Ticagrelor
Generic name: Pronounced as (tye ka' grel or)
Medical Content Reviewed By HelloPharmacist Staff
Last Revised - 01/15/2021
On this page
- Why is this medication prescribed?
- How should this medicine be used?
- Other uses for this medicine
- What special precautions should I follow?
- What special dietary instructions should I follow?
- What should I do if I forget a dose?
- What side effects can this medication cause?
- What should I know about STORAGE and DISPOSAL of this medication?
- What should I do in case of OVERDOSE?
- What OTHER INFORMATION should I know?
- Drug interactions
IMPORTANT WARNING
Ticagrelor may cause serious or life-threatening bleeding. Tell your doctor if you currently have or have had a condition that causes you to bleed more easily than normal; if you have recently had surgery or been injured in any way; or if you have or have ever had a stomach ulcer; bleeding in your stomach, intestines, or brain; a stroke or mini-stroke; a condition that may cause bleeding in your intestines such as polyps (abnormal growths in the lining of the large intestine); or liver disease. Tell your doctor and pharmacist if you are taking medications that may cause bleeding including anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven); heparin; other medications to treat or prevent blood clots; or regular use of non-steroidal anti-inflammatory medications such as ibuprofen (Advil, Motrin) and naproxen (Aleve). Your doctor also will probably not prescribe ticagrelor if you are likely to need heart bypass surgery (a certain type of open heart surgery) right away. While you are taking ticagrelor, you will probably bruise and bleed more easily than usual or bleed for longer than usual and may be more likely to have nosebleeds. However, if you experience any of the following symptoms, call your doctor immediately: bleeding that is unexplained, severe, long-lasting, or uncontrollable; pink or brown urine; red or black, tarry stools; vomit that is bloody or that looks like coffee grounds; or coughing up blood or blood clots.
If you are having surgery, including dental surgery, or any type of medical procedure, tell your doctor or dentist that you are taking ticagrelor. Your doctor will probably tell you to stop taking ticagrelor at least 5 days before your surgery is scheduled.
Your doctor will probably tell you to take a low dose of aspirin (less than 100 mg) during your treatment, but taking higher doses of aspirin may prevent ticagrelor from working as it should. Many over-the-counter (OTC) medications contain aspirin, so be sure to read all labels carefully. Do not take additional aspirin or aspirin-containing products during your treatment with ticagrelor without talking to your doctor.
Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ticagrelor and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.
Talk to your doctor about the risks of taking ticagrelor.
Why is this medication prescribed?
Ticagrelor is used to prevent a serious or life-threatening heart attack or stroke, or death in people who have had a heart attack or who have acute coronary syndrome (ACS; blockage of blood flow to the heart). It is also used to prevent blood clots from forming in people who have received coronary stents (metal tubes surgically placed in clogged blood vessels to improve blood flow) to treat ACS. Ticagrelor is used to decrease the risk of a first-time heart attack or stroke in people at risk with coronary artery disease (CAD; reduced blood flow to the heart). It is also used to decrease the risk of another more serious stroke in people who are having a mild to moderate stroke or a transient ischemic attack (TIA; ministroke). Ticagrelor is in a class of medications called antiplatelet medications. It works by preventing platelets (a type of blood cell) from collecting and forming clots that may cause a heart attack or stroke.
How should this medicine be used?
Ticagrelor comes as a tablet to take by mouth. It is usually taken with or without food two times a day. Take ticagrelor at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ticagrelor exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
If you are unable to swallow ticagrelor tablets, you may crush the tablet and mix it with water. Drink the mixture immediately, then refill the glass with water and stir and again drink the mixture immediately. If you have a nasogastric (NG) tube, your doctor or pharmacist will explain how to prepare ticagrelor to give through an NG tube.
Ticagrelor will help prevent serious problems with your heart and blood vessels only as long as you take the medication. Continue to take ticagrelor even if you feel well. Do not stop taking ticagrelor without talking to your doctor. If you stop taking ticagrelor, there is a higher risk that you may have a heart attack or stroke. If you have a stent, there is also a higher risk that you could develop a blood clot in the stent if you stop taking ticagrelor too soon.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What special precautions should I follow?
Before taking ticagrelor,
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tell your doctor and pharmacist if you are allergic to ticagrelor, any other medications, or any of the ingredients in ticagrelor tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.
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tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antibiotics such as clarithromycin (Biaxin, in PrevPak) and telithromycin (Ketek); antifungal medications such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); cholesterol-lowering medications such as lovastatin (Altoprev, in Advicor) and simvastatin (Zocor, in Simcor, in Vytorin); digoxin (Lanoxin); medications for high blood pressure; medications for human immunodeficiency virus (HIV) such as atazanavir (Reyataz, in Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Viekira Pak), and saquinavir (Invirase); medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol, others), phenobarbital, and phenytoin (Dilantin); nefazodone; opioid (narcotic) medications for pain such as hydrocodone (in Hydrocet, in Vicodin, others), morphine (Avinza, Kadian, MSIR, others), or oxycodone (OxyContin, in Percocet, in Roxicet, others); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.
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tell your doctor if you have or have ever had an irregular heartbeat that is not corrected by a pacemaker, a type of lung disease such as chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways) or asthma.
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tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking ticagrelor, call your doctor.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue your normal diet.
What should I do if I forget a dose?
Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
What side effects can this medication cause?
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Ticagrelor may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
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dizziness
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nausea
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Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:
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shortness of breath that occurs while you are at rest, after a small amount of exercise, or after any physical activity
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chest pain
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fast, slow, pounding, or irregular heartbeat
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rash
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swelling of the face, throat, tongue, lips, and eyes
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Ticagrelor may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).
What should I know about STORAGE and DISPOSAL of this medication?
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).
It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.
What should I do in case of OVERDOSE?
In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.
Symptoms of overdose may include the following:
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bleeding
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nausea
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vomiting
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diarrhea
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irregular heartbeat
What OTHER INFORMATION should I know?
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to ticagrelor.
Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking ticagrelor.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Drug interactions
Drug | Interaction |
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Montelukast | Montelukast The metabolism of Montelukast can be decreased when combined with Ticagrelor. |
Leflunomide | Leflunomide The metabolism of Leflunomide can be decreased when combined with Ticagrelor. |
Nevirapine | Nevirapine The metabolism of Nevirapine can be decreased when combined with Ticagrelor. |
Atorvastatin | Atorvastatin The serum concentration of Atorvastatin can be increased when it is combined with Ticagrelor. |
Aminophylline | Aminophylline The metabolism of Ticagrelor can be decreased when combined with Aminophylline. |
Anagrelide | Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Ticagrelor. |
Calcium Carbonate | Calcium Carbonate The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Ticagrelor. |
Candesartan | Candesartan The metabolism of Candesartan can be decreased when combined with Ticagrelor. |
Cilostazol | Cilostazol The metabolism of Cilostazol can be decreased when combined with Ticagrelor. |
Clopidogrel | Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Ticagrelor. |
Diphenoxylate | Diphenoxylate Diphenoxylate can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Erythromycin and Sulfisoxazole | Erythromycin and Sulfisoxazole The risk or severity of bleeding can be increased when Erythromycin is combined with Ticagrelor. |
Estrogen and Progestin (Oral Contraceptives) | Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the anticoagulant activities of Ticagrelor. |
Fenofibrate | Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Ticagrelor. |
Olsalazine | Olsalazine The risk or severity of bleeding and hemorrhage can be increased when Olsalazine is combined with Ticagrelor. |
Paregoric | Paregoric The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Morphine. |
Pentazocine | Pentazocine Pentazocine can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Reserpine | Reserpine The serum concentration of Ticagrelor can be increased when it is combined with Reserpine. |
Tacrolimus | Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Ticagrelor. |
Triamcinolone | Triamcinolone The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Triamcinolone. |
Doxycycline Injection | Doxycycline Injection The risk or severity of bleeding can be increased when Doxycycline is combined with Ticagrelor. |
Fluconazole Injection | Fluconazole Injection The serum concentration of Ticagrelor can be increased when it is combined with Fluconazole. |
Hydromorphone Injection | Hydromorphone Injection Ticagrelor can cause a decrease in the absorption of Hydromorphone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Interferon Beta-1b Injection | Interferon Beta-1b Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Interferon beta-1b. |
Interferon Gamma-1b Injection | Interferon Gamma-1b Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Interferon gamma-1b. |
Meperidine Injection | Meperidine Injection Ticagrelor can cause a decrease in the absorption of Meperidine resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Morphine Injection | Morphine Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Morphine. |
Zidovudine Injection | Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Ticagrelor. |
Altretamine | Altretamine The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Ticagrelor. |
Cefuroxime | Cefuroxime The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefuroxime. |
Cyclosporine | Cyclosporine The serum concentration of Ticagrelor can be increased when it is combined with Cyclosporine. |
Ondansetron | Ondansetron The metabolism of Ondansetron can be decreased when combined with Ticagrelor. |
Enoxaparin Injection | Enoxaparin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Enoxaparin. |
Torsemide | Torsemide The metabolism of Torasemide can be decreased when combined with Ticagrelor. |
Alosetron | Alosetron The metabolism of Alosetron can be decreased when combined with Ticagrelor. |
Dofetilide | Dofetilide The metabolism of Ticagrelor can be decreased when combined with Dofetilide. |
Meloxicam | Meloxicam The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Ticagrelor. |
Temozolomide | Temozolomide The risk or severity of bleeding can be increased when Ticagrelor is combined with Temozolomide. |
Linezolid | Linezolid The risk or severity of bleeding and hemorrhage can be increased when Linezolid is combined with Ticagrelor. |
Pentosan Polysulfate | Pentosan Polysulfate The risk or severity of adverse effects can be increased when Pentosan polysulfate is combined with Ticagrelor. |
Trimipramine | Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Ticagrelor. |
Tenofovir | Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Ticagrelor. |
Choline Magnesium Trisalicylate | Choline Magnesium Trisalicylate The risk or severity of bleeding and hemorrhage can be increased when Choline magnesium trisalicylate is combined with Ticagrelor. |
Sirolimus | Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Ticagrelor. |
Epirubicin | Epirubicin The risk or severity of bleeding can be increased when Ticagrelor is combined with Epirubicin. |
Escitalopram | Escitalopram The risk or severity of bleeding can be increased when Escitalopram is combined with Ticagrelor. |
Zonisamide | Zonisamide The serum concentration of Ticagrelor can be increased when it is combined with Zonisamide. |
Aripiprazole | Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Ticagrelor. |
Atazanavir | Atazanavir The metabolism of Atazanavir can be decreased when combined with Ticagrelor. |
Eletriptan | Eletriptan The metabolism of Eletriptan can be decreased when combined with Ticagrelor. |
Rosuvastatin | Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Ticagrelor. |
Vardenafil | Vardenafil The metabolism of Vardenafil can be decreased when combined with Ticagrelor. |
Alfuzosin | Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Ticagrelor. |
Tegaserod | Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Ticagrelor. |
Progesterone | Progesterone The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Progesterone. |
Rifaximin | Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Ticagrelor. |
Duloxetine | Duloxetine The risk or severity of hemorrhage can be increased when Duloxetine is combined with Ticagrelor. |
Norethindrone | Norethindrone The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Norethisterone. |
Bosentan | Bosentan The metabolism of Bosentan can be decreased when combined with Ticagrelor. |
Cefditoren | Cefditoren The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefdinir. |
Erlotinib | Erlotinib The metabolism of Erlotinib can be decreased when combined with Ticagrelor. |
Eszopiclone | Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Ticagrelor. |
Voriconazole | Voriconazole The metabolism of Voriconazole can be decreased when combined with Ticagrelor. |
Dextroamphetamine | Dextroamphetamine The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Ticagrelor. |
