Major interaction on record — check this product against your medications before combining. Based on 7 of 9 ingredients. Check your meds →
Dietary supplement

Colon Cleanse Ingredients & Drug Interactions

by BIOHM

Colon Cleanse label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Colon Cleanse against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Colon Cleanse is a dietary supplement by BIOHM with 9 active ingredients. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 1,349 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Cascara Sagrada, Rhubarb, Aloe vera. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Colon Cleanse by BIOHM

Ask about any prescription or over-the-counter medication and we check it for interactions with Colon Cleanse by BIOHM — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Colon Cleanse by BIOHM

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 12, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 9 active ingredients.
  • “BIOHM FX Probiotic Blend” is a proprietary blend — the label gives one combined amount (22 mg) without saying how much of each component you get.

BIOHM Colon Cleanse contains 9 active ingredients: three herbal laxatives (aloe vera, rhubarb, and cascara sagrada), cassia cinnamon, amylase (an enzyme), and a probiotic blend featuring L. rhamnosus 18 fx, L. acidophilus 16 axg, S. boulardii 16 mxg, and B. breve 19 bx. The herbal components are designed to support bowel function, while the probiotics aim to support gut health.

The capsules also contain vegetable cellulose and magnesium stearate as inactive ingredients.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: colon cleanse and digestive regularity.
  • We looked for evidence on: Constipation, Bowel preparation, Diarrhea, Antibiotic-associated diarrhea, Clostridioides difficile infection, Crohn disease — and 4 related terms.
  • The strongest evidence on file: Saccharomyces Boulardii is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Saccharomyces Boulardii is rated "Possibly Effective" for Rotaviral diarrhea, Travelers' diarrhea, Clostridioides difficile infection.
  • Also on file: Aloe is rated "Possibly Effective" for Constipation.

The evidence for this product's ingredients is mixed. Aloe vera is possibly effective for acne, obesity, diabetes, psoriasis, burns, and constipation.

Rhubarb shows possibly effective evidence for pancreatitis and menopausal symptoms, but insufficient evidence for constipation. Cascara sagrada has insufficient evidence for constipation and is possibly ineffective for bowel preparation.

Cassia cinnamon shows insufficient evidence across the conditions studied. For the probiotics: L. acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

S. boulardii is possibly effective for rotaviral diarrhea, traveler's diarrhea, antibiotic-associated diarrhea, and other conditions. B. breve shows insufficient evidence for most conditions and possibly ineffective for cognitive decline and sepsis.

The evidence, ingredient by ingredient Aloe Rhubarb Cascara Sagrada Cassia Cinnamon Lactobacillus Acidophilus Saccharomyces Boulardii Bifidobacterium Breve

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Aloe latex — the active form in this product — is associated with common side effects including abdominal pain, cramps, and diarrhea. Long-term use can cause serious potassium loss, muscle weakness, and irregular heartbeats.

Rhubarb root can cause cramping and diarrhea, and chronic use risks potassium depletion and kidney damage. Cascara sagrada may cause mild abdominal discomfort short-term but carries risks with long-term use, including potassium loss.

Cassia cinnamon at supplement doses may harm the liver over time due to its coumarin content. The probiotics are generally well tolerated but carry rare risks of infection in critically ill or severely immunocompromised patients — S. boulardii has been associated with fungemia in ICU patients, and B. breve bacteremia has occurred in very ill infants.

Aloe latex safety data advises against use during pregnancy because it may stimulate the uterus and act as a strong laxative, and against breastfeeding due to limited safety and laxative effects. Rhubarb and cascara sagrada are similarly rated possibly unsafe in pregnancy and lactation.

Cassia cinnamon is rated likely safe in pregnancy and lactation at food amounts, but medicinal or high-dose amounts are not well studied. The probiotics have insufficient safety data in pregnancy and lactation — talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Aloe Rhubarb Cascara Sagrada Cassia Cinnamon Lactobacillus Acidophilus Saccharomyces Boulardii Bifidobacterium Breve

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 7 of the 7 matched ingredients can interact with medications — Rhubarb, Saccharomyces Boulardii, Aloe, Cascara Sagrada, Lactobacillus Acidophilus, among others.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications; heart-rhythm medications.
  • For scale: 1,350 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take digoxin or other heart medications (Major risk from aloe). Also double-check blood thinners including warfarin, diabetes medications, water pills (diuretics), steroid medications, antifungals, or antibiotics — all carry Moderate or Minor interaction risks with ingredients in this formula.

