Aprepitant

Generic name: Pronounced as (ap re' pi tant)
Brand names
  • Emend®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 02/15/2020

Aprepitant is used with other medications in adults and children 6 months of age and older to prevent nausea and vomiting that may occur after receiving cancer chemotherapy treatment. It is also used with other medications in adults and children 6 months of age and older to prevent delayed nausea and vomiting that may occur several days after receiving certain chemotherapy medications. Aprepitant is not used to treat nausea and vomiting that you already have. Aprepitant is in a class of medications called antiemetics. It works by blocking the action of neurokinin, a natural substance in the brain that causes nausea and vomiting.

Aprepitant comes as a capsule and as an oral suspension (liquid) to take by mouth. To prevent nausea and vomiting caused by cancer chemotherapy, aprepitant is usually taken once daily, with or without food, during the first few days of your cancer chemotherapy treatment. You will probably take aprepitant 1 hour before your chemotherapy on days 1, 2, and 3 of your treatment. If you do not receive chemotherapy on days 2 and 3, then you will take aprepitant on those days in the morning. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take aprepitant exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Aprepitant capsules come in two different strengths. Your doctor may prescribe both of the strengths for you to take at different times. You should be careful to take the right strength at the right time as directed by your doctor.

Swallow the capsules whole; do not split, chew, or crush them.

The oral suspension will be prepared by your healthcare provider and given to you in an oral dispenser. Store the oral dispenser in the refrigerator until it is time for your dose; however, it can be stored at room temperature for up to 3 hours before use. When ready to use, remove the cap from the dispenser before placing it in your mouth to slowly release the medication.

Aprepitant only works to prevent nausea and vomiting. Call your doctor if you already have these symptoms and do not begin to take aprepitant.

When used to prevent nausea and vomiting caused by cancer chemotherapy, aprepitant is usually used only during the first 3 days of the chemotherapy treatment cycles. Do not continue taking aprepitant longer than instructed by your doctor.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking aprepitant,

  • tell your doctor and pharmacist if you are allergic to aprepitant, any other medications, or any of the ingredients in aprepitant capsules or oral suspension. Ask your pharmacist for a list of the ingredients.

  • do not take aprepitant if you are taking pimozide (Orap). Your doctor will probably tell you not to take aprepitant if you are taking this medication.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); antifungals such as itraconazole (Onmel, Sporanox) and ketoconazole ; benzodiazepines such as alprazolam (Xanax), diazepam (Valium), midazolam , and triazolam (Halcion); cancer chemotherapy medications such as ifosfamide (Ifex), irinotecan (Camptosar), vinblastine, and vincristine (Marqibo Kit); carbamazepine (Equetro, Tegretol, Teril); clarithromycin (Biaxin, in Prevpac); diltiazem (Cardizem, Cartia, Tiazac); HIV protease inhibitors such as nelfinavir (Viracept) and ritonavir (Norvir); hormonal contraceptives (birth control pills, patches, rings, and injections); nefazodone; oral steroids such as dexamethasone and methylprednisolone (Medrol); phenytoin (Dilantin, Phenytek); rifampin (Rifadin, Rimactane, in Rifamate, in Rifater); and troleandomycin (TAO; no longer available in U.S.). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. Many other medications may also interact with aprepitant, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list.

  • tell your doctor if you have or have ever had liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breastfeeding. If you are taking or receiving hormonal contraceptives (birth control pills, patches, rings, implants, or injections) during treatment with aprepitant, you should also use an additional method of birth control (spermicide, condom) to avoid pregnancy during treatment with aprepitant and for one month after your final dose. Talk to your doctor about birth control methods while you are taking aprepitant and after treatment. If you become pregnant while taking aprepitant, call your doctor.

Unless your doctor tells you otherwise, continue your normal diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Aprepitant may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • weakness

    • tiredness

    • dizziness

    • diarrhea

    • constipation

    • gas

    • stomach pain

    • heartburn

    • nausea

    • hiccups

    • loss of appetite

    • headache

    • fever

    • hair loss

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:

    • hives

    • rash

    • itching

    • skin peeling or blisters

    • difficulty breathing or swallowing

  • Aprepitant may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store the capsules at room temperature and away from excess heat and moisture (not in the bathroom). The prepared oral suspension dose must be used within 72 hours of preparation; discard any unused doses after 72 hours.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • drowsiness

