Sorafenib drug information | HelloPharmacist

Why is this medication prescribed?
How should this medicine be used?
Other uses for this medicine
What special precautions should I follow?
What special dietary instructions should I follow?
What should I do if I forget a dose?
What side effects can this medication cause?
What should I know about STORAGE and DISPOSAL of this medication?
What should I do in case of OVERDOSE?
What OTHER INFORMATION should I know?
Drug interactions

Why is this medication prescribed?

Sorafenib is used to treat advanced renal cell carcinoma (RCC; a type of cancer that begins in the kidneys). Sorafenib is also used to treat hepatocellular carcinoma (a type of liver cancer) that cannot be treated with surgery and a certain type of thyroid cancer that has spread to other parts of the body and cannot be treated with radioactive iodine. Sorafenib is in a class of medications called kinase inhibitors. It works by blocking the action of an abnormal protein that signals cancer cells to multiply. This helps stop the spread of cancer cells.

How should this medicine be used?

Sorafenib comes as a tablet to take by mouth. It is usually taken twice a day. Sorafenib is taken without food, 1 hour before or 2 hours after a meal. Take sorafenib at around the same times every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take sorafenib exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Swallow the tablets whole with water. Do not split, chew, or crush them.

Your doctor may decrease your dose of sorafenib during your treatment, or may tell you to temporarily or permanently stop taking sorafenib for a period of time if you experience side effects. Be sure to tell your doctor how you are feeling during your treatment with sorafenib.

Continue to take sorafenib even if you feel well. Do not stop taking sorafenib without talking to your doctor.

Sorafenib is not available in pharmacies. You can only get sorafenib through the mail from a specialty pharmacy. Ask your doctor if you have any questions about receiving your medication.

Ask your pharmacist or doctor for a copy of the manufacturer's information for the patient.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking sorafenib,

tell your doctor and pharmacist if you are allergic to sorafenib, any other medications, or any of the ingredients in sorafenib tablets. Ask your pharmacist for a list of the ingredients.

tell your doctor if you have lung cancer and are receiving treatment with carboplatin (Paraplatin) and paclitaxel (Abraxane, Onxol, Taxol) or gemcitabine (Gemzar) and cisplatin (Platinol). Your doctor will probably tell you not to take sorafenib if you have lung cancer and you are receiving these medications.

tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, and nutritional supplements you are taking or plan to take. Be sure to mention any of the following: certain medications for arrhythmias such as amiodarone (Nexterone, Pacerone), dofetilide (Tikosyn), dronedarone (Multaq), procainamide, quinidine (in Nuedexta), and sotalol (Betapace, Sorine, Sotylize); anticoagulants (blood thinners) such as warfarin (Coumadin, Jantoven); carbamazepine (Equetro, Tegretol, Teril); dexamethasone; ibutilide (Corvert); irinotecan (Camptosar); neomycin; phenobarbital; phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin); or rifampin (Rifadin, Rimactane). Many other medications may also interact with sorafenib, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

tell your doctor what herbal products you are taking, especially St. John's wort.

tell your doctor if you have or have ever had high blood pressure, bleeding problems, chest pain, heart problems, QT prolongation (an irregular heart rhythm that can lead to fainting, loss of consciousness, seizures, or sudden death), low levels of potassium, calcium, or magnesium in your blood, an irregular heartbeat, heart failure, kidney problems other than kidney cancer, or liver problems other than liver cancer.

tell your doctor if you are pregnant or plan to become pregnant. You will have to take a pregnancy test before starting treatment. If you are a woman who is able to become pregnant, you must use effective birth control during your treatment and for 6 months after your final dose. If you are male with a female partner who could become pregnant, you must use effective birth control during your treatment and for 3 months after your final dose. Talk to your doctor about birth control methods that will work for you. If you become pregnant while taking sorafenib, call your doctor immediately. Sorafenib may harm the fetus.

tell your doctor if you are breastfeeding or plan to breastfeed. You should not breastfeed while taking sorafenib and for 2 weeks after your final dose.

if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking sorafenib.

What special dietary instructions should I follow?

Unless your doctor tells you otherwise, continue your normal diet.

What should I do if I forget a dose?

Skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Sorafenib may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- tiredness
- weakness
- skin redness
- hair loss
- itching
- dry or peeling skin
- loss of appetite
- constipation
- diarrhea
- dry mouth
- weight loss
- joint pain
- numbness, pain or tingling in hands or feet
- headache

Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately:
- unusual bruising or bleeding
- black and/or tarry stools
- red blood in stools
- bloody vomit
- vomiting material that looks like coffee grounds
- fever
- severe stomach pain
- nausea
- vomiting
- chest pain
- shortness of breath
- dizziness or fainting
- excessive sweating
- fast, pounding, or irregular heartbeat
- sudden severe headache
- confusion
- changes in vision
- seizures
- rash
- redness, pain, swelling or blisters on the palms of the hands or soles of the feet
- skin blistering and peeling
- hives
- itching
- skin redness
- mouth sores
- dark urine
- yellowing of the skin or eyes
- pain in the upper right part of the stomach
Sorafenib may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

What should I know about STORAGE and DISPOSAL of this medication?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom).

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

What should I do in case of OVERDOSE?

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

diarrhea
rash or other skin problems

What OTHER INFORMATION should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to sorafenib. Your doctor will also check your blood pressure every week during the first six weeks of your treatment and then from time to time as needed.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug interactions

