Drug & supplement interaction

Oregano + Acetohexamide

Acetohexamide brand name: Dymelor.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Oregano has a moderate interaction with Acetohexamide. Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Oregano and Acetohexamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Acetohexamide

Acetohexamide falls under ANTIDIABETES DRUGS — the group Oregano interacts with.

Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the situation with concentrated oregano and acetohexamide (Dymelor). Acetohexamide is a sulfonylurea, meaning its whole job is to push your pancreas to release more insulin and bring blood sugar down. Some lab and animal studies hint that oregano extracts may also nudge blood sugar lower. If both are doing the same thing at once, the worry is that your levels could dip too far, leading to hypoglycemia, which can feel like shakiness, sweating, dizziness, confusion, or even fainting.

I want to be honest though: this is a theoretical concern based only on test-tube and animal work, not solid human data. Sprinkling oregano on your food is not something to lose sleep over. Concentrated oregano oil capsules are where I'd be more cautious. Please loop in your pharmacist or doctor before adding them, and keep an eye on your readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256. PubMed
  2. McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
  3. Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Oregano Also Interacts With Other Medications

Oregano has 207 moderate known drug interactions in our database — the Acetohexamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Acetohexamide)
Taking anything else?

Check Another of Your Medications Against Oregano

Covers the 2,830 medications we’ve checked against Oregano. Pick one to open its full report.

From our Q&A

Questions About Oregano or Acetohexamide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Oregano or Acetohexamide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Acetohexamide

This page covers Oregano only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetohexamide page lists 296 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Acai (moderate).

By severity: 4 major · 254 moderate · 38 minor.

From our pharmacist’s overview on the Acetohexamide page

“Acetohexamide (Dymelor) is an older sulfonylurea, a pill with one job, pulling blood sugar down, so anything else that lowers glucose stacks on top of it. That is what most of this list does.”

Reviewed by 2 · Jul 18, 2026

Open the Acetohexamide interaction page

One more smart check

Taking Oregano as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,632 real supplement products containing Oregano, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Oregano. Your product may carry other ingredients that interact with Acetohexamide too, on top of Oregano — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Oregano and Acetohexamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oregano
Top 10%

#133 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetohexamide
Top half

#781 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Oregano

What is Oregano?

Oregano
  • Digestive upset
  • Respiratory and cold symptoms
  • Antimicrobial support
  • Intestinal parasites
  • Skin and fungal concerns

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may have antimicrobial and antioxidant properties, strong human evidence for treating any specific health condition is limited. Used as a food, oregano is very safe; concentrated oregano oil supplements should be used cautiously and discussed with your pharmacist or doctor.

Read the full Oregano monograph & all interactions
Keep checking

Other Drugs & Oregano

Browse every other medication we’ve checked against Oregano — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
0Minor
2,622No known interaction
207 Moderate 2,622 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Oregano page.

No interaction 2,622 drugs checked — show the list

We also checked Oregano against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Oregano list.

See the full Oregano interactions page
See every supplement checked against Acetohexamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Oregano monograph › Uses, safety, and every drug interaction in one place Acetohexamide supplement interactions › Every supplement checked against Acetohexamide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Oregano and Acetohexamide Together: Common Questions

Can you take Oregano with Acetohexamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Oregano and Acetohexamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetohexamide and Oregano?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.