Oregano - Steglatro (Ertugliflozin) Interaction
Herbal: Oregano
Also Known As: Origanum vulgare, Carvacrol, European Oregano, Marjolaine Sauvage, Marjolaine Vivace, Mediterranean Oregano, Mountain Mint, Oil of Oregano, Oregano Oil, Organy, Origan, Origan Européen, Origani Vulgaris Herba, Origano, Winter Marjoram, Wintersweet
Drug: Ertugliflozin
Brand names:
Steglatro

Medical Content Editor Dr. Brian Staiger, PharmD
Last updated
May 18, 2025
Interaction Details
Ertugliflozin is classified as belonging to the following category: Antidiabetes Drugs
Theoretically, oregano might increase the risk for hypoglycemia when taken with antidiabetes drugs.
In vitro and animal research shows that oregano extracts might lower blood glucose levels.
Interaction Rating
Likelihood of Occurrence
PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
Pharmacist Analysis
Several studies suggest that oregano supplements may help lower blood glucose (i.e., sugar) levels. In vitro and animal research has shown that oregano extracts might stimulate glucose uptake and reduce blood glucose levels.
For example, a study on diabetic rats found that oregano oil significantly decreased blood glucose levels, increased insulin levels, and improved glucose tolerance.
Therefore, based on the available evidence, combining oregano oil with antidiabetic drugs could potentially cause blood sugar levels to drop too low, leading to hypoglycemia.
However, it is important to note that studies reporting that oregano can reduce blood glucose levels have not reported it causing hypoglycemia.
Nevertheless, a theoretical interaction remains here due to the potential additive blood-sugar-lowering effects of oregano and certain antidiabetic drugs.
It should be noted that some drugs may be riskier than others.
A drug like metformin, a very commonly used oral drug for diabetes, has a very low risk of hypoglycemia, and combining it with oregano wouldn't generally be considered dangerous.
Other drugs, like insulin and sulfonylureas, (e.g., glipizide), carry a higher risk of hypoglycemia and may put you more at risk of your blood sugar dropping too low if you take oregano. It's certainly possible dosage adjuments may be needed if oregano is combined with them.
Be sure to talk to your doctor and don't make any changes to your medication regimen before doing so.
- Dr. Brian Staiger, PharmDReferences
- Lemhadri, A., Zeggwagh, N. A., Maghrani, M., Jouad, H., and Eddouks, M. Anti-hyperglycaemic activity of the aqueous extract of Origanum vulgare growing wild in Tafilalet region. J Ethnopharmacol. 2004;92(2-3):251-256.
- McCue, P., Vattem, D., and Shetty, K. Inhibitory effect of clonal oregano extracts against porcine pancreatic amylase in vitro. Asia Pac.J Clin.Nutr. 2004;13(4):401-408.
- Silva MLAE, Lucarini R, Dos Santos FF, et al. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. Nat Prod Res 2022;36(17):4525-4531.
Oregano Overview

Ertugliflozin Overview
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Ertugliflozin is used along with diet and exercise, and sometimes with other medications, to lower blood sugar levels in people with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Ertugliflozin is in a class of medications called sodium-glucose co-transporter 2 (SGLT2) inhibitors. It lowers blood sugar by causing the kidneys to get rid of more glucose in the urine. Ertugliflozin is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may develop if high blood sugar is not treated).
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Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.
Oregano - More Interactions
Oregano interacts with 205 drugs
Interaction Rating Key
These severity listings are for informational use only. Never start, stop or otherwise change your therapy before speaking with your provider.
Major | The combined use of these agents is strongly discouraged as serious side effects or other negative outcomes could occur. |
Moderate | Use cautiously under the care of a healthcare professional or avoid this combination. A significant interaction or negative outcome could occur. |
Minor | Be aware that there is a chance of an interaction. Watch for warning signs of a potential interaction. |
Unknown | No interactions have been reported or no interaction data is currently available. |
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
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