Drug	Interaction
Moxifloxacin	Moxifloxacin The metabolism of Sorafenib can be decreased when combined with Moxifloxacin.
Repaglinide	Repaglinide The metabolism of Repaglinide can be decreased when combined with Sorafenib.
Montelukast	Montelukast The metabolism of Montelukast can be decreased when combined with Sorafenib.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The metabolism of Sorafenib can be increased when combined with Insulin glargine.
Leflunomide	Leflunomide The risk or severity of adverse effects can be increased when Leflunomide is combined with Sorafenib.
Delavirdine	Delavirdine The metabolism of Sorafenib can be decreased when combined with Delavirdine.
Nevirapine	Nevirapine The metabolism of Nevirapine can be decreased when combined with Sorafenib.
Atorvastatin	Atorvastatin The metabolism of Atorvastatin can be decreased when combined with Sorafenib.
Dolasetron	Dolasetron The metabolism of Dolasetron can be decreased when combined with Sorafenib.
Aminophylline	Aminophylline The metabolism of Aminophylline can be decreased when combined with Sorafenib.
Anagrelide	Anagrelide The metabolism of Anagrelide can be decreased when combined with Sorafenib.
Candesartan	Candesartan The metabolism of Candesartan can be decreased when combined with Sorafenib.
Cilostazol	Cilostazol The serum concentration of Cilostazol can be increased when it is combined with Sorafenib.
Clopidogrel	Clopidogrel The metabolism of Clopidogrel can be decreased when combined with Sorafenib.
Erythromycin and Sulfisoxazole	Erythromycin and Sulfisoxazole The metabolism of Erythromycin can be decreased when combined with Sorafenib.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) The metabolism of Conjugated estrogens can be decreased when combined with Sorafenib.
Fenofibrate	Fenofibrate The metabolism of Fenofibrate can be decreased when combined with Sorafenib.
Guanfacine	Guanfacine Sorafenib may decrease the excretion rate of Guanfacine which could result in a higher serum level.
Magnesium Hydroxide	Magnesium Hydroxide Sorafenib may decrease the excretion rate of Magnesium hydroxide which could result in a higher serum level.
Methylergonovine	Methylergonovine The metabolism of Sorafenib can be decreased when combined with Methylergometrine.
Mycophenolate	Mycophenolate The metabolism of Mycophenolic acid can be decreased when combined with Sorafenib.
Olsalazine	Olsalazine Olsalazine may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Paregoric	Paregoric The metabolism of Morphine can be decreased when combined with Sorafenib.
Penbutolol	Penbutolol The metabolism of Acebutolol can be decreased when combined with Sorafenib.
Potassium	Potassium Potassium may increase the excretion rate of Sorafenib which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone The risk or severity of adverse effects can be increased when Sorafenib is combined with Prednisone.
Ranitidine	Ranitidine The metabolism of Ranitidine can be decreased when combined with Sorafenib.
Reserpine	Reserpine The metabolism of Sorafenib can be increased when combined with Reserpine.
Rizatriptan	Rizatriptan Sorafenib may decrease the excretion rate of Rizatriptan which could result in a higher serum level.
Sumatriptan	Sumatriptan Sorafenib may decrease the excretion rate of Sumatriptan which could result in a higher serum level.
Tacrolimus	Tacrolimus The serum concentration of Tacrolimus can be increased when it is combined with Sorafenib.
Tizanidine	Tizanidine The metabolism of Tizanidine can be decreased when combined with Sorafenib.
Triamcinolone	Triamcinolone The metabolism of Triamcinolone can be increased when combined with Sorafenib.
Zolmitriptan	Zolmitriptan The metabolism of Sorafenib can be decreased when combined with Zolmitriptan.
Ampicillin Injection	Ampicillin Injection Sorafenib may decrease the excretion rate of Ampicillin which could result in a higher serum level.
Doxycycline Injection	Doxycycline Injection The metabolism of Sorafenib can be decreased when combined with Doxycycline.
Famotidine Injection	Famotidine Injection The metabolism of Famotidine can be decreased when combined with Sorafenib.
Fluconazole Injection	Fluconazole Injection The metabolism of Sorafenib can be decreased when combined with Fluconazole.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection The metabolism of Hydromorphone can be decreased when combined with Sorafenib.
Interferon Beta-1b Injection	Interferon Beta-1b Injection The risk or severity of adverse effects can be increased when Interferon beta-1b is combined with Sorafenib.
Interferon Gamma-1b Injection	Interferon Gamma-1b Injection The risk or severity of adverse effects can be increased when Interferon gamma-1b is combined with Sorafenib.
Levofloxacin Injection	Levofloxacin Injection The metabolism of Sorafenib can be decreased when combined with Levofloxacin.
Meperidine Injection	Meperidine Injection The metabolism of Sorafenib can be increased when combined with Meperidine.
Methylprednisolone Injection	Methylprednisolone Injection The metabolism of Methylprednisolone can be increased when combined with Sorafenib.
Metoclopramide Injection	Metoclopramide Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Metoclopramide.
Metronidazole Injection	Metronidazole Injection The metabolism of Metronidazole can be decreased when combined with Sorafenib.
Morphine Injection	Morphine Injection The metabolism of Morphine can be decreased when combined with Sorafenib.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Sorafenib may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Zidovudine Injection	Zidovudine Injection The metabolism of Zidovudine can be decreased when combined with Sorafenib.
Altretamine	Altretamine The metabolism of Amphetamine can be decreased when combined with Sorafenib.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Cyclosporine	Cyclosporine Sorafenib may increase the immunosuppressive activities of Cyclosporine.
Ondansetron	Ondansetron The metabolism of Ondansetron can be decreased when combined with Sorafenib.
Enoxaparin Injection	Enoxaparin Injection The risk or severity of bleeding can be increased when Enoxaparin is combined with Sorafenib.
Granisetron	Granisetron The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Granisetron.
Torsemide	Torsemide The metabolism of Torasemide can be decreased when combined with Sorafenib.
Olanzapine	Olanzapine The metabolism of Sorafenib can be decreased when combined with Olanzapine.
Alosetron	Alosetron The metabolism of Alosetron can be decreased when combined with Sorafenib.
Dofetilide	Dofetilide The metabolism of Dofetilide can be decreased when combined with Sorafenib.
Entacapone	Entacapone The metabolism of Entacapone can be decreased when combined with Sorafenib.
Hydroxychloroquine	Hydroxychloroquine The metabolism of Hydroxychloroquine can be decreased when combined with Sorafenib.
Meloxicam	Meloxicam The metabolism of Meloxicam can be decreased when combined with Sorafenib.
Orlistat	Orlistat The metabolism of Sorafenib can be increased when combined with Orlistat.
Oxcarbazepine	Oxcarbazepine The metabolism of Sorafenib can be increased when combined with Oxcarbazepine.
Pantoprazole	Pantoprazole Pantoprazole may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Telmisartan	Telmisartan Telmisartan may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Temozolomide	Temozolomide The risk or severity of adverse effects can be increased when Sorafenib is combined with Temozolomide.
Zaleplon	Zaleplon The metabolism of Zaleplon can be decreased when combined with Sorafenib.
Anakinra	Anakinra The metabolism of Sorafenib can be increased when combined with Anakinra.
Desloratadine	Desloratadine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Desloratadine.
Linezolid	Linezolid The risk or severity of adverse effects can be increased when Sorafenib is combined with Linezolid.
Pentosan Polysulfate	Pentosan Polysulfate The risk or severity of bleeding can be increased when Pentosan polysulfate is combined with Sorafenib.
Trimipramine	Trimipramine The serum concentration of Trimipramine can be increased when it is combined with Sorafenib.
Etanercept Injection	Etanercept Injection The metabolism of Sorafenib can be increased when combined with Etanercept.
Modafinil	Modafinil The metabolism of Sorafenib can be increased when combined with Modafinil.
Perindopril	Perindopril Sorafenib may decrease the excretion rate of Perindopril which could result in a higher serum level.
Tenofovir	Tenofovir The metabolism of Sorafenib can be decreased when combined with Tenofovir.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate Choline magnesium trisalicylate may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Sirolimus	Sirolimus The serum concentration of Sirolimus can be increased when it is combined with Sorafenib.
Dutasteride	Dutasteride The metabolism of Dutasteride can be decreased when combined with Sorafenib.
Epinephrine Injection	Epinephrine Injection The metabolism of Sorafenib can be decreased when combined with Epinephrine.
Epirubicin	Epirubicin The risk or severity of adverse effects can be increased when Epirubicin is combined with Sorafenib.
Eplerenone	Eplerenone The metabolism of Eplerenone can be decreased when combined with Sorafenib.
Escitalopram	Escitalopram The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Escitalopram.
Zonisamide	Zonisamide The metabolism of Zonisamide can be decreased when combined with Sorafenib.
Adalimumab Injection	Adalimumab Injection The metabolism of Sorafenib can be increased when combined with Adalimumab.
Aripiprazole	Aripiprazole The metabolism of Aripiprazole can be decreased when combined with Sorafenib.
Atomoxetine	Atomoxetine The metabolism of Atomoxetine can be decreased when combined with Sorafenib.
Ezetimibe	Ezetimibe The metabolism of Ezetimibe can be decreased when combined with Sorafenib.
Glatiramer Injection	Glatiramer Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Glatiramer.
Teriparatide Injection	Teriparatide Injection The therapeutic efficacy of Teriparatide can be decreased when used in combination with Sorafenib.
Atazanavir	Atazanavir The metabolism of Atazanavir can be decreased when combined with Sorafenib.
Almotriptan	Almotriptan The metabolism of Almotriptan can be decreased when combined with Sorafenib.
Eletriptan	Eletriptan The metabolism of Eletriptan can be decreased when combined with Sorafenib.
Mefloquine	Mefloquine The metabolism of Sorafenib can be decreased when combined with Mefloquine.
Rosuvastatin	Rosuvastatin The metabolism of Rosuvastatin can be decreased when combined with Sorafenib.
Vardenafil	Vardenafil The metabolism of Vardenafil can be decreased when combined with Sorafenib.
Alfuzosin	Alfuzosin The metabolism of Alfuzosin can be decreased when combined with Sorafenib.
Aprepitant	Aprepitant The metabolism of Sorafenib can be decreased when combined with Aprepitant.
Emtricitabine	Emtricitabine Sorafenib may decrease the excretion rate of Emtricitabine which could result in a higher serum level.
Interferon Beta-1a Subcutaneous Injection	Interferon Beta-1a Subcutaneous Injection The metabolism of Sorafenib can be decreased when combined with Interferon beta-1a.
Memantine	Memantine Sorafenib may decrease the excretion rate of Memantine which could result in a higher serum level.
Tegaserod	Tegaserod The metabolism of Sorafenib can be decreased when combined with Tegaserod.
Tadalafil	Tadalafil The metabolism of Tadalafil can be decreased when combined with Sorafenib.
Frovatriptan	Frovatriptan The metabolism of Frovatriptan can be decreased when combined with Sorafenib.
Gemifloxacin	Gemifloxacin The metabolism of Gemifloxacin can be decreased when combined with Sorafenib.
Progesterone	Progesterone The metabolism of Progesterone can be increased when combined with Sorafenib.
Apomorphine Injection	Apomorphine Injection The metabolism of Apomorphine can be decreased when combined with Sorafenib.
Darbepoetin Alfa Injection	Darbepoetin Alfa Injection The risk or severity of Thrombosis can be increased when Darbepoetin alfa is combined with Sorafenib.
Infliximab Injection	Infliximab Injection The metabolism of Sorafenib can be increased when combined with Infliximab.
Protriptyline	Protriptyline The risk or severity of QTc prolongation can be increased when Protriptyline is combined with Sorafenib.
Rifaximin	Rifaximin The serum concentration of Rifaximin can be increased when it is combined with Sorafenib.
Duloxetine	Duloxetine The metabolism of Duloxetine can be decreased when combined with Sorafenib.
Norethindrone	Norethindrone The metabolism of Norethisterone can be decreased when combined with Sorafenib.
Tinidazole	Tinidazole Sorafenib may decrease the excretion rate of Tinidazole which could result in a higher serum level.
Bosentan	Bosentan The metabolism of Bosentan can be increased when combined with Sorafenib.
