Drug & supplement interaction

Kombucha + Acetohexamide

Acetohexamide brand name: Dymelor.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Kombucha has a moderate interaction with Acetohexamide. Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Kombucha and Acetohexamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Acetohexamide

Acetohexamide falls under ANTIDIABETES DRUGS — the group Kombucha interacts with.

Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research shows that administering kombucha can lower blood glucose levels.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Acetohexamide is an older sulfonylurea, which means it works by pushing your pancreas to release more insulin and lower your blood sugar. Kombucha may have a mild blood-sugar-lowering effect of its own, at least based on animal studies. So the worry here is simple addition: if both nudge your sugar down at the same time, you could dip too low.

I want to be honest about how solid this is. This is a theoretical concern based mostly on lab and animal data, not strong human proof, so please don't panic. Still, watch for signs of low blood sugar like shakiness, sweating, dizziness, or feeling suddenly hungry or confused. If you enjoy kombucha regularly, just mention it to your pharmacist or doctor so they can keep an eye on your readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Aloulou, A., Hamden, K., Elloumi, D., Ali, M. B., Hargafi, K., Jaouadi, B., Ayadi, F., Elfeki, A., and Ammar, E. Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats. BMC.Complement Altern.Med. 2012;12:63. PubMed
  2. Xu S, Wang Y, Wang J, Geng W. Kombucha reduces hyperglycemia in type 2 diabetes of mice by regulating gut microbiota and Its metabolites. Foods 2022;11(5):754. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Kombucha Also Interacts With Other Medications

Kombucha has 85 moderate, 1 minor known drug interactions in our database — the Acetohexamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 Minor 1 No known interaction 2,744 (incl. Acetohexamide)
Taking anything else?

Check Another of Your Medications Against Kombucha

Covers the 2,830 medications we’ve checked against Kombucha. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetohexamide

This page covers Kombucha only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetohexamide page lists 296 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Acai (moderate).

By severity: 4 major · 254 moderate · 38 minor.

From our pharmacist’s overview on the Acetohexamide page

“Acetohexamide (Dymelor) is an older sulfonylurea, a pill with one job, pulling blood sugar down, so anything else that lowers glucose stacks on top of it. That is what most of this list does.”

Reviewed by 2 · Jul 18, 2026

Open the Acetohexamide interaction page

One more smart check

Taking Kombucha as Part of a Dietary Supplement Product? Check It for Interactions

We hold 30 real supplement products containing Kombucha, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Kombucha. Your product may carry other ingredients that interact with Acetohexamide too, on top of Kombucha — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Kombucha and Acetohexamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Kombucha
Steady interest

#1,074 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetohexamide
Top half

#799 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Kombucha

What is Kombucha?

  • General wellness and gut health
  • Digestion
  • Immune support
  • Energy and detox claims
  • Source of probiotics

Kombucha is a fermented tea that many people enjoy as a probiotic-rich beverage, but solid human research proving specific health benefits is lacking. It is generally fine in moderate amounts for healthy adults, though homemade or unpasteurized versions can carry contamination risks. Pregnant people, those who are breastfeeding, and people with weakened immune systems should be cautious or avoid it.

Read the full Kombucha monograph & all interactions
Keep checking

Other Drugs & Kombucha

Browse every other medication we’ve checked against Kombucha — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
1Minor
2,743No known interaction
85 Moderate 1 Minor 2,743 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Kombucha page.

Minor

1 interaction

No interaction 2,743 drugs checked — show the list

We also checked Kombucha against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Kombucha list.

See the full Kombucha interactions page
See every supplement checked against Acetohexamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Kombucha monograph › Uses, safety, and every drug interaction in one place Acetohexamide supplement interactions › Every supplement checked against Acetohexamide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Kombucha and Acetohexamide Together: Common Questions

Can you take Kombucha with Acetohexamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Kombucha and Acetohexamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetohexamide and Kombucha?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.