Peginterferon Alfa-2a Injection | Peginterferon Alfa-2a Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Peginterferon alfa-2a. |
Peginterferon Alfa-2b (PEG-Intron) | Peginterferon Alfa-2b (PEG-Intron) The risk or severity of bleeding can be increased when Ticagrelor is combined with Peginterferon alfa-2b. |
Isocarboxazid | Isocarboxazid The risk or severity of bleeding and hemorrhage can be increased when Isocarboxazid is combined with Ticagrelor. |
Ramelteon | Ramelteon The metabolism of Ramelteon can be decreased when combined with Ticagrelor. |
Fentanyl | Fentanyl The metabolism of Fentanyl can be decreased when combined with Ticagrelor. |
Deferasirox | Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Ticagrelor is combined with Deferasirox. |
Tipranavir | Tipranavir Tipranavir may increase the antiplatelet activities of Ticagrelor. |
Ranolazine | Ranolazine The serum concentration of Ticagrelor can be increased when it is combined with Ranolazine. |
Rasagiline | Rasagiline The risk or severity of bleeding and hemorrhage can be increased when Rasagiline is combined with Ticagrelor. |
Imatinib | Imatinib The metabolism of Imatinib can be decreased when combined with Ticagrelor. |
Sitagliptin | Sitagliptin The serum concentration of Ticagrelor can be increased when it is combined with Sitagliptin. |
Paliperidone | Paliperidone The serum concentration of Ticagrelor can be increased when it is combined with Paliperidone. |
Bortezomib | Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Ticagrelor. |
Clofarabine Injection | Clofarabine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Clofarabine. |
Oxaliplatin Injection | Oxaliplatin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Oxaliplatin. |
Posaconazole | Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Ticagrelor. |
Rituximab Injection | Rituximab Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Rituximab. |
Bismuth Subsalicylate | Bismuth Subsalicylate The risk or severity of bleeding can be increased when Bismuth subsalicylate is combined with Ticagrelor. |
Pemetrexed Injection | Pemetrexed Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Pemetrexed. |
Retapamulin | Retapamulin The metabolism of Retapamulin can be decreased when combined with Ticagrelor. |
Vorinostat | Vorinostat The risk or severity of bleeding can be increased when Ticagrelor is combined with Vorinostat. |
Sorafenib | Sorafenib The metabolism of Ticagrelor can be decreased when combined with Sorafenib. |
Sunitinib | Sunitinib The metabolism of Sunitinib can be decreased when combined with Ticagrelor. |
Dronabinol | Dronabinol The metabolism of Dronabinol can be decreased when combined with Ticagrelor. |
Lapatinib | Lapatinib The serum concentration of Ticagrelor can be increased when it is combined with Lapatinib. |
Dasatinib | Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Ticagrelor. |
Omega-3 Fatty Acids | Omega-3 Fatty Acids Omega-3 fatty acids may increase the antiplatelet activities of Ticagrelor. |
Azacitidine Injection | Azacitidine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Azacitidine. |
Temsirolimus | Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Ticagrelor. |
Nelarabine Injection | Nelarabine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Nelarabine. |
Lenalidomide | Lenalidomide The risk or severity of bleeding can be increased when Ticagrelor is combined with Lenalidomide. |
Nilotinib | Nilotinib The metabolism of Ticagrelor can be decreased when combined with Nilotinib. |
Toremifene | Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Ticagrelor. |
Bexarotene | Bexarotene The metabolism of Bexarotene can be decreased when combined with Ticagrelor. |
Chloramphenicol Injection | Chloramphenicol Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Chloramphenicol. |
Decitabine Injection | Decitabine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Decitabine. |
Etravirine | Etravirine The metabolism of Etravirine can be decreased when combined with Ticagrelor. |
Arsenic Trioxide Injection | Arsenic Trioxide Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Arsenic trioxide. |
Mitoxantrone Injection | Mitoxantrone Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Mitoxantrone. |
Desvenlafaxine | Desvenlafaxine The risk or severity of hemorrhage can be increased when Desvenlafaxine is combined with Ticagrelor. |
Tretinoin | Tretinoin The metabolism of Tretinoin can be decreased when combined with Ticagrelor. |
Bendamustine Injection | Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Ticagrelor. |
Ixabepilone Injection | Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Ticagrelor. |
Irinotecan Injection | Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Ticagrelor. |
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) | Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of bleeding can be increased when Ticagrelor is combined with Alemtuzumab. |
Rufinamide | Rufinamide The metabolism of Rufinamide can be decreased when combined with Ticagrelor. |
Silodosin | Silodosin The serum concentration of Silodosin can be increased when it is combined with Ticagrelor. |
Midazolam | Midazolam The serum concentration of Midazolam can be increased when it is combined with Ticagrelor. |
Naltrexone Injection | Naltrexone Injection Naltrexone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Dexrazoxane Injection | Dexrazoxane Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Dexrazoxane. |
Ibritumomab Injection | Ibritumomab Injection The risk or severity of adverse effects can be increased when Ticagrelor is combined with Ibritumomab tiuxetan. |
Milnacipran | Milnacipran The risk or severity of hemorrhage can be increased when Milnacipran is combined with Ticagrelor. |
Iloperidone | Iloperidone The metabolism of Iloperidone can be decreased when combined with Ticagrelor. |
Prasugrel | Prasugrel The risk or severity of bleeding can be increased when Prasugrel is combined with Ticagrelor. |
Lacosamide | Lacosamide The metabolism of Lacosamide can be decreased when combined with Ticagrelor. |
Everolimus | Everolimus The serum concentration of Everolimus can be increased when it is combined with Ticagrelor. |
Tolvaptan (low blood sodium) | Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Ticagrelor. |
Dronedarone | Dronedarone The metabolism of Ticagrelor can be decreased when combined with Dronedarone. |
Romidepsin Injection | Romidepsin Injection The serum concentration of Ticagrelor can be increased when it is combined with Romidepsin. |
Tapentadol | Tapentadol Ticagrelor can cause a decrease in the absorption of Tapentadol resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Topotecan | Topotecan The serum concentration of Topotecan can be increased when it is combined with Ticagrelor. |
Pazopanib | Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Ticagrelor. |
Pitavastatin | Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Ticagrelor. |
Albendazole | Albendazole The metabolism of Albendazole can be decreased when combined with Ticagrelor. |