Cefditoren	Cefditoren Sorafenib may decrease the excretion rate of Cefdinir which could result in a higher serum level.
Cinacalcet	Cinacalcet The metabolism of Cinacalcet can be decreased when combined with Sorafenib.
Natalizumab Injection	Natalizumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Natalizumab.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Erlotinib	Erlotinib The metabolism of Erlotinib can be decreased when combined with Sorafenib.
Eszopiclone	Eszopiclone The metabolism of Eszopiclone can be decreased when combined with Sorafenib.
Ganciclovir	Ganciclovir Sorafenib may decrease the excretion rate of Ganciclovir which could result in a higher serum level.
Palifermin	Palifermin The therapeutic efficacy of Palifermin can be decreased when used in combination with Sorafenib.
Ribavirin	Ribavirin Sorafenib may decrease the excretion rate of Ribavirin which could result in a higher serum level.
Solifenacin	Solifenacin The metabolism of Solifenacin can be decreased when combined with Sorafenib.
Valganciclovir	Valganciclovir Sorafenib may decrease the excretion rate of Valganciclovir which could result in a higher serum level.
Voriconazole	Voriconazole The metabolism of Voriconazole can be decreased when combined with Sorafenib.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine The metabolism of Amphetamine can be decreased when combined with Sorafenib.
Entecavir	Entecavir The metabolism of Entecavir can be decreased when combined with Sorafenib.
Peginterferon Alfa-2a Injection	Peginterferon Alfa-2a Injection The risk or severity of adverse effects can be increased when Peginterferon alfa-2a is combined with Sorafenib.
Peginterferon Alfa-2b (PEG-Intron)	Peginterferon Alfa-2b (PEG-Intron) The serum concentration of Sorafenib can be increased when it is combined with Peginterferon alfa-2b.
Ibandronate	Ibandronate The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Ibandronate.
Ramelteon	Ramelteon The metabolism of Ramelteon can be decreased when combined with Sorafenib.
Darifenacin	Darifenacin The metabolism of Darifenacin can be decreased when combined with Sorafenib.
Fentanyl	Fentanyl The metabolism of Fentanyl can be decreased when combined with Sorafenib.
Pregabalin	Pregabalin The risk or severity of QTc prolongation can be increased when Pregabalin is combined with Sorafenib.
Deferasirox	Deferasirox The serum concentration of Sorafenib can be increased when it is combined with Deferasirox.
Phenylephrine	Phenylephrine The metabolism of Sorafenib can be increased when combined with Phenylephrine.
Tipranavir	Tipranavir The metabolism of Tipranavir can be decreased when combined with Sorafenib.
Felbamate	Felbamate The metabolism of Felbamate can be increased when combined with Sorafenib.
Ranolazine	Ranolazine The serum concentration of Ranolazine can be increased when it is combined with Sorafenib.
Abatacept Injection	Abatacept Injection The metabolism of Sorafenib can be increased when combined with Abatacept.
Rasagiline	Rasagiline The metabolism of Rasagiline can be decreased when combined with Sorafenib.
Imatinib	Imatinib The metabolism of Imatinib can be decreased when combined with Sorafenib.
Sitagliptin	Sitagliptin The metabolism of Sitagliptin can be decreased when combined with Sorafenib.
Varenicline	Varenicline Sorafenib may decrease the excretion rate of Varenicline which could result in a higher serum level.
Bevacizumab Injection	Bevacizumab Injection The risk or severity of adverse effects can be increased when Bevacizumab is combined with Sorafenib.
Gefitinib	Gefitinib The metabolism of Sorafenib can be decreased when combined with Gefitinib.
Albuterol	Albuterol The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Salbutamol.
Paliperidone	Paliperidone The metabolism of Paliperidone can be decreased when combined with Sorafenib.
Bortezomib	Bortezomib The metabolism of Sorafenib can be decreased when combined with Bortezomib.
Clofarabine Injection	Clofarabine Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Clofarabine.
Hepatitis B Vaccine	Hepatitis B Vaccine The therapeutic efficacy of Hepatitis B Vaccine (Recombinant) can be decreased when used in combination with Sorafenib.
Influenza Vaccine, Inactivated or Recombinant	Influenza Vaccine, Inactivated or Recombinant The therapeutic efficacy of Corynebacterium diphtheriae toxoid antigen (formaldehyde inactivated) can be decreased when used in combination with Sorafenib.
Influenza Vaccine, Live Intranasal	Influenza Vaccine, Live Intranasal The risk or severity of infection can be increased when Typhoid Vaccine Live is combined with Sorafenib.
Live Shingles (Zoster) Vaccine (ZVL)	Live Shingles (Zoster) Vaccine (ZVL) The risk or severity of infection can be increased when Varicella Zoster Vaccine (Live/attenuated) is combined with Sorafenib.
Fulvestrant Injection	Fulvestrant Injection The metabolism of Fulvestrant can be decreased when combined with Sorafenib.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The metabolism of Sorafenib can be increased when combined with Insulin glulisine.
Lubiprostone	Lubiprostone Sorafenib may decrease the excretion rate of Lubiprostone which could result in a higher serum level.
Oxaliplatin Injection	Oxaliplatin Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Oxaliplatin.
Posaconazole	Posaconazole The metabolism of Posaconazole can be decreased when combined with Sorafenib.
Primaquine	Primaquine The metabolism of Sorafenib can be decreased when combined with Primaquine.
Rituximab Injection	Rituximab Injection The risk or severity of adverse effects can be increased when Rituximab is combined with Sorafenib.
Darunavir	Darunavir The serum concentration of Sorafenib can be increased when it is combined with Darunavir.
Pemetrexed Injection	Pemetrexed Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Pemetrexed.
Dimenhydrinate	Dimenhydrinate The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Dimenhydrinate.
Lisdexamfetamine	Lisdexamfetamine The metabolism of Lisdexamfetamine can be decreased when combined with Sorafenib.
Nabilone	Nabilone The metabolism of Sorafenib can be decreased when combined with Nabilone.
Retapamulin	Retapamulin The metabolism of Retapamulin can be decreased when combined with Sorafenib.
Vorinostat	Vorinostat The risk or severity of adverse effects can be increased when Sorafenib is combined with Vorinostat.
Sunitinib	Sunitinib The metabolism of Sunitinib can be decreased when combined with Sorafenib.
Dronabinol	Dronabinol The metabolism of Dronabinol can be decreased when combined with Sorafenib.
Lapatinib	Lapatinib The metabolism of Lapatinib can be decreased when combined with Sorafenib.
Levocetirizine	Levocetirizine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Levocetirizine.
Pegaptanib Injection	Pegaptanib Injection Sorafenib may decrease the excretion rate of Pegaptanib which could result in a higher serum level.
Dasatinib	Dasatinib The metabolism of Dasatinib can be decreased when combined with Sorafenib.
Mexiletine	Mexiletine The metabolism of Sorafenib can be decreased when combined with Mexiletine.
Armodafinil	Armodafinil The metabolism of Sorafenib can be increased when combined with Armodafinil.
Azacitidine Injection	Azacitidine Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Azacitidine.
Ivermectin	Ivermectin The metabolism of Ivermectin can be increased when combined with Sorafenib.
Temsirolimus	Temsirolimus The serum concentration of Temsirolimus can be increased when it is combined with Sorafenib.
Nelarabine Injection	Nelarabine Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Nelarabine.
Lenalidomide	Lenalidomide The risk or severity of adverse effects can be increased when Sorafenib is combined with Lenalidomide.
Nilotinib	Nilotinib The metabolism of Nilotinib can be decreased when combined with Sorafenib.
Toremifene	Toremifene The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Toremifene.
Raltegravir	Raltegravir The metabolism of Raltegravir can be decreased when combined with Sorafenib.
Bexarotene	Bexarotene The metabolism of Sorafenib can be increased when combined with Bexarotene.
Budesonide	Budesonide The metabolism of Sorafenib can be increased when combined with Budesonide.
Chloramphenicol Injection	Chloramphenicol Injection The metabolism of Chloramphenicol can be decreased when combined with Sorafenib.
Decitabine Injection	Decitabine Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Decitabine.
Desmopressin	Desmopressin Desmopressin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Doripenem Injection	Doripenem Injection Sorafenib may decrease the excretion rate of Doripenem which could result in a higher serum level.
Etravirine	Etravirine The metabolism of Etravirine can be increased when combined with Sorafenib.
Arsenic Trioxide Injection	Arsenic Trioxide Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Arsenic trioxide.
Mitoxantrone Injection	Mitoxantrone Injection The metabolism of Mitoxantrone can be decreased when combined with Sorafenib.
Desvenlafaxine	Desvenlafaxine The metabolism of Desvenlafaxine can be decreased when combined with Sorafenib.
Cevimeline	Cevimeline The metabolism of Sorafenib can be decreased when combined with Cevimeline.
Nebivolol	Nebivolol The metabolism of Nebivolol can be decreased when combined with Sorafenib.
Tretinoin	Tretinoin The metabolism of Tretinoin can be decreased when combined with Sorafenib.
Bendamustine Injection	Bendamustine Injection The serum concentration of Bendamustine can be increased when it is combined with Sorafenib.
Pilocarpine	Pilocarpine The metabolism of Sorafenib can be decreased when combined with Pilocarpine.
Flecainide	Flecainide The metabolism of Flecainide can be decreased when combined with Sorafenib.
Certolizumab Injection	Certolizumab Injection The metabolism of Sorafenib can be increased when combined with Certolizumab pegol.
Ixabepilone Injection	Ixabepilone Injection The metabolism of Ixabepilone can be decreased when combined with Sorafenib.
Irinotecan Injection	Irinotecan Injection The risk or severity of neutropenia can be increased when Sorafenib is combined with Irinotecan.
Daptomycin Injection	Daptomycin Injection Daptomycin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Estramustine	Estramustine The risk or severity of adverse effects can be increased when Sorafenib is combined with Estramustine.
Praziquantel	Praziquantel The metabolism of Praziquantel can be decreased when combined with Sorafenib.
Mitotane	Mitotane The metabolism of Sorafenib can be increased when combined with Mitotane.
Methylnaltrexone Injection	Methylnaltrexone Injection Sorafenib may decrease the excretion rate of Methylnaltrexone which could result in a higher serum level.
Alemtuzumab Injection (Chronic Lymphocytic Leukemia)	Alemtuzumab Injection (Chronic Lymphocytic Leukemia) The risk or severity of adverse effects can be increased when Alemtuzumab is combined with Sorafenib.
Rufinamide	Rufinamide The metabolism of Rufinamide can be increased when combined with Sorafenib.
Silodosin	Silodosin The serum concentration of Silodosin can be increased when it is combined with Sorafenib.
Midazolam	Midazolam The serum concentration of Midazolam can be increased when it is combined with Sorafenib.
Naltrexone Injection	Naltrexone Injection The metabolism of Naltrexone can be decreased when combined with Sorafenib.
Dexrazoxane Injection	Dexrazoxane Injection The risk or severity of adverse effects can be increased when Dexrazoxane is combined with Sorafenib.
Eltrombopag	Eltrombopag The metabolism of Eltrombopag can be decreased when combined with Sorafenib.
Ibritumomab Injection	Ibritumomab Injection The risk or severity of adverse effects can be increased when Ibritumomab tiuxetan is combined with Sorafenib.
Milnacipran	Milnacipran The metabolism of Milnacipran can be decreased when combined with Sorafenib.
Dexlansoprazole	Dexlansoprazole The metabolism of Dexlansoprazole can be decreased when combined with Sorafenib.
Plerixafor Injection	Plerixafor Injection Sorafenib may decrease the excretion rate of Plerixafor which could result in a higher serum level.
Fesoterodine	Fesoterodine The metabolism of Fesoterodine can be decreased when combined with Sorafenib.
Degarelix Injection	Degarelix Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Degarelix.
Betaxolol	Betaxolol The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Betaxolol.
Iloperidone	Iloperidone The metabolism of Iloperidone can be decreased when combined with Sorafenib.
Prasugrel	Prasugrel The metabolism of Prasugrel can be decreased when combined with Sorafenib.
Lacosamide	Lacosamide The metabolism of Lacosamide can be decreased when combined with Sorafenib.
Everolimus	Everolimus The serum concentration of Everolimus can be increased when it is combined with Sorafenib.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) The serum concentration of Tolvaptan can be increased when it is combined with Sorafenib.