  • headache

Keep all appointments with your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Montelukast Montelukast The metabolism of Montelukast can be decreased when combined with Aprepitant.
Leflunomide Leflunomide The metabolism of Leflunomide can be decreased when combined with Aprepitant.
Delavirdine Delavirdine The metabolism of Aprepitant can be decreased when combined with Delavirdine.
Nevirapine Nevirapine The metabolism of Nevirapine can be decreased when combined with Aprepitant.
Atorvastatin Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Aprepitant.
Aminophylline Aminophylline The metabolism of Aminophylline can be decreased when combined with Aprepitant.
Candesartan Candesartan The metabolism of Candesartan can be decreased when combined with Aprepitant.
Cilostazol Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Aprepitant.
Clopidogrel Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Aprepitant.
Erythromycin and Sulfisoxazole Erythromycin and Sulfisoxazole The metabolism of Aprepitant can be decreased when combined with Erythromycin.
Fenofibrate Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Aprepitant.
Reserpine Reserpine The metabolism of Aprepitant can be increased when combined with Reserpine.
Tacrolimus Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Aprepitant.
Triamcinolone Triamcinolone The metabolism of Triamcinolone can be decreased when combined with Aprepitant.
Fluconazole Injection Fluconazole Injection The metabolism of Aprepitant can be decreased when combined with Fluconazole.
Hydromorphone Injection Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Aprepitant.
Meperidine Injection Meperidine Injection The metabolism of Meperidine can be decreased when combined with Aprepitant.
Metronidazole Injection Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Aprepitant.
Zidovudine Injection Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Aprepitant.
Cyclosporine Cyclosporine The metabolism of Aprepitant can be decreased when combined with Cyclosporine.
Ondansetron Ondansetron The metabolism of Ondansetron can be decreased when combined with Aprepitant.
Torsemide Torsemide The metabolism of Torasemide can be decreased when combined with Aprepitant.
Alosetron Alosetron The metabolism of Alosetron can be decreased when combined with Aprepitant.
Dofetilide Dofetilide The metabolism of Dofetilide can be decreased when combined with Aprepitant.
Meloxicam Meloxicam The metabolism of Meloxicam can be decreased when combined with Aprepitant.
Oxcarbazepine Oxcarbazepine The metabolism of Aprepitant can be increased when combined with Oxcarbazepine.
Pantoprazole Pantoprazole The metabolism of Pantoprazole can be decreased when combined with Aprepitant.
Zaleplon Zaleplon The metabolism of Zaleplon can be decreased when combined with Aprepitant.
Anakinra Anakinra The metabolism of Aprepitant can be increased when combined with Anakinra.
Trimipramine Trimipramine The metabolism of Trimipramine can be decreased when combined with Aprepitant.
Etanercept Injection Etanercept Injection The metabolism of Aprepitant can be increased when combined with Etanercept.
Modafinil Modafinil The metabolism of Aprepitant can be increased when combined with Modafinil.
Tenofovir Tenofovir The metabolism of Tenofovir can be decreased when combined with Aprepitant.
Sirolimus Sirolimus The metabolism of Sirolimus can be decreased when combined with Aprepitant.
Dutasteride Dutasteride The metabolism of Dutasteride can be decreased when combined with Aprepitant.
Eplerenone Eplerenone The metabolism of Eplerenone can be decreased when combined with Aprepitant.
Escitalopram Escitalopram The metabolism of Escitalopram can be decreased when combined with Aprepitant.
Zonisamide Zonisamide The metabolism of Zonisamide can be decreased when combined with Aprepitant.
Adalimumab Injection Adalimumab Injection The metabolism of Aprepitant can be increased when combined with Adalimumab.
Aripiprazole Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Aprepitant.
Atazanavir Atazanavir The metabolism of Atazanavir can be decreased when combined with Aprepitant.
Eletriptan Eletriptan The metabolism of Eletriptan can be decreased when combined with Aprepitant.
Rosuvastatin Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Aprepitant.
Vardenafil Vardenafil The metabolism of Vardenafil can be decreased when combined with Aprepitant.
Alfuzosin Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Aprepitant.
Tadalafil Tadalafil The metabolism of Tadalafil can be decreased when combined with Aprepitant.
Progesterone Progesterone The metabolism of Progesterone can be decreased when combined with Aprepitant.
Apomorphine Injection Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Aprepitant.
Infliximab Injection Infliximab Injection The metabolism of Aprepitant can be increased when combined with Infliximab.
Duloxetine Duloxetine The metabolism of Duloxetine can be decreased when combined with Aprepitant.
Norethindrone Norethindrone The metabolism of Norethisterone can be decreased when combined with Aprepitant.
