Medication interaction hub

What Supplements Interact with Acetohexamide?

Acetohexamide brand name: Dymelor. Every interaction below applies to the brands too.

296 Interactions 4 Major 254 Moderate 38 Minor
Curated & coded by · Clinical Pharmacist · Updated September 25, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Acetohexamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Acetohexamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Acetohexamide (Dymelor) is an older sulfonylurea, a pill with one job, pulling blood sugar down, so anything else that lowers glucose stacks on top of it. That is what most of this list does. Of the 296 ingredients on file, 239 can add to the glucose drop, and the risk each time is hypoglycemia, the shaky, confused, sometimes dangerous kind of low. Read this page with genuine care.

Four entries are rated major. Alcohol (listed as beer and wine) and the herb Siberian cocklebur have each been tied to liver injury, a risk that compounds alongside this drug, while activated charcoal soaks up the medication in the gut so less reaches your blood. The remaining 254 moderate and 38 minor entries mostly repeat the low-blood-sugar theme, with a small cluster adding sun sensitivity, so check your glucose more often when starting any new supplement.

— , Clinical Pharmacist · July 18, 2026

Major 4 Moderate 254 Minor 38 No known interaction 1,156

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Acetohexamide: Top Interactions at a Glance

The Acetohexamide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 296 interacting ingredients — plus 1,156 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Acetohexamide Combinations Today

The Acetohexamide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Apple + Acetohexamidei

Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Probable Magnesium + Acetohexamidei

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.

Read the full interaction Moderate Likelihood Possible Aloe + Acetohexamidei

Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Minor Likelihood Unlikely Black Tea + Acetohexamidei

Theoretically, taking black tea with antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Minor Likelihood Unlikely Coffee + Acetohexamidei

Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.

Read the full interaction Moderate Likelihood Possible Soy + Acetohexamidei

Soy can lower blood glucose and have additive effects with antidiabetes drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Acetohexamide

All 1,452 ingredients in our database, ranked by severity — 296 with a Acetohexamide interaction on file and 1,156 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Acetohexamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Apple with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, consuming apple juice with antidiabetes drugs might interfere with blood glucose control.

Full Apple + Acetohexamide answer

Can you take Magnesium with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.

Full Magnesium + Acetohexamide answer

Can you take Aloe with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Aloe + Acetohexamide answer

Can you take Black Tea with Acetohexamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, taking black tea with antidiabetes drugs might interfere with blood glucose control.

Full Black Tea + Acetohexamide answer

Can you take Coffee with Acetohexamide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, concomitant use of coffee and antidiabetes drugs might interfere with blood glucose control.

Full Coffee + Acetohexamide answer

Can you take Soy with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Soy can lower blood glucose and have additive effects with antidiabetes drugs.

Full Soy + Acetohexamide answer

Can you take Spearmint with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of spearmint might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Spearmint + Acetohexamide answer

Can you take Spinach with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There are claims that spinach leaves have hypoglycemic effects.

Full Spinach + Acetohexamide answer

Can you take St. John's Wort with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, St.

Full St. John's Wort + Acetohexamide answer

Can you take Stereospermum with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Animal research suggests that stereospermum can have hypoglycemic effects.

Full Stereospermum + Acetohexamide answer

Can you take Stinging Nettle with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, stinging nettle might have additive effects with antidiabetes drugs.

Full Stinging Nettle + Acetohexamide answer

Can you take Sunflower Oil with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.

Full Sunflower Oil + Acetohexamide answer

Can you take Sweet Annie with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Acetohexamide answer

Can you take Sweet Clover with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Acetohexamide answer

Can you take Syrian Rue with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, high doses of Syrian rue might increase the risk of liver damage when taken with hepatotoxic drugs.

Full Syrian Rue + Acetohexamide answer

Can you take Tamarind with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tamarind seed extract might have additive effects when used with antidiabetes drugs.

Full Tamarind + Acetohexamide answer

Can you take Terminalia with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica or Terminalia chebula with antidiabetes drugs could affect blood sugar control and in...

Full Terminalia + Acetohexamide answer

Can you take Terminalia Bellirica with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia bellirica with antidiabetes drugs could affect blood sugar control and increase the risk of hyp...

Full Terminalia Bellirica + Acetohexamide answer

Can you take Terminalia Chebula with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypog...

Full Terminalia Chebula + Acetohexamide answer

Can you take Testolone with Acetohexamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Acetohexamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Acetohexamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Acetohexamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Acetohexamide sits in 5 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Acetohexamide through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Acetohexamide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Acetohexamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Acetohexamide through this category.

Sulfonylureas 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Acetohexamide through this category.

Related: does Acetohexamide deplete any nutrients?

Acetohexamide has 1 reported nutrient association in the research literature — see the Acetohexamide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Acetohexamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Acetohexamide.

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Pharmacist Counseling Corner

Acetohexamide & Supplements: Common Questions

What supplements interact with Acetohexamide?
In our interaction database, 296 supplement and herbal ingredients have an interaction with Acetohexamide on file — 4 rated major, 254 moderate, and 38 minor. That number sounds scarier than it is: severity matters far more than the count, which is why the list on this page is ranked instead of alphabetical. Start at the top. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, Beer.
Which Acetohexamide supplement interactions are the most serious?
The 4 major-rated combinations — led by Siberian Cocklebur, Activated Charcoal, Beer and Wine — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Acetohexamide?
That depends entirely on which supplement. The honest answer for Acetohexamide is in the ranked list above — and if what you take is a combination product with a dozen ingredients, don't check them one by one: photograph the label with our scanner and we'll check the whole thing at once. Try the label scanner or the interaction checker.
Do brands like Dymelor have the same supplement interactions as Acetohexamide?
Yes — Dymelor all contain Acetohexamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Acetohexamide deplete any vitamins or nutrients?
It might — Acetohexamide has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Acetohexamide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Acetohexamide and my other medications?
This page covers Acetohexamide against supplements and herbal ingredients. Checking Acetohexamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 25, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.