Dronedarone	Dronedarone The serum concentration of Dronedarone can be increased when it is combined with Sorafenib.
Pralatrexate Injection	Pralatrexate Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Pralatrexate.
Palonosetron Injection	Palonosetron Injection The metabolism of Sorafenib can be decreased when combined with Palonosetron.
Saxagliptin	Saxagliptin The metabolism of Saxagliptin can be decreased when combined with Sorafenib.
Telavancin Injection	Telavancin Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Telavancin.
Romidepsin Injection	Romidepsin Injection The metabolism of Romidepsin can be decreased when combined with Sorafenib.
Tapentadol	Tapentadol The metabolism of Tapentadol can be decreased when combined with Sorafenib.
Topotecan	Topotecan The serum concentration of Topotecan can be increased when it is combined with Sorafenib.
Golimumab Injection	Golimumab Injection The metabolism of Sorafenib can be increased when combined with Golimumab.
Pazopanib	Pazopanib The serum concentration of Pazopanib can be increased when it is combined with Sorafenib.
Asenapine	Asenapine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Asenapine.
Pitavastatin	Pitavastatin The metabolism of Pitavastatin can be decreased when combined with Sorafenib.
Albendazole	Albendazole The metabolism of Albendazole can be decreased when combined with Sorafenib.
Levonorgestrel	Levonorgestrel The metabolism of Sorafenib can be decreased when combined with Levonorgestrel.
Oxymorphone	Oxymorphone The metabolism of Oxymorphone can be decreased when combined with Sorafenib.
Denosumab Injection	Denosumab Injection The risk or severity of adverse effects can be increased when Denosumab is combined with Sorafenib.
Dabigatran	Dabigatran The risk or severity of bleeding can be increased when Dabigatran is combined with Sorafenib.
Tocilizumab Injection	Tocilizumab Injection The metabolism of Sorafenib can be increased when combined with Tocilizumab.
Dalfampridine	Dalfampridine Sorafenib may decrease the excretion rate of Dalfampridine which could result in a higher serum level.
Fingolimod	Fingolimod Sorafenib may increase the immunosuppressive activities of Fingolimod.
Eribulin Injection	Eribulin Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Eribulin.
Cabazitaxel Injection	Cabazitaxel Injection The serum concentration of Cabazitaxel can be increased when it is combined with Sorafenib.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Lurasidone	Lurasidone The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Lurasidone.
Acetaminophen Injection	Acetaminophen Injection The metabolism of Sorafenib can be increased when combined with Acetaminophen.
Vilazodone	Vilazodone The metabolism of Vilazodone can be decreased when combined with Sorafenib.
Ipilimumab Injection	Ipilimumab Injection Sorafenib may decrease the excretion rate of Ipilimumab which could result in a higher serum level.
Denileukin Diftitox Injection	Denileukin Diftitox Injection The metabolism of Sorafenib can be decreased when combined with Aldesleukin.
Sipuleucel-T Injection	Sipuleucel-T Injection The therapeutic efficacy of Sipuleucel-T can be decreased when used in combination with Sorafenib.
Terbutaline Injection	Terbutaline Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Terbutaline.
Belimumab Injection	Belimumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Belimumab.
Busulfan Injection	Busulfan Injection The metabolism of Busulfan can be decreased when combined with Sorafenib.
Roflumilast	Roflumilast Roflumilast may increase the immunosuppressive activities of Sorafenib.
Linagliptin	Linagliptin The metabolism of Linagliptin can be decreased when combined with Sorafenib.
Rilpivirine	Rilpivirine The metabolism of Sorafenib can be decreased when combined with Rilpivirine.
Telaprevir	Telaprevir The metabolism of Glecaprevir can be decreased when combined with Sorafenib.
Potassium Iodide	Potassium Iodide The therapeutic efficacy of Potassium Iodide can be decreased when used in combination with Sorafenib.
Cyclophosphamide Injection	Cyclophosphamide Injection The metabolism of Cyclophosphamide can be increased when combined with Sorafenib.
Abiraterone	Abiraterone The serum concentration of Sorafenib can be increased when it is combined with Abiraterone.
Triptorelin Injection	Triptorelin Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Triptorelin.
Rivaroxaban	Rivaroxaban The metabolism of Rivaroxaban can be decreased when combined with Sorafenib.
Ticagrelor	Ticagrelor The metabolism of Ticagrelor can be decreased when combined with Sorafenib.
Brentuximab Vedotin Injection	Brentuximab Vedotin Injection The serum concentration of Brentuximab vedotin can be increased when it is combined with Sorafenib.
Ruxolitinib	Ruxolitinib The metabolism of Ruxolitinib can be decreased when combined with Sorafenib.
Vandetanib	Vandetanib The metabolism of Vandetanib can be decreased when combined with Sorafenib.
Clobazam	Clobazam The metabolism of Clobazam can be increased when combined with Sorafenib.
Vemurafenib	Vemurafenib The serum concentration of Vemurafenib can be increased when it is combined with Sorafenib.
Vismodegib	Vismodegib The metabolism of Vismodegib can be decreased when combined with Sorafenib.
Belatacept Injection	Belatacept Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Belatacept.
Ivacaftor	Ivacaftor The metabolism of Ivacaftor can be decreased when combined with Sorafenib.
Basiliximab Injection	Basiliximab Injection The risk or severity of adverse effects can be increased when Basiliximab is combined with Sorafenib.
Deferiprone	Deferiprone Sorafenib may decrease the excretion rate of Deferiprone which could result in a higher serum level.
Axitinib	Axitinib The metabolism of Axitinib can be decreased when combined with Sorafenib.
Crizotinib	Crizotinib The metabolism of Crizotinib can be decreased when combined with Sorafenib.
Melphalan Injection	Melphalan Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Melphalan.
Cabergoline	Cabergoline The metabolism of Sorafenib can be decreased when combined with Cabergoline.
Naloxone Injection	Naloxone Injection The metabolism of Naloxone can be decreased when combined with Sorafenib.
Ambrisentan	Ambrisentan The metabolism of Ambrisentan can be decreased when combined with Sorafenib.
Eculizumab Injection	Eculizumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Eculizumab.
Fondaparinux Injection	Fondaparinux Injection Sorafenib may decrease the excretion rate of Fondaparinux which could result in a higher serum level.
Ezogabine	Ezogabine The metabolism of Tiagabine can be decreased when combined with Sorafenib.
Carfilzomib Injection	Carfilzomib Injection The serum concentration of Carfilzomib can be increased when it is combined with Sorafenib.
Iloprost	Iloprost The risk or severity of bleeding can be increased when Iloprost is combined with Sorafenib.
Enzalutamide	Enzalutamide The serum concentration of Enzalutamide can be increased when it is combined with Sorafenib.
Mirabegron	Mirabegron The serum concentration of Mirabegron can be increased when it is combined with Sorafenib.
Regorafenib	Regorafenib The metabolism of Regorafenib can be decreased when combined with Sorafenib.
Bosutinib	Bosutinib The serum concentration of Bosutinib can be increased when it is combined with Sorafenib.
Corticotropin, Repository Injection	Corticotropin, Repository Injection The metabolism of Corticotropin can be increased when combined with Sorafenib.
Teriflunomide	Teriflunomide The serum concentration of Sorafenib can be decreased when it is combined with Teriflunomide.
Cabozantinib (thyroid cancer)	Cabozantinib (thyroid cancer) The metabolism of Cabozantinib can be decreased when combined with Sorafenib.
Teduglutide Injection	Teduglutide Injection Sorafenib may decrease the excretion rate of Teduglutide which could result in a higher serum level.
Bedaquiline	Bedaquiline The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Bedaquiline.
Icosapent Ethyl	Icosapent Ethyl The risk or severity of bleeding can be increased when Icosapent ethyl is combined with Sorafenib.
Tofacitinib	Tofacitinib The metabolism of Tofacitinib can be decreased when combined with Sorafenib.
Alogliptin	Alogliptin The metabolism of Alogliptin can be decreased when combined with Sorafenib.
Dimethyl Fumarate	Dimethyl Fumarate The risk or severity of adverse effects can be increased when Sorafenib is combined with Dimethyl fumarate.
Ponatinib	Ponatinib The metabolism of Ponatinib can be decreased when combined with Sorafenib.
Pomalidomide	Pomalidomide The serum concentration of Pomalidomide can be increased when it is combined with Sorafenib.
Ado-trastuzumab Emtansine Injection	Ado-trastuzumab Emtansine Injection The serum concentration of Trastuzumab emtansine can be increased when it is combined with Sorafenib.
Apixaban	Apixaban The metabolism of Apixaban can be decreased when combined with Sorafenib.
Canagliflozin	Canagliflozin The metabolism of Canagliflozin can be decreased when combined with Sorafenib.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Sorafenib which could result in a lower serum level and potentially a reduction in efficacy.
Dabrafenib	Dabrafenib The serum concentration of Dabrafenib can be increased when it is combined with Sorafenib.
Ospemifene	Ospemifene The metabolism of Ospemifene can be decreased when combined with Sorafenib.
Trametinib	Trametinib The metabolism of Sorafenib can be increased when combined with Trametinib.
Dolutegravir	Dolutegravir The metabolism of Dolutegravir can be decreased when combined with Sorafenib.
Afatinib	Afatinib The serum concentration of Afatinib can be increased when it is combined with Sorafenib.
Levomilnacipran	Levomilnacipran The metabolism of Levomilnacipran can be decreased when combined with Sorafenib.
Ertapenem Injection	Ertapenem Injection Ertapenem may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Vortioxetine	Vortioxetine The metabolism of Vortioxetine can be decreased when combined with Sorafenib.
Perampanel	Perampanel The metabolism of Perampanel can be increased when combined with Sorafenib.
Ibrutinib	Ibrutinib The metabolism of Ibrutinib can be decreased when combined with Sorafenib.
Lomitapide	Lomitapide The metabolism of Lomitapide can be decreased when combined with Sorafenib.
Ketorolac Injection	Ketorolac Injection The metabolism of Sorafenib can be decreased when combined with Ketorolac.
Obinutuzumab Injection	Obinutuzumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Obinutuzumab.
Simeprevir	Simeprevir The metabolism of Sorafenib can be decreased when combined with Simeprevir.
Sofosbuvir	Sofosbuvir The serum concentration of Sofosbuvir can be increased when it is combined with Sorafenib.
Dapagliflozin	Dapagliflozin The metabolism of Dapagliflozin can be decreased when combined with Sorafenib.
Apremilast	Apremilast The metabolism of Sorafenib can be increased when combined with Apremilast.
Droxidopa	Droxidopa Sorafenib may decrease the excretion rate of Droxidopa which could result in a higher serum level.
Ceritinib	Ceritinib The serum concentration of Ceritinib can be increased when it is combined with Sorafenib.
Siltuximab Injection	Siltuximab Injection The metabolism of Sorafenib can be increased when combined with Siltuximab.
Eslicarbazepine	Eslicarbazepine The metabolism of Eslicarbazepine can be increased when combined with Sorafenib.
Vedolizumab Injection	Vedolizumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Vedolizumab.
Belinostat Injection	Belinostat Injection The metabolism of Belinostat can be decreased when combined with Sorafenib.
Idelalisib	Idelalisib The metabolism of Idelalisib can be decreased when combined with Sorafenib.
Testosterone Injection	Testosterone Injection The metabolism of Testosterone can be increased when combined with Sorafenib.
Oritavancin Injection	Oritavancin Injection The metabolism of Sorafenib can be increased when combined with Oritavancin.
Vorapaxar	Vorapaxar The metabolism of Vorapaxar can be decreased when combined with Sorafenib.
Hydrocodone	Hydrocodone The metabolism of Hydrocodone can be decreased when combined with Sorafenib.
Suvorexant	Suvorexant The metabolism of Suvorexant can be decreased when combined with Sorafenib.
Edoxaban	Edoxaban The serum concentration of Edoxaban can be increased when it is combined with Sorafenib.
Peginterferon Beta-1a Injection	Peginterferon Beta-1a Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Peginterferon beta-1a.
Olaparib	Olaparib The metabolism of Olaparib can be decreased when combined with Sorafenib.
Blinatumomab Injection	Blinatumomab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Blinatumomab.
Caspofungin Injection	Caspofungin Injection The excretion of Caspofungin can be decreased when combined with Sorafenib.
Methamphetamine	Methamphetamine The metabolism of Metamfetamine can be decreased when combined with Sorafenib.