Bosentan Bosentan The metabolism of Bosentan can be decreased when combined with Aprepitant.
Erlotinib Erlotinib The metabolism of Erlotinib can be decreased when combined with Aprepitant.
Eszopiclone Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Aprepitant.
Voriconazole Voriconazole The metabolism of Aprepitant can be decreased when combined with Voriconazole.
Ramelteon Ramelteon The metabolism of Ramelteon can be decreased when combined with Aprepitant.
Fentanyl Fentanyl The metabolism of Fentanyl can be decreased when combined with Aprepitant.
Ranolazine Ranolazine The metabolism of Aprepitant can be decreased when combined with Ranolazine.
Abatacept Injection Abatacept Injection The metabolism of Aprepitant can be increased when combined with Abatacept.
Imatinib Imatinib The metabolism of Aprepitant can be decreased when combined with Imatinib.
Gefitinib Gefitinib The metabolism of Gefitinib can be decreased when combined with Aprepitant.
Paliperidone Paliperidone The metabolism of Paliperidone can be decreased when combined with Aprepitant.
Bortezomib Bortezomib The metabolism of Bortezomib can be decreased when combined with Aprepitant.
Retapamulin Retapamulin The metabolism of Retapamulin can be decreased when combined with Aprepitant.
Sorafenib Sorafenib The metabolism of Sorafenib can be decreased when combined with Aprepitant.
Sunitinib Sunitinib The metabolism of Sunitinib can be decreased when combined with Aprepitant.
Dronabinol Dronabinol The metabolism of Dronabinol can be decreased when combined with Aprepitant.
Lapatinib Lapatinib The metabolism of Lapatinib can be decreased when combined with Aprepitant.
Dasatinib Dasatinib The metabolism of Dasatinib can be decreased when combined with Aprepitant.
Armodafinil Armodafinil The metabolism of Aprepitant can be increased when combined with Armodafinil.
Temsirolimus Temsirolimus The metabolism of Temsirolimus can be decreased when combined with Aprepitant.
Nilotinib Nilotinib The metabolism of Nilotinib can be decreased when combined with Aprepitant.
Bexarotene Bexarotene The metabolism of Bexarotene can be decreased when combined with Aprepitant.
Budesonide Budesonide The metabolism of Aprepitant can be increased when combined with Budesonide.
Chloramphenicol Injection Chloramphenicol Injection The metabolism of Aprepitant can be decreased when combined with Chloramphenicol.
Etravirine Etravirine The metabolism of Etravirine can be decreased when combined with Aprepitant.
Nebivolol Nebivolol The metabolism of Nebivolol can be decreased when combined with Aprepitant.
Tretinoin Tretinoin The metabolism of Tretinoin can be decreased when combined with Aprepitant.
Certolizumab Injection Certolizumab Injection The metabolism of Aprepitant can be increased when combined with Certolizumab pegol.
Ixabepilone Injection Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Aprepitant.
Irinotecan Injection Irinotecan Injection The metabolism of Irinotecan can be decreased when combined with Aprepitant.
Praziquantel Praziquantel The metabolism of Praziquantel can be decreased when combined with Aprepitant.
Rufinamide Rufinamide The metabolism of Rufinamide can be decreased when combined with Aprepitant.
Midazolam Midazolam The serum concentration of Midazolam can be increased when it is combined with Aprepitant.
Dexlansoprazole Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Aprepitant.
Iloperidone Iloperidone The metabolism of Iloperidone can be decreased when combined with Aprepitant.
Prasugrel Prasugrel The metabolism of Prasugrel can be decreased when combined with Aprepitant.
Lacosamide Lacosamide The metabolism of Lacosamide can be decreased when combined with Aprepitant.
Everolimus Everolimus The metabolism of Everolimus can be decreased when combined with Aprepitant.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) The metabolism of Tolvaptan can be decreased when combined with Aprepitant.
Dronedarone Dronedarone The metabolism of Dronedarone can be decreased when combined with Aprepitant.
Saxagliptin Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Aprepitant.
Romidepsin Injection Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Aprepitant.
Tapentadol Tapentadol The metabolism of Tapentadol can be decreased when combined with Aprepitant.
Golimumab Injection Golimumab Injection The metabolism of Aprepitant can be increased when combined with Golimumab.
Pazopanib Pazopanib The metabolism of Pazopanib can be decreased when combined with Aprepitant.
Pitavastatin Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Aprepitant.
Albendazole Albendazole The metabolism of Albendazole can be decreased when combined with Aprepitant.
Ulipristal Ulipristal The serum concentration of Ulipristal can be decreased when it is combined with Aprepitant.
Levonorgestrel Levonorgestrel The metabolism of Levonorgestrel can be decreased when combined with Aprepitant.
Tocilizumab Injection Tocilizumab Injection The metabolism of Aprepitant can be increased when combined with Tocilizumab.
Cabazitaxel Injection Cabazitaxel Injection The metabolism of Cabazitaxel can be decreased when combined with Aprepitant.
