Ticagrelor

Generic name: Pronounced as (tye ka' grel or)
Brand names
  • Brilinta®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 01/15/2021

Ticagrelor may cause serious or life-threatening bleeding. Tell your doctor if you currently have or have had a condition that causes you to bleed more easily than normal; if you have recently had surgery or been injured in any way; or if you have or have ever had a stomach ulcer; bleeding in your stomach, intestines, or brain; a stroke or mini-stroke; a condition that may cause bleeding in your intestines such as polyps (abnormal growths in the lining of the large intestine); or liver disease. Tell your doctor and pharmacist if you are taking medications that may cause bleeding including anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven); heparin; other medications to treat or prevent blood clots; or regular use of non-steroidal anti-inflammatory medications such as ibuprofen (Advil, Motrin) and naproxen (Aleve). Your doctor also will probably not prescribe ticagrelor if you are likely to need heart bypass surgery (a certain type of open heart surgery) right away. While you are taking ticagrelor, you will probably bruise and bleed more easily than usual or bleed for longer than usual and may be more likely to have nosebleeds. However, if you experience any of the following symptoms, call your doctor immediately: bleeding that is unexplained, severe, long-lasting, or uncontrollable; pink or brown urine; red or black, tarry stools; vomit that is bloody or that looks like coffee grounds; or coughing up blood or blood clots.

If you are having surgery, including dental surgery, or any type of medical procedure, tell your doctor or dentist that you are taking ticagrelor. Your doctor will probably tell you to stop taking ticagrelor at least 5 days before your surgery is scheduled.

Your doctor will probably tell you to take a low dose of aspirin (less than 100 mg) during your treatment, but taking higher doses of aspirin may prevent ticagrelor from working as it should. Many over-the-counter (OTC) medications contain aspirin, so be sure to read all labels carefully. Do not take additional aspirin or aspirin-containing products during your treatment with ticagrelor without talking to your doctor.

Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ticagrelor and each time you refill your prescription. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm) or the manufacturer's website to obtain the Medication Guide.

Talk to your doctor about the risks of taking ticagrelor.

Ticagrelor is used to prevent a serious or life-threatening heart attack or stroke, or death in people who have had a heart attack or who have acute coronary syndrome (ACS; blockage of blood flow to the heart). It is also used to prevent blood clots from forming in people who have received coronary stents (metal tubes surgically placed in clogged blood vessels to improve blood flow) to treat ACS. Ticagrelor is used to decrease the risk of a first-time heart attack or stroke in people at risk with coronary artery disease (CAD; reduced blood flow to the heart). It is also used to decrease the risk of another more serious stroke in people who are having a mild to moderate stroke or a transient ischemic attack (TIA; ministroke). Ticagrelor is in a class of medications called antiplatelet medications. It works by preventing platelets (a type of blood cell) from collecting and forming clots that may cause a heart attack or stroke.

Ticagrelor comes as a tablet to take by mouth. It is usually taken with or without food two times a day. Take ticagrelor at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ticagrelor exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

If you are unable to swallow ticagrelor tablets, you may crush the tablet and mix it with water. Drink the mixture immediately, then refill the glass with water and stir and again drink the mixture immediately. If you have a nasogastric (NG) tube, your doctor or pharmacist will explain how to prepare ticagrelor to give through an NG tube.

Ticagrelor will help prevent serious problems with your heart and blood vessels only as long as you take the medication. Continue to take ticagrelor even if you feel well. Do not stop taking ticagrelor without talking to your doctor. If you stop taking ticagrelor, there is a higher risk that you may have a heart attack or stroke. If you have a stent, there is also a higher risk that you could develop a blood clot in the stent if you stop taking ticagrelor too soon.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking ticagrelor,

  • tell your doctor and pharmacist if you are allergic to ticagrelor, any other medications, or any of the ingredients in ticagrelor tablets. Ask your pharmacist or check the Medication Guide for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: antibiotics such as clarithromycin (Biaxin, in PrevPak) and telithromycin (Ketek); antifungal medications such as itraconazole (Onmel, Sporanox), ketoconazole (Nizoral), and voriconazole (Vfend); cholesterol-lowering medications such as lovastatin (Altoprev, in Advicor) and simvastatin (Zocor, in Simcor, in Vytorin); digoxin (Lanoxin); medications for high blood pressure; medications for human immunodeficiency virus (HIV) such as atazanavir (Reyataz, in Evotaz), indinavir (Crixivan), nelfinavir (Viracept), ritonavir (Norvir, in Kaletra, in Viekira Pak), and saquinavir (Invirase); medications for seizures such as carbamazepine (Carbatrol, Equetro, Tegretol, others), phenobarbital, and phenytoin (Dilantin); nefazodone; opioid (narcotic) medications for pain such as hydrocodone (in Hydrocet, in Vicodin, others), morphine (Avinza, Kadian, MSIR, others), or oxycodone (OxyContin, in Percocet, in Roxicet, others); and rifampin (Rifadin, Rimactane, in Rifamate, in Rifater). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have or have ever had an irregular heartbeat that is not corrected by a pacemaker, a type of lung disease such as chronic obstructive pulmonary disease (COPD; a group of diseases that affect the lungs and airways) or asthma.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you become pregnant while taking ticagrelor, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Ticagrelor may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • dizziness