Tasimelteon	Tasimelteon The metabolism of Tasimelteon can be decreased when combined with Sorafenib.
Riociguat	Riociguat The metabolism of Riociguat can be decreased when combined with Sorafenib.
Lanreotide Injection	Lanreotide Injection The metabolism of Sorafenib can be decreased when combined with Lanreotide.
Pirfenidone	Pirfenidone The risk or severity of adverse effects can be increased when Sorafenib is combined with Pirfenidone.
Nintedanib	Nintedanib The metabolism of Nintedanib can be decreased when combined with Sorafenib.
Secukinumab Injection	Secukinumab Injection The metabolism of Sorafenib can be increased when combined with Secukinumab.
Risperidone Injection	Risperidone Injection The metabolism of Risperidone can be decreased when combined with Sorafenib.
Palbociclib	Palbociclib The metabolism of Palbociclib can be decreased when combined with Sorafenib.
Insulin Human Inhalation	Insulin Human Inhalation The metabolism of Sorafenib can be increased when combined with Insulin human.
Lenvatinib	Lenvatinib The metabolism of Sorafenib can be increased when combined with Lenvatinib.
Naloxegol	Naloxegol The serum concentration of Naloxegol can be increased when it is combined with Sorafenib.
Panobinostat	Panobinostat The metabolism of Panobinostat can be decreased when combined with Sorafenib.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Dinutuximab.
Haloperidol Injection	Haloperidol Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Haloperidol.
Ivabradine	Ivabradine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Ivabradine.
Amiloride	Amiloride Amiloride may increase the excretion rate of Sorafenib which could result in a lower serum level and potentially a reduction in efficacy.
Isavuconazonium Injection	Isavuconazonium Injection The metabolism of Sorafenib can be increased when combined with Isavuconazonium.
Macitentan	Macitentan Sorafenib may decrease the excretion rate of Macitentan which could result in a higher serum level.
Sonidegib	Sonidegib The metabolism of Sonidegib can be decreased when combined with Sorafenib.
Rolapitant	Rolapitant Rolapitant may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Prednisolone	Prednisolone The metabolism of Prednisolone can be increased when combined with Sorafenib.
Daclatasvir	Daclatasvir The metabolism of Sorafenib can be decreased when combined with Daclatasvir.
Brexpiprazole	Brexpiprazole The metabolism of Brexpiprazole can be decreased when combined with Sorafenib.
Ziprasidone Injection	Ziprasidone Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Ziprasidone.
Cariprazine	Cariprazine The metabolism of Cariprazine can be decreased when combined with Sorafenib.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Sorafenib may decrease the excretion rate of Procaine benzylpenicillin which could result in a higher serum level.
Eluxadoline	Eluxadoline The serum concentration of Eluxadoline can be increased when it is combined with Sorafenib.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The metabolism of Sorafenib can be increased when combined with Insulin degludec.
Cobimetinib	Cobimetinib The serum concentration of Cobimetinib can be increased when it is combined with Sorafenib.
Mepolizumab Injection	Mepolizumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Mepolizumab.
Trabectedin Injection	Trabectedin Injection The metabolism of Trabectedin can be decreased when combined with Sorafenib.
Osimertinib	Osimertinib The serum concentration of Sorafenib can be decreased when it is combined with Osimertinib.
Alectinib	Alectinib The metabolism of Sorafenib can be decreased when combined with Alectinib.
Ixazomib	Ixazomib The metabolism of Ixazomib can be decreased when combined with Sorafenib.
Rifapentine	Rifapentine The metabolism of Sorafenib can be increased when combined with Rifapentine.
Lesinurad	Lesinurad The metabolism of Lesinurad can be increased when combined with Sorafenib.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection The metabolism of Sorafenib can be decreased when combined with Amphotericin B.
Dexamethasone Injection	Dexamethasone Injection The metabolism of Dexamethasone can be increased when combined with Sorafenib.
Defibrotide Injection	Defibrotide Injection The risk or severity of bleeding can be increased when Defibrotide is combined with Sorafenib.
Ixekizumab Injection	Ixekizumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Ixekizumab.
Brivaracetam Injection	Brivaracetam Injection The metabolism of Brivaracetam can be decreased when combined with Sorafenib.
Venetoclax	Venetoclax The metabolism of Venetoclax can be decreased when combined with Sorafenib.
Cobicistat	Cobicistat The metabolism of Sorafenib can be decreased when combined with Cobicistat.
Selexipag	Selexipag The metabolism of Selexipag can be decreased when combined with Sorafenib.
Obeticholic Acid	Obeticholic Acid The risk or severity of adverse effects can be increased when Obeticholic acid is combined with Sorafenib.
Diphenhydramine Injection	Diphenhydramine Injection The metabolism of Diphenhydramine can be decreased when combined with Sorafenib.
Furosemide Injection	Furosemide Injection The metabolism of Furosemide can be decreased when combined with Sorafenib.
Rucaparib	Rucaparib The metabolism of Rucaparib can be decreased when combined with Sorafenib.
Lixisenatide Injection	Lixisenatide Injection Sorafenib may decrease the excretion rate of Lixisenatide which could result in a higher serum level.
Ribociclib	Ribociclib The metabolism of Ribociclib can be decreased when combined with Sorafenib.
Brodalumab Injection	Brodalumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Brodalumab.
Parathyroid Hormone Injection	Parathyroid Hormone Injection The therapeutic efficacy of Parathyroid hormone can be decreased when used in combination with Sorafenib.
Brigatinib	Brigatinib The metabolism of Brigatinib can be increased when combined with Sorafenib.
Doxepin (Insomnia)	Doxepin (Insomnia) The metabolism of Doxepin can be decreased when combined with Sorafenib.
Deutetrabenazine	Deutetrabenazine The metabolism of Deutetrabenazine can be decreased when combined with Sorafenib.
Valbenazine	Valbenazine The metabolism of Valbenazine can be decreased when combined with Sorafenib.
Deflazacort	Deflazacort The metabolism of Deflazacort can be increased when combined with Sorafenib.
Safinamide	Safinamide The metabolism of Sorafenib can be decreased when combined with Safinamide.
Ocrelizumab Injection	Ocrelizumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Ocrelizumab.
Naldemedine	Naldemedine Sorafenib may decrease the excretion rate of Naldemedine which could result in a higher serum level.
Sarilumab Injection	Sarilumab Injection The metabolism of Sarilumab can be increased when combined with Sorafenib.
Midostaurin	Midostaurin The metabolism of Sorafenib can be increased when combined with Midostaurin.
Neratinib	Neratinib The metabolism of Neratinib can be decreased when combined with Sorafenib.
Guselkumab Injection	Guselkumab Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Guselkumab.
Abaloparatide Injection	Abaloparatide Injection The therapeutic efficacy of Abaloparatide can be decreased when used in combination with Sorafenib.
Enasidenib	Enasidenib The metabolism of Enasidenib can be decreased when combined with Sorafenib.
Inotuzumab Ozogamicin Injection	Inotuzumab Ozogamicin Injection The serum concentration of Inotuzumab ozogamicin can be increased when it is combined with Sorafenib.
Aprepitant/Fosaprepitant Injection	Aprepitant/Fosaprepitant Injection The metabolism of Fosaprepitant can be increased when combined with Sorafenib.
Benznidazole	Benznidazole Sorafenib may decrease the excretion rate of Benznidazole which could result in a higher serum level.
Copanlisib Injection	Copanlisib Injection The serum concentration of Copanlisib can be increased when it is combined with Sorafenib.
Delafloxacin	Delafloxacin The metabolism of Delafloxacin can be decreased when combined with Sorafenib.
Abemaciclib	Abemaciclib The metabolism of Abemaciclib can be decreased when combined with Sorafenib.
Betrixaban	Betrixaban The serum concentration of Betrixaban can be increased when it is combined with Sorafenib.
Acalabrutinib	Acalabrutinib The metabolism of Sorafenib can be decreased when combined with Acalabrutinib.
Gemtuzumab Ozogamicin Injection	Gemtuzumab Ozogamicin Injection The risk or severity of adverse effects can be increased when Gemtuzumab ozogamicin is combined with Sorafenib.
Letermovir	Letermovir The metabolism of Letermovir can be decreased when combined with Sorafenib.
Tetrabenazine	Tetrabenazine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Tetrabenazine.
Ertugliflozin	Ertugliflozin The metabolism of Ertugliflozin can be decreased when combined with Sorafenib.
Buprenorphine Injection	Buprenorphine Injection The metabolism of Buprenorphine can be decreased when combined with Sorafenib.
Apalutamide	Apalutamide The serum concentration of Apalutamide can be increased when it is combined with Sorafenib.
Penicillamine	Penicillamine The risk or severity of adverse effects can be increased when Sorafenib is combined with Penicillamine.
Fostamatinib	Fostamatinib The metabolism of Fostamatinib can be decreased when combined with Sorafenib.
Avatrombopag	Avatrombopag The metabolism of Avatrombopag can be increased when combined with Sorafenib.
Baricitinib	Baricitinib The metabolism of Baricitinib can be decreased when combined with Sorafenib.
Lofexidine	Lofexidine The metabolism of Lofexidine can be decreased when combined with Sorafenib.
Plazomicin Injection	Plazomicin Injection Sorafenib may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Eliglustat	Eliglustat The metabolism of Eliglustat can be decreased when combined with Sorafenib.
Encorafenib	Encorafenib The metabolism of Encorafenib can be decreased when combined with Sorafenib.
Binimetinib	Binimetinib The serum concentration of Binimetinib can be increased when it is combined with Sorafenib.
Ivosidenib	Ivosidenib The metabolism of Ivosidenib can be increased when combined with Sorafenib.
Lusutrombopag	Lusutrombopag The serum concentration of Lusutrombopag can be increased when it is combined with Sorafenib.
Elagolix	Elagolix The metabolism of Elagolix can be decreased when combined with Sorafenib.
Doravirine	Doravirine The metabolism of Doravirine can be decreased when combined with Sorafenib.
Tafenoquine	Tafenoquine The metabolism of Tafenoquine can be decreased when combined with Sorafenib.
Cannabidiol	Cannabidiol The metabolism of Cannabidiol can be decreased when combined with Sorafenib.
Dacomitinib	Dacomitinib The serum concentration of Dacomitinib can be increased when it is combined with Sorafenib.
Duvelisib	Duvelisib The metabolism of Duvelisib can be decreased when combined with Sorafenib.
Omadacycline	Omadacycline The serum concentration of Omadacycline can be increased when it is combined with Sorafenib.
Stiripentol	Stiripentol The metabolism of Sorafenib can be decreased when combined with Stiripentol.
Talazoparib	Talazoparib The serum concentration of Talazoparib can be increased when it is combined with Sorafenib.
Gilteritinib	Gilteritinib The metabolism of Sorafenib can be decreased when combined with Gilteritinib.
Glasdegib	Glasdegib The metabolism of Glasdegib can be decreased when combined with Sorafenib.
Lorlatinib	Lorlatinib The metabolism of Lorlatinib can be decreased when combined with Sorafenib.
Larotrectinib	Larotrectinib The serum concentration of Larotrectinib can be increased when it is combined with Sorafenib.
Methoxy Polyethylene Glycol-Epoetin Beta Injection	Methoxy Polyethylene Glycol-Epoetin Beta Injection The risk or severity of Thrombosis can be increased when Methoxy polyethylene glycol-epoetin beta is combined with Sorafenib.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Paclitaxel.
Rifamycin	Rifamycin The metabolism of Rifamycin can be increased when combined with Sorafenib.
Prucalopride	Prucalopride The serum concentration of Prucalopride can be increased when it is combined with Sorafenib.
Ravulizumab-cwvz Injection	Ravulizumab-cwvz Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Ravulizumab.
Emapalumab-lzsg Injection	Emapalumab-lzsg Injection The metabolism of Sorafenib can be increased when combined with Emapalumab.
Siponimod	Siponimod The risk or severity of adverse effects can be increased when Sorafenib is combined with Siponimod.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Caplacizumab-yhdp Injection	Caplacizumab-yhdp Injection The risk or severity of bleeding can be increased when Caplacizumab is combined with Sorafenib.
Erdafitinib	Erdafitinib The metabolism of Erdafitinib can be decreased when combined with Sorafenib.
Esomeprazole Injection	Esomeprazole Injection The metabolism of Esomeprazole can be decreased when combined with Sorafenib.