Lurasidone Lurasidone The metabolism of Lurasidone can be decreased when combined with Aprepitant.
Vilazodone Vilazodone The metabolism of Vilazodone can be decreased when combined with Aprepitant.
Busulfan Injection Busulfan Injection The metabolism of Busulfan can be decreased when combined with Aprepitant.
Roflumilast Roflumilast The metabolism of Roflumilast can be decreased when combined with Aprepitant.
Linagliptin Linagliptin The metabolism of Linagliptin can be decreased when combined with Aprepitant.
Cyclophosphamide Injection Cyclophosphamide Injection The metabolism of Cyclophosphamide can be decreased when combined with Aprepitant.
Rivaroxaban Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Aprepitant.
Brentuximab Vedotin Injection Brentuximab Vedotin Injection The metabolism of Brentuximab vedotin can be decreased when combined with Aprepitant.
Ruxolitinib Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Aprepitant.
Vandetanib Vandetanib The metabolism of Vandetanib can be decreased when combined with Aprepitant.
Clobazam Clobazam The metabolism of Clobazam can be decreased when combined with Aprepitant.
Vemurafenib Vemurafenib The metabolism of Vemurafenib can be decreased when combined with Aprepitant.
Vismodegib Vismodegib The metabolism of Vismodegib can be decreased when combined with Aprepitant.
Ivacaftor Ivacaftor The metabolism of Aprepitant can be decreased when combined with Ivacaftor.
Axitinib Axitinib The metabolism of Axitinib can be decreased when combined with Aprepitant.
Crizotinib Crizotinib The metabolism of Crizotinib can be decreased when combined with Aprepitant.
Cabergoline Cabergoline The metabolism of Cabergoline can be decreased when combined with Aprepitant.
Ambrisentan Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Aprepitant.
Enzalutamide Enzalutamide The metabolism of Enzalutamide can be decreased when combined with Aprepitant.
Regorafenib Regorafenib The metabolism of Regorafenib can be decreased when combined with Aprepitant.
Bosutinib Bosutinib The metabolism of Bosutinib can be decreased when combined with Aprepitant.
Cabozantinib (thyroid cancer) Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Aprepitant.
Tofacitinib Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Aprepitant.
Ponatinib Ponatinib The metabolism of Ponatinib can be decreased when combined with Aprepitant.
Pomalidomide Pomalidomide The metabolism of Pomalidomide can be decreased when combined with Aprepitant.
Ado-trastuzumab Emtansine Injection Ado-trastuzumab Emtansine Injection The metabolism of Trastuzumab emtansine can be decreased when combined with Aprepitant.
Apixaban Apixaban The metabolism of Apixaban can be decreased when combined with Aprepitant.
Dabrafenib Dabrafenib The metabolism of Dabrafenib can be decreased when combined with Aprepitant.
Ospemifene Ospemifene The metabolism of Ospemifene can be decreased when combined with Aprepitant.
Vortioxetine Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Aprepitant.
Perampanel Perampanel The metabolism of Perampanel can be decreased when combined with Aprepitant.
Ibrutinib Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Aprepitant.
Lomitapide Lomitapide The metabolism of Lomitapide can be decreased when combined with Aprepitant.
Avanafil Avanafil The metabolism of Avanafil can be decreased when combined with Aprepitant.
Ketorolac Injection Ketorolac Injection The metabolism of Ketorolac can be decreased when combined with Aprepitant.
Dapagliflozin Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Aprepitant.
Apremilast Apremilast The metabolism of Aprepitant can be increased when combined with Apremilast.
Ceritinib Ceritinib The metabolism of Ceritinib can be decreased when combined with Aprepitant.
Siltuximab Injection Siltuximab Injection The metabolism of Aprepitant can be increased when combined with Siltuximab.
Idelalisib Idelalisib The metabolism of Idelalisib can be decreased when combined with Aprepitant.
Testosterone Injection Testosterone Injection The metabolism of Testosterone can be decreased when combined with Aprepitant.
Vorapaxar Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Aprepitant.
Suvorexant Suvorexant The metabolism of Suvorexant can be decreased when combined with Aprepitant.
Olaparib Olaparib The metabolism of Aprepitant can be decreased when combined with Olaparib.
Tasimelteon Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Aprepitant.
Nintedanib Nintedanib The metabolism of Nintedanib can be decreased when combined with Aprepitant.
Secukinumab Injection Secukinumab Injection The metabolism of Aprepitant can be increased when combined with Secukinumab.
Risperidone Injection Risperidone Injection The metabolism of Risperidone can be decreased when combined with Aprepitant.
Palbociclib Palbociclib The metabolism of Palbociclib can be decreased when combined with Aprepitant.
Naloxegol Naloxegol The metabolism of Naloxegol can be decreased when combined with Aprepitant.
Panobinostat Panobinostat The metabolism of Panobinostat can be decreased when combined with Aprepitant.
Haloperidol Injection Haloperidol Injection The serum concentration of Haloperidol can be increased when it is combined with Aprepitant.