Ulipristal | Ulipristal The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ulipristal. |
Levonorgestrel | Levonorgestrel The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Levonorgestrel. |
Oxymorphone | Oxymorphone Oxymorphone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Dabigatran | Dabigatran The risk or severity of bleeding can be increased when Ticagrelor is combined with Dabigatran. |
Eribulin Injection | Eribulin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Eribulin. |
Cabazitaxel Injection | Cabazitaxel Injection The serum concentration of Ticagrelor can be increased when it is combined with Cabazitaxel. |
Ceftaroline Injection | Ceftaroline Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ceftaroline fosamil. |
Denileukin Diftitox Injection | Denileukin Diftitox Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Aldesleukin. |
Busulfan Injection | Busulfan Injection The metabolism of Ticagrelor can be decreased when combined with Busulfan. |
Roflumilast | Roflumilast The metabolism of Roflumilast can be decreased when combined with Ticagrelor. |
Linagliptin | Linagliptin The metabolism of Linagliptin can be decreased when combined with Ticagrelor. |
Telaprevir | Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Ticagrelor. |
Potassium Iodide | Potassium Iodide Potassium Iodide may increase the anticoagulant activities of Ticagrelor. |
Cyclophosphamide Injection | Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Ticagrelor. |
Rivaroxaban | Rivaroxaban Ticagrelor may increase the anticoagulant activities of Rivaroxaban. |
Brentuximab Vedotin Injection | Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Ticagrelor. |
Ruxolitinib | Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Ticagrelor. |
Vandetanib | Vandetanib The metabolism of Ticagrelor can be decreased when combined with Vandetanib. |
Clobazam | Clobazam The serum concentration of Clobazam can be increased when it is combined with Ticagrelor. |
Vemurafenib | Vemurafenib The serum concentration of Ticagrelor can be increased when it is combined with Vemurafenib. |
Vismodegib | Vismodegib The metabolism of Vismodegib can be decreased when combined with Ticagrelor. |
Ivacaftor | Ivacaftor The serum concentration of Ticagrelor can be increased when it is combined with Ivacaftor. |
Axitinib | Axitinib The metabolism of Axitinib can be decreased when combined with Ticagrelor. |
Crizotinib | Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Ticagrelor. |
Melphalan Injection | Melphalan Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Melphalan. |
Cabergoline | Cabergoline The metabolism of Cabergoline can be decreased when combined with Ticagrelor. |
Ambrisentan | Ambrisentan The serum concentration of Ticagrelor can be increased when it is combined with Ambrisentan. |
Fondaparinux Injection | Fondaparinux Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Fondaparinux. |
Collagenase Clostridium Histolyticum Injection | Collagenase Clostridium Histolyticum Injection The risk or severity of adverse effects can be increased when Ticagrelor is combined with Collagenase clostridium histolyticum. |
Carfilzomib Injection | Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Ticagrelor. |
Iloprost | Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Ticagrelor. |
Enzalutamide | Enzalutamide The serum concentration of Ticagrelor can be increased when it is combined with Enzalutamide. |
Mirabegron | Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Ticagrelor. |
Regorafenib | Regorafenib The serum concentration of Ticagrelor can be increased when it is combined with Regorafenib. |
Bosutinib | Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Ticagrelor. |
Cabozantinib (thyroid cancer) | Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Ticagrelor. |
Icosapent Ethyl | Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Ticagrelor. |
Tofacitinib | Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Ticagrelor. |
Ponatinib | Ponatinib The metabolism of Ponatinib can be decreased when combined with Ticagrelor. |
Pomalidomide | Pomalidomide The serum concentration of Ticagrelor can be increased when it is combined with Pomalidomide. |
Ado-trastuzumab Emtansine Injection | Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Ticagrelor. |
Apixaban | Apixaban Apixaban may increase the anticoagulant activities of Ticagrelor. |
Canagliflozin | Canagliflozin The serum concentration of Ticagrelor can be increased when it is combined with Canagliflozin. |
Dabrafenib | Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Ticagrelor. |
Ospemifene | Ospemifene The metabolism of Ospemifene can be decreased when combined with Ticagrelor. |
Dolutegravir | Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Ticagrelor. |
Afatinib | Afatinib The serum concentration of Afatinib can be increased when it is combined with Ticagrelor. |
Levomilnacipran | Levomilnacipran The risk or severity of hemorrhage can be increased when Levomilnacipran is combined with Ticagrelor. |
Vortioxetine | Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Ticagrelor. |
Ibrutinib | Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Ticagrelor. |
Lomitapide | Lomitapide The metabolism of Ticagrelor can be decreased when combined with Lomitapide. |
Ketorolac Injection | Ketorolac Injection The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Ticagrelor. |
Obinutuzumab Injection | Obinutuzumab Injection The risk or severity of adverse effects can be increased when Ticagrelor is combined with Obinutuzumab. |
Simeprevir | Simeprevir The serum concentration of Ticagrelor can be increased when it is combined with Simeprevir. |
Sofosbuvir | Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Ticagrelor. |
Dapagliflozin | Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Ticagrelor. |
Ceritinib | Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Ticagrelor. |
Belinostat Injection | Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Ticagrelor. |
Idelalisib | Idelalisib The metabolism of Idelalisib can be decreased when combined with Ticagrelor. |
Testosterone Injection | Testosterone Injection Testosterone may increase the anticoagulant activities of Ticagrelor. |
Vorapaxar | Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Ticagrelor. |
Hydrocodone | Hydrocodone Hydrocodone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Suvorexant | Suvorexant The serum concentration of Ticagrelor can be increased when it is combined with Suvorexant. |
Edoxaban | Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Ticagrelor. |
Peginterferon Beta-1a Injection | Peginterferon Beta-1a Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Peginterferon beta-1a. |
Olaparib | Olaparib The metabolism of Olaparib can be decreased when combined with Ticagrelor. |
Blinatumomab Injection | Blinatumomab Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Blinatumomab. |
Tasimelteon | Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Ticagrelor. |
Nintedanib | Nintedanib The risk or severity of bleeding can be increased when Ticagrelor is combined with Nintedanib. |
