Andrachne Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Andrachne interacts with medications. The heart of this page is the interaction list — every drug Andrachne is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Andrachne is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Andrachne against your medication
Add one medicationDrugs that interact with Andrachne
0 medications have a known interaction with Andrachne, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Andrachne. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Andrachne combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Andrachne: Uses, Safety & Side Effects
Andrachne is a group of flowering plants used in some traditional medicine systems for fever, diarrhea, and urinary problems, but there is very little human research to support these uses. Because its safety has not been well studied, it is best to be cautious and talk with a pharmacist or doctor before trying it.

- Family
- Phyllanthaceae
- Part used
- Leaves, stems, and roots
- Common forms
- Traditional teas, decoctions, and crude plant extracts
- Fever
- Diarrhea
- Urinary tract complaints
- Antimicrobial support
- Antioxidant support
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
There is very little reliable safety data on Andrachne in humans.
Safety is unknown, so it is best to avoid use during pregnancy.
There is no safety data during breastfeeding, so avoid use.
Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Andrachne is a genus of small flowering plants in the Phyllanthaceae family. It includes roughly 30 species that grow in parts of Africa, Asia, and Europe. The plants are known for their small, plain flowers and simple leaves.
Some species, such as Andrachne telephioides and Andrachne aspera, have been used in traditional or folk medicine. People have used the leaves, stems, and roots in teas or extracts. It is not a common commercial supplement, and you are unlikely to find standardized products in most pharmacies.
Uses & effectiveness
In traditional medicine, Andrachne has been used for fever, diarrhea, and urinary tract problems. These uses suggest people believed it had antimicrobial and fever-reducing effects.
However, the scientific evidence is very limited. Most of what we know comes from laboratory studies of plant extracts, not from carefully designed human trials. For example, some lab research has looked at whether extracts can slow the growth of certain bacteria. These early findings are interesting but do not prove that Andrachne works in people.
Overall, there is not enough good-quality human evidence to say that Andrachne is effective for any health condition. It should not be used in place of proven treatments.
How it works
Andrachne plants contain natural compounds such as flavonoids, phenolic acids, and tannins. These compounds are known to have antioxidant activity, meaning they may help protect cells from damage caused by unstable molecules called free radicals.
Some lab studies suggest that certain extracts may have antimicrobial effects against specific bacteria. Tannins, in particular, are sometimes linked to a drying or astringent effect that could relate to traditional use for diarrhea.
It is important to know that these mechanisms come mostly from test-tube and animal research. We do not have solid evidence on how Andrachne behaves in the human body.
Safety & precautions
The safety of Andrachne in humans has not been well studied. Because we do not know how pure or strong different plant products are, the risks are hard to predict.
People who are pregnant or breastfeeding should avoid Andrachne, since there is no safety information for these situations. Children, older adults, and people with liver, kidney, or other chronic health conditions should also be cautious and avoid use unless advised by a healthcare professional.
Always talk with a pharmacist or doctor before using Andrachne, especially if you take prescription medicines or have an ongoing medical condition.
Side effects
Because Andrachne has not been studied much in people, its full side effect profile is unknown. Plants high in tannins can sometimes cause stomach upset, nausea, or digestive discomfort.
As with any plant product, there is a chance of an allergic reaction. Stop using it and seek medical care right away if you notice signs such as rash, swelling, or trouble breathing. Since quality and contents can vary between products, unexpected effects are possible.
Dosing
There is no established or standardized dose for Andrachne. Because it has not been well studied, experts cannot recommend a safe and effective amount.
If you are considering a product that contains Andrachne, follow the directions on the label and do not exceed them. It is best to check with a pharmacist or doctor first, since they can help you weigh the unknown risks against any possible benefit.
References & further reading
The 3 sources that drive our Andrachne monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
- Phyllanthaceae and related medicinal plants — MedlinePlus Source
- Using Dietary Supplements Wisely — NIH NCCIH Source
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Andrachne: Common Questions
Does Andrachne interact with prescription medications?
How are Andrachne interactions rated?
Is it safe to take Andrachne with my medications?
Where does this Andrachne interaction information come from?
What is Andrachne used for?
Is Andrachne safe to take?
Can I use Andrachne during pregnancy or breastfeeding?
Does Andrachne actually fight infections?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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