    • nausea

  • Some side effects can be serious. If you experience any of these symptoms or those listed in the IMPORTANT WARNING section, call your doctor immediately:

    • shortness of breath that occurs while you are at rest, after a small amount of exercise, or after any physical activity

    • chest pain

    • fast, slow, pounding, or irregular heartbeat

    • rash

    • swelling of the face, throat, tongue, lips, and eyes

  • Ticagrelor may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • bleeding

  • nausea

  • vomiting

  • diarrhea

  • irregular heartbeat

Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to ticagrelor.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking ticagrelor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Ticagrelor.
Leflunomide Leflunomide The metabolism of Leflunomide can be decreased when combined with Ticagrelor.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Ticagrelor.
Atorvastatin Atorvastatin The serum concentration of Atorvastatin can be increased when it is combined with Ticagrelor.
Aminophylline Aminophylline The metabolism of Ticagrelor can be decreased when combined with Aminophylline.
Anagrelide Anagrelide The risk or severity of bleeding can be increased when Anagrelide is combined with Ticagrelor.
Calcium Carbonate Calcium Carbonate The therapeutic efficacy of Calcium carbonate can be decreased when used in combination with Ticagrelor.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Ticagrelor.
Cilostazol Cilostazol The metabolism of Cilostazol can be decreased when combined with Ticagrelor.
Clopidogrel Clopidogrel The risk or severity of bleeding can be increased when Clopidogrel is combined with Ticagrelor.
Diphenoxylate Diphenoxylate Diphenoxylate can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The risk or severity of bleeding can be increased when Erythromycin is combined with Ticagrelor.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may decrease the anticoagulant activities of Ticagrelor.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Ticagrelor.
Olsalazine Olsalazine The risk or severity of bleeding and hemorrhage can be increased when Olsalazine is combined with Ticagrelor.
Paregoric Paregoric The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Morphine.
Pentazocine Pentazocine Pentazocine can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Reserpine Reserpine The serum concentration of Ticagrelor can be increased when it is combined with Reserpine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Ticagrelor.
Triamcinolone Triamcinolone The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Triamcinolone.
Doxycycline Injection Doxycycline Injection The risk or severity of bleeding can be increased when Doxycycline is combined with Ticagrelor.
Fluconazole Injection Fluconazole Injection The serum concentration of Ticagrelor can be increased when it is combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection Ticagrelor can cause a decrease in the absorption of Hydromorphone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Interferon Beta-1b Injection Interferon Beta-1b Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Interferon beta-1b.
Interferon Gamma-1b Injection Interferon Gamma-1b Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Interferon gamma-1b.
Meperidine Injection Meperidine Injection Ticagrelor can cause a decrease in the absorption of Meperidine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Morphine Injection Morphine Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Morphine.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Ticagrelor.
Altretamine Altretamine The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Ticagrelor.
Cefuroxime Cefuroxime The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefuroxime.
Cyclosporine Cyclosporine The serum concentration of Ticagrelor can be increased when it is combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Ticagrelor.
Enoxaparin Injection Enoxaparin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Enoxaparin.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Ticagrelor.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Ticagrelor.
Dofetilide Dofetilide The metabolism of Ticagrelor can be decreased when combined with Dofetilide.
Meloxicam Meloxicam The risk or severity of bleeding and hemorrhage can be increased when Meloxicam is combined with Ticagrelor.
Temozolomide Temozolomide The risk or severity of bleeding can be increased when Ticagrelor is combined with Temozolomide.
Linezolid Linezolid The risk or severity of bleeding and hemorrhage can be increased when Linezolid is combined with Ticagrelor.
Pentosan Polysulfate Pentosan Polysulfate The risk or severity of adverse effects can be increased when Pentosan polysulfate is combined with Ticagrelor.
Trimipramine Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Ticagrelor.
Tenofovir Tenofovir The serum concentration of Tenofovir can be increased when it is combined with Ticagrelor.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The risk or severity of bleeding and hemorrhage can be increased when Choline magnesium trisalicylate is combined with Ticagrelor.
Sirolimus Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Ticagrelor.
Epirubicin Epirubicin The risk or severity of bleeding can be increased when Ticagrelor is combined with Epirubicin.
Escitalopram Escitalopram The risk or severity of bleeding can be increased when Escitalopram is combined with Ticagrelor.
Zonisamide Zonisamide The serum concentration of Ticagrelor can be increased when it is combined with Zonisamide.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Ticagrelor.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Ticagrelor.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Ticagrelor.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Ticagrelor.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Ticagrelor.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Ticagrelor.
Tegaserod Tegaserod The serum concentration of Tegaserod can be increased when it is combined with Ticagrelor.
Progesterone Progesterone The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Progesterone.
Rifaximin Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Ticagrelor.
Duloxetine Duloxetine The risk or severity of hemorrhage can be increased when Duloxetine is combined with Ticagrelor.
Norethindrone Norethindrone The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Norethisterone.
Bosentan Bosentan The metabolism of Bosentan can be decreased when combined with Ticagrelor.
