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Neomycin, Polymyxin, and Bacitracin Ophthalmic

Neomycin, polymyxin B, and bacitracin is a triple-antibiotic combination used to help prevent infection in minor cuts, scrapes, and burns, available in topical and ophthalmic forms.

Brand names triple antibioticMedi-firstNeosporin OriginalAntibioticGood Sense First Aid Antibiotic +11 more
Drug classes Aminoglycoside Antibacterial
Rx/OTC Forms 3
Dr. Brian Staiger, PharmD, BCPS
Reviewed by Last reviewed Jul 10, 2026 Content updated Oct 2, 2026
🧬 Where this information comes from Click to expand

The clinical label records used on this page are FDA-filed Structured Product Labeling (SPL) retrieved through openFDA. We identified 172 clinical label sets within the page’s selected clinical scope after exact ingredient or ingredient-combination matching and applicable route/form matching. Forms, routes, brands, labelers, strengths, and NDC product-record counts are built separately from matching FDA National Drug Code Directory records. The linked DailyMed document is a representative official source for verification, not the page’s only clinical source. View the linked label on DailyMed →

✓No current FDA shortage listed · checked Oct 6, 2026
Other forms & routes:
Topical
Neomycin, Polymyxin, and Bacitracin Ophthalmic at a glance The quick version — the full detail is in the Patient Information Guide below.
Dr. Brian Staiger, PharmD, BCPS
The Pharmacist’s Take By · Clinical pharmacist · Written

This is the familiar first-aid triple antibiotic (neomycin, polymyxin B and bacitracin) made as a prescription ointment for the eye, an older standby on the market since about 1995 and available generically; its three ingredients attack bacteria by scrambling their protein making, breaking their outer membrane and blocking cell wall building. Most people tolerate it well, and what they notice is mild redness, itching or irritation of the eye. Watch for allergy, most often to neomycin, which looks like swelling, itching or redness that gets worse after starting, and get emergency care for facial swelling or trouble breathing, since anaphylaxis (a severe whole-body reaction) has rarely been reported.

Clinical pearls

  • Never put Neosporin skin ointment or cream in an eye; only the product labeled ophthalmic is made for eye use.
  • If skin Neosporin ever caused an itchy rash, tell your prescriber, because the same three antibiotics are in this eye ointment.
  • Store the tube away from children and never swallow it; if a child does, call Poison Control right away.
How we write & review this content — our editorial policy →
How you get itPrescription and over the counter
Comes asTopical cream, ointment or gel, Eye ointment, Topical solution
Earliest FDA record1995
Companies listing it with the FDA97
FDA label last updatedFeb 2, 2022
FDA’s strongest warning (boxed)None on the label

Patient information guide A plain-language walkthrough of Neomycin, Polymyxin, and Bacitracin Ophthalmic, written from its FDA label.

What Neomycin, Polymyxin, and Bacitracin Ophthalmic is used for

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This triple-antibiotic combination is used across several product types for first aid and skin antisepsis. Supported uses include:

  • First aid to help prevent infection in minor cuts, scrapes, and burns (topical skin products and ophthalmic ointment)
  • Temporary relief of pain and itching from minor burns, cuts, scrapes, and insect bites (select topical products — check your label)
  • First Aid Antibiotic topical solution: preparation and antiseptic cleansing of the skin before an injection
  • First Aid Antibiotic topical solution: antiseptic cleansing of the face, hands, and body
  • Neomycin and Polymyxin B Sulfates and Bacitracin Zinc ophthalmic ointment: applied in the eye as directed by a prescriber

How Neomycin, Polymyxin, and Bacitracin Ophthalmic works

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Each of the three antibiotics targets bacteria in a different way, which is why they're combined. Neomycin is an aminoglycoside — it binds to the part of a bacterial cell that reads genetic instructions (ribosomal RNA), causing the bacterium to make faulty proteins and die. Polymyxin B punches holes in the outer membrane of gram-negative bacteria (the ones with a tougher outer layer), causing the cell to leak. Bacitracin blocks gram-positive and some gram-negative bacteria from rebuilding their cell walls, so they can't survive.

