHM

These are the 13 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

PreforPro

15 mg per serving
  • › LH01-Myoviridae
  • › LL5-Siphoviridae
  • › T4D-Myoviridae
  • › LL12-Myoviridae

Women's Proprietary Blend

175 mg per serving

Pomegranate Hull Extract

Interacts with
922 drugs
150 mg per serving

Pomegranate is a nutrient-rich fruit that is high in antioxidants and is widely enjoyed as food and juice. Early research suggests it may support hear...

Pomegranate Hull Extract monograph & interactions

Other (inactive) ingredients: Rice Maltodextrin, Hypromellose, Pectin, Water, Rice, Medium Chain Triglyceride. These complete the product’s ingredient list but are not active constituents.

Interaction report

Women's Balanced Probiotic by BIOHM Drug Interactions

Want to check YOUR meds against Women's Balanced Probiotic?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
1,119Drugs
537 Moderate 582 Minor

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Women's Balanced Probiotic with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Pomegranate Hull Extract9 drug types · 922 drugs

Ace Inhibitors (Aceis)

Theoretically, taking pomegranate with ACEIs might increase the risk of adverse effects.
Pomegranate juice is thought to have ACE inhibitor-like effects.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, taking pomegranate with antihypertensive drugs might increase the risk of hypotension.
Consuming pomegranate juice can modestly lower blood pressure.

Likelihood Possible Evidence B
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2D6.
In vitro, pomegranate juice inhibits CYP2D6. However, the clinical significance of this potential interaction in humans is not known.

Likelihood Possible Evidence D
Rosuvastatin (Crestor)

Theoretically, taking pomegranate with rosuvastatin might increase the risk of adverse effects.
In one case, a patient taking rosuvastatin 5 mg every other day in combination with ezetimibe 10 mg daily developed rhabdomyolysis after drinking pomegranate juice 200 mL twice weekly for 3 weeks. This patient had a history of elevated creatine kinase levels while not receiving any statin treatment. This suggests a possible underlying myopathy and predisposition to rhabdomyolysis.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, pomegranate might increase warfarin levels and increase the risk of bleeding. Also, discontinuing regular consumption of pomegranate juice might decrease warfarin levels.
In one case report, a patient had a stable, therapeutic bleeding time, as measured by international normalized ratio (INR), while taking warfarin in combination with pomegranate juice 2-3 times per week. The patient became subtherapeutic within about 10 days after discontinuing pomegranate juice, which required a warfarin dose increase. In another case report, a patient with a stable INR for over one year presented with an INR of 14. The patient noted no changes to medications or diet but did report consuming around 3 liters of pomegranate juice over the previous week. The patient's INR stabilized upon moderation of pomegranate juice consumption. The mechanism of this potential interaction is unclear.

Likelihood Possible Evidence D
Carbamazepine (Tegretol)

Theoretically, taking pomegranate with carbamazepine might increase the risk of adverse effects, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice may inhibit cytochrome P450 3A4 (CYP3A4) metabolism of carbamazepine and increase levels of carbamazepine by 1.5 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP3A4, but might not inhibit hepatic CYP3A4. However, some human research suggests that pomegranate does not significantly inhibit CYP3A4 drug metabolism in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP2C9.
Some animal and in vitro research shows that pomegranate juice inhibits intestinal, but not hepatic, CYP2C9 isoenzyme activity. However, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, pomegranate might increase levels of drugs metabolized by CYP3A4, but most research suggests this interaction is unlikely to be clinically significant.
Pomegranate contains several polyphenols that have individually been shown to inhibit CYP3A4. However, there is contradictory evidence about the effect of whole pomegranate juice on CYP3A4 activity. In vitro, pomegranate juice significantly inhibits the CYP3A4 enzyme, with comparable inhibition to grapefruit juice. In an animal model, pomegranate juice inhibits CYP3A4 metabolism of carbamazepine and increases levels of carbamazepine by 1.5 times; however, in human volunteers, drinking a single glass of pomegranate juice 240 mL or taking 200 mL daily for 2 weeks does not significantly affect levels of the CYP3A4 substrate midazolam after oral or intravenous administration. Another study in healthy volunteers shows that consuming pomegranate juice 300 mL three times daily for three days also does not significantly affect levels of simvastatin, a CYP3A4 substrate This suggests that pomegranate is unlikely to significantly affect levels of CYP3A4 substrates in humans.