Cefditoren Cefditoren The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefdinir.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Ticagrelor.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Ticagrelor.
Voriconazole Voriconazole The metabolism of Voriconazole can be decreased when combined with Ticagrelor.
Dextroamphetamine Dextroamphetamine The risk or severity of bleeding and hemorrhage can be increased when Amphetamine is combined with Ticagrelor.
Peginterferon Alfa-2a Injection Peginterferon Alfa-2a Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Peginterferon alfa-2a.
Peginterferon Alfa-2b (PEG-Intron) Peginterferon Alfa-2b (PEG-Intron) The risk or severity of bleeding can be increased when Ticagrelor is combined with Peginterferon alfa-2b.
Isocarboxazid Isocarboxazid The risk or severity of bleeding and hemorrhage can be increased when Isocarboxazid is combined with Ticagrelor.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Ticagrelor.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Ticagrelor.
Deferasirox Deferasirox The risk or severity of gastrointestinal bleeding can be increased when Ticagrelor is combined with Deferasirox.
Tipranavir Tipranavir Tipranavir may increase the antiplatelet activities of Ticagrelor.
Ranolazine Ranolazine The serum concentration of Ticagrelor can be increased when it is combined with Ranolazine.
Rasagiline Rasagiline The risk or severity of bleeding and hemorrhage can be increased when Rasagiline is combined with Ticagrelor.
Imatinib Imatinib The metabolism of Imatinib can be decreased when combined with Ticagrelor.
Sitagliptin Sitagliptin The serum concentration of Ticagrelor can be increased when it is combined with Sitagliptin.
Paliperidone Paliperidone The serum concentration of Ticagrelor can be increased when it is combined with Paliperidone.
Bortezomib Bortezomib The serum concentration of Bortezomib can be increased when it is combined with Ticagrelor.
Clofarabine Injection Clofarabine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Clofarabine.
Oxaliplatin Injection Oxaliplatin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Oxaliplatin.
Posaconazole Posaconazole The serum concentration of Posaconazole can be increased when it is combined with Ticagrelor.
Rituximab Injection Rituximab Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Rituximab.
Bismuth Subsalicylate Bismuth Subsalicylate The risk or severity of bleeding can be increased when Bismuth subsalicylate is combined with Ticagrelor.
Pemetrexed Injection Pemetrexed Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Pemetrexed.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Ticagrelor.
Vorinostat Vorinostat The risk or severity of bleeding can be increased when Ticagrelor is combined with Vorinostat.
Sorafenib Sorafenib The metabolism of Ticagrelor can be decreased when combined with Sorafenib.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Ticagrelor.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Ticagrelor.
Lapatinib Lapatinib The serum concentration of Ticagrelor can be increased when it is combined with Lapatinib.
Dasatinib Dasatinib The risk or severity of bleeding and hemorrhage can be increased when Dasatinib is combined with Ticagrelor.
Omega-3 Fatty Acids Omega-3 Fatty Acids Omega-3 fatty acids may increase the antiplatelet activities of Ticagrelor.
Azacitidine Injection Azacitidine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Azacitidine.
Temsirolimus Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Ticagrelor.
Nelarabine Injection Nelarabine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Nelarabine.
Lenalidomide Lenalidomide The risk or severity of bleeding can be increased when Ticagrelor is combined with Lenalidomide.
Nilotinib Nilotinib The metabolism of Ticagrelor can be decreased when combined with Nilotinib.
Toremifene Toremifene The risk or severity of bleeding can be increased when Toremifene is combined with Ticagrelor.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Ticagrelor.
Chloramphenicol Injection Chloramphenicol Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Chloramphenicol.
Decitabine Injection Decitabine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Decitabine.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Ticagrelor.
Arsenic Trioxide Injection Arsenic Trioxide Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Arsenic trioxide.
Mitoxantrone Injection Mitoxantrone Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Mitoxantrone.
Desvenlafaxine Desvenlafaxine The risk or severity of hemorrhage can be increased when Desvenlafaxine is combined with Ticagrelor.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Ticagrelor.
Bendamustine Injection Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Ticagrelor.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Ticagrelor.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Ticagrelor.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia) Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of bleeding can be increased when Ticagrelor is combined with Alemtuzumab.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Ticagrelor.
Silodosin Silodosin The serum concentration of Silodosin can be increased when it is combined with Ticagrelor.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Ticagrelor.
Naltrexone Injection Naltrexone Injection Naltrexone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dexrazoxane Injection Dexrazoxane Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Dexrazoxane.
Ibritumomab Injection Ibritumomab Injection The risk or severity of adverse effects can be increased when Ticagrelor is combined with Ibritumomab tiuxetan.
Milnacipran Milnacipran The risk or severity of hemorrhage can be increased when Milnacipran is combined with Ticagrelor.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Ticagrelor.
Prasugrel Prasugrel The risk or severity of bleeding can be increased when Prasugrel is combined with Ticagrelor.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Ticagrelor.
Everolimus Everolimus The serum concentration of Everolimus can be increased when it is combined with Ticagrelor.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Ticagrelor.
Dronedarone Dronedarone The metabolism of Ticagrelor can be decreased when combined with Dronedarone.
Romidepsin Injection Romidepsin Injection The serum concentration of Ticagrelor can be increased when it is combined with Romidepsin.
Tapentadol Tapentadol Ticagrelor can cause a decrease in the absorption of Tapentadol resulting in a reduced serum concentration and potentially a decrease in efficacy.
Topotecan Topotecan The serum concentration of Topotecan can be increased when it is combined with Ticagrelor.
