Drug & supplement interaction

Oregano + Aspirin, Codeine Phosphate, Methocarbamol

Aspirin, Codeine Phosphate, Methocarbamol brand name: Robaxisal C.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Oregano has a moderate interaction with Aspirin, Codeine Phosphate, Methocarbamol. Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Oregano and Aspirin, Codeine Phosphate, Methocarbamol

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTICOAGULANT/ANTIPLATELET DRUGS

Why this applies to Aspirin, Codeine Phosphate, Methocarbamol

Aspirin, Codeine Phosphate, Methocarbamol falls under ANTICOAGULANT/ANTIPLATELET DRUGS — the group Oregano interacts with.

Theoretically, oregano might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aristolochic acid isolated from oregano leaves has antithrombin activity. It has also been reported that oregano oil inhibits arachidonic acid-induced, and ADP-induced, platelet aggregation.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

The combo pill you're asking about (Robaxisal C) contains aspirin, which is the piece that matters here. Aspirin already thins the blood by blocking platelets from sticking together. Lab studies hint that concentrated oregano oil may do something similar, slowing platelets and acting a little like a blood thinner. Stack the two and, in theory, you could bruise more easily, take longer to stop bleeding from a small cut, or have a touch more stomach upset or GI bleeding risk.

Keep in mind this is a theoretical concern based on test-tube research, not solid human studies. Sprinkling oregano on your food is no problem at all. Concentrated oregano oil capsules are the part worth running past your pharmacist or doctor first.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Tognolini, M., Barocelli, E., Ballabeni, V., Bruni, R., Bianchi, A., Chiavarini, M., and Impicciatore, M. Comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity. Life Sci. 2-23-2006;78(13):1419-1432. PubMed
  2. Goun, E., Cunningham, G., Solodnikov, S., Krasnykch, O., and Miles, H. Antithrombin activity of some constituents from Origanum vulgare. Fitoterapia 2002;73(7-8):692-694. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Oregano Also Interacts With Other Medications

Oregano has 207 moderate known drug interactions in our database — the Aspirin, Codeine Phosphate, Methocarbamol one above is one of them. If you take anything else, check it against the full list below.

Moderate 207 No known interaction 2,623 (incl. Aspirin, Codeine Phosphate, Methocarbamol)
Taking anything else?

Check Another of Your Medications Against Oregano

Covers the 2,830 medications we’ve checked against Oregano. Pick one to open its full report.

From our Q&A

Questions About Oregano or Aspirin, Codeine Phosphate, Methocarbamol

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Oregano or Aspirin, Codeine Phosphate, Methocarbamol, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Aspirin, Codeine Phosphate, Methocarbamol

This page covers Oregano only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Aspirin, Codeine Phosphate, Methocarbamol page lists 328 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Asarabacca (major), Beer (major) and Danshen (major).

By severity: 12 major · 282 moderate · 34 minor.

From our pharmacist’s overview on the Aspirin, Codeine Phosphate, Methocarbamol page

“Alcohol is the single riskiest thing to combine with Robaxisal C (aspirin, codeine phosphate, and methocarbamol). Beer and wine both carry major ratings backed by solid human evidence, because codeine and methocarbamol already slow breathing and reflexes, and alcohol deepens that sedation.”

Reviewed by 2 · Jul 18, 2026

Open the Aspirin, Codeine Phosphate, Methocarbamol interaction page

One more smart check

Taking Oregano as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1,632 real supplement products containing Oregano, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Oregano. Your product may carry other ingredients that interact with Aspirin, Codeine Phosphate, Methocarbamol too, on top of Oregano — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Oregano and Aspirin, Codeine Phosphate, Methocarbamol Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Oregano
Top 10%

#140 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Aspirin, Codeine Phosphate, Methocarbamol
Top 25%

#529 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Oregano

What is Oregano?

Oregano
  • Digestive upset
  • Respiratory and cold symptoms
  • Antimicrobial support
  • Intestinal parasites
  • Skin and fungal concerns

Oregano is a common Mediterranean cooking herb that is also sold as a concentrated oil or supplement, often standardized for a compound called carvacrol. While lab studies suggest it may have antimicrobial and antioxidant properties, strong human evidence for treating any specific health condition is limited. Used as a food, oregano is very safe; concentrated oregano oil supplements should be used cautiously and discussed with your pharmacist or doctor.

Read the full Oregano monograph & all interactions
Keep checking

Other Drugs & Oregano

Browse every other medication we’ve checked against Oregano — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
207Moderate
0Minor
2,622No known interaction
207 Moderate 2,622 No interaction
Moderate

207 interactions

Showing 60 of 207 moderate interactions — see all 207 on the Oregano page.

No interaction 2,622 drugs checked — show the list

We also checked Oregano against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,622 medications checked with no known interaction — see the full Oregano list.

See the full Oregano interactions page
See every supplement checked against Aspirin, Codeine Phosphate, Methocarbamol, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Oregano monograph › Uses, safety, and every drug interaction in one place Aspirin, Codeine Phosphate, Methocarbamol supplement interactions › Every supplement checked against Aspirin, Codeine Phosphate, Methocarbamol, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Oregano and Aspirin, Codeine Phosphate, Methocarbamol Together: Common Questions

Can you take Oregano with Aspirin, Codeine Phosphate, Methocarbamol?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Oregano and Aspirin, Codeine Phosphate, Methocarbamol interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Aspirin, Codeine Phosphate, Methocarbamol and Oregano?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.