Ivabradine Ivabradine The metabolism of Aprepitant can be decreased when combined with Ivabradine.
Sonidegib Sonidegib The metabolism of Aprepitant can be decreased when combined with Sonidegib.
Flibanserin Flibanserin The metabolism of Aprepitant can be decreased when combined with Flibanserin.
Daclatasvir Daclatasvir The metabolism of Daclatasvir can be decreased when combined with Aprepitant.
Brexpiprazole Brexpiprazole The metabolism of Aprepitant can be decreased when combined with Brexpiprazole.
Ziprasidone Injection Ziprasidone Injection The metabolism of Ziprasidone can be decreased when combined with Aprepitant.
Cobimetinib Cobimetinib The metabolism of Aprepitant can be decreased when combined with Cobimetinib.
Trabectedin Injection Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Aprepitant.
Osimertinib Osimertinib The metabolism of Osimertinib can be decreased when combined with Aprepitant.
Alectinib Alectinib The metabolism of Alectinib can be decreased when combined with Aprepitant.
Ixazomib Ixazomib The metabolism of Ixazomib can be decreased when combined with Aprepitant.
Lesinurad Lesinurad The metabolism of Lesinurad can be decreased when combined with Aprepitant.
Dexamethasone Injection Dexamethasone Injection The metabolism of Dexamethasone can be decreased when combined with Aprepitant.
Brivaracetam Injection Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Aprepitant.
Venetoclax Venetoclax The metabolism of Venetoclax can be decreased when combined with Aprepitant.
Cobicistat Cobicistat The metabolism of Aprepitant can be decreased when combined with Cobicistat.
Diphenhydramine Injection Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Aprepitant.
Rucaparib Rucaparib The metabolism of Aprepitant can be decreased when combined with Rucaparib.
Ribociclib Ribociclib The metabolism of Ribociclib can be decreased when combined with Aprepitant.
Brigatinib Brigatinib The metabolism of Brigatinib can be decreased when combined with Aprepitant.
Doxepin (Insomnia) Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Aprepitant.
Deutetrabenazine Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Aprepitant.
Valbenazine Valbenazine The metabolism of Valbenazine can be decreased when combined with Aprepitant.
Deflazacort Deflazacort The serum concentration of Aprepitant can be increased when it is combined with Deflazacort.
Safinamide Safinamide The metabolism of Aprepitant can be decreased when combined with Safinamide.
Midostaurin Midostaurin The metabolism of Aprepitant can be decreased when combined with Midostaurin.
Neratinib Neratinib The metabolism of Neratinib can be decreased when combined with Aprepitant.
Enasidenib Enasidenib The metabolism of Enasidenib can be decreased when combined with Aprepitant.
Aprepitant/Fosaprepitant Injection Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be decreased when combined with Aprepitant.
Copanlisib Injection Copanlisib Injection The metabolism of Copanlisib can be decreased when combined with Aprepitant.
Abemaciclib Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Aprepitant.
Acalabrutinib Acalabrutinib The metabolism of Aprepitant can be decreased when combined with Acalabrutinib.
Letermovir Letermovir The metabolism of Aprepitant can be decreased when combined with Letermovir.
Buprenorphine Injection Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Aprepitant.
Baricitinib Baricitinib The metabolism of Baricitinib can be decreased when combined with Aprepitant.
Eliglustat Eliglustat The metabolism of Eliglustat can be decreased when combined with Aprepitant.
Ivosidenib Ivosidenib The metabolism of Ivosidenib can be decreased when combined with Aprepitant.
Doravirine Doravirine The metabolism of Doravirine can be decreased when combined with Aprepitant.
Cannabidiol Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Aprepitant.
Dacomitinib Dacomitinib The metabolism of Dacomitinib can be decreased when combined with Aprepitant.
Duvelisib Duvelisib The metabolism of Duvelisib can be decreased when combined with Aprepitant.
Gilteritinib Gilteritinib The metabolism of Gilteritinib can be decreased when combined with Aprepitant.
Lorlatinib Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Aprepitant.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The metabolism of Paclitaxel can be decreased when combined with Aprepitant.
Prucalopride Prucalopride The metabolism of Prucalopride can be decreased when combined with Aprepitant.
Emapalumab-lzsg Injection Emapalumab-lzsg Injection The metabolism of Aprepitant can be increased when combined with Emapalumab.
Siponimod Siponimod The risk or severity of adverse effects can be increased when Aprepitant is combined with Siponimod.
Erdafitinib Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Aprepitant.
Esomeprazole Injection Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Aprepitant.
Alpelisib Alpelisib The metabolism of Alpelisib can be decreased when combined with Aprepitant.
Triclabendazole Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Aprepitant.