Pazopanib Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Ticagrelor.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Ticagrelor.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Ticagrelor.
Ulipristal Ulipristal The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ulipristal.
Levonorgestrel Levonorgestrel The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Levonorgestrel.
Oxymorphone Oxymorphone Oxymorphone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Dabigatran Dabigatran The risk or severity of bleeding can be increased when Ticagrelor is combined with Dabigatran.
Eribulin Injection Eribulin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Eribulin.
Cabazitaxel Injection Cabazitaxel Injection The serum concentration of Ticagrelor can be increased when it is combined with Cabazitaxel.
Ceftaroline Injection Ceftaroline Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ceftaroline fosamil.
Denileukin Diftitox Injection Denileukin Diftitox Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Aldesleukin.
Busulfan Injection Busulfan Injection The metabolism of Ticagrelor can be decreased when combined with Busulfan.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Ticagrelor.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Ticagrelor.
Telaprevir Telaprevir The serum concentration of Glecaprevir can be increased when it is combined with Ticagrelor.
Potassium Iodide Potassium Iodide Potassium Iodide may increase the anticoagulant activities of Ticagrelor.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Ticagrelor.
Rivaroxaban Rivaroxaban Ticagrelor may increase the anticoagulant activities of Rivaroxaban.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Ticagrelor.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Ticagrelor.
Vandetanib Vandetanib The metabolism of Ticagrelor can be decreased when combined with Vandetanib.
Clobazam Clobazam The serum concentration of Clobazam can be increased when it is combined with Ticagrelor.
Vemurafenib Vemurafenib The serum concentration of Ticagrelor can be increased when it is combined with Vemurafenib.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Ticagrelor.
Ivacaftor Ivacaftor The serum concentration of Ticagrelor can be increased when it is combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Ticagrelor.
Crizotinib Crizotinib The serum concentration of Crizotinib can be increased when it is combined with Ticagrelor.
Melphalan Injection Melphalan Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Melphalan.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Ticagrelor.
Ambrisentan Ambrisentan The serum concentration of Ticagrelor can be increased when it is combined with Ambrisentan.
Fondaparinux Injection Fondaparinux Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Fondaparinux.
Collagenase Clostridium Histolyticum Injection Collagenase Clostridium Histolyticum Injection The risk or severity of adverse effects can be increased when Ticagrelor is combined with Collagenase clostridium histolyticum.
Carfilzomib Injection Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Ticagrelor.
Iloprost Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Ticagrelor.
Enzalutamide Enzalutamide The serum concentration of Ticagrelor can be increased when it is combined with Enzalutamide.
Mirabegron Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Ticagrelor.
Regorafenib Regorafenib The serum concentration of Ticagrelor can be increased when it is combined with Regorafenib.
Bosutinib Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Ticagrelor.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Ticagrelor.
Icosapent Ethyl Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Ticagrelor.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Ticagrelor.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Ticagrelor.
Pomalidomide Pomalidomide The serum concentration of Ticagrelor can be increased when it is combined with Pomalidomide.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Ticagrelor.
Apixaban Apixaban Apixaban may increase the anticoagulant activities of Ticagrelor.
Canagliflozin Canagliflozin The serum concentration of Ticagrelor can be increased when it is combined with Canagliflozin.
Dabrafenib Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Ticagrelor.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Ticagrelor.
Dolutegravir Dolutegravir The serum concentration of Dolutegravir can be increased when it is combined with Ticagrelor.
Afatinib Afatinib The serum concentration of Afatinib can be increased when it is combined with Ticagrelor.
Levomilnacipran Levomilnacipran The risk or severity of hemorrhage can be increased when Levomilnacipran is combined with Ticagrelor.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Ticagrelor.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Ticagrelor.
Lomitapide Lomitapide The metabolism of Ticagrelor can be decreased when combined with Lomitapide.
Ketorolac Injection Ketorolac Injection The risk or severity of bleeding and hemorrhage can be increased when Ketorolac is combined with Ticagrelor.
Obinutuzumab Injection Obinutuzumab Injection The risk or severity of adverse effects can be increased when Ticagrelor is combined with Obinutuzumab.
Simeprevir Simeprevir The serum concentration of Ticagrelor can be increased when it is combined with Simeprevir.
Sofosbuvir Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Ticagrelor.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Ticagrelor.
Ceritinib Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Ticagrelor.
Belinostat Injection Belinostat Injection The serum concentration of Belinostat can be increased when it is combined with Ticagrelor.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Ticagrelor.
Testosterone Injection Testosterone Injection Testosterone may increase the anticoagulant activities of Ticagrelor.
Vorapaxar Vorapaxar The risk or severity of bleeding and hemorrhage can be increased when Vorapaxar is combined with Ticagrelor.
Hydrocodone Hydrocodone Hydrocodone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Suvorexant Suvorexant The serum concentration of Ticagrelor can be increased when it is combined with Suvorexant.
Edoxaban Edoxaban The risk or severity of bleeding can be increased when Edoxaban is combined with Ticagrelor.
Peginterferon Beta-1a Injection Peginterferon Beta-1a Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Peginterferon beta-1a.
Olaparib Olaparib The metabolism of Olaparib can be decreased when combined with Ticagrelor.
Blinatumomab Injection Blinatumomab Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Blinatumomab.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Ticagrelor.