Risankizumab-rzaa Injection	Risankizumab-rzaa Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Risankizumab.
Alpelisib	Alpelisib The serum concentration of Alpelisib can be increased when it is combined with Sorafenib.
Cladribine	Cladribine The risk or severity of adverse effects can be increased when Cladribine is combined with Sorafenib.
Solriamfetol	Solriamfetol Sorafenib may decrease the excretion rate of Solriamfetol which could result in a higher serum level.
Darolutamide	Darolutamide The serum concentration of Darolutamide can be increased when it is combined with Sorafenib.
Triclabendazole	Triclabendazole The metabolism of Triclabendazole can be decreased when combined with Sorafenib.
Entrectinib	Entrectinib The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Entrectinib.
Pexidartinib	Pexidartinib The metabolism of Pexidartinib can be decreased when combined with Sorafenib.
Istradefylline	Istradefylline The metabolism of Istradefylline can be decreased when combined with Sorafenib.
Pitolisant	Pitolisant The serum concentration of Sorafenib can be decreased when it is combined with Pitolisant.
Fedratinib	Fedratinib Fedratinib may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Lefamulin	Lefamulin Sorafenib may increase the QTc-prolonging activities of Lefamulin.
Phenytoin Injection	Phenytoin Injection The metabolism of Phenytoin can be decreased when combined with Sorafenib.
Fosphenytoin Injection	Fosphenytoin Injection The metabolism of Fosphenytoin can be decreased when combined with Sorafenib.
Enfortumab vedotin-ejfv Injection	Enfortumab vedotin-ejfv Injection The serum concentration of Enfortumab vedotin can be increased when it is combined with Sorafenib.
Zanubrutinib	Zanubrutinib The metabolism of Zanubrutinib can be decreased when combined with Sorafenib.
Voxelotor	Voxelotor The serum concentration of Voxelotor can be increased when it is combined with Sorafenib.
Avapritinib	Avapritinib The metabolism of Avapritinib can be decreased when combined with Sorafenib.
Lumateperone	Lumateperone The serum concentration of Lumateperone can be increased when it is combined with Sorafenib.
Lasmiditan	Lasmiditan The serum concentration of Sorafenib can be increased when it is combined with Lasmiditan.
Ubrogepant	Ubrogepant The serum concentration of Ubrogepant can be increased when it is combined with Sorafenib.
Tazemetostat	Tazemetostat The metabolism of Tazemetostat can be decreased when combined with Sorafenib.
Cenobamate	Cenobamate The serum concentration of Sorafenib can be decreased when it is combined with Cenobamate.
Ozanimod	Ozanimod The metabolism of Ozanimod can be decreased when combined with Sorafenib.
Selumetinib	Selumetinib The metabolism of Selumetinib can be decreased when combined with Sorafenib.
Rimegepant	Rimegepant The serum concentration of Rimegepant can be increased when it is combined with Sorafenib.
Tucatinib	Tucatinib The metabolism of Tucatinib can be decreased when combined with Sorafenib.
Remdesivir Injection	Remdesivir Injection The serum concentration of Remdesivir can be increased when it is combined with Sorafenib.
Sacituzumab govitecan-hziy Injection	Sacituzumab govitecan-hziy Injection The serum concentration of Sacituzumab govitecan can be increased when it is combined with Sorafenib.
Ripretinib	Ripretinib Sorafenib may decrease the excretion rate of Ripretinib which could result in a higher serum level.
Selpercatinib	Selpercatinib The serum concentration of Sorafenib can be increased when it is combined with Selpercatinib.
Capmatinib	Capmatinib The serum concentration of Sorafenib can be increased when it is combined with Capmatinib.
Lemborexant	Lemborexant The metabolism of Lemborexant can be decreased when combined with Sorafenib.
Fostemsavir	Fostemsavir Sorafenib may decrease the excretion rate of Fostemsavir which could result in a higher serum level.
Octreotide	Octreotide The serum concentration of Sorafenib can be increased when it is combined with Octreotide.
Belantamab Mafodotin-blmf Injection	Belantamab Mafodotin-blmf Injection The serum concentration of Belantamab mafodotin can be increased when it is combined with Sorafenib.
Pralsetinib	Pralsetinib The serum concentration of Pralsetinib can be increased when it is combined with Sorafenib.
Opicapone	Opicapone The metabolism of Sorafenib can be decreased when combined with Opicapone.
Satralizumab-mwge Injection	Satralizumab-mwge Injection The serum concentration of Sorafenib can be decreased when it is combined with Satralizumab.
Relugolix	Relugolix The serum concentration of Relugolix can be increased when it is combined with Sorafenib.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives The metabolism of Drospirenone can be decreased when combined with Sorafenib.
Viloxazine	Viloxazine The metabolism of Viloxazine can be decreased when combined with Sorafenib.
Vitamin E (Alpha-Tocopherol)	Vitamin E (Alpha-Tocopherol) The metabolism of Sorafenib can be increased when combined with Vitamin E.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Theophylline	Theophylline The metabolism of Theophylline can be decreased when combined with Sorafenib.
Fenoprofen	Fenoprofen Fenoprofen may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Indomethacin	Indomethacin The metabolism of Indomethacin can be decreased when combined with Sorafenib.
Mefenamic Acid	Mefenamic Acid The metabolism of Mefenamic acid can be decreased when combined with Sorafenib.
Naproxen	Naproxen The metabolism of Naproxen can be decreased when combined with Sorafenib.
Tolmetin	Tolmetin Tolmetin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Sulindac	Sulindac Sulindac may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Trazodone	Trazodone The risk or severity of QTc prolongation can be increased when Trazodone is combined with Sorafenib.
Isotretinoin	Isotretinoin Sorafenib may decrease the excretion rate of Isotretinoin which could result in a higher serum level.
Sucralfate	Sucralfate Sucralfate may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Hydroxyurea	Hydroxyurea The risk or severity of adverse effects can be increased when Sorafenib is combined with Hydroxyurea.
Floxuridine	Floxuridine The risk or severity of adverse effects can be increased when Floxuridine is combined with Sorafenib.
Phenobarbital	Phenobarbital The metabolism of Phenobarbital can be increased when combined with Sorafenib.
Metaxalone	Metaxalone Sorafenib may decrease the excretion rate of Metaxalone which could result in a higher serum level.
Methotrexate Injection	Methotrexate Injection The metabolism of Methotrexate can be decreased when combined with Sorafenib.
Primidone	Primidone The metabolism of Primidone can be increased when combined with Sorafenib.
Methsuximide	Methsuximide The metabolism of Methsuximide can be decreased when combined with Sorafenib.
Chlorpromazine	Chlorpromazine The metabolism of Chlorpromazine can be increased when combined with Sorafenib.
Diazepam	Diazepam The metabolism of Diazepam can be decreased when combined with Sorafenib.
Oxazepam	Oxazepam The metabolism of Oxazepam can be decreased when combined with Sorafenib.
Flurazepam	Flurazepam Sorafenib may decrease the excretion rate of Flurazepam which could result in a higher serum level.
Clorazepate	Clorazepate Sorafenib may decrease the excretion rate of Clorazepic acid which could result in a higher serum level.
Lorazepam	Lorazepam The metabolism of Sorafenib can be decreased when combined with Lorazepam.
Carmustine	Carmustine The risk or severity of adverse effects can be increased when Carmustine is combined with Sorafenib.
Amantadine	Amantadine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Amantadine.
Codeine	Codeine The metabolism of Sorafenib can be decreased when combined with Codeine.
Bromocriptine	Bromocriptine The metabolism of Sorafenib can be decreased when combined with Bromocriptine.
Tranylcypromine	Tranylcypromine The metabolism of Sorafenib can be decreased when combined with Tranylcypromine.
Phenelzine	Phenelzine The metabolism of Sorafenib can be decreased when combined with Phenelzine.
Procarbazine	Procarbazine The risk or severity of adverse effects can be increased when Sorafenib is combined with Procarbazine.
Tetracycline	Tetracycline The metabolism of Tetracycline can be decreased when combined with Sorafenib.
Thioguanine	Thioguanine The risk or severity of adverse effects can be increased when Tioguanine is combined with Sorafenib.
Prochlorperazine	Prochlorperazine The metabolism of Prochlorperazine can be decreased when combined with Sorafenib.
Thioridazine	Thioridazine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Thioridazine.
Trifluoperazine	Trifluoperazine The metabolism of Trifluoperazine can be decreased when combined with Sorafenib.
Bleomycin	Bleomycin The risk or severity of adverse effects can be increased when Bleomycin is combined with Sorafenib.
Dapsone	Dapsone The metabolism of Dapsone can be decreased when combined with Sorafenib.
Sulfadiazine	Sulfadiazine The metabolism of Sulfadiazine can be decreased when combined with Sorafenib.
Oxycodone	Oxycodone The metabolism of Oxycodone can be decreased when combined with Sorafenib.
Methadone	Methadone The metabolism of Methadone can be increased when combined with Sorafenib.
Oxybutynin	Oxybutynin The metabolism of Sorafenib can be decreased when combined with Oxybutynin.
Benztropine	Benztropine The metabolism of Benzatropine can be decreased when combined with Sorafenib.
Maprotiline	Maprotiline The metabolism of Maprotiline can be decreased when combined with Sorafenib.
Ibuprofen	Ibuprofen The metabolism of Ibuprofen can be decreased when combined with Sorafenib.
Orphenadrine	Orphenadrine The metabolism of Sorafenib can be decreased when combined with Orphenadrine.
Perphenazine	Perphenazine The metabolism of Perphenazine can be decreased when combined with Sorafenib.
Azathioprine	Azathioprine The risk or severity of adverse effects can be increased when Sorafenib is combined with Azathioprine.
Phentermine	Phentermine The metabolism of Phentermine can be decreased when combined with Sorafenib.
Methylphenidate	Methylphenidate Sorafenib may decrease the excretion rate of Methylphenidate which could result in a higher serum level.
Amoxapine	Amoxapine The metabolism of Amoxapine can be decreased when combined with Sorafenib.
Sulfasalazine	Sulfasalazine The risk or severity of adverse effects can be increased when Sorafenib is combined with Sulfasalazine.
Hydrocortisone	Hydrocortisone The metabolism of Sorafenib can be increased when combined with Hydrocortisone.
Lomustine	Lomustine The risk or severity of adverse effects can be increased when Sorafenib is combined with Lomustine.
Doxorubicin	Doxorubicin The serum concentration of Doxorubicin can be increased when it is combined with Sorafenib.
Cytarabine	Cytarabine The risk or severity of adverse effects can be increased when Sorafenib is combined with Cytarabine.
Mechlorethamine	Mechlorethamine The risk or severity of adverse effects can be increased when Sorafenib is combined with Mechlorethamine.
Dactinomycin	Dactinomycin The serum concentration of Dactinomycin can be increased when it is combined with Sorafenib.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Carbamazepine	Carbamazepine The metabolism of Carbamazepine can be decreased when combined with Sorafenib.
Methyldopa	Methyldopa Sorafenib may decrease the excretion rate of Methyldopa which could result in a higher serum level.
Clonidine	Clonidine The metabolism of Clonidine can be decreased when combined with Sorafenib.
Prazosin	Prazosin Sorafenib may decrease the excretion rate of Prazosin which could result in a higher serum level.
Hydralazine	Hydralazine The metabolism of Hydralazine can be decreased when combined with Sorafenib.
Cimetidine	Cimetidine The metabolism of Sorafenib can be decreased when combined with Cimetidine.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Warfarin	Warfarin Sorafenib may increase the anticoagulant activities of Warfarin.
Clonazepam	Clonazepam Sorafenib may decrease the excretion rate of Clonazepam which could result in a higher serum level.
Loperamide	Loperamide The metabolism of Loperamide can be decreased when combined with Sorafenib.
Promethazine	Promethazine The metabolism of Promethazine can be decreased when combined with Sorafenib.
Meclofenamate	Meclofenamate Meclofenamic acid may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Daunorubicin	Daunorubicin The metabolism of Daunorubicin can be decreased when combined with Sorafenib.
Nitrofurantoin	Nitrofurantoin Sorafenib may decrease the excretion rate of Nitrofurantoin which could result in a higher serum level.
Griseofulvin	Griseofulvin The metabolism of Sorafenib can be increased when combined with Griseofulvin.
Digoxin	Digoxin Sorafenib may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine	Chloroquine The metabolism of Chloroquine can be decreased when combined with Sorafenib.