No interactions are documented for amylase or L. rhamnosus 18 fx, as we hold no data for these.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This product combines three strong herbal laxatives with probiotics. It may help with short-term constipation, but the laxative ingredients carry real risks — especially potassium loss and interactions with heart, blood-thinner, and diabetes medications.

If you take digoxin, warfarin, water pills, steroid medications, diabetes drugs, or antibiotics, you need to check with your pharmacist before starting. People who are critically ill, immunocompromised, or pregnant or breastfeeding should not use it without medical guidance.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 9 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Colon Cleanse, straight from the product label.

Brand BIOHM
Barcode (UPC) 855486007742
Net contents 14 Veggie Capsule(s)
Market status On market
Date entered into DSLD Jun 22, 2023
DSLD ID 291954
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Colon Cleanse by BIOHM, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Veggie Capsule(s)
Maximum serving Sizes:
2 Veggie Capsule(s)
Servings per container
7
UPC/BARCODE
855486007742
IngredientAmount% DV
Amylase0 NP--
Aloe vera5 mg--
Rhubarb250 mg--
Cascara Sagrada400 mg--
Cassia Cinnamon370 mg--
BIOHM FX Probiotic Blend22 mg--
L. rhamnosus 18 fx0 NP--
L. acidophilus 16 axg0 NP--
S. boulardii 16 mxg0 NP--
B. breve 19 bx0 NP--

Other ingredients: Vegetable Cellulose Capsule, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions Take two (2) capsules once per day. For short term use only; do not take continuously for more than 2 weeks. Do not exceed recommended dose. Take with a full 8-ounce glass of water.

Precautions

For short term use only; do not take continuously for more than 2 weeks.

Warnings For adults only. Do not use if any part of this package is torn, open, or damaged.

As with any dietary supplement, consult your healthcare provider before using this product especially if you are pregnant, nursing, or otherwise under medical supervision.

Keep out of reach of children.

Notice: This product contains cascara sagrada and aloe vera. Read and follow the directions carefully. Do not use if you have or develop diarrhea or abdominal pain because cascara sagrada and aloe vera may worsen these conditions and be harmful to your health. Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.

Formulation

Non-GMO

Vegetarian product

A gentle cleanse to optimize your digestive journey.

Storage

Store at room temperature.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

Herbals + Probiotics

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Colon Cleanse by BIOHM label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Colon Cleanse label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Colon Cleanse by BIOHM

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Veggie Capsule(s) Dosage formCapsule Servings per container7 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Aloe vera

Interacts with
461 drugs
5 mg per serving

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...

Aloe vera monograph & interactions

Rhubarb

Interacts with
658 drugs
250 mg per serving

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal clai...

Rhubarb monograph & interactions

Cascara Sagrada

Interacts with
745 drugs
400 mg per serving

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Becaus...

Cascara Sagrada monograph & interactions

Cassia Cinnamon

Interacts with
442 drugs
370 mg per serving

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evi...

Cassia Cinnamon monograph & interactions

BIOHM FX Probiotic Blend

22 mg per serving

Other (inactive) ingredients: Vegetable Cellulose Capsule, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Colon Cleanse by BIOHM Drug Interactions

Want to check YOUR meds against Colon Cleanse?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,349Drugs
1 Major 871 Moderate 477 Minor

Ingredients driving the most interactions

Cascara Sagrada 745
Rhubarb 658
Aloe vera 461
Cassia Cinnamon 442
L. acidophilus 16 axg 182

Individual Drug Interactions

The ingredients in Colon Cleanse interact with 1,349 drugs. Click any drug to see the details.

7 of the 9 ingredients in Colon Cleanse interact with drugs. Each result below shows which ingredient is responsible. Cascara Sagrada Rhubarb Aloe vera Cassia Cinnamon L. acidophilus 16 axg B. breve 19 bx S. boulardii 16 mxg

Each ingredient & the kinds of drugs it affects

For each ingredient in Colon Cleanse with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Cascara Sagrada6 drug types · 745 drugs