Nintedanib Nintedanib The risk or severity of bleeding can be increased when Ticagrelor is combined with Nintedanib.
Palbociclib Palbociclib The metabolism of Ticagrelor can be decreased when combined with Palbociclib.
Lenvatinib Lenvatinib The serum concentration of Lenvatinib can be increased when it is combined with Ticagrelor.
Naloxegol Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Ticagrelor.
Panobinostat Panobinostat The metabolism of Ticagrelor can be decreased when combined with Panobinostat.
Dinutuximab Injection Dinutuximab Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Dinutuximab.
Haloperidol Injection Haloperidol Injection The serum concentration of Ticagrelor can be increased when it is combined with Haloperidol.
Deoxycholic Acid Injection Deoxycholic Acid Injection The risk or severity of adverse effects can be increased when Ticagrelor is combined with Deoxycholic acid.
Isavuconazonium Injection Isavuconazonium Injection The serum concentration of Ticagrelor can be increased when it is combined with Isavuconazonium.
Sonidegib Sonidegib The metabolism of Sonidegib can be decreased when combined with Ticagrelor.
Flibanserin Flibanserin The serum concentration of Ticagrelor can be increased when it is combined with Flibanserin.
Rolapitant Rolapitant The serum concentration of Ticagrelor can be increased when it is combined with Rolapitant.
Daclatasvir Daclatasvir The serum concentration of Ticagrelor can be increased when it is combined with Daclatasvir.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Ticagrelor.
Eluxadoline Eluxadoline Eluxadoline can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Cobimetinib Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Ticagrelor.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Ticagrelor.
Osimertinib Osimertinib The serum concentration of Osimertinib can be increased when it is combined with Ticagrelor.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Ticagrelor.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Ticagrelor.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Ticagrelor.
Defibrotide Injection Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Ticagrelor.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Ticagrelor.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Ticagrelor.
Cobicistat Cobicistat The serum concentration of Ticagrelor can be increased when it is combined with Cobicistat.
Selexipag Selexipag The serum concentration of Ticagrelor can be increased when it is combined with Selexipag.
Obeticholic Acid Obeticholic Acid The risk or severity of adverse effects can be increased when Ticagrelor is combined with Obeticholic acid.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Ticagrelor.
Rucaparib Rucaparib The serum concentration of Rucaparib can be increased when it is combined with Ticagrelor.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Ticagrelor.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Ticagrelor.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Ticagrelor.
Safinamide Safinamide The risk or severity of bleeding and hemorrhage can be increased when Safinamide is combined with Ticagrelor.
Midostaurin Midostaurin The metabolism of Midostaurin can be decreased when combined with Ticagrelor.
Neratinib Neratinib The metabolism of Ticagrelor can be decreased when combined with Neratinib.
Enasidenib Enasidenib The metabolism of Ticagrelor can be decreased when combined with Enasidenib.
Inotuzumab Ozogamicin Injection Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Ticagrelor.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Ticagrelor.
Copanlisib Injection Copanlisib Injection The serum concentration of Ticagrelor can be increased when it is combined with Copanlisib.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Ticagrelor.
Betrixaban Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Ticagrelor.
Acalabrutinib Acalabrutinib The metabolism of Acalabrutinib can be decreased when combined with Ticagrelor.
Gemtuzumab Ozogamicin Injection Gemtuzumab Ozogamicin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Gemtuzumab ozogamicin.
Ertugliflozin Ertugliflozin The serum concentration of Ertugliflozin can be increased when it is combined with Ticagrelor.
Buprenorphine Injection Buprenorphine Injection Ticagrelor can cause a decrease in the absorption of Buprenorphine resulting in a reduced serum concentration and potentially a decrease in efficacy.
Apalutamide Apalutamide The serum concentration of Ticagrelor can be decreased when it is combined with Apalutamide.
Penicillamine Penicillamine The risk or severity of bleeding can be increased when Ticagrelor is combined with Penicillamine.
Avatrombopag Avatrombopag The serum concentration of Avatrombopag can be increased when it is combined with Ticagrelor.
Baricitinib Baricitinib The metabolism of Ticagrelor can be decreased when combined with Baricitinib.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Ticagrelor.
Binimetinib Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Ticagrelor.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Ticagrelor.
Lusutrombopag Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Ticagrelor.
Elagolix Elagolix The serum concentration of Elagolix can be increased when it is combined with Ticagrelor.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Ticagrelor.
Dacomitinib Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Ticagrelor.
Duvelisib Duvelisib The serum concentration of Duvelisib can be increased when it is combined with Ticagrelor.
Omadacycline Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Ticagrelor.
Sarecycline Sarecycline The serum concentration of Ticagrelor can be increased when it is combined with Sarecycline.
Talazoparib Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Ticagrelor.
Gilteritinib Gilteritinib The serum concentration of Gilteritinib can be increased when it is combined with Ticagrelor.
Glasdegib Glasdegib The serum concentration of Ticagrelor can be increased when it is combined with Glasdegib.
Larotrectinib Larotrectinib The serum concentration of Ticagrelor can be increased when it is combined with Larotrectinib.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Ticagrelor.
Rifamycin Rifamycin The serum concentration of Rifamycin can be increased when it is combined with Ticagrelor.
Prucalopride Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Ticagrelor.
Siponimod Siponimod The metabolism of Siponimod can be decreased when combined with Ticagrelor.
Caplacizumab-yhdp Injection Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Ticagrelor.