Palbociclib | Palbociclib The metabolism of Ticagrelor can be decreased when combined with Palbociclib. |
Lenvatinib | Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Ticagrelor. |
Naloxegol | Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Ticagrelor. |
Panobinostat | Panobinostat The metabolism of Ticagrelor can be decreased when combined with Panobinostat. |
Dinutuximab Injection | Dinutuximab Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Dinutuximab. |
Haloperidol Injection | Haloperidol Injection The serum concentration of Ticagrelor can be increased when it is combined with Haloperidol. |
Deoxycholic Acid Injection | Deoxycholic Acid Injection The risk or severity of adverse effects can be increased when Ticagrelor is combined with Deoxycholic acid. |
Isavuconazonium Injection | Isavuconazonium Injection The serum concentration of Ticagrelor can be increased when it is combined with Isavuconazonium. |
Sonidegib | Sonidegib The metabolism of Sonidegib can be decreased when combined with Ticagrelor. |
Flibanserin | Flibanserin The serum concentration of Ticagrelor can be increased when it is combined with Flibanserin. |
Rolapitant | Rolapitant The serum concentration of Ticagrelor can be increased when it is combined with Rolapitant. |
Daclatasvir | Daclatasvir The serum concentration of Ticagrelor can be increased when it is combined with Daclatasvir. |
Ziprasidone Injection | Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Ticagrelor. |
Eluxadoline | Eluxadoline Eluxadoline can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Cobimetinib | Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Ticagrelor. |
Trabectedin Injection | Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Ticagrelor. |
Osimertinib | Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Ticagrelor. |
Alectinib | Alectinib The metabolism of Alectinib can be decreased when combined with Ticagrelor. |
Ixazomib | Ixazomib The metabolism of Ixazomib can be decreased when combined with Ticagrelor. |
Lesinurad | Lesinurad The metabolism of Lesinurad can be decreased when combined with Ticagrelor. |
Defibrotide Injection | Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Ticagrelor. |
Brivaracetam Injection | Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Ticagrelor. |
Venetoclax | Venetoclax The metabolism of Venetoclax can be decreased when combined with Ticagrelor. |
Cobicistat | Cobicistat The serum concentration of Ticagrelor can be increased when it is combined with Cobicistat. |
Selexipag | Selexipag The serum concentration of Ticagrelor can be increased when it is combined with Selexipag. |
Obeticholic Acid | Obeticholic Acid The risk or severity of adverse effects can be increased when Ticagrelor is combined with Obeticholic acid. |
Diphenhydramine Injection | Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Ticagrelor. |
Rucaparib | Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Ticagrelor. |
Ribociclib | Ribociclib The metabolism of Ribociclib can be decreased when combined with Ticagrelor. |
Brigatinib | Brigatinib The metabolism of Brigatinib can be decreased when combined with Ticagrelor. |
Doxepin (Insomnia) | Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Ticagrelor. |
Safinamide | Safinamide The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Ticagrelor. |
Midostaurin | Midostaurin The metabolism of Midostaurin can be decreased when combined with Ticagrelor. |
Neratinib | Neratinib The metabolism of Ticagrelor can be decreased when combined with Neratinib. |
Enasidenib | Enasidenib The metabolism of Ticagrelor can be decreased when combined with Enasidenib. |
Inotuzumab Ozogamicin Injection | Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Ticagrelor. |
Aprepitant/Fosaprepitant Injection | Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Ticagrelor. |
Copanlisib Injection | Copanlisib Injection The serum concentration of Ticagrelor can be increased when it is combined with Copanlisib. |
Abemaciclib | Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Ticagrelor. |
Betrixaban | Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Ticagrelor. |
Acalabrutinib | Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Ticagrelor. |
Gemtuzumab Ozogamicin Injection | Gemtuzumab Ozogamicin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Gemtuzumab ozogamicin. |
Ertugliflozin | Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Ticagrelor. |
Buprenorphine Injection | Buprenorphine Injection Ticagrelor can cause a decrease in the absorption of Buprenorphine resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Apalutamide | Apalutamide The serum concentration of Ticagrelor can be decreased when it is combined with Apalutamide. |
Penicillamine | Penicillamine The risk or severity of bleeding can be increased when Ticagrelor is combined with Penicillamine. |
Avatrombopag | Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Ticagrelor. |
Baricitinib | Baricitinib The metabolism of Ticagrelor can be decreased when combined with Baricitinib. |
Eliglustat | Eliglustat The metabolism of Eliglustat can be decreased when combined with Ticagrelor. |
Binimetinib | Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Ticagrelor. |
Ivosidenib | Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Ticagrelor. |
Lusutrombopag | Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Ticagrelor. |
Elagolix | Elagolix The serum concentration of Elagolix can be increased when it is combined with Ticagrelor. |
Cannabidiol | Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Ticagrelor. |
Dacomitinib | Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Ticagrelor. |
Duvelisib | Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Ticagrelor. |
Omadacycline | Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Ticagrelor. |
Sarecycline | Sarecycline The serum concentration of Ticagrelor can be increased when it is combined with Sarecycline. |
Talazoparib | Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Ticagrelor. |
Gilteritinib | Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Ticagrelor. |
Glasdegib | Glasdegib The serum concentration of Ticagrelor can be increased when it is combined with Glasdegib. |
Larotrectinib | Larotrectinib The serum concentration of Ticagrelor can be increased when it is combined with Larotrectinib. |
Paclitaxel (with albumin) Injection | Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Ticagrelor. |
Rifamycin | Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Ticagrelor. |
Prucalopride | Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Ticagrelor. |
Siponimod | Siponimod The metabolism of Siponimod can be decreased when combined with Ticagrelor. |
Caplacizumab-yhdp Injection | Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Ticagrelor. |
Erdafitinib | Erdafitinib The serum concentration of Ticagrelor can be increased when it is combined with Erdafitinib. |
Alpelisib | Alpelisib The metabolism of Alpelisib can be decreased when combined with Ticagrelor. |
