Tree Of Heaven Drug Interactions, Uses, Safety & More
What is this page for?
First and foremost: how Tree Of Heaven interacts with medications. The heart of this page is the interaction list — every drug Tree Of Heaven is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Tree Of Heaven is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Tree Of Heaven against your medication
Add one medicationTree Of Heaven Drug Interactions: The Bottom Line
From the HelloPharmacist Editorial Team · Updated July 2026Based on the available evidence, the overall risk of a clinically significant Tree Of Heaven drug interaction appears low for most people, since the only known concern is theoretical and has not been confirmed in humans. None of the listed interactions are rated major, and every one traces back to a single lab-based finding rather than to problems reported in people.
The interactions that deserve the most attention involve blood thinners, meaning anticoagulant and antiplatelet medications. Lab research suggests Tree Of Heaven extract may make platelets less sticky, which could in theory add to the bleeding risk these medicines already carry. This effect has not been seen in humans, but because bleeding is a serious outcome, we treat the combination with extra caution rather than dismissing it.
Although the number of medications on this list is large, that does not mean each combination has been shown to cause harm. Nearly all of these entries flow from one predicted effect on platelets observed only in laboratory studies. Until human research clarifies the picture, these remain cautions based on possibility, not proven interactions.
Based on HelloPharmacist’s Tree Of Heaven interaction data and reviewed under our editorial standards.
Drugs that interact with Tree Of Heaven
122 medications have a known interaction with Tree Of Heaven, graded by severity. Select any drug for the full evidence-based detail.
Don’t want to scroll the list? Just ask.
Tell us the medications you take and we’ll check each one against Tree Of Heaven using our pharmacist-reviewed interaction data.
AI summaries are generated from our Tree Of Heaven interaction data for education only — always confirm with your pharmacist. How we use AI
No drugs match “”.
AbciximabReoPro
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Abciximab interactionAbrocitinibCibinqo
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Abrocitinib interaction Abrocitinib drug page: uses, dosage & side effectsAcenocoumarolSintrom
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, IbuprofenCombogesic
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Acetaminophen, Ibuprofen interactionAcetylsalicylic AcidEntrophen
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Acetylsalicylic Acid interaction Acetylsalicylic Acid drug page: uses, dosage & side effectsAlteplase, TpaActilyse, Activase
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interaction Aluminum Hydroxide, Aspirin, Magnesium Hydroxide drug page: uses, dosage & side effectsAnacaulase-bcdbNexoBrid
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Anacaulase-bcdb interactionAnagrelideAgrylin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Anagrelide interaction Anagrelide drug page: uses, dosage & side effectsAnisindioneMiradon
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Anisindione interactionAntithrombin IiiThrombate III
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Antithrombin Iii interactionApixabanEliquis
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Apixaban interaction Apixaban drug page: uses, dosage & side effectsArgatrobanArgatroban
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Argatroban interactionAspirinAngettes 75, ASA, Asaphen, Aspirin, Caprin, Cartia +8 more
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin interaction Aspirin drug page: uses, dosage & side effectsAspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #3
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Aluminum Hydroxide, Codeine Phosphate, Magnesium Hydroxide interactionAspirin, ButalbitalAxotal
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Butalbital interactionAspirin, Butalbital, CaffeineFiorinal
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Butalbital, Caffeine interaction Aspirin, Butalbital, Caffeine drug page: uses, dosage & side effectsAspirin, Butalbital, Caffeine, Codeine PhosphateFiorinal w/ Codeine
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Butalbital, Caffeine, Codeine Phosphate interactionAspirin, Butalbital, Caffeine, PhenacetinMarnal
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Butalbital, Caffeine, Phenacetin interactionAspirin, CaffeineAnacin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Caffeine interactionAspirin, Caffeine, Codeine PhosphateAnacin w/ Codeine
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Caffeine, Codeine Phosphate interactionAspirin, Caffeine, Dihydrocodeine BitartrateSynalgos DC
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Caffeine, Dihydrocodeine Bitartrate interactionAspirin, Caffeine, Dover's PwdAcedoval, Dovacet
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Caffeine, Dover's Pwd interactionAspirin, Caffeine, HydrocodoneDamason-P
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Caffeine, Hydrocodone interactionAspirin, Caffeine, Isobutylallylbarbituric Acid, PhenacetinLanorinal
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin interaction Aspirin, Caffeine, Isobutylallylbarbituric Acid, Phenacetin drug page: uses, dosage & side effectsAspirin, Caffeine, OrphenadrineInvagesic, Invagesic Forte, Norgesic, Norgesic Forte, Orphengesic, Orphengesic Forte
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Caffeine, Orphenadrine interactionAspirin, Caffeine, Phenacetin, PropoxypheneMargesic Comp. 65
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Caffeine, Phenacetin, Propoxyphene interactionAspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium OxideBufferin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide interaction Aspirin, Calcium Carbonate, Magnesium Carbonate, Magnesium Oxide drug page: uses, dosage & side effectsAspirin, CarisoprodolSoma Compound
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Carisoprodol interactionAspirin, Carisoprodol, Codeine PhosphateSoma Compound w/ Codeine
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Carisoprodol, Codeine Phosphate interactionAspirin, Chlorpheniramine, PhenylpropanolamineAlka-Seltzer Plus Cold
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Chlorpheniramine, Phenylpropanolamine interactionAspirin, Citric Acid, Sodium BicarbonateAlka-Seltzer Pain Reliever and Antacid
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Citric Acid, Sodium Bicarbonate interactionAspirin, Codeine PhosphateAspirin w/ Codeine
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Codeine Phosphate interactionAspirin, Codeine Phosphate, MethocarbamolRobaxisal C
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Codeine Phosphate, Methocarbamol interactionAspirin, Codeine Phosphate, PhenobarbitalPhenaphen
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Codeine Phosphate, Phenobarbital interactionAspirin, Diphenhydramine, PhenylpropanolamineAlka Seltzer Plus Night Time Effervescent
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Diphenhydramine, Phenylpropanolamine interactionAspirin, DipyridamoleAggrenox, Asasantin Retard
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Dipyridamole interactionAspirin, Ethoheptazine, MeprobamateEquagesic
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Ethoheptazine, Meprobamate interactionAspirin, HydrocodoneAlor 5 500, Lortab ASA
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Hydrocodone interactionAspirin, MeprobamateMicrainin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Meprobamate interactionAspirin, MethocarbamolRobaxisal
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Methocarbamol interactionAspirin, OmeprazoleYosprala
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Omeprazole interactionAspirin, OxycodonePercodan
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Oxycodone interactionAspirin, PentazocineTalwin Compound
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Aspirin, Pentazocine interactionBetrixabanBevyxxa
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Betrixaban interactionBivalirudinAngiomax, Angiomax Rtu, Angiox
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Bivalirudin interactionBromfenac SodiumBromsite, Prolensa
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Bromfenac Sodium interaction Bromfenac Sodium drug page: uses, dosage & side effectsCabliviCablivi
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Cablivi interaction Cablivi drug page: uses, dosage & side effectsCangrelorKengreal
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Cangrelor interactionCilostazolPletal
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Cilostazol interaction Cilostazol drug page: uses, dosage & side effectsClopidogrelPlavix
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Clopidogrel interaction Clopidogrel drug page: uses, dosage & side effectsDalteparinFragmin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Dalteparin interaction Dalteparin drug page: uses, dosage & side effectsDanaparoidOrgaran
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Danaparoid interactionDefibrotide SodiumDefitelio
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Defibrotide Sodium interaction Defibrotide Sodium drug page: uses, dosage & side effectsDiclofenacZorvolex
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Diclofenac interaction Diclofenac drug page: uses, dosage & side effectsDiclofenac PotassiumCambia, Cataflam, Cataflam IR, Voltaren Rapide, Voltarol Rapid
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Diclofenac Potassium interaction Diclofenac Potassium drug page: uses, dosage & side effectsDiclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Diclofenac Sodium interaction Diclofenac Sodium drug page: uses, dosage & side effectsDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Diclofenac Epolamine interactionDicumarolDicumarol
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Dicumarol interactionDiphenhydramine Hydrochloride, Naproxen SodiumAleve PM
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Diphenhydramine Hydrochloride, Naproxen Sodium interactionDipyridamoleDipyridamole, Persantin, Persantin Injection, Persantin Retard, Persantine
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Dipyridamole interaction Dipyridamole drug page: uses, dosage & side effectsEdoxabanSavaysa
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Edoxaban interaction Edoxaban drug page: uses, dosage & side effectsEffientPrasugrel
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Effient interaction Effient drug page: uses, dosage & side effectsEnoxaparinLovenox
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Enoxaparin interaction Enoxaparin drug page: uses, dosage & side effectsEptifibatideIntegrilin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Eptifibatide interactionEsomeprazole, NaproxenVimovo
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Esomeprazole, Naproxen interactionFamotidine, IbuprofenDuexis
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Famotidine, Ibuprofen interactionFish Oil TriglyceridesOmegaven
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Fish Oil Triglycerides interactionFondaparinuxArixtra
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Fondaparinux interaction Fondaparinux drug page: uses, dosage & side effectsHeparinHeparin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Heparin interaction Heparin drug page: uses, dosage & side effectsHydrocodone, IbuprofenVicoprofen
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Hydrocodone, Ibuprofen interactionIbrutinibImbruvica
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ibrutinib interaction Ibrutinib drug page: uses, dosage & side effectsIbuprofenAdvil, Arthrofen, Brufen, Brufen Retard, Calodor, Calprofen +14 more
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ibuprofen interaction Ibuprofen drug page: uses, dosage & side effectsIbuprofen LysineNeoProfen
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ibuprofen Lysine interaction Ibuprofen Lysine drug page: uses, dosage & side effectsIbuprofen, AcetaminophenAdvil Dual Action
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ibuprofen, Acetaminophen interactionIbuprofen, HydrocodoneIbucodone
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ibuprofen, Hydrocodone interactionIbuprofen, OxycodoneCombunox
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ibuprofen, Oxycodone interactionIbuprofen, PseudoephedrineDristan
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ibuprofen, Pseudoephedrine interactionIcosapent Ethyl (prescription Drug)Vascepa
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Icosapent Ethyl (prescription Drug) interaction Icosapent Ethyl (prescription Drug) drug page: uses, dosage & side effectsIloprostAurlumyn, Ventavis
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Iloprost interaction Iloprost drug page: uses, dosage & side effectsInotersenTegsedi
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Inotersen interactionKetoprofenOrudis, Oruvail Gel, Oruvail Injection, Powergel
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ketoprofen interaction Ketoprofen drug page: uses, dosage & side effectsLepirudinRefludan
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Lepirudin interactionMinocyclineAcnamino MR, Aknemin, Amzeeq, Arestin Miscrosperes, Dynacin, Minocin +6 more
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Minocycline interaction Minocycline drug page: uses, dosage & side effectsNadroparinFraxiparine
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Nadroparin interactionNaproxenAleve, Anaprox, Anaprox DS, Arthroxen, EC-Naprosyn, Naprelan +7 more
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Naproxen interaction Naproxen drug page: uses, dosage & side effectsNaproxen SodiumMidol Extended Relief
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Naproxen Sodium interactionNaproxen, PseudoephedrineAleve Cold and Sinus
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Naproxen, Pseudoephedrine interactionNaproxen, SumatriptanTreximet
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Naproxen, Sumatriptan interactionNintedanib EsylateOfev
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Nintedanib Esylate interaction Nintedanib Esylate drug page: uses, dosage & side effectsNusinersen SodiumSpinraza
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Nusinersen Sodium interaction Nusinersen Sodium drug page: uses, dosage & side effectsOmega-3 Fatty Acids (prescription Drug)Lovaza
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Omega-3 Fatty Acids (prescription Drug) interactionPazopanibVotrient
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Pazopanib interaction Pazopanib drug page: uses, dosage & side effectsPentoxifyllineTrental
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Pentoxifylline interaction Pentoxifylline drug page: uses, dosage & side effectsPhenprocoumonLiquamar
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Phenprocoumon interactionPiroxicamFeldene, Feldene Gel
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Piroxicam interaction Piroxicam drug page: uses, dosage & side effectsRivaroxabanXarelto
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Rivaroxaban interaction Rivaroxaban drug page: uses, dosage & side effectsSelexipagUptravi
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Selexipag interaction Selexipag drug page: uses, dosage & side effectsSelumetinib SulfateKoselugo
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Selumetinib Sulfate interaction Selumetinib Sulfate drug page: uses, dosage & side effectsSorafenibNexavar
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Sorafenib interaction Sorafenib drug page: uses, dosage & side effectsStreptokinaseKabikinase, Streptase
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Streptokinase interactionTenecteplaseTNKase
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Tenecteplase interactionTicagrelorBrilinta
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ticagrelor interaction Ticagrelor drug page: uses, dosage & side effectsTiclopidineTiclid, Ticlopidine
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Ticlopidine interaction Ticlopidine drug page: uses, dosage & side effectsTinzaparinInnohep
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Tinzaparin interactionTirofibanAggrastat
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Tirofiban interaction Tirofiban drug page: uses, dosage & side effectsTivozanib HydrochlorideFotivda
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Tivozanib Hydrochloride interaction Tivozanib Hydrochloride drug page: uses, dosage & side effectsTreprostinil
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Treprostinil interaction Treprostinil drug page: uses, dosage & side effectsTreprostinil (iv)Remodulin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Treprostinil (iv) interaction Treprostinil (iv) drug page: uses, dosage & side effectsTreprostinil (inh)Tyvaso
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Treprostinil (inh) interaction Treprostinil (inh) drug page: uses, dosage & side effectsTreprostinil (oral)Orenitram, Remodulin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Treprostinil (oral) interaction Treprostinil (oral) drug page: uses, dosage & side effectsUrokinaseAbbokinase
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Urokinase interactionVorapaxarZontivity
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Vorapaxar interaction Vorapaxar drug page: uses, dosage & side effectsWarfarinWarfarin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Warfarin interaction Warfarin drug page: uses, dosage & side effectsWarfarin SodiumCoumadin, Panwarfin, Sofarin
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Warfarin Sodium interaction Warfarin Sodium drug page: uses, dosage & side effectsAnistreplase, ApsacEminase
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Anistreplase, Apsac interactionDabigatranPradax, Pradaxa
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Dabigatran interaction Dabigatran drug page: uses, dosage & side effectsReteplaseRetevase
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs.
Read the full Tree Of Heaven + Reteplase interactionWhat Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Tree Of Heaven combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
The kinds of drugs Tree Of Heaven affects
Every type of medication (drug category) Tree Of Heaven is known to interact with. Open any category for the detail — or search your exact drug in the checker above.
Anticoagulant/Antiplatelet Drugs
Theoretically, tree of heaven extract might reduce platelet aggregation and increase the risk of bleeding if used with antiplatelet or anticoagulant drugs. In vitro evidence shows that tree of heaven crude extract attenuates epinephrine and adenosine diphosphate-induced platelet aggregation. This interaction has not been seen in humans. Until more is known, use with caution in patients taking anticoagulant or antiplatelet drugs.
Tree Of Heaven: Uses, Safety & Side Effects
Tree of Heaven (Ailanthus altissima) is a fast-growing, invasive tree whose bark has been used in traditional medicine, mostly for digestive complaints and parasites. Modern scientific evidence in humans is very limited, and the plant can cause stomach upset and skin reactions, so it should be used cautiously and not without professional guidance.
- Scientific name
- Ailanthus altissima
- Family
- Simaroubaceae
- Part used
- Bark (especially root and stem bark), leaves
- Common forms
- Dried bark, tinctures, teas/decoctions, traditional herbal preparations
- Diarrhea and dysentery
- Intestinal parasites
- Menstrual or vaginal complaints
- Asthma and cough (traditional use)
- Skin conditions (topical, traditional use)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Human safety data are limited, and the plant can irritate the stomach and skin.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Tree of Heaven (Ailanthus altissima) is a fast-growing deciduous tree that is native to China and parts of Asia. It has spread widely around the world and is now considered an invasive weed in many regions, including North America and Europe. You may recognize it by its long, feathery leaves and a strong, unpleasant smell when the leaves or bark are crushed.
In traditional Chinese medicine and some folk medicine systems, the bark (especially the root and stem bark) has been used to treat digestive problems and other complaints. The leaves have also been used in some preparations. Despite its long history of traditional use, it is not a common supplement on store shelves today, and high-quality human studies are scarce.
Uses & effectiveness
People have traditionally used Tree of Heaven bark for diarrhea, dysentery, and intestinal parasites (worms). It has also been used for menstrual and vaginal complaints, asthma, cough, and, applied to the skin, for certain skin conditions.
It is important to be honest about the evidence: there is very little reliable research in humans to show that Tree of Heaven works for any of these conditions. Most of what we know comes from laboratory studies (such as testing extracts against bacteria, parasites, or cancer cells in a dish) and from a small number of animal studies. These early findings do not prove that the plant is safe or effective for people.
Because the evidence is so limited, Tree of Heaven should not be relied on to treat any medical condition. If you have symptoms like ongoing diarrhea or a suspected parasite infection, see a healthcare provider for proven treatment.
How it works
Tree of Heaven contains a variety of natural compounds. Among the most studied are quassinoids (bitter substances, such as ailanthone), along with alkaloids, flavonoids, and other plant chemicals. These compounds are responsible for the plant's bitter taste and many of its biological effects.
In laboratory research, extracts have shown antimicrobial, antiparasitic, anti-inflammatory, and cell-growth-blocking activity. Quassinoids in particular have drawn interest for their effects on bacteria, parasites, and cancer cells in test-tube studies.
It is important to understand that these are mainly laboratory and animal findings. What happens in a dish or in an animal does not always translate to a safe or helpful effect in the human body, and the doses used in labs may not match what a person could safely take.
Safety & precautions
The overall safety of Tree of Heaven in people is not well established. Handling the plant can cause skin irritation in some people, and the bark and leaves can irritate the digestive tract when taken by mouth. Some of its compounds are bitter and potentially toxic in larger amounts.
People who should be especially careful include those with sensitive stomachs, anyone with liver or kidney problems, and people who are prone to allergic or skin reactions. Because product quality and strength can vary widely and standardized products are uncommon, it is hard to know exactly what you are getting.
Pregnancy: Avoid Tree of Heaven during pregnancy. There is not enough safety information, and its traditional use to affect menstruation raises concern about potential harm. Breastfeeding: Avoid it while breastfeeding, since there is no reliable safety data. Always talk with a pharmacist or doctor before using any herbal product.
Side effects
Reported and likely side effects include nausea, vomiting, stomach cramps, and diarrhea, especially with larger amounts. Direct contact with the sap, leaves, or bark may cause skin irritation or rash in sensitive people.
Because the plant contains potentially toxic compounds, taking too much could cause more serious problems. Stop using it and seek medical care if you have severe stomach pain, persistent vomiting, signs of an allergic reaction, or any unusual symptoms.
Tree Of Heaven: Reported Adverse Effects
Documented safety reports on Tree Of Heaven from the evidence-graded Natural Medicines (TRC Healthcare) database, shown word-for-word from the licensed record.
There is currently a limited amount of information available about the safety of tree of heaven. Orally, large amounts of the bark have been reported to cause queasiness, dizziness, headache, limb tingling, and diarrhea.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Cluster headache Neurologic/CNS
Orally, large amounts of tree of heaven bark have been reported to cause dizziness, headache, and limb tingling.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Diarrhea Gastrointestinal
Orally, large amounts of tree of heaven bark have been reported to cause queasiness and diarrhea.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Adverse-effects data: Natural Medicines, Therapeutic Research Center
Dosing
There is no well-established or standardized dose for Tree of Heaven. Traditional preparations such as bark decoctions varied widely, and they were not measured against modern safety standards.
If you choose to use a commercial product, follow the directions on the label and do not exceed them. Because strength and quality differ between products, and because human safety data are limited, it is best to check with a pharmacist or doctor first, especially if you take other medicines or have a health condition.
Tree Of Heaven & Pregnancy
Tree Of Heaven & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 references that drive our Tree Of Heaven monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.
- Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
- Rahman HMA, Rasool MF, Imran I. Pharmacological Studies Pertaining to Smooth Muscle Relaxant, Platelet Aggregation Inhibitory and Hypotensive Effects of Ailanthus altissima. Evid Based Complement Alternat Med. 2019;2019:1871696.
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC
Brands that make products with Tree Of Heaven
6 brands in our database make a supplement containing Tree Of Heaven.
Supplement products with Tree Of Heaven
14 products in our database contain Tree Of Heaven. Open any to see its full ingredient list and every drug interaction we check.
Tree Of Heaven: Common Questions
Does Tree Of Heaven interact with prescription medications?
How are Tree Of Heaven interactions rated?
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Where does this Tree Of Heaven interaction information come from?
What is Tree Of Heaven used for?
Is Tree Of Heaven safe to take?
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Is Tree Of Heaven the same as the tree growing in my yard?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Products that contain Tree Of Heaven
A rotating sample of real supplements in our database that list Tree Of Heaven — open any to see its full ingredients and every drug interaction we check.
- Ailanthus Alcohol Free by Herbal Terra
- Yu Dai Teapills by Plum Flower
- Source QI by Health Concerns
- Ailanthus Non-Alcohol by Hawaii Pharm
- Ailanthus by Herbal Terra
- Ailanthus by Hawaii Pharm
- Ailanthus by Hawaii Pharm
- Ailanthus Alcohol Free by Hawaii Pharm
- Yudai Wan by Min Shan
- Ailanthus by Hawaii Pharm
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