Together, these three cover a broad spectrum of bacteria, including Staphylococcus aureus, streptococci, E. coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa. Note: this combination does not provide adequate coverage against Serratia marcescens.

Neomycin, Polymyxin, and Bacitracin Ophthalmic dosage

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How you use this product depends entirely on the form you have — do not swap forms or brands.

  • Topical skin products (creams, ointments, gels): Clean the area, apply a small fingertip-sized amount up to 3 times daily, and cover with a sterile bandage if needed. Children under 2: ask a doctor first.
  • First Aid Antibiotic topical solution (injection prep): Wipe the site firmly with a towelette and discard immediately after single use.
  • Ophthalmic ointment: Applied to the eye — follow your prescriber's exact instructions for this form.

Do not use any topical skin product for more than 1 week without a doctor's direction. Always follow the directions on your specific product label.

Dosing details from the FDA-approved label

From the Neomycin, Polymyxin, and Bacitracin Ophthalmic prescribing information (“Dosage and Administration”). Doses are set by your prescriber for your product, condition, kidney function and age — never change a dose on your own.

  • Adults and children 2 years of age and older
    • Clean the affected area
    • Apply a small amount of this product (an amount equal to the surface area of the tip of a finger) on the area 1 to 3 times daily
    • May be covered with a sterile bandage
    • Maximum: not more than 3 times daily
  • Children under 2 years of age
    • Consult a doctor
Read the label’s full dosing text

Directions • Clean the affected area. • Apply a small amount of this product (an amount equal to the surface area of the tip of a finger) on the area 1 to 3 times daily. • May be covered with a sterile bandage.

Directions Clean the affected area Adults and children 2 years of age and older: Apply a small amount of this product to affected area not more than 3 times daily Children under 2 years of age: consult a doctor May be covered with a sterile bandage

Directions: Wipe injection site vigorously and discard.

Directions: Tear open packet, unfold towelette and use to cleanse desired skin area. Discard towelette appropriately after single use.

Read the full Dosage and Administration section on DailyMed →

Neomycin, Polymyxin, and Bacitracin Ophthalmic side effects

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Most people tolerate these products well, but some reactions can occur:

Common side effects

  • Itching or skin irritation at the application site
  • Swelling at the site of use
  • Allergic skin rash
  • Redness or irritation (including in the eye for ophthalmic ointment)
  • Conjunctival erythema (eye redness) with the ophthalmic form
  • Redness or local irritation

When to get medical help

  • Get medical help right away if you swallow any of this product
  • Call your doctor if the wound or skin condition gets worse or does not improve within 7 days
  • Stop use and call your doctor if a rash or signs of an allergic reaction develop
  • Seek emergency care if you have signs of a severe allergic reaction (such as swelling, difficulty breathing, or anaphylaxis) — this has been rarely reported with the ophthalmic form
  • Call your doctor before using if you have deep or puncture wounds, animal bites, or serious burns

More serious reactions, including anaphylaxis (a severe, life-threatening allergic response), have been rarely reported with the ophthalmic form. Stop use and seek medical attention right away if you develop significant swelling, difficulty breathing, or signs of a severe allergic reaction.

Neomycin, Polymyxin, and Bacitracin Ophthalmic warnings and precautions

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  • External use only: Never swallow these products. If swallowed, call Poison Control or get emergency help immediately.
  • Do not use in the eyes unless you have the ophthalmic ointment specifically formulated for eye use.
  • Do not apply over large areas of the body.
  • Do not use for more than 1 week without a doctor's guidance.
  • Ask a doctor before use if you have deep or puncture wounds, animal bites, or serious burns — these need professional care.
  • Stop use and call your doctor if the wound gets worse, doesn't improve within 7 days, or a rash or allergic reaction develops.
  • Topical solution products (First Aid Antibiotic) are flammable — keep away from fire and flame; do not use with electrocautery.
  • Do not use on broken, blistered, or raw skin areas (specific to some topical products — check your label).

Neomycin, Polymyxin, and Bacitracin Ophthalmic interactions

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The FDA label for these products does not list specific drug-drug interactions.

    Not a complete list. The label covers the interactions the manufacturer studied or reported, and our own interaction database does not cover every medicine either. Bring your full medication list, including vitamins and herbal products, to your pharmacist.