Cladribine | Cladribine The risk or severity of bleeding can be increased when Ticagrelor is combined with Cladribine. |
Darolutamide | Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Ticagrelor. |
Triclabendazole | Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Ticagrelor. |
Entrectinib | Entrectinib The metabolism of Entrectinib can be decreased when combined with Ticagrelor. |
Pexidartinib | Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Ticagrelor. |
Istradefylline | Istradefylline The serum concentration of Ticagrelor can be increased when it is combined with Istradefylline. |
Pitolisant | Pitolisant The serum concentration of Ticagrelor can be decreased when it is combined with Pitolisant. |
Fedratinib | Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Ticagrelor. |
Lefamulin | Lefamulin Ticagrelor may decrease the excretion rate of Lefamulin which could result in a higher serum level. |
Phenytoin Injection | Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Ticagrelor. |
Fosphenytoin Injection | Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Ticagrelor. |
Enfortumab vedotin-ejfv Injection | Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Ticagrelor. |
Zanubrutinib | Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Ticagrelor. |
Voxelotor | Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Ticagrelor. |
Avapritinib | Avapritinib The metabolism of Avapritinib can be decreased when combined with Ticagrelor. |
Lasmiditan | Lasmiditan The serum concentration of Ticagrelor can be increased when it is combined with Lasmiditan. |
Ubrogepant | Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Ticagrelor. |
Calcium Acetate | Calcium Acetate The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Ticagrelor. |
Tazemetostat | Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Ticagrelor. |
Cenobamate | Cenobamate The serum concentration of Ticagrelor can be decreased when it is combined with Cenobamate. |
Selumetinib | Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Ticagrelor. |
Rimegepant | Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Ticagrelor. |
Tucatinib | Tucatinib Ticagrelor may decrease the excretion rate of Tucatinib which could result in a higher serum level. |
Remdesivir Injection | Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Ticagrelor. |
Ripretinib | Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Ticagrelor. |
Lemborexant | Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Ticagrelor. |
Fostemsavir | Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Ticagrelor. |
Belantamab Mafodotin-blmf Injection | Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Ticagrelor. |
Pralsetinib | Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Ticagrelor. |
Satralizumab-mwge Injection | Satralizumab-mwge Injection The serum concentration of Ticagrelor can be decreased when it is combined with Satralizumab. |
Relugolix | Relugolix The serum concentration of Relugolix can be increased when it is combined with Ticagrelor. |
Progestin-Only (drospirenone) Oral Contraceptives | Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Drospirenone. |
Vitamin E (Alpha-Tocopherol) | Vitamin E (Alpha-Tocopherol) Vitamin E may increase the antiplatelet activities of Ticagrelor. |
Theophylline | Theophylline The metabolism of Theophylline can be decreased when combined with Ticagrelor. |
Fenoprofen | Fenoprofen The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Ticagrelor. |
Indomethacin | Indomethacin The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Ticagrelor. |
Mefenamic Acid | Mefenamic Acid The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Ticagrelor. |
Naproxen | Naproxen The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Ticagrelor. |
Tolmetin | Tolmetin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Ticagrelor. |
Sulindac | Sulindac The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Ticagrelor. |
Trazodone | Trazodone The risk or severity of bleeding can be increased when Trazodone is combined with Ticagrelor. |
Hydroxyurea | Hydroxyurea The risk or severity of bleeding can be increased when Ticagrelor is combined with Hydroxyurea. |
Floxuridine | Floxuridine The risk or severity of bleeding can be increased when Ticagrelor is combined with Floxuridine. |
Phenobarbital | Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Ticagrelor. |
Methotrexate Injection | Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Ticagrelor. |
Levorphanol | Levorphanol Levorphanol can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Primidone | Primidone The metabolism of Primidone can be decreased when combined with Ticagrelor. |
Chlorpromazine | Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Ticagrelor. |
Diazepam | Diazepam The metabolism of Diazepam can be decreased when combined with Ticagrelor. |
Lorazepam | Lorazepam The metabolism of Lorazepam can be decreased when combined with Ticagrelor. |
Carmustine | Carmustine The risk or severity of bleeding can be increased when Ticagrelor is combined with Carmustine. |
Codeine | Codeine Codeine can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Tranylcypromine | Tranylcypromine The risk or severity of bleeding and hemorrhage can be increased when Tranylcypromine is combined with Ticagrelor. |
Phenelzine | Phenelzine The risk or severity of bleeding and hemorrhage can be increased when Phenelzine is combined with Ticagrelor. |
Procarbazine | Procarbazine The risk or severity of bleeding and hemorrhage can be increased when Procarbazine is combined with Ticagrelor. |
Thioguanine | Thioguanine The risk or severity of bleeding can be increased when Ticagrelor is combined with Tioguanine. |
Prochlorperazine | Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Ticagrelor. |
Dapsone | Dapsone The metabolism of Dapsone can be decreased when combined with Ticagrelor. |
Oxycodone | Oxycodone Oxycodone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Methadone | Methadone Ticagrelor can cause a decrease in the absorption of Methadone resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Ibuprofen | Ibuprofen The risk or severity of bleeding can be increased when Ibuprofen is combined with Ticagrelor. |
Phentermine | Phentermine The metabolism of Phentermine can be decreased when combined with Ticagrelor. |
Sulfasalazine | Sulfasalazine The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Ticagrelor. |
Lomustine | Lomustine The risk or severity of bleeding can be increased when Ticagrelor is combined with Lomustine. |
Doxorubicin | Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Ticagrelor. |
Cytarabine | Cytarabine The risk or severity of bleeding can be increased when Ticagrelor is combined with Cytarabine. |
Mechlorethamine | Mechlorethamine The risk or severity of bleeding can be increased when Ticagrelor is combined with Mechlorethamine. |
Dactinomycin | Dactinomycin The serum concentration of Ticagrelor can be increased when it is combined with Dactinomycin. |
Carbamazepine | Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Ticagrelor. |