Quinine	Quinine The metabolism of Quinine can be increased when combined with Sorafenib.
Ethosuximide	Ethosuximide The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Ethosuximide.
Calcitriol	Calcitriol The metabolism of Sorafenib can be increased when combined with Calcitriol.
Triamterene	Triamterene The metabolism of Sorafenib can be decreased when combined with Triamterene.
Sulfinpyrazone	Sulfinpyrazone The metabolism of Sorafenib can be increased when combined with Sulfinpyrazone.
Chlorothiazide	Chlorothiazide Chlorothiazide may increase the excretion rate of Sorafenib which could result in a lower serum level and potentially a reduction in efficacy.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the excretion rate of Sorafenib which could result in a lower serum level and potentially a reduction in efficacy.
Metolazone	Metolazone Sorafenib may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Sorafenib which could result in a lower serum level and potentially a reduction in efficacy.
Clindamycin Injection	Clindamycin Injection The metabolism of Clindamycin can be decreased when combined with Sorafenib.
Secobarbital	Secobarbital The metabolism of Sorafenib can be increased when combined with Secobarbital.
Desipramine	Desipramine The metabolism of Desipramine can be decreased when combined with Sorafenib.
Amitriptyline	Amitriptyline The metabolism of Amitriptyline can be decreased when combined with Sorafenib.
Imipramine	Imipramine The metabolism of Sorafenib can be decreased when combined with Imipramine.
Probenecid	Probenecid The metabolism of Probenecid can be increased when combined with Sorafenib.
Quinidine	Quinidine The serum concentration of Quinidine can be increased when it is combined with Sorafenib.
Procainamide	Procainamide The metabolism of Procainamide can be decreased when combined with Sorafenib.
Isoniazid	Isoniazid The metabolism of Sorafenib can be decreased when combined with Isoniazid.
Pyrazinamide	Pyrazinamide Pyrazinamide may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Rifampin	Rifampin The metabolism of Sorafenib can be increased when combined with Rifampicin.
Disopyramide	Disopyramide The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Disopyramide.
Valproic Acid	Valproic Acid The metabolism of Valproic acid can be decreased when combined with Sorafenib.
Tamoxifen	Tamoxifen The metabolism of Tamoxifen can be increased when combined with Sorafenib.
Mitomycin	Mitomycin The risk or severity of adverse effects can be increased when Mitomycin is combined with Sorafenib.
Butabarbital	Butabarbital Butabarbital may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Levothyroxine	Levothyroxine The therapeutic efficacy of Levothyroxine can be decreased when used in combination with Sorafenib.
Liothyronine	Liothyronine The therapeutic efficacy of Sorafenib can be decreased when used in combination with Liothyronine.
Methimazole	Methimazole The therapeutic efficacy of Methimazole can be decreased when used in combination with Sorafenib.
Propylthiouracil	Propylthiouracil The therapeutic efficacy of Propylthiouracil can be decreased when used in combination with Sorafenib.
Chlorpropamide	Chlorpropamide The metabolism of Chlorpropamide can be decreased when combined with Sorafenib.
Tolbutamide	Tolbutamide The metabolism of Tolbutamide can be decreased when combined with Sorafenib.
Tolazamide	Tolazamide The metabolism of Tolazamide can be decreased when combined with Sorafenib.
Dextromethorphan	Dextromethorphan The metabolism of Dextromethorphan can be decreased when combined with Sorafenib.
Dinoprostone	Dinoprostone The excretion of Dinoprostone can be decreased when combined with Sorafenib.
Cyclobenzaprine	Cyclobenzaprine The metabolism of Cyclobenzaprine can be decreased when combined with Sorafenib.
Niacin	Niacin The metabolism of Sorafenib can be decreased when combined with Niacin.
Baclofen	Baclofen Baclofen may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Doxylamine	Doxylamine The risk or severity of QTc prolongation can be increased when Doxylamine is combined with Sorafenib.
Cyproheptadine	Cyproheptadine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Cyproheptadine.
Clemastine	Clemastine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Clemastine.
Chlorpheniramine	Chlorpheniramine The metabolism of Chlorpheniramine can be decreased when combined with Sorafenib.
Brompheniramine	Brompheniramine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Dexbrompheniramine.
Meclizine	Meclizine The metabolism of Meclizine can be decreased when combined with Sorafenib.
Ethambutol	Ethambutol Ethambutol may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Methyclothiazide	Methyclothiazide Methyclothiazide may increase the excretion rate of Sorafenib which could result in a lower serum level and potentially a reduction in efficacy.
Hydrochlorothiazide	Hydrochlorothiazide Hydrochlorothiazide may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Chlorzoxazone	Chlorzoxazone The metabolism of Sorafenib can be decreased when combined with Chlorzoxazone.
Carisoprodol	Carisoprodol The metabolism of Carisoprodol can be decreased when combined with Sorafenib.
Pyridoxine	Pyridoxine Pyridoxine may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Folic Acid	Folic Acid Sorafenib may decrease the excretion rate of Folic acid which could result in a higher serum level.
Danazol	Danazol The metabolism of Sorafenib can be decreased when combined with Danazol.
Disulfiram	Disulfiram The metabolism of Disulfiram can be decreased when combined with Sorafenib.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) The serum concentration of Propranolol can be increased when it is combined with Sorafenib.
Minoxidil	Minoxidil The metabolism of Minoxidil can be decreased when combined with Sorafenib.
Nortriptyline	Nortriptyline The serum concentration of Nortriptyline can be increased when it is combined with Sorafenib.
Spironolactone	Spironolactone The metabolism of Sorafenib can be decreased when combined with Spironolactone.
Amphotericin B Injection	Amphotericin B Injection The metabolism of Sorafenib can be decreased when combined with Amphotericin B.
Mercaptopurine	Mercaptopurine The risk or severity of adverse effects can be increased when Sorafenib is combined with Mercaptopurine.
Phytonadione	Phytonadione Sorafenib may decrease the excretion rate of Phylloquinone which could result in a higher serum level.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Nadolol	Nadolol The metabolism of Nadolol can be decreased when combined with Sorafenib.
Allopurinol	Allopurinol The risk or severity of adverse effects can be increased when Allopurinol is combined with Sorafenib.
Oxytocin Injection	Oxytocin Injection The risk or severity of QTc prolongation can be increased when Oxytocin is combined with Sorafenib.
Clomiphene	Clomiphene The serum concentration of Clomifene can be increased when it is combined with Sorafenib.
Flavoxate	Flavoxate Sorafenib may decrease the excretion rate of Flavoxate which could result in a higher serum level.
Papaverine	Papaverine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Papaverine.
Fluorouracil Injection	Fluorouracil Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Fluorouracil.
Colchicine	Colchicine The metabolism of Colchicine can be decreased when combined with Sorafenib.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Cephalexin	Cephalexin The metabolism of Sorafenib can be decreased when combined with Cephalexin.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Dacarbazine	Dacarbazine The serum concentration of 5-amino-imidazole-4-carboxamide (AIC), an active metabolite of Dacarbazine, can be increased when used in combination with Sorafenib.
Acetazolamide	Acetazolamide The metabolism of Sorafenib can be decreased when combined with Acetazolamide.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection The therapeutic efficacy of Sorafenib can be decreased when used in combination with Salmon calcitonin.
Bacillus Calmette-Guerin (BCG) Vaccine	Bacillus Calmette-Guerin (BCG) Vaccine The risk or severity of infection can be increased when Bacillus calmette-guerin substrain tice live antigen is combined with Sorafenib.
Ketoconazole	Ketoconazole The metabolism of Sorafenib can be decreased when combined with Ketoconazole.
Pyrantel	Pyrantel Sorafenib may decrease the excretion rate of Pyrantel which could result in a higher serum level.
Thiotepa Injection	Thiotepa Injection The metabolism of Thiotepa can be decreased when combined with Sorafenib.
Vincristine Injection	Vincristine Injection The excretion of Vincristine can be decreased when combined with Sorafenib.
Dipyridamole	Dipyridamole The risk or severity of bleeding can be increased when Dipyridamole is combined with Sorafenib.
Vinblastine	Vinblastine The metabolism of Vinblastine can be decreased when combined with Sorafenib.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Metoprolol	Metoprolol The metabolism of Metoprolol can be decreased when combined with Sorafenib.
Hydroxyzine	Hydroxyzine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Hydroxyzine.
Thiothixene	Thiothixene The metabolism of Thiothixene can be decreased when combined with Sorafenib.
Aspirin	Aspirin The metabolism of Acetylsalicylic acid can be decreased when combined with Sorafenib.
Salsalate	Salsalate Salsalate may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Chlorambucil	Chlorambucil The risk or severity of adverse effects can be increased when Chlorambucil is combined with Sorafenib.
Alprazolam	Alprazolam The metabolism of Alprazolam can be decreased when combined with Sorafenib.
Temazepam	Temazepam Temazepam may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Triazolam	Triazolam The metabolism of Triazolam can be decreased when combined with Sorafenib.
Dicyclomine	Dicyclomine Sorafenib may decrease the excretion rate of Dicyclomine which could result in a higher serum level.
Hyoscyamine	Hyoscyamine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Hyoscyamine.
Propantheline	Propantheline Sorafenib may decrease the excretion rate of Propantheline which could result in a higher serum level.
Trimethoprim	Trimethoprim The metabolism of Trimethoprim can be decreased when combined with Sorafenib.
Diltiazem	Diltiazem The metabolism of Diltiazem can be decreased when combined with Sorafenib.
Nifedipine	Nifedipine The metabolism of Sorafenib can be increased when combined with Nifedipine.
Timolol	Timolol The metabolism of Timolol can be decreased when combined with Sorafenib.
Verapamil	Verapamil The metabolism of Verapamil can be decreased when combined with Sorafenib.
Atenolol	Atenolol The metabolism of Atenolol can be decreased when combined with Sorafenib.
Pindolol	Pindolol The metabolism of Pindolol can be decreased when combined with Sorafenib.
Cisplatin Injection	Cisplatin Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Cisplatin.
Diflunisal	Diflunisal The metabolism of Sorafenib can be decreased when combined with Diflunisal.
Piroxicam	Piroxicam The metabolism of Piroxicam can be decreased when combined with Sorafenib.
Bumetanide	Bumetanide Sorafenib may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Streptozocin	Streptozocin The risk or severity of adverse effects can be increased when Sorafenib is combined with Streptozocin.
Etoposide	Etoposide The serum concentration of Etoposide can be increased when it is combined with Sorafenib.
Glyburide	Glyburide The metabolism of Glyburide can be decreased when combined with Sorafenib.
Glipizide	Glipizide The metabolism of Glipizide can be decreased when combined with Sorafenib.
Indapamide	Indapamide Sorafenib may increase the excretion rate of Indapamide which could result in a lower serum level and potentially a reduction in efficacy.
Amoxicillin	Amoxicillin Sorafenib may decrease the excretion rate of Amoxicillin which could result in a higher serum level.
Dicloxacillin	Dicloxacillin The metabolism of Sorafenib can be increased when combined with Dicloxacillin.
Nafcillin Injection	Nafcillin Injection The metabolism of Sorafenib can be increased when combined with Nafcillin.
Oxacillin Injection	Oxacillin Injection Sorafenib may decrease the excretion rate of Oxacillin which could result in a higher serum level.
Pentoxifylline	Pentoxifylline The metabolism of Pentoxifylline can be decreased when combined with Sorafenib.
Pentamidine Injection	Pentamidine Injection The metabolism of Pentamidine can be decreased when combined with Sorafenib.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Labetalol	Labetalol The metabolism of Labetalol can be decreased when combined with Sorafenib.
Auranofin	Auranofin Sorafenib may decrease the excretion rate of Auranofin which could result in a higher serum level.
Leuprolide Injection	Leuprolide Injection The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Leuprolide.