    Check Neomycin, Polymyxin, and Bacitracin Ophthalmic against a supplement or herb →

    Before taking Neomycin, Polymyxin, and Bacitracin Ophthalmic

    ▾
    • Do not use if you are allergic to neomycin, polymyxin B, bacitracin, or any other ingredient in your specific product
    • Ask a doctor before using on deep or puncture wounds, animal bites, or serious burns
    • Children under 2 years of age: consult a doctor before using topical products
    • Keep all forms out of reach of children
    • The ophthalmic ointment is contraindicated (must not be used) in anyone with a known hypersensitivity to any of its components

    Neomycin, Polymyxin, and Bacitracin Ophthalmic overdose

    ▾

    If any of these products is accidentally swallowed, contact a Poison Control Center or seek emergency medical help right away. Keep all forms stored safely out of children's reach.

    How to store Neomycin, Polymyxin, and Bacitracin Ophthalmic

    ▾

    Store at 20° to 25°C (68° to 77°F) .

    Written from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

    Neomycin, Polymyxin, and Bacitracin Ophthalmic: pharmacist answers to common questions

    Quick, plain-English answers to the questions patients ask most about Neomycin, Polymyxin, and Bacitracin Ophthalmic — the kind of thing our pharmacy team would talk through with you at the counter.

    What's the difference between the skin ointment and the eye ointment — can I use them interchangeably?

    ▾
    No, and this is really important. The ophthalmic ointment (Neomycin and Polymyxin B Sulfates and Bacitracin Zinc) is specially formulated and sterile for use in the eye. The topical skin products — like Antibiotic, Good Sense First Aid Antibiotic, and the others — are meant for skin only, not the eye. Using the wrong form in the wrong place could cause irritation or harm. Always check your label and use only the product meant for your situation.

    How much do I put on, and how often?

    ▾
    For the topical skin products, apply a small amount — about the size of the tip of your finger — to the cleaned area up to 3 times a day. You can cover it with a sterile bandage if you'd like. Don't apply more, and don't use it for more than a week without checking with your doctor. For the eye ointment or injection-prep solution, follow the directions on your specific product exactly.

    How will I know if I'm having an allergic reaction?

    ▾
    Watch for new itching, redness, swelling, or a rash that appears after you start using it — those are signs of an allergic reaction. Stop using the product and contact your doctor if that happens. In rare cases, especially with the eye ointment, a more serious allergic reaction called anaphylaxis can occur — symptoms include significant swelling, hives, or trouble breathing. That's an emergency, so get help right away if you notice those signs.

    Can I use this on any wound, including deep cuts or animal bites?

    ▾
    These products are designed for minor cuts, scrapes, and burns — not deep or puncture wounds, animal bites, or serious burns. If you have any of those, you really should check with a doctor first. Those injuries may need more than a topical antibiotic, and using this without professional guidance could give you a false sense of security.

    How long should I use it before expecting results — and when should I stop?

    ▾
    If things are going well, you should see the area improving within a week. If your wound or skin condition isn't getting better — or if it's actually getting worse — stop using it and call your doctor. Don't use it for more than 7 days on your own; if you still need treatment after that, a doctor should take a look.

    Is it safe to use the topical solution near a stove or candle?

    ▾
    No — some First Aid Antibiotic topical solution products are flammable. Keep them away from fire, open flames, and heat sources. The label specifically warns not to use them with electrocautery (a medical tool that uses electrical current and heat). Make sure the area is dry before any heat exposure.

    Is Neomycin, Polymyxin, and Bacitracin Ophthalmic available over the counter?

    ▾
    Both. Some Neomycin, Polymyxin, and Bacitracin Ophthalmic products are sold over the counter and others need a prescription. According to their FDA listings, the topical cream, ointment or gel and topical solution forms are sold over the counter and the eye ointment form needs a prescription. The package says which kind you have. Your pharmacist can tell you which product is right for you.

    When was Neomycin, Polymyxin, and Bacitracin Ophthalmic first available?