Entrectinib Entrectinib The metabolism of Entrectinib can be decreased when combined with Aprepitant.
Pexidartinib Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Aprepitant.
Istradefylline Istradefylline The metabolism of Istradefylline can be decreased when combined with Aprepitant.
Pitolisant Pitolisant The serum concentration of Aprepitant can be decreased when it is combined with Pitolisant.
Pretomanid Pretomanid The serum concentration of Pretomanid can be increased when it is combined with Aprepitant.
Fedratinib Fedratinib The metabolism of Fedratinib can be decreased when combined with Aprepitant.
Lefamulin Lefamulin The serum concentration of Lefamulin can be increased when it is combined with Aprepitant.
Phenytoin Injection Phenytoin Injection The metabolism of Aprepitant can be decreased when combined with Phenytoin.
Fosphenytoin Injection Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Aprepitant.
Zanubrutinib Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Aprepitant.
Voxelotor Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Aprepitant.
Avapritinib Avapritinib The metabolism of Avapritinib can be decreased when combined with Aprepitant.
Lumateperone Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Aprepitant.
Ubrogepant Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Aprepitant.
Tazemetostat Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Aprepitant.
Cenobamate Cenobamate The serum concentration of Aprepitant can be decreased when it is combined with Cenobamate.
Pemigatinib Pemigatinib The metabolism of Pemigatinib can be decreased when combined with Aprepitant.
Selumetinib Selumetinib The serum concentration of Selumetinib can be increased when it is combined with Aprepitant.
Rimegepant Rimegepant The metabolism of Rimegepant can be decreased when combined with Aprepitant.
Tucatinib Tucatinib The metabolism of Tucatinib can be decreased when combined with Aprepitant.
Lemborexant Lemborexant The metabolism of Lemborexant can be decreased when combined with Aprepitant.
Lurbinectedin Injection Lurbinectedin Injection The serum concentration of Lurbinectedin can be increased when it is combined with Aprepitant.
Pralsetinib Pralsetinib The metabolism of Aprepitant can be decreased when combined with Pralsetinib.
Satralizumab-mwge Injection Satralizumab-mwge Injection The serum concentration of Aprepitant can be decreased when it is combined with Satralizumab.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Aprepitant.
Theophylline Theophylline The metabolism of Theophylline can be decreased when combined with Aprepitant.
Indomethacin Indomethacin The metabolism of Indomethacin can be decreased when combined with Aprepitant.
Mefenamic Acid Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Aprepitant.
Naproxen Naproxen The metabolism of Naproxen can be decreased when combined with Aprepitant.
Trazodone Trazodone The metabolism of Trazodone can be decreased when combined with Aprepitant.
Phenobarbital Phenobarbital The metabolism of Aprepitant can be decreased when combined with Phenobarbital.
Methotrexate Injection Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Aprepitant.
Primidone Primidone The metabolism of Primidone can be decreased when combined with Aprepitant.
Methsuximide Methsuximide The metabolism of Methsuximide can be decreased when combined with Aprepitant.
Chlorpromazine Chlorpromazine The metabolism of Chlorpromazine can be decreased when combined with Aprepitant.
Diazepam Diazepam The metabolism of Diazepam can be decreased when combined with Aprepitant.
Lorazepam Lorazepam The metabolism of Lorazepam can be decreased when combined with Aprepitant.
Phenelzine Phenelzine The metabolism of Aprepitant can be decreased when combined with Phenelzine.
Prochlorperazine Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Aprepitant.
Thioridazine Thioridazine The metabolism of Thioridazine can be decreased when combined with Aprepitant.
Dapsone Dapsone The metabolism of Dapsone can be decreased when combined with Aprepitant.
Oxycodone Oxycodone The metabolism of Oxycodone can be decreased when combined with Aprepitant.
Methadone Methadone The metabolism of Methadone can be decreased when combined with Aprepitant.
Oxybutynin Oxybutynin The metabolism of Oxybutynin can be decreased when combined with Aprepitant.
Ibuprofen Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Aprepitant.
Phentermine Phentermine The metabolism of Phentermine can be decreased when combined with Aprepitant.
Hydrocortisone Hydrocortisone The metabolism of Hydrocortisone can be decreased when combined with Aprepitant.
Doxorubicin Doxorubicin The metabolism of Doxorubicin can be decreased when combined with Aprepitant.
Carbamazepine Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Aprepitant.
Clonidine Clonidine The metabolism of Clonidine can be decreased when combined with Aprepitant.
Cimetidine Cimetidine The metabolism of Aprepitant can be decreased when combined with Cimetidine.
Warfarin Warfarin The serum concentration of Warfarin can be increased when it is combined with Aprepitant.
Daunorubicin Daunorubicin The metabolism of Aprepitant can be increased when combined with Daunorubicin.