Gemfibrozil	Gemfibrozil The metabolism of Sorafenib can be increased when combined with Gemfibrozil.
Guanabenz	Guanabenz The metabolism of Guanabenz can be decreased when combined with Sorafenib.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Ketoprofen	Ketoprofen The metabolism of Sorafenib can be decreased when combined with Ketoprofen.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Pimozide	Pimozide The metabolism of Pimozide can be decreased when combined with Sorafenib.
Enalapril	Enalapril The excretion of Enalapril can be decreased when combined with Sorafenib.
Flurbiprofen	Flurbiprofen The metabolism of Flurbiprofen can be decreased when combined with Sorafenib.
Amiodarone	Amiodarone The metabolism of Amiodarone can be decreased when combined with Sorafenib.
Aztreonam Injection	Aztreonam Injection Aztreonam may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Buspirone	Buspirone The metabolism of Buspirone can be decreased when combined with Sorafenib.
Lovastatin	Lovastatin The metabolism of Lovastatin can be decreased when combined with Sorafenib.
Ciprofloxacin	Ciprofloxacin The metabolism of Sorafenib can be decreased when combined with Ciprofloxacin.
Mesalamine	Mesalamine Mesalazine may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Diclofenac	Diclofenac The metabolism of Diclofenac can be decreased when combined with Sorafenib.
Fluoxetine	Fluoxetine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Fluoxetine.
Nimodipine	Nimodipine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Nimodipine.
Interferon Alfa-2b Injection	Interferon Alfa-2b Injection The risk or severity of adverse effects can be increased when Interferon alfa-2b is combined with Sorafenib.
Clozapine	Clozapine The risk or severity of neutropenia can be increased when Sorafenib is combined with Clozapine.
Estazolam	Estazolam Sorafenib may decrease the excretion rate of Estazolam which could result in a higher serum level.
Idarubicin	Idarubicin The risk or severity of adverse effects can be increased when Sorafenib is combined with Idarubicin.
Ofloxacin	Ofloxacin The metabolism of Ofloxacin can be decreased when combined with Sorafenib.
Didanosine	Didanosine Sorafenib may decrease the excretion rate of Didanosine which could result in a higher serum level.
Fludarabine Injection	Fludarabine Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Fludarabine.
Pentostatin Injection	Pentostatin Injection The risk or severity of adverse effects can be increased when Sorafenib is combined with Pentostatin.
Clarithromycin	Clarithromycin The metabolism of Sorafenib can be decreased when combined with Clarithromycin.
Etodolac	Etodolac The metabolism of Etodolac can be decreased when combined with Sorafenib.
Felodipine	Felodipine The metabolism of Sorafenib can be decreased when combined with Felodipine.
Fosinopril	Fosinopril Sorafenib may decrease the excretion rate of Fosinopril which could result in a higher serum level.
Nabumetone	Nabumetone The metabolism of Nabumetone can be decreased when combined with Sorafenib.
Pravastatin	Pravastatin The serum concentration of Pravastatin can be increased when it is combined with Sorafenib.
Simvastatin	Simvastatin The metabolism of Simvastatin can be decreased when combined with Sorafenib.
Epoetin Alfa, Injection	Epoetin Alfa, Injection The risk or severity of Thrombosis can be increased when Erythropoietin is combined with Sorafenib.
Teniposide Injection	Teniposide Injection The metabolism of Teniposide can be decreased when combined with Sorafenib.
Itraconazole	Itraconazole The metabolism of Sorafenib can be decreased when combined with Itraconazole.
Lisinopril	Lisinopril Sorafenib may decrease the excretion rate of Lisinopril which could result in a higher serum level.
Oxaprozin	Oxaprozin Oxaprozin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Rifabutin	Rifabutin The metabolism of Sorafenib can be increased when combined with Rifabutin.
Sotalol	Sotalol The metabolism of Sotalol can be decreased when combined with Sorafenib.
Bisoprolol	Bisoprolol The serum concentration of Bisoprolol can be increased when it is combined with Sorafenib.
Zolpidem	Zolpidem The metabolism of Zolpidem can be decreased when combined with Sorafenib.
Doxazosin	Doxazosin The metabolism of Doxazosin can be decreased when combined with Sorafenib.
Isradipine	Isradipine The metabolism of Sorafenib can be decreased when combined with Isradipine.
Omeprazole	Omeprazole The metabolism of Omeprazole can be increased when combined with Sorafenib.
Cisapride	Cisapride The metabolism of Sorafenib can be decreased when combined with Cisapride.
Fluvastatin	Fluvastatin The metabolism of Fluvastatin can be decreased when combined with Sorafenib.
Venlafaxine	Venlafaxine The metabolism of Venlafaxine can be decreased when combined with Sorafenib.
Famciclovir	Famciclovir The metabolism of Famciclovir can be decreased when combined with Sorafenib.
Fluvoxamine	Fluvoxamine The metabolism of Sorafenib can be decreased when combined with Fluvoxamine.
Nefazodone	Nefazodone The metabolism of Nefazodone can be decreased when combined with Sorafenib.
Lamotrigine	Lamotrigine The metabolism of Lamotrigine can be decreased when combined with Sorafenib.
Losartan	Losartan The metabolism of Losartan can be decreased when combined with Sorafenib.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Tramadol	Tramadol The metabolism of Tramadol can be decreased when combined with Sorafenib.
Vinorelbine Injection	Vinorelbine Injection The metabolism of Sorafenib can be decreased when combined with Vinorelbine.
Carboplatin Injection	Carboplatin Injection The risk or severity of death can be increased when Sorafenib is combined with Carboplatin.
Moexipril	Moexipril The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Moexipril.
Lansoprazole	Lansoprazole The metabolism of Lansoprazole can be increased when combined with Sorafenib.
Ifosfamide Injection	Ifosfamide Injection The metabolism of Ifosfamide can be increased when combined with Sorafenib.
Pegaspargase Injection	Pegaspargase Injection The risk or severity of adverse effects can be increased when Pegaspargase is combined with Sorafenib.
Nicardipine	Nicardipine The metabolism of Nicardipine can be decreased when combined with Sorafenib.
Bupropion	Bupropion The serum concentration of Bupropion can be increased when it is combined with Sorafenib.
Ticlopidine	Ticlopidine The metabolism of Sorafenib can be decreased when combined with Ticlopidine.
Saquinavir	Saquinavir The metabolism of Sorafenib can be decreased when combined with Saquinavir.
Metformin	Metformin Metformin may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Dalteparin Injection	Dalteparin Injection The risk or severity of bleeding can be increased when Dalteparin is combined with Sorafenib.
Nisoldipine	Nisoldipine The metabolism of Nisoldipine can be decreased when combined with Sorafenib.
Lamivudine	Lamivudine Sorafenib may decrease the excretion rate of Lamivudine which could result in a higher serum level.
Riluzole	Riluzole Sorafenib may decrease the excretion rate of Riluzole which could result in a higher serum level.
Acarbose	Acarbose Acarbose may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Glimepiride	Glimepiride The metabolism of Glimepiride can be decreased when combined with Sorafenib.
Anastrozole	Anastrozole The metabolism of Sorafenib can be decreased when combined with Anastrozole.
Gemcitabine Injection	Gemcitabine Injection The serum concentration of Gemcitabine can be increased when it is combined with Sorafenib.
Indinavir	Indinavir The metabolism of Sorafenib can be decreased when combined with Indinavir.
Ritonavir	Ritonavir The serum concentration of Sorafenib can be increased when it is combined with Ritonavir.
Docetaxel Injection	Docetaxel Injection The serum concentration of Docetaxel can be increased when it is combined with Sorafenib.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Sorafenib may decrease the excretion rate of Meropenem which could result in a higher serum level.
Clomipramine	Clomipramine The metabolism of Clomipramine can be decreased when combined with Sorafenib.
Zafirlukast	Zafirlukast The metabolism of Zafirlukast can be decreased when combined with Sorafenib.
Fosfomycin	Fosfomycin Sorafenib may decrease the excretion rate of Fosfomycin which could result in a higher serum level.
Mirtazapine	Mirtazapine The metabolism of Sorafenib can be decreased when combined with Mirtazapine.
Topiramate	Topiramate The metabolism of Sorafenib can be increased when combined with Topiramate.
Zileuton	Zileuton The metabolism of Zileuton can be decreased when combined with Sorafenib.
Valsartan	Valsartan The metabolism of Valsartan can be decreased when combined with Sorafenib.
Insulin Lispro Injection	Insulin Lispro Injection The metabolism of Sorafenib can be increased when combined with Insulin lispro.
Pramipexole	Pramipexole Sorafenib may decrease the excretion rate of Pramipexole which could result in a higher serum level.
Donepezil	Donepezil The metabolism of Donepezil can be decreased when combined with Sorafenib.
Nelfinavir	Nelfinavir The metabolism of Sorafenib can be decreased when combined with Nelfinavir.
Fexofenadine	Fexofenadine The serum concentration of Fexofenadine can be increased when it is combined with Sorafenib.
Azithromycin	Azithromycin The metabolism of Azithromycin can be decreased when combined with Sorafenib.
Loratadine	Loratadine The metabolism of Sorafenib can be decreased when combined with Loratadine.
Carvedilol	Carvedilol The metabolism of Carvedilol can be decreased when combined with Sorafenib.
Nilutamide	Nilutamide The metabolism of Sorafenib can be decreased when combined with Nilutamide.
Flutamide	Flutamide The metabolism of Flutamide can be decreased when combined with Sorafenib.
Selegiline	Selegiline The metabolism of Selegiline can be decreased when combined with Sorafenib.
Bicalutamide	Bicalutamide The metabolism of Sorafenib can be decreased when combined with Bicalutamide.
Sertraline	Sertraline The metabolism of Sertraline can be decreased when combined with Sorafenib.
Propafenone	Propafenone The metabolism of Sorafenib can be decreased when combined with Propafenone.
Raloxifene	Raloxifene The metabolism of Raloxifene can be decreased when combined with Sorafenib.
Irbesartan	Irbesartan The metabolism of Irbesartan can be decreased when combined with Sorafenib.
Tamsulosin	Tamsulosin The metabolism of Tamsulosin can be decreased when combined with Sorafenib.
Finasteride	Finasteride The metabolism of Finasteride can be decreased when combined with Sorafenib.
Quetiapine	Quetiapine The metabolism of Quetiapine can be decreased when combined with Sorafenib.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Cetirizine	Cetirizine The risk or severity of QTc prolongation can be increased when Cetirizine is combined with Sorafenib.
Paroxetine	Paroxetine The metabolism of Paroxetine can be decreased when combined with Sorafenib.
Tolcapone	Tolcapone Tolcapone may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Citalopram	Citalopram Sorafenib may increase the QTc-prolonging activities of Citalopram.
Capecitabine	Capecitabine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Capecitabine.
Efavirenz	Efavirenz The metabolism of Sorafenib can be increased when combined with Efavirenz.
Abacavir	Abacavir The metabolism of Abacavir can be decreased when combined with Sorafenib.
Sildenafil	Sildenafil The metabolism of Sorafenib can be decreased when combined with Sildenafil.
Pioglitazone	Pioglitazone The serum concentration of Pioglitazone can be increased when it is combined with Sorafenib.
Trastuzumab Injection	Trastuzumab Injection Trastuzumab may increase the neutropenic activities of Sorafenib.
Celecoxib	Celecoxib The metabolism of Celecoxib can be decreased when combined with Sorafenib.
Rosiglitazone	Rosiglitazone The metabolism of Rosiglitazone can be decreased when combined with Sorafenib.
Tolterodine	Tolterodine The metabolism of Tolterodine can be decreased when combined with Sorafenib.
Thalidomide	Thalidomide The risk or severity of adverse effects can be increased when Sorafenib is combined with Thalidomide.
Oseltamivir	Oseltamivir Oseltamivir may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Balsalazide	Balsalazide Balsalazide may decrease the excretion rate of Sorafenib which could result in a higher serum level.
Nateglinide	Nateglinide The metabolism of Nateglinide can be decreased when combined with Sorafenib.
Galantamine	Galantamine The risk or severity of QTc prolongation can be increased when Sorafenib is combined with Galantamine.
Rabeprazole	Rabeprazole The metabolism of Sorafenib can be decreased when combined with Rabeprazole.
Terbinafine	Terbinafine The metabolism of Terbinafine can be increased when combined with Sorafenib.

Sorafenib

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