    ▾
    The earliest FDA record we hold for Neomycin, Polymyxin, and Bacitracin Ophthalmic is from 1995: its first approval in Drugs@FDA or its earliest product listing in the NDC Directory, whichever is older. Many older medicines were in use before their first formal FDA approval, so this is the earliest date on record, not necessarily when Neomycin, Polymyxin, and Bacitracin Ophthalmic was first used.

    Who makes Neomycin, Polymyxin, and Bacitracin Ophthalmic?

    ▾
    97 companies currently list Neomycin, Polymyxin, and Bacitracin Ophthalmic products in the FDA's NDC Directory, including Nantong Health & Beyond Hygienic Products Inc., Unifirst First Aid Corporation, Trifecta Pharmaceuticals Usa Llc. That count includes repackagers and distributors as well as manufacturers (companies that sell only the raw ingredient are not counted), so fewer companies actually make it; the label on your bottle names the one that supplied yours.

    Answers drafted from the FDA-approved label with AI and reviewed by our pharmacy team. How we use AI →

    More about Neomycin, Polymyxin, and Bacitracin Ophthalmic on HelloPharmacist

    🌿Drug & Supplement CheckerNeomycin, Polymyxin, and Bacitracin Ophthalmic vs. vitamins & herbs 💬Ask a PharmacistFree answer, usually < 24h 🔎NDC & pricing lookupFind Neomycin, Polymyxin, and Bacitracin Ophthalmic NDCs & costs 🅰️Browse Drugs A–ZLook up any medication
    Detailed data & references for Neomycin, Polymyxin, and Bacitracin Ophthalmic Forms & strengths, pricing, billing codes, manufacturers, safety reports and sourcing — the data behind the page. Most people can stop here. Each section below opens on a tap.

    Neomycin, Polymyxin, and Bacitracin Ophthalmic forms and strengths (how it comes)

    Neomycin, Polymyxin, and Bacitracin Ophthalmic is available in 3 forms. Different forms and brands can have different approved uses, doses, schedules, and directions. Follow the instructions for your exact product, and do not switch forms without guidance from your prescriber or pharmacist.

    Need a version that does not list lactose, a gluten source, a dye or gelatin? Inactive ingredients differ by manufacturer: see Neomycin, Polymyxin, and Bacitracin Ophthalmic inactive ingredients by manufacturer.