Chloroquine Chloroquine The metabolism of Chloroquine can be decreased when combined with Aprepitant.
Quinine Quinine The metabolism of Quinine can be decreased when combined with Aprepitant.
Isosorbide Isosorbide The serum concentration of Isosorbide can be decreased when it is combined with Aprepitant.
Clindamycin Injection Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Aprepitant.
Amitriptyline Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Aprepitant.
Imipramine Imipramine The metabolism of Imipramine can be decreased when combined with Aprepitant.
Quinidine Quinidine The metabolism of Aprepitant can be decreased when combined with Quinidine.
Rifampin Rifampin The metabolism of Aprepitant can be increased when combined with Rifampicin.
Valproic Acid Valproic Acid The metabolism of Valproic acid can be decreased when combined with Aprepitant.
Tamoxifen Tamoxifen The metabolism of Tamoxifen can be decreased when combined with Aprepitant.
Chlorpropamide Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Aprepitant.
Tolbutamide Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Aprepitant.
Tolazamide Tolazamide The metabolism of Tolazamide can be decreased when combined with Aprepitant.
Dextromethorphan Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Aprepitant.
Chlorpheniramine Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Aprepitant.
Carisoprodol Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Aprepitant.
Disulfiram Disulfiram The metabolism of Disulfiram can be decreased when combined with Aprepitant.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Aprepitant.
Nortriptyline Nortriptyline The metabolism of Nortriptyline can be decreased when combined with Aprepitant.
Colchicine Colchicine The metabolism of Colchicine can be decreased when combined with Aprepitant.
Cephalexin Cephalexin The metabolism of Cephalexin can be decreased when combined with Aprepitant.
Ketoconazole Ketoconazole The metabolism of Aprepitant can be decreased when combined with Ketoconazole.
Thiotepa Injection Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Aprepitant.
Vincristine Injection Vincristine Injection The metabolism of Vincristine can be decreased when combined with Aprepitant.
Vinblastine Vinblastine The metabolism of Vinblastine can be decreased when combined with Aprepitant.
Metoprolol Metoprolol The metabolism of Metoprolol can be decreased when combined with Aprepitant.
Hydroxyzine Hydroxyzine The metabolism of Hydroxyzine can be decreased when combined with Aprepitant.
Aspirin Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Aprepitant.
Alprazolam Alprazolam The metabolism of Alprazolam can be decreased when combined with Aprepitant.
Triazolam Triazolam The metabolism of Triazolam can be decreased when combined with Aprepitant.
Trimethoprim Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Aprepitant.
Diltiazem Diltiazem The metabolism of Aprepitant can be decreased when combined with Diltiazem.
Nifedipine Nifedipine The metabolism of Nifedipine can be decreased when combined with Aprepitant.
Timolol Timolol The metabolism of Timolol can be decreased when combined with Aprepitant.
Verapamil Verapamil The metabolism of Aprepitant can be decreased when combined with Verapamil.
Piroxicam Piroxicam The metabolism of Piroxicam can be decreased when combined with Aprepitant.
Etoposide Etoposide The metabolism of Etoposide can be decreased when combined with Aprepitant.
Glyburide Glyburide The metabolism of Glyburide can be decreased when combined with Aprepitant.
Glipizide Glipizide The metabolism of Glipizide can be decreased when combined with Aprepitant.
Pentamidine Injection Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Aprepitant.
Labetalol Labetalol The metabolism of Labetalol can be decreased when combined with Aprepitant.
Pimozide Pimozide The metabolism of Pimozide can be decreased when combined with Aprepitant.
Flurbiprofen Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Aprepitant.
Amiodarone Amiodarone The metabolism of Amiodarone can be decreased when combined with Aprepitant.
Buspirone Buspirone The metabolism of Buspirone can be decreased when combined with Aprepitant.
Lovastatin Lovastatin The metabolism of Lovastatin can be decreased when combined with Aprepitant.
Ciprofloxacin Ciprofloxacin The metabolism of Aprepitant can be decreased when combined with Ciprofloxacin.
Diclofenac Diclofenac The metabolism of Diclofenac can be decreased when combined with Aprepitant.
Fluoxetine Fluoxetine The metabolism of Fluoxetine can be decreased when combined with Aprepitant.
Clozapine Clozapine The metabolism of Clozapine can be decreased when combined with Aprepitant.
Idarubicin Idarubicin The metabolism of Idarubicin can be decreased when combined with Aprepitant.
Clarithromycin Clarithromycin The metabolism of Aprepitant can be decreased when combined with Clarithromycin.
Etodolac Etodolac The metabolism of Etodolac can be decreased when combined with Aprepitant.
Felodipine Felodipine The metabolism of Felodipine can be decreased when combined with Aprepitant.