Corticosteroids

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with corticosteroids.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, cascara sagrada might cause hypokalemia, potentially increasing the risk of digoxin toxicity.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, cascara sagrada might increase the risk of hypokalemia when taken with diuretic drugs.
Cascara sagrada has stimulant laxative effects, and long-term use has been associated with hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, cascara sagrada might have additive adverse effects when taken with stimulant laxatives.
Cascara sagrada has stimulant laxative effects and might compound fluid and electrolyte losses when taken with stimulant laxatives.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, cascara sagrada might increase the risk of bleeding when taken with warfarin.
Cascara sagrada has stimulant laxative effects. In some people, cascara sagrada can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, cascara sagrada might decrease the effects of CYP3A4 substrates.
In vitro research suggests that cascara sagrada can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Cascara Sagrada full monograph & interactions

Rhubarb8 drug types · 658 drugs

Corticosteroids

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia when taken with corticosteroids.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might compound corticosteroid-induced potassium loss.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, taking rhubarb with cyclosporine might reduce cyclosporine levels.
Animal research shows that co-administration of rhubarb decoction 0.25 or 1 gram/kg with cyclosporine 2.5 mg/kg, decreases cyclosporine maximum plasma concentration and overall exposure levels when compared with taking cyclosporine alone. The authors theorize that rhubarb might reduce cyclosporine bioavailability by inducing of P-glycoprotein and/or cytochrome P450 3A4. However, since rhubarb was administered as a single oral dose and enzyme induction usually occurs after multiple doses, it is possible that cyclosporine absorption was actually reduced via rhubarb's stimulant laxative effects. Also, the composition of the rhubarb decoction was not described.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, overuse of rhubarb might increase the risk of adverse effects when taken with digoxin.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion, increasing the risk of digoxin toxicity.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, frequent and high doses of rhubarb might increase the risk of hypokalemia.
Rhubarb has stimulant laxative effects. Overuse of rhubarb might cause potassium depletion and compound diuretic-induced potassium loss.

Likelihood Possible Evidence D
Hepatotoxic Drugs

Theoretically, concomitant use of rhubarb with potentially hepatotoxic drugs might increase the risk of developing liver damage.
Some animal research suggests that anthraquinones in rhubarb might have hepatotoxic effects. Also, rhubarb use has been linked to at least 24 cases of liver injury, although details on the dose of rhubarb and duration of use in these cases is unclear.

Likelihood Possible Evidence D
Nephrotoxic Drugs

Theoretically, long-term use of anthraquinones from rhubarb might increase the risk of nephrotoxicity when used with nephrotoxic drugs.
The anthraquinone constituents of rhubarb have been shown to induce nephrotoxicity in animal research. Additionally, in a case report, a 23-year old female presented with kidney failure after taking 6 tablets of a proprietary slimming agent (found to contain the anthraquinones emodin and aloe-emodin from rhubarb) daily for 6 weeks and then adding diclofenac 25 mg 4 times daily for 2 days. The authors postulate that the anthraquinone constituents of rhubarb contributed to the renal dysfunction, and the addition of diclofenac, a nephrotoxic drug, led to renal failure. Until more is known, advise patients to avoid taking rhubarb if they are taking other potentially nephrotoxic drugs.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, rhubarb might increase the risk for fluid and electrolyte loss when taken with other stimulant laxatives.
Rhubarb has stimulant laxative effects. Concomitant use with stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, excessive use of rhubarb might increase the risk of bleeding when taken with warfarin.
Rhubarb has stimulant laxative effects and can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of rhubarb.

Likelihood Possible Evidence D
Rhubarb full monograph & interactions

Aloe vera7 drug types · 461 drugs

Digoxin (Lanoxin)

Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.

Likelihood Possible Evidence D
Antidiabetes Drugs

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.

Likelihood Possible Evidence D
Diuretic Drugs

Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.

Likelihood Possible Evidence D
Stimulant Laxatives

Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Aloe vera full monograph & interactions

Cassia Cinnamon2 drug types · 442 drugs

Antidiabetes Drugs

Theoretically, cassia cinnamon may have additive effects with antidiabetes drugs.
Cassia cinnamon may lower blood glucose levels, and have additive effects in patients treated with antidiabetic agents. Dose adjustments to diabetes medications might be necessary.

Likelihood Possible Evidence B
Hepatotoxic Drugs

Theoretically, large doses of cassia cinnamon might cause additive effects when used with hepatotoxic drugs.
There is some concern that ingesting large amounts of cassia cinnamon for an extended duration might cause hepatotoxicity in some people. Cassia cinnamon contains coumarin, which can cause hepatotoxicity in animal models. In humans, very high doses of coumarin from 50-7000 mg/day can result in hepatotoxicity that resolves when coumarin use is discontinued. Lower amounts might also cause liver problems in sensitive people, such as those with liver disease or those taking potentially hepatotoxic agents.