    Topical cream, ointment or gel

    On the skin
    Brands American Safety and First Aid Triple Antibiotic Antibiotic CareALL Triple Antibiotic Crane Safety Triple Antibiotic Ecolab Triple Antibiotic First Aid Antibiotic Good Sense First Aid Antibiotic Medi-first Medi-First Plus Triple Antibiotic Medi-First Triple Antibiotic Neosporin Original Thompson Triple Antibiotic Triple Antibiotic
    How this form is used
    What it may be used for
    • First aid to help prevent infection in minor cuts, scrapes, and burns
    • Temporary relief of pain and itching associated with minor burns, minor cuts, and scrapes (check your specific product label, as not all brands list this use)
    Important instructions
    • Clean the affected area before applying
    • Apply a small amount (about the size of a fingertip) to the affected area up to 3 times daily
    • May be covered with a sterile bandage
    • Do not use in the eyes, over large areas of the body, or for more than 1 week unless directed by a doctor
    Available strengths 32 strengths
    NEOMYCIN SULFATE 3.5 mg/g; BACITRACIN ZINC 400 [USP'U]/g; POLYMYXIN B SULFATE 5000 [USP'U]/g NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 5000 [USP'U]/g; BACITRACIN ZINC 400 [USP'U]/g 400 [USP'U]/g / 0.0035 g/g / 5000 [USP'U]/g 400 U/g / 3.5 mg/g / 5000 U/g 400 [CFU]/g / 3.5 mg/g / 5000 [CFU]/g 400 [IU]/g / 3.5 mg/g / 5000 [IU]/g
    Show 26 more strengths Show fewer strengths
    400 [USP'U]/g / 3.5 mg/g / 5000 [USP'U]/g 400 [IU]/g / 5 mg/g / 5000 [IU]/g 400 [USP'U]/g / 5 mg/g / 5000 [USP'U]/g 400 [IU]/g / 35 mg/g / 5000 [IU]/g BACITRACIN 400 [USP'U]/1; NEOMYCIN 3.5 mg/1; POLYMYXIN B 5000 [USP'U] BACITRACIN 400 [USP'U]/1; POLYMYXIN B 5000 [USP'U]/1; NEOMYCIN 3.5 mg BACITRACIN ZINC 400 U/9.4 g; NEOMYCIN SULFATE 3.5 mg/9.4 g; POLYMYXIN B SULFATE 5000 U/9.4 g 400 U/g / 5 mg/g / 5000 U/g BACITRACIN ZINC 400 [CFU]/g; NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 5000 [CFU]/g BACITRACIN ZINC 400 [IU]/g; NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 5000 [IU]/g BACITRACIN ZINC 400 [IU]/g; NEOMYCIN SULFATE 5 mg/g; POLYMYXIN B SULFATE 5000 [IU]/g BACITRACIN ZINC 400 [IU]/g; NEOMYCIN SULFATE 35 mg/g; POLYMYXIN B SULFATE 5000 [IU]/g BACITRACIN ZINC 400 [USP'U]/g; NEOMYCIN SULFATE 0.0035 g/g; POLYMYXIN B SULFATE 5000 [USP'U]/g BACITRACIN ZINC 400 [USP'U]/g; NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 5000 [USP'U]/g BACITRACIN ZINC 400 [USP'U]/g; NEOMYCIN SULFATE 5 mg/g; POLYMYXIN B SULFATE 5000 [USP'U]/g BACITRACIN ZINC 400 [USP'U]/g; POLYMYXIN B SULFATE 5000 [USP'U]/g; NEOMYCIN SULFATE 3.5 mg/g 500 U/g / 3.5 mg/g / 10000 U/g 500 [IU]/g / 3.5 mg/g / 10000 [IU]/g BACITRACIN ZINC 500 [IU]/g; NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 10000 [IU]/g BACITRACIN ZINC 500 [USP'U]/g; NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 10000 [USP'U]/g; PRAMOXINE HYDROCHLORIDE 10 mg/g POLYMYXIN B 5000 [USP'U]/1; BACITRACIN 400 [USP'U]/1; NEOMYCIN 3.5 mg POLYMYXIN B SULFATE 5000 [IU]/g; BACITRACIN ZINC 400 [IU]/g; NEOMYCIN SULFATE 3.5 mg/g POLYMYXIN B SULFATE 5000 [IU]/g; NEOMYCIN SULFATE 5 mg/g; BACITRACIN ZINC 400 [IU]/g POLYMYXIN B SULFATE 5000 [USP'U]/g; BACITRACIN ZINC 400 [USP'U]/g; NEOMYCIN SULFATE 3.5 mg/g POLYMYXIN B SULFATE 5000 [USP'U]/g; NEOMYCIN SULFATE 3.5 mg/g; BACITRACIN ZINC 400 [USP'U]/g POLYMYXIN B SULFATE 50000 [IU]/g; NEOMYCIN SULFATE 5 mg/g; BACITRACIN ZINC 400 [IU]/g
    289 FDA-listed product records ⓘ

    Eye ointment

    In the eye
    Brands Neomycin and Polymyxin B Sulfates, and Bacitracin Zinc Neomycin and Polymyxin B Sulfates and Bacitracin Zinc
    How this form is used
    What it may be used for
    • Neomycin and Polymyxin B Sulfates and Bacitracin Zinc ophthalmic ointment is used in the eye as directed by a prescriber
    • Neomycin and Polymyxin B Sulfates and Bacitracin Zinc ophthalmic ointment is contraindicated in anyone with a known allergy to any of its ingredients
    Important instructions
    • Neomycin and Polymyxin B Sulfates and Bacitracin Zinc ophthalmic ointment is applied to the eye — follow your prescriber's specific directions
    • Do not use this ophthalmic ointment on the skin; it is formulated specifically for the eye
    • Stop use and contact your doctor if redness, irritation, swelling, or signs of allergic reaction develop
    Available strengths 2 strengths
    NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 10000 [USP'U]/g; BACITRACIN ZINC 400 [USP'U]/g 400 [USP'U]/g / 3.5 mg/g / 10000 [USP'U]/g
    3 FDA-listed product records ⓘ