Erdafitinib Erdafitinib The serum concentration of Ticagrelor can be increased when it is combined with Erdafitinib.
Alpelisib Alpelisib The metabolism of Alpelisib can be decreased when combined with Ticagrelor.
Cladribine Cladribine The risk or severity of bleeding can be increased when Ticagrelor is combined with Cladribine.
Darolutamide Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Ticagrelor.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Ticagrelor.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Ticagrelor.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Ticagrelor.
Istradefylline Istradefylline The serum concentration of Ticagrelor can be increased when it is combined with Istradefylline.
Pitolisant Pitolisant The serum concentration of Ticagrelor can be decreased when it is combined with Pitolisant.
Fedratinib Fedratinib The serum concentration of Fedratinib can be increased when it is combined with Ticagrelor.
Lefamulin Lefamulin Ticagrelor may decrease the excretion rate of Lefamulin which could result in a higher serum level.
Phenytoin Injection Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Ticagrelor.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Ticagrelor.
Enfortumab vedotin-ejfv Injection Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Ticagrelor.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Ticagrelor.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Ticagrelor.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Ticagrelor.
Lasmiditan Lasmiditan The serum concentration of Ticagrelor can be increased when it is combined with Lasmiditan.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Ticagrelor.
Calcium Acetate Calcium Acetate The therapeutic efficacy of Calcium acetate can be decreased when used in combination with Ticagrelor.
Tazemetostat Tazemetostat The serum concentration of Tazemetostat can be increased when it is combined with Ticagrelor.
Cenobamate Cenobamate The serum concentration of Ticagrelor can be decreased when it is combined with Cenobamate.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Ticagrelor.
Rimegepant Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Ticagrelor.
Tucatinib Tucatinib Ticagrelor may decrease the excretion rate of Tucatinib which could result in a higher serum level.
Remdesivir Injection Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Ticagrelor.
Ripretinib Ripretinib The serum concentration of Ripretinib can be increased when it is combined with Ticagrelor.
Lemborexant Lemborexant The serum concentration of Lemborexant can be increased when it is combined with Ticagrelor.
Fostemsavir Fostemsavir The serum concentration of Fostemsavir can be increased when it is combined with Ticagrelor.
Belantamab Mafodotin-blmf Injection Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Ticagrelor.
Pralsetinib Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Ticagrelor.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Ticagrelor can be decreased when it is combined with Satralizumab.
Relugolix Relugolix The serum concentration of Relugolix can be increased when it is combined with Ticagrelor.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Drospirenone.
Vitamin E (Alpha-Tocopherol) Vitamin E (Alpha-Tocopherol) Vitamin E may increase the antiplatelet activities of Ticagrelor.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Ticagrelor.
Fenoprofen Fenoprofen The risk or severity of bleeding and hemorrhage can be increased when Fenoprofen is combined with Ticagrelor.
Indomethacin Indomethacin The risk or severity of bleeding and hemorrhage can be increased when Indomethacin is combined with Ticagrelor.
Mefenamic Acid Mefenamic Acid The risk or severity of bleeding and hemorrhage can be increased when Mefenamic acid is combined with Ticagrelor.
Naproxen Naproxen The risk or severity of bleeding and hemorrhage can be increased when Naproxen is combined with Ticagrelor.
Tolmetin Tolmetin The risk or severity of bleeding and hemorrhage can be increased when Tolmetin is combined with Ticagrelor.
Sulindac Sulindac The risk or severity of bleeding and hemorrhage can be increased when Sulindac is combined with Ticagrelor.
Trazodone Trazodone The risk or severity of bleeding can be increased when Trazodone is combined with Ticagrelor.
Hydroxyurea Hydroxyurea The risk or severity of bleeding can be increased when Ticagrelor is combined with Hydroxyurea.
Floxuridine Floxuridine The risk or severity of bleeding can be increased when Ticagrelor is combined with Floxuridine.
Phenobarbital Phenobarbital The metabolism of Phenobarbital can be decreased when combined with Ticagrelor.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Ticagrelor.
Levorphanol Levorphanol Levorphanol can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Ticagrelor.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Ticagrelor.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Ticagrelor.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Ticagrelor.
Carmustine Carmustine The risk or severity of bleeding can be increased when Ticagrelor is combined with Carmustine.
Codeine Codeine Codeine can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Tranylcypromine Tranylcypromine The risk or severity of bleeding and hemorrhage can be increased when Tranylcypromine is combined with Ticagrelor.
Phenelzine Phenelzine The risk or severity of bleeding and hemorrhage can be increased when Phenelzine is combined with Ticagrelor.
Procarbazine Procarbazine The risk or severity of bleeding and hemorrhage can be increased when Procarbazine is combined with Ticagrelor.
Thioguanine Thioguanine The risk or severity of bleeding can be increased when Ticagrelor is combined with Tioguanine.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Ticagrelor.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Ticagrelor.
Oxycodone Oxycodone Oxycodone can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Methadone Methadone Ticagrelor can cause a decrease in the absorption of Methadone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Ibuprofen Ibuprofen The risk or severity of bleeding can be increased when Ibuprofen is combined with Ticagrelor.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Ticagrelor.
Sulfasalazine Sulfasalazine The risk or severity of bleeding and hemorrhage can be increased when Sulfasalazine is combined with Ticagrelor.
Lomustine Lomustine The risk or severity of bleeding can be increased when Ticagrelor is combined with Lomustine.
Doxorubicin Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Ticagrelor.
Cytarabine Cytarabine The risk or severity of bleeding can be increased when Ticagrelor is combined with Cytarabine.