Nabumetone Nabumetone The metabolism of Nabumetone can be decreased when combined with Aprepitant.
Simvastatin Simvastatin The metabolism of Simvastatin can be decreased when combined with Aprepitant.
Teniposide Injection Teniposide Injection The metabolism of Teniposide can be decreased when combined with Aprepitant.
Itraconazole Itraconazole The metabolism of Aprepitant can be decreased when combined with Itraconazole.
Zolpidem Zolpidem The metabolism of Zolpidem can be decreased when combined with Aprepitant.
Doxazosin Doxazosin The metabolism of Doxazosin can be decreased when combined with Aprepitant.
Omeprazole Omeprazole The metabolism of Omeprazole can be decreased when combined with Aprepitant.
Cisapride Cisapride The metabolism of Cisapride can be decreased when combined with Aprepitant.
Fluvastatin Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Aprepitant.
Venlafaxine Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Aprepitant.
Famciclovir Famciclovir The metabolism of Famciclovir can be decreased when combined with Aprepitant.
Fluvoxamine Fluvoxamine The metabolism of Aprepitant can be decreased when combined with Fluvoxamine.
Losartan Losartan The metabolism of Losartan can be decreased when combined with Aprepitant.
Tramadol Tramadol The metabolism of Tramadol can be decreased when combined with Aprepitant.
Vinorelbine Injection Vinorelbine Injection The metabolism of Vinorelbine can be decreased when combined with Aprepitant.
Lansoprazole Lansoprazole The metabolism of Lansoprazole can be decreased when combined with Aprepitant.
Ifosfamide Injection Ifosfamide Injection The metabolism of Ifosfamide can be decreased when combined with Aprepitant.
Bupropion Bupropion The metabolism of Bupropion can be decreased when combined with Aprepitant.
Ticlopidine Ticlopidine The metabolism of Ticlopidine can be decreased when combined with Aprepitant.
Saquinavir Saquinavir The metabolism of Aprepitant can be decreased when combined with Saquinavir.
Nisoldipine Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Aprepitant.
Glimepiride Glimepiride The metabolism of Glimepiride can be decreased when combined with Aprepitant.
Indinavir Indinavir The metabolism of Indinavir can be decreased when combined with Aprepitant.
Ritonavir Ritonavir The serum concentration of Aprepitant can be increased when it is combined with Ritonavir.
Docetaxel Injection Docetaxel Injection The metabolism of Docetaxel can be decreased when combined with Aprepitant.
Clomipramine Clomipramine The metabolism of Clomipramine can be decreased when combined with Aprepitant.
Zafirlukast Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Aprepitant.
Zileuton Zileuton The metabolism of Zileuton can be decreased when combined with Aprepitant.
Valsartan Valsartan The metabolism of Valsartan can be decreased when combined with Aprepitant.
Donepezil Donepezil The metabolism of Donepezil can be decreased when combined with Aprepitant.
Nelfinavir Nelfinavir The metabolism of Aprepitant can be decreased when combined with Nelfinavir.
Azithromycin Azithromycin The metabolism of Azithromycin can be decreased when combined with Aprepitant.
Carvedilol Carvedilol The metabolism of Carvedilol can be decreased when combined with Aprepitant.
Flutamide Flutamide The metabolism of Flutamide can be decreased when combined with Aprepitant.
Selegiline Selegiline The metabolism of Selegiline can be decreased when combined with Aprepitant.
Bicalutamide Bicalutamide The metabolism of Bicalutamide can be decreased when combined with Aprepitant.
Sertraline Sertraline The metabolism of Sertraline can be decreased when combined with Aprepitant.
Irbesartan Irbesartan The metabolism of Irbesartan can be decreased when combined with Aprepitant.
Finasteride Finasteride The metabolism of Finasteride can be decreased when combined with Aprepitant.
Quetiapine Quetiapine The metabolism of Quetiapine can be decreased when combined with Aprepitant.
Paroxetine Paroxetine The metabolism of Paroxetine can be decreased when combined with Aprepitant.
Citalopram Citalopram Aprepitant may increase the QTc-prolonging activities of Citalopram.
Capecitabine Capecitabine The metabolism of Capecitabine can be increased when combined with Aprepitant.
Efavirenz Efavirenz The metabolism of Aprepitant can be increased when combined with Efavirenz.
Sildenafil Sildenafil The metabolism of Sildenafil can be decreased when combined with Aprepitant.
Celecoxib Celecoxib The metabolism of Celecoxib can be decreased when combined with Aprepitant.
Rosiglitazone Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Aprepitant.
Tolterodine Tolterodine The metabolism of Tolterodine can be decreased when combined with Aprepitant.
Thalidomide Thalidomide The metabolism of Aprepitant can be increased when combined with Thalidomide.
Nateglinide Nateglinide The metabolism of Nateglinide can be decreased when combined with Aprepitant.
Rabeprazole Rabeprazole The metabolism of Rabeprazole can be decreased when combined with Aprepitant.
Terbinafine Terbinafine The metabolism of Terbinafine can be decreased when combined with Aprepitant.

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