    Topical solution

    On the skin
    Brands First Aid Antibiotic
    How this form is used
    What it may be used for
    • First Aid Antibiotic topical solution is used to prepare and cleanse the skin before an injection
    • First Aid Antibiotic topical solution provides antiseptic cleansing of the face, hands, and body
    • First Aid Antibiotic topical solution is used for temporary relief of pain and itching from minor burns, scrapes, and insect bites
    Important instructions
    • First Aid Antibiotic injection-prep towelettes: tear open the packet, unfold, and wipe the injection site vigorously; discard after single use
    • First Aid Antibiotic topical solution is flammable — keep away from fire or flame
    • Do not use First Aid Antibiotic topical solution in the eyes; if contact occurs, rinse thoroughly with water
    • Stop use and consult a doctor if irritation or redness develop, or if condition persists for more than 72 hours
    Available strengths 1 strength
    400 U/g / 3.5 mg/g / 5000 U/g
    2 FDA-listed product records ⓘ

    Neomycin, Polymyxin, and Bacitracin Ophthalmic on the U.S. market: products, makers and brands

    How Neomycin, Polymyxin, and Bacitracin Ophthalmic appears in the FDA’s National Drug Code Directory — including its dosage forms, strengths, brand names, manufacturers, and FDA-listed product records. These are directory records, not sales or prescription volume.

    97 companies list 156 Neomycin, Polymyxin, and Bacitracin Ophthalmic product records with the FDA, mostly as topical cream, ointment or gel, eye ointment, topical solution; the earliest marketing or approval year on record is 1995. Brand names on the directory include triple antibiotic, Medi-first, Neosporin Original and 13 more; the rest are generics.

    3
    Dose forms ⓘ
    97
    Labelers (makers, repackagers, distributors)
    40
    Brand names
    156
    FDA-listed product records ⓘ
    1995
    Earliest FDA record ⓘ

    FDA-listed product records by dose form (tablet variants merged) — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

    Also listed with the FDA, not a patient dose form: Kit (3) — bulk drug substance sold to compounders/manufacturers and multi-item kits. These aren’t counted in the dose-form total above.

    Nantong Health & Beyond Hygienic Products Inc.8%
    Unifirst First Aid Corporation6%
    Trifecta Pharmaceuticals Usa Llc4%
    Orazen Inc3%
    ProStat First Aid, LLC.3%
    A-S Medication Solutions2%
    Other makers75%

    Share of FDA-listed product records by manufacturer — FDA National Drug Code Directory. Record counts are not sales or prescription volume.

    How widely Neomycin, Polymyxin, and Bacitracin Ophthalmic is used (Medicaid data)

    A general measure of how commonly Neomycin, Polymyxin, and Bacitracin Ophthalmic is prescribed, based on Medicaid — one of the largest public drug programs. The figure below is prescriptions filled in Q1 2025 – Q1 2026, summed across every form and brand of the drug.

    Think of this as a proxy for how widely Neomycin, Polymyxin, and Bacitracin Ophthalmic is used, drawn from freely available public data. Medicaid is just one program — these numbers don’t include Medicare, other government coverage, or commercial and cash-pay prescriptions, so real-world use is higher than what’s shown here.

    46,914
    Medicaid prescriptions filled (Q1 2025 – Q1 2026)
    $538,176 gross Medicaid reimbursement (before mandatory rebates — net cost is lower)

    How commonly is Neomycin, Polymyxin, and Bacitracin Ophthalmic prescribed? Of the 1,601 medications we measure, Neomycin, Polymyxin, and Bacitracin Ophthalmic ranks #645 by Medicaid prescriptions — more than 60% of them.