Mechlorethamine Mechlorethamine The risk or severity of bleeding can be increased when Ticagrelor is combined with Mechlorethamine.
Dactinomycin Dactinomycin The serum concentration of Ticagrelor can be increased when it is combined with Dactinomycin.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Ticagrelor.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Ticagrelor.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Ticagrelor.
Loperamide Loperamide The serum concentration of Loperamide can be increased when it is combined with Ticagrelor.
Meclofenamate Meclofenamate The risk or severity of bleeding and hemorrhage can be increased when Meclofenamic acid is combined with Ticagrelor.
Daunorubicin Daunorubicin The risk or severity of bleeding can be increased when Ticagrelor is combined with Daunorubicin.
Digoxin Digoxin The serum concentration of Digoxin can be increased when it is combined with Ticagrelor.
Loxapine Loxapine The serum concentration of Ticagrelor can be increased when it is combined with Loxapine.
Quinine Quinine The therapeutic efficacy of Ticagrelor can be increased when used in combination with Quinine.
Sulfinpyrazone Sulfinpyrazone The risk or severity of bleeding can be increased when Sulfinpyrazone is combined with Ticagrelor.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Chlorothiazide.
Isosorbide Isosorbide The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Isosorbide.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Ticagrelor.
Imipramine Imipramine The serum concentration of Imipramine can be increased when it is combined with Ticagrelor.
Quinidine Quinidine The therapeutic efficacy of Ticagrelor can be increased when used in combination with Quinidine.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Ticagrelor.
Tamoxifen Tamoxifen The risk or severity of bleeding can be increased when Tamoxifen is combined with Ticagrelor.
Mitomycin Mitomycin The risk or severity of bleeding can be increased when Ticagrelor is combined with Mitomycin.
Methimazole Methimazole Methimazole may increase the anticoagulant activities of Ticagrelor.
Propylthiouracil Propylthiouracil Propylthiouracil may increase the anticoagulant activities of Ticagrelor.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Ticagrelor.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Ticagrelor.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Ticagrelor.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Ticagrelor.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Hydrochlorothiazide.
Nortriptyline Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Ticagrelor.
Mercaptopurine Mercaptopurine The risk or severity of bleeding can be increased when Ticagrelor is combined with Mercaptopurine.
Butorphanol Injection Butorphanol Injection Butorphanol can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Nalbuphine Injection Nalbuphine Injection Nalbuphine can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Clomiphene Clomiphene The serum concentration of Clomifene can be increased when it is combined with Ticagrelor.
Fluorouracil Injection Fluorouracil Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Fluorouracil.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Ticagrelor.
Cefaclor Cefaclor The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefaclor.
Cefadroxil Cefadroxil The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefadroxil.
Cefazolin Injection Cefazolin Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefazolin.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Ticagrelor.
Cefoxitin Injection Cefoxitin Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefoxitin.
Dacarbazine Dacarbazine The risk or severity of bleeding can be increased when Ticagrelor is combined with Dacarbazine.
Cefotaxime Injection Cefotaxime Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefotaxime.
Ketoconazole Ketoconazole The serum concentration of Ticagrelor can be increased when it is combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Ticagrelor.
Vincristine Injection Vincristine Injection The excretion of Vincristine can be decreased when combined with Ticagrelor.
Dipyridamole Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Ticagrelor.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Ticagrelor.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Ticagrelor.
Aspirin Aspirin The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Acetylsalicylic acid.
Salsalate Salsalate The risk or severity of bleeding and hemorrhage can be increased when Salsalate is combined with Ticagrelor.
Chlorambucil Chlorambucil The risk or severity of bleeding can be increased when Ticagrelor is combined with Chlorambucil.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Ticagrelor.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Ticagrelor.
Diltiazem Diltiazem The metabolism of Diltiazem can be decreased when combined with Ticagrelor.
Verapamil Verapamil The serum concentration of Ticagrelor can be increased when it is combined with Verapamil.
Cisplatin Injection Cisplatin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Cisplatin.
Diflunisal Diflunisal The risk or severity of bleeding and hemorrhage can be increased when Diflunisal is combined with Ticagrelor.
Piroxicam Piroxicam The risk or severity of bleeding and hemorrhage can be increased when Piroxicam is combined with Ticagrelor.
Streptozocin Streptozocin The risk or severity of bleeding can be increased when Ticagrelor is combined with Streptozocin.
Etoposide Etoposide The serum concentration of Etoposide can be increased when it is combined with Ticagrelor.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Ticagrelor.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Ticagrelor.
Pentoxifylline Pentoxifylline The therapeutic efficacy of Ticagrelor can be increased when used in combination with Pentoxifylline.
Ceftriaxone Injection Ceftriaxone Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ceftriaxone.
Ceftazidime Injection Ceftazidime Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Ceftazidime.
Ketoprofen Ketoprofen The risk or severity of bleeding and hemorrhage can be increased when Ketoprofen is combined with Ticagrelor.
Cefotetan Injection Cefotetan Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefotetan.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Ticagrelor.
Flurbiprofen Flurbiprofen The risk or severity of bleeding and hemorrhage can be increased when Flurbiprofen is combined with Ticagrelor.
Amiodarone Amiodarone The metabolism of Ticagrelor can be decreased when combined with Amiodarone.
Lovastatin Lovastatin The serum concentration of Lovastatin can be increased when it is combined with Ticagrelor.