Clonidine | Clonidine The metabolism of Clonidine can be decreased when combined with Ticagrelor. |
Warfarin | Warfarin The serum concentration of Warfarin can be increased when it is combined with Ticagrelor. |
Loperamide | Loperamide The serum concentration of Loperamide can be increased when it is combined with Ticagrelor. |
Meclofenamate | Meclofenamate The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Ticagrelor. |
Daunorubicin | Daunorubicin The risk or severity of bleeding can be increased when Ticagrelor is combined with Daunorubicin. |
Digoxin | Digoxin The serum concentration of Digoxin can be increased when it is combined with Ticagrelor. |
Loxapine | Loxapine The serum concentration of Ticagrelor can be increased when it is combined with Loxapine. |
Quinine | Quinine The therapeutic efficacy of Ticagrelor can be increased when used in combination with Quinine. |
Sulfinpyrazone | Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Ticagrelor. |
Chlorothiazide | Chlorothiazide The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Chlorothiazide. |
Isosorbide | Isosorbide The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Isosorbide. |
Amitriptyline | Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Ticagrelor. |
Imipramine | Imipramine The serum concentration of Imipramine can be increased when it is combined with Ticagrelor. |
Quinidine | Quinidine The therapeutic efficacy of Ticagrelor can be increased when used in combination with Quinidine. |
Valproic Acid | Valproic Acid The metabolism of Valproic acid can be decreased when combined with Ticagrelor. |
Tamoxifen | Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Ticagrelor. |
Mitomycin | Mitomycin The risk or severity of bleeding can be increased when Ticagrelor is combined with Mitomycin. |
Methimazole | Methimazole Methimazole may increase the anticoagulant activities of Ticagrelor. |
Propylthiouracil | Propylthiouracil Propylthiouracil may increase the anticoagulant activities of Ticagrelor. |
Chlorpropamide | Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Ticagrelor. |
Tolbutamide | Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Ticagrelor. |
Tolazamide | Tolazamide The metabolism of Tolazamide can be decreased when combined with Ticagrelor. |
Dextromethorphan | Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Ticagrelor. |
Methyclothiazide | Methyclothiazide The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Methyclothiazide. |
Hydrochlorothiazide | Hydrochlorothiazide The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Hydrochlorothiazide. |
Nortriptyline | Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Ticagrelor. |
Mercaptopurine | Mercaptopurine The risk or severity of bleeding can be increased when Ticagrelor is combined with Mercaptopurine. |
Butorphanol Injection | Butorphanol Injection Butorphanol can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Nalbuphine Injection | Nalbuphine Injection Nalbuphine can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Clomiphene | Clomiphene The serum concentration of Clomifene can be increased when it is combined with Ticagrelor. |
Fluorouracil Injection | Fluorouracil Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Fluorouracil. |
Colchicine | Colchicine The metabolism of Colchicine can be decreased when combined with Ticagrelor. |
Cefaclor | Cefaclor The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefaclor. |
Cefadroxil | Cefadroxil The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefadroxil. |
Cefazolin Injection | Cefazolin Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefazolin. |
Cephalexin | Cephalexin The metabolism of Cephalexin can be decreased when combined with Ticagrelor. |
Cefoxitin Injection | Cefoxitin Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefoxitin. |
Dacarbazine | Dacarbazine The risk or severity of bleeding can be increased when Ticagrelor is combined with Dacarbazine. |
Cefotaxime Injection | Cefotaxime Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefotaxime. |
Ketoconazole | Ketoconazole The serum concentration of Ticagrelor can be increased when it is combined with Ketoconazole. |
Thiotepa Injection | Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Ticagrelor. |
Vincristine Injection | Vincristine Injection The excretion of Vincristine can be decreased when combined with Ticagrelor. |
Dipyridamole | Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Ticagrelor. |
Vinblastine | Vinblastine The metabolism of Vinblastine can be decreased when combined with Ticagrelor. |
Metoprolol | Metoprolol The metabolism of Metoprolol can be decreased when combined with Ticagrelor. |
Aspirin | Aspirin The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Acetylsalicylic acid. |
Salsalate | Salsalate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Ticagrelor. |
Chlorambucil | Chlorambucil The risk or severity of bleeding can be increased when Ticagrelor is combined with Chlorambucil. |
Alprazolam | Alprazolam The metabolism of Alprazolam can be decreased when combined with Ticagrelor. |
Trimethoprim | Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Ticagrelor. |
Diltiazem | Diltiazem The metabolism of Diltiazem can be decreased when combined with Ticagrelor. |
Verapamil | Verapamil The serum concentration of Ticagrelor can be increased when it is combined with Verapamil. |
Cisplatin Injection | Cisplatin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Cisplatin. |
Diflunisal | Diflunisal The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Ticagrelor. |
Piroxicam | Piroxicam The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Ticagrelor. |
Streptozocin | Streptozocin The risk or severity of bleeding can be increased when Ticagrelor is combined with Streptozocin. |
Etoposide | Etoposide The serum concentration of Etoposide can be increased when it is combined with Ticagrelor. |
Glyburide | Glyburide The metabolism of Glyburide can be decreased when combined with Ticagrelor. |
Glipizide | Glipizide The metabolism of Glipizide can be decreased when combined with Ticagrelor. |
Pentoxifylline | Pentoxifylline The therapeutic efficacy of Ticagrelor can be increased when used in combination with Pentoxifylline. |
Ceftriaxone Injection | Ceftriaxone Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ceftriaxone. |
Ceftazidime Injection | Ceftazidime Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ceftazidime. |
Ketoprofen | Ketoprofen The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Ticagrelor. |
Cefotetan Injection | Cefotetan Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefotetan. |
Pimozide | Pimozide The metabolism of Pimozide can be decreased when combined with Ticagrelor. |
Flurbiprofen | Flurbiprofen The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Ticagrelor. |
Amiodarone | Amiodarone The metabolism of Ticagrelor can be decreased when combined with Amiodarone. |
Lovastatin | Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Ticagrelor. |
Mesalamine | Mesalamine The risk or severity of bleeding and hemorrhage can be increased when Mesalazine is combined with Ticagrelor. |