Likelihood Unlikely Evidence B
Tolbutamide (Orinase)

Theoretically, pomegranate might increase levels of tolbutamide, although research suggests this interaction is unlikely to be clinically significant.
Animal research shows that pomegranate juice inhibits the cytochrome P450 2C9 (CYP2C9) metabolism of tolbutamide. Pomegranate juice increased tolbutamide levels by 1.2 times without prolonging the elimination half-life. This suggests that pomegranate juice inhibits intestinal CYP2C9, but might not inhibit hepatic CYP2C9. Despite this evidence, clinical research shows that neither pomegranate juice nor pomegranate extract have a significant effect on CYP2C9 activity in humans. This interaction does not appear to be clinically significant in humans.

Likelihood Unlikely Evidence D

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D

Bacillus subtilis DE-1111 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Women's Balanced Probiotic, from the product label.

BIOHM

See all BIOHM products
Name
BIOHM Health Inc.
Street Address
425 Literary Road, Suite 100
City
Cleveland
State
OH
ZipCode
44113
Web Address
BIOHMHEALTH.COM
Pharmacist Counseling Corner

Women's Balanced Probiotic by BIOHM: Common Questions

Does Women's Balanced Probiotic by BIOHM interact with any medications?
Yes. Based on its ingredients, Women's Balanced Probiotic has a known interaction with 1,119 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Women's Balanced Probiotic contains 13 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while I'm on antibiotics?
Not at the same time. The antibiotic will kill the live bacteria in the probiotic, so it won't work. Ask your pharmacist to help you space them out—typically you'd finish your antibiotic course first, then start the probiotic after a day or two, or take the probiotic in between doses if timing allows.
Is this safe if I'm pregnant or breastfeeding?
The pomegranate extract and Lacticaseibacillus rhamnosus are listed as possibly safe in pregnancy and lactation, but the other probiotic strains don't have safety data on file. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy or while nursing.
What are these phages (bacteriophages) for?
The four bacteriophages in this product are viruses that specifically target and help eliminate harmful bacteria in your gut. They're part of the formula to support a balanced microbiome, but we don't have effectiveness ratings for them in our data.
Can I take this every day?
Yes, most healthy adults take probiotics daily. That said, if you experience bloating, gas, or abdominal pain, you may want to dial back the dose or check with your doctor. Stop and call your doctor if you develop severe symptoms or if you're very ill or immunocompromised.
Will this help my irritable bowel syndrome (IBS)?
Lactobacillus acidophilus in this product is possibly effective for IBS based on the data we hold. Results vary by person, so give it a few weeks and see how you feel. If it's not helping, or if symptoms get worse, let your doctor know.
Is there any sugar or allergens in this?
The inactive ingredients are rice maltodextrin, hypromellose, pectin, water, rice, and medium chain triglyceride—no added sugar listed. For full allergen information or if you're sensitive to rice or coconut (source of MCT), check the label or call the manufacturer directly.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Women's Balanced Probiotic label
Sources

Sources & How We Checked

Women's Balanced Probiotic's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 121 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Saccharomyces Boulardii 26 references
  1. Niault M, Thomas F, Prost J, et al. Fungemia due to Saccharomyces species in a patient treated with enteral Saccharomyces boulardii. Clin Infect Dis 1999;28:930.
  2. Pletinex M, Legein J, Vandenplas Y. Fungemia with Saccharomyces boulardii in a 1-year-old girl with protracted diarrhea. J Pediatr Gastroenterol Nutr 1995;21:113-5. DOI
  3. Fredenucci I, Chomarat M, Boucaud C, et al. Saccharomyces boulardii fungemia in a patient receiving ultra-levure therapy. Clin Infect Dis 1998;27:222-3.
  4. Elmer GW, McFarland LV, Surawicz CM, et al. Behaviour of Saccharomyces boulardii in recurrent Clostridium difficile disease patients. Aliment Pharmacol Ther 1999;13:1663-8.
  5. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  6. Cesaro S, Chinello P, Rossi L, Zanesco L. Saccharomyces cerevisiae fungemia in a neutropenic patient treated with Saccharomyces boulardii. Support Care Cancer 2000;8:504-5. PubMed
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Lacticaseibacillus Rhamnosus 34 references
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Bifidobacterium Breve 9 references
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Pomegranate 27 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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