Mesalamine Mesalamine The risk or severity of bleeding and hemorrhage can be increased when Mesalazine is combined with Ticagrelor.
Diclofenac Diclofenac The risk or severity of bleeding and hemorrhage can be increased when Diclofenac is combined with Ticagrelor.
Fluoxetine Fluoxetine The risk or severity of hemorrhage can be increased when Fluoxetine is combined with Ticagrelor.
Interferon Alfa-2b Injection Interferon Alfa-2b Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Interferon alfa-2b.
Cefixime Cefixime The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefixime.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Ticagrelor.
Idarubicin Idarubicin The risk or severity of bleeding can be increased when Ticagrelor is combined with Idarubicin.
Fludarabine Injection Fludarabine Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Fludarabine.
Pentostatin Injection Pentostatin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Pentostatin.
Clarithromycin Clarithromycin The serum concentration of Ticagrelor can be increased when it is combined with Clarithromycin.
Etodolac Etodolac The risk or severity of bleeding and hemorrhage can be increased when Etodolac is combined with Ticagrelor.
Nabumetone Nabumetone The risk or severity of bleeding and hemorrhage can be increased when Nabumetone is combined with Ticagrelor.
Pravastatin Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Ticagrelor.
Simvastatin Simvastatin The serum concentration of Simvastatin can be increased when it is combined with Ticagrelor.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Ticagrelor.
Itraconazole Itraconazole The serum concentration of Ticagrelor can be increased when it is combined with Itraconazole.
Oxaprozin Oxaprozin The risk or severity of bleeding and hemorrhage can be increased when Oxaprozin is combined with Ticagrelor.
Bisoprolol Bisoprolol The serum concentration of Ticagrelor can be increased when it is combined with Bisoprolol.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Ticagrelor.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Ticagrelor.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Ticagrelor.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Ticagrelor.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Ticagrelor.
Venlafaxine Venlafaxine Venlafaxine may increase the antiplatelet activities of Ticagrelor.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Ticagrelor.
Fluvoxamine Fluvoxamine The risk or severity of hemorrhage can be increased when Fluvoxamine is combined with Ticagrelor.
Nefazodone Nefazodone The risk or severity of hemorrhage can be increased when Nefazodone is combined with Ticagrelor.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Ticagrelor.
Tramadol Tramadol Tramadol can cause a decrease in the absorption of Ticagrelor resulting in a reduced serum concentration and potentially a decrease in efficacy.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Ticagrelor.
Carboplatin Injection Carboplatin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Carboplatin.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Ticagrelor.
Ifosfamide Injection Ifosfamide Injection The risk or severity of bleeding can be increased when Ifosfamide is combined with Ticagrelor.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Ticagrelor.
Ticlopidine Ticlopidine The risk or severity of bleeding can be increased when Ticlopidine is combined with Ticagrelor.
Saquinavir Saquinavir The serum concentration of Ticagrelor can be increased when it is combined with Saquinavir.
Dalteparin Injection Dalteparin Injection The risk or severity of bleeding can be increased when Ticagrelor is combined with Dalteparin.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Ticagrelor.
Gemcitabine Injection Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Ticagrelor.
Ritonavir Ritonavir The serum concentration of Ticagrelor can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Ticagrelor.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Ticagrelor.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Ticagrelor.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Ticagrelor.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Ticagrelor.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Ticagrelor.
Fexofenadine Fexofenadine The serum concentration of Ticagrelor can be increased when it is combined with Fexofenadine.
Azithromycin Azithromycin The risk or severity of adverse effects can be increased when Azithromycin is combined with Ticagrelor.
Carvedilol Carvedilol The serum concentration of Ticagrelor can be increased when it is combined with Carvedilol.
Selegiline Selegiline The risk or severity of bleeding and hemorrhage can be increased when Selegiline is combined with Ticagrelor.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Ticagrelor.
Sertraline Sertraline The risk or severity of bleeding can be increased when Sertraline is combined with Ticagrelor.
Propafenone Propafenone The serum concentration of Ticagrelor can be increased when it is combined with Propafenone.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Ticagrelor.
Cefepime Injection Cefepime Injection The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefepime.
Cefprozil Cefprozil The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefprozil.
Cefpodoxime Cefpodoxime The therapeutic efficacy of Ticagrelor can be decreased when used in combination with Cefpodoxime.
Paroxetine Paroxetine The risk or severity of hemorrhage can be increased when Paroxetine is combined with Ticagrelor.
Citalopram Citalopram The risk or severity of hemorrhage can be increased when Citalopram is combined with Ticagrelor.
Capecitabine Capecitabine The metabolism of Capecitabine can be decreased when combined with Ticagrelor.
Sildenafil Sildenafil The risk or severity of hemorrhage can be increased when Ticagrelor is combined with Sildenafil.
Celecoxib Celecoxib The risk or severity of bleeding and hemorrhage can be increased when Celecoxib is combined with Ticagrelor.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Ticagrelor.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Ticagrelor.
Thalidomide Thalidomide The risk or severity of bleeding can be increased when Ticagrelor is combined with Thalidomide.
Balsalazide Balsalazide The risk or severity of bleeding and hemorrhage can be increased when Balsalazide is combined with Ticagrelor.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Ticagrelor.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Ticagrelor.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists

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