Likelihood Possible Evidence D
Cassia Cinnamon full monograph & interactions

L. acidophilus 16 axg1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
L. acidophilus 16 axg full monograph & interactions

B. breve 19 bx1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
B. breve 19 bx full monograph & interactions

S. boulardii 16 mxg1 drug type · 40 drugs

Antifungals

Theoretically, taking antifungals with Saccharomyces boulardii might decrease the effectiveness of Saccharomyces boulardii.
S. boulardii is a live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
S. boulardii 16 mxg full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Colon Cleanse, from the product label.

BIOHM

See all BIOHM products
Name
BIOHM Health LLC
Street Address
425 Literary Road, Suite 100
City
Cleveland
State
OH
ZipCode
44113
Web Address
BIOHMHEALTH.COM
Pharmacist Counseling Corner

Colon Cleanse by BIOHM: Common Questions

Does Colon Cleanse by BIOHM interact with any medications?
Yes. Based on its ingredients, Colon Cleanse has a known interaction with 1,349 medications, including 1 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Colon Cleanse contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this product while I'm on antibiotics?
Probably not at the same time. L. acidophilus and B. breve are live beneficial bacteria, and antibiotics can kill them, making the probiotics ineffective. Ask your pharmacist about separating the timing — they may suggest taking the antibiotic and the probiotic at different times of day.
Is it safe to use this if I take a water pill for blood pressure?
Not without checking first. Aloe, rhubarb, and cascara sagrada all have strong laxative effects and can cause potassium loss, which can be dangerous on top of potassium loss from diuretics. Talk to your pharmacist or doctor before using this product.
Can I take this while pregnant?
The safety data advises against it. Aloe latex and rhubarb are rated possibly unsafe in pregnancy because they may stimulate the uterus and act as strong laxatives. Cascara sagrada is also rated possibly unsafe. Talk with your doctor or pharmacist about safer options.
Does this product actually work for constipation?
The evidence is mixed. Aloe is possibly effective for constipation, but rhubarb and cascara sagrada have insufficient evidence for it. Because these are strong laxatives, they may provide short-term relief, but they carry real risks with long-term use.
What are the most common side effects from taking this?
Abdominal pain, cramps, and diarrhea are typical, especially from the aloe, rhubarb, and cascara sagrada. The probiotics may occasionally cause bloating, flatulence, or mild gastrointestinal discomfort, but these are less common.
Is it safe to use this long-term?
No. Long-term use of the stimulant laxatives in this product — especially aloe and cascara sagrada — can cause potassium depletion, muscle weakness, and kidney or liver damage. These ingredients are best used short-term under medical guidance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Colon Cleanse is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Colon Cleanse label
Go deeper

The Full Monographs Behind Colon Cleanse’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Aloe

Interacts with 461 drugs

Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a strong laxative that can cause cramping and...

Read the full Aloe monograph → Herb & supplement monograph

Rhubarb

Interacts with 658 drugs

Rhubarb root has a long history of use as a laxative and in traditional Chinese medicine, and its edible stalks are a common food. Most medicinal claims are backed by limited or low-quality...

Read the full Rhubarb monograph → Herb & supplement monograph

Cascara Sagrada

Interacts with 745 drugs

Cascara sagrada is a stimulant laxative made from the aged bark of a Pacific Northwest tree, used mainly for short-term relief of constipation. Because it can cause cramping, dehydration, an...

Read the full Cascara Sagrada monograph → Herb & supplement monograph

Cassia Cinnamon

Interacts with 442 drugs

Cassia cinnamon is the common, inexpensive cinnamon used in cooking, and it is also taken as a supplement, most often for blood sugar support. The evidence for its health benefits is mixed a...

Read the full Cassia Cinnamon monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Saccharomyces Boulardii

Interacts with 40 drugs

Saccharomyces boulardii is a beneficial yeast used as a probiotic, with the strongest evidence for preventing and treating certain types of diarrhea, including antibiotic-associated diarrhea...

Read the full Saccharomyces Boulardii monograph → Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph →
Sources

Sources & How We Checked

Colon Cleanse's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 140 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Aloe 41 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
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Rhubarb 20 references
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Cascara Sagrada 9 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
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Cassia Cinnamon 20 references
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Lactobacillus Acidophilus 15 references
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Saccharomyces Boulardii 26 references
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Bifidobacterium Breve 9 references
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  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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