    Where Neomycin, Polymyxin, and Bacitracin Ophthalmic ranks among the drugs we measure · Q1 2025 – Q1 2026 · neighbors ±5
    Total prescriptions — #645 of 1,601
    #640 Darbepoetin Alfa Injec... 47,924 Rx #641 Sofosbuvir and Velpata... 47,731 Rx #642 Asenapine 47,447 Rx #643 Omeprazole / Sodium Bi... 47,423 Rx #644 Aprepitant 47,287 Rx #645 Neomycin, Polymyxin, a... 46,914 Rx #646 Capsaicin Topical 46,781 Rx #647 Bimatoprost 46,752 Rx #648 Conjugated Estrogens /... 46,742 Rx #649 Trastuzumab Injection 46,422 Rx #650 Bimatoprost Ophthalmic 46,251 Rx

    Source: Medicaid State Drug Utilization Data (CMS), aggregated by generic ingredient — summed across every NDC (all brands, strengths, salt forms and dosage forms) of Neomycin, Polymyxin, and Bacitracin Ophthalmic, and across all states and both fee-for-service and managed-care claims. A general popularity signal; it excludes Medicare, commercial insurance and cash prescriptions, so it is not total U.S. use. Based on the 12 of 362 listed Neomycin, Polymyxin, and Bacitracin Ophthalmic NDCs with Medicaid activity.

    Compare Neomycin, Polymyxin, and Bacitracin Ophthalmic products

    A representative set of FDA-listed product records for Neomycin, Polymyxin, and Bacitracin Ophthalmic — across manufacturers, strengths, and dosage forms, grouped by form with each product’s manufacturer and how the FDA approved it. The same medicine may be made and packaged by different companies, so a single drug can have many directory entries. (It’s also why a refill can look different — a new shape, color, or box — even though it contains the same medication.)

    Showing 156 of 156 products — FDA National Drug Code Directory. See every product, package size and price: browse all 156 Neomycin, Polymyxin, and Bacitracin Ophthalmic NDCs →

    Neomycin, Polymyxin, and Bacitracin Ophthalmic recall history

    A recall is when a specific batch of a medicine is pulled from the market — usually a manufacturing issue, not a problem with the drug itself. Class I is most serious, Class III least.

    The FDA’s enforcement reports list no Neomycin, Polymyxin, and Bacitracin recalls since July 2021.

    ✅No Neomycin, Polymyxin, and Bacitracin recalls on record since July 2021

    Source: FDA enforcement (recall) reports, via openFDA; our copy was last updated Sep 24, 2026.

    💵 What Neomycin, Polymyxin, and Bacitracin Ophthalmic costs pharmacies (NADAC benchmark)

    The national average invoice price pharmacies pay for the drug itself, from CMS's NADAC survey (data as of Sep 30, 2026). This is a supply-cost benchmark — not a retail price and not what you'd pay at the counter.

    FormStrengthPharmacy acquisition benchmark
    Ointment · Topical 400; 3.5; 5000 [USP'U]/g; mg/g; [USP'U]/g $0.089–$0.137 per gram NDC details & price history
    Ointment · Topical BACITRACIN ZINC 400 [USP'U]/g; NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 5000 [USP'U]/g $0.089–$0.137 per gram NDC details & price history
    Ointment · Ophthalmic 400; 3.5; 10000 [USP'U]/g; mg/g; [USP'U]/g $4.70 per gram NDC details & price history
    Ointment · Ophthalmic NEOMYCIN SULFATE 3.5 mg/g; POLYMYXIN B SULFATE 10000 [USP'U]/g; BACITRACIN ZINC 400 [USP'U]/g $4.70 per gram NDC details & price history
    Why show this? Your out-of-pocket cost depends on insurance, pharmacy markup, and discounts — but the acquisition benchmark tells you whether the medication itself is inexpensive or costly, which strengths cost more per dose, and whether a cash-price quote is in a reasonable range. Each row links to the NDC-level record with its full price history.

    Source: CMS National Average Drug Acquisition Cost (NADAC), a survey of retail pharmacy invoice prices. Benchmarks shown are the range across package sizes of a representative product for each form and strength — other manufacturers' products may differ.