Diclofenac | Diclofenac The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Ticagrelor. |
Fluoxetine | Fluoxetine The risk or severity of hemorrhage can be increased when Fluoxetine is combined with Ticagrelor. |
Interferon Alfa-2b Injection | Interferon Alfa-2b Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Interferon alfa-2b. |
Cefixime | Cefixime The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefixime. |
Clozapine | Clozapine The metabolism of Clozapine can be decreased when combined with Ticagrelor. |
Idarubicin | Idarubicin The risk or severity of bleeding can be increased when Ticagrelor is combined with Idarubicin. |
Fludarabine Injection | Fludarabine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Fludarabine. |
Pentostatin Injection | Pentostatin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Pentostatin. |
Clarithromycin | Clarithromycin The serum concentration of Ticagrelor can be increased when it is combined with Clarithromycin. |
Etodolac | Etodolac The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Ticagrelor. |
Nabumetone | Nabumetone The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Ticagrelor. |
Pravastatin | Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Ticagrelor. |
Simvastatin | Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Ticagrelor. |
Teniposide Injection | Teniposide Injection The metabolism of Teniposide can be decreased when combined with Ticagrelor. |
Itraconazole | Itraconazole The serum concentration of Ticagrelor can be increased when it is combined with Itraconazole. |
Oxaprozin | Oxaprozin The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Ticagrelor. |
Bisoprolol | Bisoprolol The serum concentration of Ticagrelor can be increased when it is combined with Bisoprolol. |
Zolpidem | Zolpidem The metabolism of Zolpidem can be decreased when combined with Ticagrelor. |
Doxazosin | Doxazosin The metabolism of Doxazosin can be decreased when combined with Ticagrelor. |
Omeprazole | Omeprazole The metabolism of Omeprazole can be decreased when combined with Ticagrelor. |
Cisapride | Cisapride The metabolism of Cisapride can be decreased when combined with Ticagrelor. |
Fluvastatin | Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Ticagrelor. |
Venlafaxine | Venlafaxine Venlafaxine may increase the antiplatelet activities of Ticagrelor. |
Famciclovir | Famciclovir The metabolism of Famciclovir can be decreased when combined with Ticagrelor. |
Fluvoxamine | Fluvoxamine The risk or severity of hemorrhage can be increased when Fluvoxamine is combined with Ticagrelor. |
Nefazodone | Nefazodone The risk or severity of hemorrhage can be increased when Nefazodone is combined with Ticagrelor. |
Losartan | Losartan The metabolism of Losartan can be decreased when combined with Ticagrelor. |
Tramadol | Tramadol Tramadol can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy. |
Vinorelbine Injection | Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Ticagrelor. |
Carboplatin Injection | Carboplatin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Carboplatin. |
Lansoprazole | Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Ticagrelor. |
Ifosfamide Injection | Ifosfamide Injection The risk or severity of bleeding can be increased when Ifosfamide is combined with Ticagrelor. |
Bupropion | Bupropion The metabolism of Bupropion can be decreased when combined with Ticagrelor. |
Ticlopidine | Ticlopidine The risk or severity of bleeding can be increased when Ticlopidine is combined with Ticagrelor. |
Saquinavir | Saquinavir The serum concentration of Ticagrelor can be increased when it is combined with Saquinavir. |
Dalteparin Injection | Dalteparin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Dalteparin. |
Glimepiride | Glimepiride The metabolism of Glimepiride can be decreased when combined with Ticagrelor. |
Gemcitabine Injection | Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Ticagrelor. |
Ritonavir | Ritonavir The serum concentration of Ticagrelor can be increased when it is combined with Ritonavir. |
Docetaxel Injection | Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Ticagrelor. |
Clomipramine | Clomipramine The metabolism of Clomipramine can be decreased when combined with Ticagrelor. |
Zafirlukast | Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Ticagrelor. |
Zileuton | Zileuton The metabolism of Zileuton can be decreased when combined with Ticagrelor. |
Valsartan | Valsartan The metabolism of Valsartan can be decreased when combined with Ticagrelor. |
Donepezil | Donepezil The metabolism of Donepezil can be decreased when combined with Ticagrelor. |
Fexofenadine | Fexofenadine The serum concentration of Ticagrelor can be increased when it is combined with Fexofenadine. |
Azithromycin | Azithromycin The risk or severity of adverse effects can be increased when Azithromycin is combined with Ticagrelor. |
Carvedilol | Carvedilol The serum concentration of Ticagrelor can be increased when it is combined with Carvedilol. |
Selegiline | Selegiline The risk or severity of bleeding and hemorrhage can be increased when Selegiline is combined with Ticagrelor. |
Bicalutamide | Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Ticagrelor. |
Sertraline | Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Ticagrelor. |
Propafenone | Propafenone The serum concentration of Ticagrelor can be increased when it is combined with Propafenone. |
Irbesartan | Irbesartan The metabolism of Irbesartan can be decreased when combined with Ticagrelor. |
Cefepime Injection | Cefepime Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefepime. |
Cefprozil | Cefprozil The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefprozil. |
Cefpodoxime | Cefpodoxime The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefpodoxime. |
Paroxetine | Paroxetine The risk or severity of hemorrhage can be increased when Paroxetine is combined with Ticagrelor. |
Citalopram | Citalopram The risk or severity of hemorrhage can be increased when Citalopram is combined with Ticagrelor. |
Capecitabine | Capecitabine The metabolism of Capecitabine can be decreased when combined with Ticagrelor. |
Sildenafil | Sildenafil The risk or severity of hemorrhage can be increased when Ticagrelor is combined with Sildenafil. |
Celecoxib | Celecoxib The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Ticagrelor. |
Rosiglitazone | Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Ticagrelor. |
Tolterodine | Tolterodine The metabolism of Tolterodine can be decreased when combined with Ticagrelor. |
Thalidomide | Thalidomide The risk or severity of bleeding can be increased when Ticagrelor is combined with Thalidomide. |
Balsalazide | Balsalazide The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Ticagrelor. |
Nateglinide | Nateglinide The metabolism of Nateglinide can be decreased when combined with Ticagrelor. |
Terbinafine | Terbinafine The metabolism of Terbinafine can be decreased when combined with Ticagrelor. |
Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists