Drug & supplement interaction

Tree Of Heaven + Cephalothin

Cephalothin brand name: Keflin.

No Known Interaction

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated July 2026 · Pair last verified Sep 13, 2026

The bottom line No known interaction

We found no known interaction between Tree Of Heaven and Cephalothin in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Tree Of Heaven and Cephalothin

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Cephalothin and Tree Of Heaven in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Tree Of Heaven safety at a glance

Tree Of Heaven overall Use caution Human safety data are limited, and the plant can irritate the stomach and skin.

Pregnancy Avoid Not enough safety information; traditional use for menstrual effects raises concern, so avoid in pregnancy.

Breastfeeding Avoid No reliable safety data during breastfeeding, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Cephalothin and Tree Of Heaven? Ask Dr. Brian Staiger, PharmD, BCPS directly ›

How we checked

Why No Interaction Is Listed for Cephalothin

Interactions in our licensed database are recorded against drug classes, not just single drug names. Cephalothin is filed under 5 classifications — including organic anion transporter 3 (oat3) substrates, organic anion transporter 1 (oat1) substrates, nephrotoxic drugs. Tree Of Heaven has documented interactions with 1 drug class — the most serious being anticoagulant/antiplatelet drugs (moderate) — and none of Cephalothin’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Tree Of Heaven Does Interact With Other Medications

Tree Of Heaven has 122 moderate known drug interactions in our database — Cephalothin isn’t one of them. If you take anything else, check it against the full list below.

Moderate 122 No known interaction 2,708 (incl. Cephalothin)

Taking anything else?

Check Another of Your Medications Against Tree Of Heaven

Covers the 2,830 medications we’ve checked against Tree Of Heaven. Pick one to open its full report.

What to actually watch for

What Tree Of Heaven Itself Has Been Linked To

This is not an interaction — nothing below involves Cephalothin. It is the side-effect record for Tree Of Heaven on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Tree Of Heaven, this list is the first place to look.

Numbness or tingling / Dizziness / Headache Additional detail
“There is currently a limited amount of information available about the safety of tree of heaven. Orally, large amounts of the bark have been reported to cause queasiness, dizziness, headache, limb tingling, and diarrhea (18).”

Tree Of Heaven · Natural Medicines adverse-effect record, reported in cluster headache.
1 source cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
“Orally, large amounts of tree of heaven bark have been reported to cause dizziness, headache, and limb tingling (18).”

Tree Of Heaven · Natural Medicines adverse-effect record, reported in cluster headache.
1 source cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Diarrhea / Nausea Additional detail
“Orally, large amounts of tree of heaven bark have been reported to cause queasiness and diarrhea (18).”

Tree Of Heaven · Natural Medicines adverse-effect record, reported in diarrhea.
1 source cited

18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

Everything above comes from the Natural Medicines adverse-effect record for Tree Of Heaven — expand a row for the licensed statement it rests on. We haven’t matched Cephalothin to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Cephalothin.

Everything else you take

See Every Supplement That Interacts With Cephalothin

This page covers Tree Of Heaven only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Cephalothin page lists 33 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Asarabacca (major), Siberian Cocklebur (major), African Wild Potato (moderate) and Aristolochia (moderate).

By severity: 3 major · 20 moderate · 10 minor.

From our pharmacist’s overview on the Cephalothin page

“Cephalothin, sold as Keflin, is a cephalosporin antibiotic given by injection for serious infections, and its 33 documented supplement interactions are not a list to shrug off, least of all the three rated major. Two of those involve herbs that can damage the kidneys outright, Siberian cocklebur and asarabacca (often contaminated with…”

Reviewed by 2 · Jul 18, 2026

Open the Cephalothin interaction page

One more smart check

Taking Tree Of Heaven as Part of a Dietary Supplement Product? Check It for Interactions

We hold 14 real supplement products containing Tree Of Heaven, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Tree Of Heaven. Even though Tree Of Heaven itself has no known interaction with Cephalothin, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Tree Of Heaven and Cephalothin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Tree Of Heaven

Steady interest

#1,036 of 1,452 supplements looked up here in the last 7 days

29 days ago today

Medication Cephalothin

Steady interest

#1,787 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?

Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Tree Of Heaven reference on this page ↓
Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Tree Of Heaven and Cephalothin records this page draws on were last updated July 10, 2026.
What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.

Data structure & sourcing designed and verified by Dr. Brian Staiger, PharmD, BCPS.

Supplement

About Tree Of Heaven

What is Tree Of Heaven?

Diarrhea and dysentery
Intestinal parasites
Menstrual or vaginal complaints
Asthma and cough (traditional use)
Skin conditions (topical, traditional use)

Tree of Heaven (Ailanthus altissima) is a fast-growing, invasive tree whose bark has been used in traditional medicine, mostly for digestive complaints and parasites. Modern scientific evidence in humans is very limited, and the plant can cause stomach upset and skin reactions, so it should be used cautiously and not without professional guidance.

Ailanthus altissima · Simaroubaceae · Bark (especially root and stem bark), leaves · Dried bark, tinctures, teas/decoctions, traditional herbal preparations

An interaction check asks whether these two react with each other — it does not ask whether Tree Of Heaven is a good idea for someone in your situation. Here is what our Tree Of Heaven record says about it on its own.

Tree Of Heaven: dosing

There is no well-established or standardized dose for Tree of Heaven. Traditional preparations such as bark decoctions varied widely, and they were not measured against modern safety standards.If you choose to use a commercial product, follow the directions on the label and do not exceed them.

From our Tree Of Heaven monograph — the full record covers uses, side effects and every documented interaction.

Read the full Tree Of Heaven monograph & all interactions

Keep checking

Other Drugs & Tree Of Heaven

Browse every other medication we’ve checked against Tree Of Heaven — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major

122Moderate

0Minor

2,707No known interaction

122 Moderate 2,707 No interaction

Moderate

122 interactions

Showing 60 of 122 moderate interactions — see all 122 on the Tree Of Heaven page.

No interaction 2,707 drugs checked — show the list

We also checked Tree Of Heaven against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,707 medications checked with no known interaction — see the full Tree Of Heaven list.

See the full Tree Of Heaven interactions page

See every supplement checked against Cephalothin, ranked by severity

Evidence & sources

Tree Of Heaven References

The 2 references that drive our Tree Of Heaven monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
Rahman HMA, Rasool MF, Imran I. Pharmacological Studies Pertaining to Smooth Muscle Relaxant, Platelet Aggregation Inhibitory and Hypotensive Effects of Ailanthus altissima. Evid Based Complement Alternat Med. 2019;2019:1871696.

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Tree Of Heaven and Cephalothin Together: Common Questions

Is it safe to take Tree Of Heaven with Cephalothin?

We do not list a known interaction between Tree Of Heaven and Cephalothin. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.

How was the Tree Of Heaven and Cephalothin combination checked?

Interactions in our licensed database are recorded against drug classes. Cephalothin is filed under 5 classifications, and Tree Of Heaven has documented interactions with 1 drug class — none of Cephalothin's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.

Does Tree Of Heaven interact with any other medications?

Yes. Tree Of Heaven has 122 documented drug interactions in our database — Cephalothin is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.

Does Cephalothin interact with any supplements?

Yes. Cephalothin has documented interactions with 33 supplements in our database — Tree Of Heaven is not one of them. The Cephalothin interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Tree Of Heaven monograph Uses, safety profile, and every drug interaction in one place Cephalothin supplement interactions Every supplement checked against Cephalothin, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Cephalothin and Tree Of Heaven?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.