Drug & supplement interaction

Algal Oil + Acetohexamide

Acetohexamide brand name: Dymelor.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Algal Oil has a moderate interaction with Acetohexamide. Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Algal Oil and Acetohexamide

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Acetohexamide

Acetohexamide falls under ANTIDIABETES DRUGS — the group Algal Oil interacts with.

Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.
Most algal oil contains docosahexaenoic acid (DHA). Clinical research in people with type 2 diabetes, including those taking antidiabetes drugs, shows that taking DHA 4 grams daily for 6 weeks increases fasting blood glucose levels by about 18 mg/dL when compared with taking olive oil.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist for acetohexamide (Dymelor), which is an older sulfonylurea that lowers your blood sugar by nudging your pancreas to release more insulin. The concern with algal oil isn't about how your body breaks the drug down. Instead, the omega-3 fat DHA may slightly raise blood sugar on its own, which could work against your medication and make it a touch less effective.

To be fair, this is mostly theoretical. One study saw fasting sugar climb by about 18 mg/dL with a hefty 4 grams of DHA daily, so smaller doses may matter little. Still, if you start algal oil, it's smart to keep an eye on your home glucose readings and let your pharmacist or doctor know so they can confirm everything's steady.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Woodman RJ, Mori TA, Burke V, et al. Effects of purified eicosapentaenoic and docosahexaenoic acids on glycemic control, blood pressure, and serum lipids in type 2 diabetic patients with treated hypertension. Am J Clin Nutr 2002;76:1007-15.. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Algal Oil Also Interacts With Other Medications

Algal Oil has 257 moderate, 117 minor known drug interactions in our database — the Acetohexamide one above is one of them. If you take anything else, check it against the full list below.

Moderate 257 Minor 117 No known interaction 2,456 (incl. Acetohexamide)
Taking anything else?

Check Another of Your Medications Against Algal Oil

Covers the 2,830 medications we’ve checked against Algal Oil. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Acetohexamide

This page covers Algal Oil only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Acetohexamide page lists 296 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Beer (major), Siberian Cocklebur (major), Wine (major) and Acai (moderate).

By severity: 4 major · 254 moderate · 38 minor.

From our pharmacist’s overview on the Acetohexamide page

“Acetohexamide (Dymelor) is an older sulfonylurea, a pill with one job, pulling blood sugar down, so anything else that lowers glucose stacks on top of it. That is what most of this list does.”

Reviewed by 2 · Jul 18, 2026

Open the Acetohexamide interaction page

One more smart check

Taking Algal Oil as Part of a Dietary Supplement Product? Check It for Interactions

We hold 188 real supplement products containing Algal Oil, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Algal Oil. Your product may carry other ingredients that interact with Acetohexamide too, on top of Algal Oil — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Algal Oil and Acetohexamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Algal Oil
Top 25%

#320 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Acetohexamide
Top 25%

#685 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Algal Oil

What is Algal Oil?

Algal Oil
  • Vegan/vegetarian source of omega-3s (DHA and EPA)
  • Heart and triglyceride health
  • Brain and eye support
  • Pregnancy and infant nutrition
  • General anti-inflammatory support

Algal oil is a plant-based source of the omega-3 fats DHA and (in some products) EPA, making it a popular alternative to fish oil for vegetarians, vegans, and people who dislike fish. There is reasonable evidence that omega-3s can lower triglycerides and support heart and brain health, though more research is needed for many specific uses. It is generally well tolerated, but check with your pharmacist or doctor before starting, especially if you take blood thinners or are pregnant.

Read the full Algal Oil monograph & all interactions
Keep checking

Other Drugs & Algal Oil

Browse every other medication we’ve checked against Algal Oil — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
257Moderate
117Minor
2,455No known interaction
257 Moderate 117 Minor 2,455 No interaction
Moderate

257 interactions

Showing 60 of 257 moderate interactions — see all 257 on the Algal Oil page.

Minor

117 interactions

Showing 60 of 117 minor interactions — see all 117 on the Algal Oil page.

No interaction 2,455 drugs checked — show the list

We also checked Algal Oil against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,455 medications checked with no known interaction — see the full Algal Oil list.

See the full Algal Oil interactions page
See every supplement checked against Acetohexamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Algal Oil monograph › Uses, safety, and every drug interaction in one place Acetohexamide supplement interactions › Every supplement checked against Acetohexamide, ranked by severity Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Algal Oil and Acetohexamide Together: Common Questions

Can you take Algal Oil with Acetohexamide?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Algal Oil and Acetohexamide interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Acetohexamide and Algal Oil?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.