    Neomycin, Polymyxin, and Bacitracin Ophthalmic brand names

    Neomycin, Polymyxin, and Bacitracin Ophthalmic is sold under 16 brand names in the FDA directory — triple antibiotic, Medi-first, Neosporin Original, Antibiotic and others. A brand and its generic contain the same active ingredient; the brand name belongs to one company's product.

    triple antibiotic Medi-first Neosporin Original Antibiotic Good Sense First Aid Antibiotic First Aid Antibiotic American Safety and First Aid Triple Antibiotic Thompson Triple Antibiotic Medi-First Triple Antibiotic Medi-First Plus Triple Antibiotic CareALL Triple Antibiotic Vitacilina First Aid Antibiotic Drs. pharmacy triple antibiotic Crane Safety Triple Antibiotic Ever Ready First Aid Triple Antibiotic Ecolab Triple Antibiotic

    Who makes Neomycin, Polymyxin, and Bacitracin Ophthalmic: manufacturers and labelers

    97 companies list Neomycin, Polymyxin, and Bacitracin Ophthalmic products with the FDA. By number of product records, the largest are Nantong Health & Beyond Hygienic Products Inc., Unifirst First Aid Corporation, Trifecta Pharmaceuticals Usa Llc. Labelers include manufacturers and repackagers; the product in your bottle depends on which one your pharmacy stocks.

    Nantong Health & Beyond Hygienic Products Inc. 12 Unifirst First Aid Corporation 9 Trifecta Pharmaceuticals Usa Llc 6 Orazen Inc 5 ProStat First Aid, LLC. 4 A-S Medication Solutions 3 Acme United Corporation 3 GFA Production (Xiamen) Co., Ltd. 3 HART Health 3 Kenvue Brands LLC 3 Safetec of America, Inc. 3 Veridian Healthcare 3 CVS Pharmacy 2 Chain Drug Marketing Association Inc. 2 Ever Ready First Aid 2 Fourstar Group Usa, Inc. 2 Front Pharmaceutical Plc 2 Henry Schein 2 J&A Digital Inc. 2 New World Imports, Inc 2 Ol Pharma Tech, Llc 2 Premier Value Alliance LLC. 2 Thompson 2 Topco Associates LLC 2

    …and 73 more on the FDA NDC directory.

    Neomycin, Polymyxin, and Bacitracin Ophthalmic drug class (RxNorm)

    Neomycin, Polymyxin, and Bacitracin Ophthalmic belongs to the Other antibiotics for topical use class.

    Drug family (ATC) Other antibiotics for topical use, Other antibacterials, Antibiotics

    Classified by RxNorm RxClass — the U.S. National Library of Medicine's standardized drug-classification service (Established Pharmacologic Class from the FDA, the ATC drug family from the WHO, and mechanism of action). Reference only, not medical advice.

    Sources for this Neomycin, Polymyxin, and Bacitracin Ophthalmic page

    Core label, product, RxNorm, safety, and utilization data on this page come from the sources identified below. AI-written, editorial, and licensed sections are labeled separately.

    📄
    FDA-filed drug labels (SPL) Uses, dosing, warnings & side effects from SPL records retrieved through openFDA; the linked representative set can be verified on DailyMed. ✓ Linked label effective Feb 2, 2022
    🏭
    Forms, brands & labelersAggregated from ingredient-matched FDA National Drug Code Directory product records for Neomycin, Polymyxin, and Bacitracin Ophthalmic.
    📈
    Real-world reportsThe FDA Adverse Event Reporting System (FAERS), served through openFDA.
    🚨
    Recalls & shortagesopenFDA drug-enforcement reports and the FDA drug-shortage database.
    🧾 Clinical label set — FDA-filed SPL labels retained for Neomycin, Polymyxin, and Bacitracin Ophthalmic after exact ingredient or ingredient-combination matching and applicable route/form matching
    Clinical labels in scope
    172
    Finished products in the current FDA directory
    156
    Companies listing them (makers, repackagers, distributors)
    97
    FDA labeler codes behind them ⓘ
    91
    Linked representative label ⓘ
    Mwi
    Linked label effective
    Feb 2, 2022
    Composite sections available
    14
    Linked SPL Set ID
    0f651b47-ef7e-4d07-b3b1-8baade8b9031
    Linked SPL Document ID
    95de95d4-4393-4a34-a9c7-63169e112f85
    Open the linked representative label on DailyMed ↗

    How this page is built

    HelloPharmacist combines public FDA and NLM records and does not author the underlying clinical facts. The plain-language sections are written with AI from the FDA-approved label text and reviewed by our pharmacy team before publication. Mwi is the representative DailyMed label linked for verification and dates. This is general education, not medical advice: always talk to your doctor or pharmacist about your own medicines. How we build and review drug pages →