Medication interaction hub

What Supplements Interact with Glipizide?

Glipizide brand names: Glucotrol, Glucotrol XL. Every interaction below applies to the brands too.

307 Interactions 2 Major 256 Moderate 49 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Glipizide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Glipizide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Glipizide (Glucotrol, Glucotrol XL) lowers blood sugar by prompting the pancreas to release more insulin, and that same power is why I read its supplement list with real seriousness. Of the 307 ingredients on file, 239 also act on blood glucose, so stacking them can drive sugar dangerously low. Only two carry a major rating, and both are worth knowing first: Siberian cocklebur has caused severe hypoglycemia in people, and activated charcoal can soak up the drug before it ever gets absorbed.

Most of the 256 moderate entries repeat that additive pattern, everyday items (even beer) nudging glucose down or unsettling control, while 49 rate minor. A smaller cluster slows the liver enzyme that clears glipizide, which can quietly raise its level, and about twenty add extra sun sensitivity. New shakiness, sweating, or confusion after starting a supplement is low blood sugar until a meter proves otherwise.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 256 Minor 49 No known interaction 1,145

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Glipizide: Top Interactions at a Glance

The Glipizide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 307 interacting ingredients — plus 1,145 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Glipizide Combinations Today

The Glipizide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Minor Likelihood Possible Andrographis + Glipizidei

Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effects are seen with the...

Read the full interaction Moderate Likelihood Possible Ceylon Cinnamon + Glipizidei

Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Ipriflavone + Glipizidei

Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9).

Read the full interaction Moderate Likelihood Possible Irvingia Gabonensis + Glipizidei

Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.

Read the full interaction Moderate Likelihood Possible Winter Cherry + Glipizidei

In animal diabetic models, winter cherry extract decreases blood glucose.

Read the full interaction Moderate Likelihood Possible Eleuthero + Glipizidei

Theoretically, eleuthero might increase levels of drugs metabolized by CYP2C9.

Read the full interaction
The complete list

Every Supplement Checked Against Glipizide

All 1,452 ingredients in our database, ranked by severity — 307 with a Glipizide interaction on file and 1,145 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Glipizide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Andrographis with Glipizide?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, andrographis extract might increase the maximum concentration and area under the curve of glipizide; however, opposite effect...

Full Andrographis + Glipizide answer

Can you take Ceylon Cinnamon with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Ceylon cinnamon may have additive effects with antidiabetes drugs.

Full Ceylon Cinnamon + Glipizide answer

Can you take Ipriflavone with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Ipriflavone is thought to competitively inhibit cytochrome P450 2C9 (CYP2C9).

Full Ipriflavone + Glipizide answer

Can you take Irvingia Gabonensis with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Irvingia gabonensis with antidiabetes drugs might increase the risk of hypoglycemia in some patients.

Full Irvingia Gabonensis + Glipizide answer

Can you take Winter Cherry with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In animal diabetic models, winter cherry extract decreases blood glucose.

Full Winter Cherry + Glipizide answer

Can you take Vanadium with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, vanadium might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Vanadium + Glipizide answer

Can you take Wild Carrot with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might result in increased photosensitivity.

Full Wild Carrot + Glipizide answer

Can you take Wine with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use may interfere with blood glucose control.

Full Wine + Glipizide answer

Can you take Acai with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking acai with antidiabetes drugs might interfere with glycemic control.

Full Acai + Glipizide answer

Can you take Adrafinil with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, adrafinil might increase the levels and clinical effects of CYP2C9 substrates.

Full Adrafinil + Glipizide answer

Can you take African Wild Potato with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In vitro research shows that African wild potato extract inhibits cytochrome P450 2C9 (CYP2C9).

Full African Wild Potato + Glipizide answer

Can you take Agaricus Mushroom with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agaricus mushroom with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agaricus Mushroom + Glipizide answer

Can you take Agmatine with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, agmatine might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Agmatine + Glipizide answer

Can you take Agrimony with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking agrimony with antidiabetes drugs might increase the risk of hypoglycemia.

Full Agrimony + Glipizide answer

Can you take Alfalfa with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.

Full Alfalfa + Glipizide answer

Can you take Algal Oil with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking algal oil with antidiabetes drugs might interfere with the effects of antidiabetes drugs and reduce their effects.

Full Algal Oil + Glipizide answer

Can you take Aloe with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Aloe + Glipizide answer

Can you take Ambrette with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of ambrette with antidiabetes drugs might increase the risk of hypoglycemia.

Full Ambrette + Glipizide answer

Can you take Angelica Archangelica with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Angelica archangelica, whether ingested or applied to the skin, has the potential to induce photosensitivity reactions.

Full Angelica Archangelica + Glipizide answer

Can you take Anise with Glipizide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, anise seed might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Anise + Glipizide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Glipizide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Glipizide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Glipizide sits in 6 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Glipizide through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Glipizide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Glipizide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Glipizide through this category.

Glipizide (Glucotrol) 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glipizide through this category.

Sulfonylureas 1 ingredient

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

1 of the supplement ingredient on this page reaches Glipizide through this category.

About Glipizide

Glipizide is a sulfonylurea that lowers blood sugar in people with type 2 diabetes by stimulating the pancreas to produce insulin.

Generic name: Glipizide  ·  Brand names: Glucotrol, Glucotrol XL.

See the full Glipizide drug information

Related: does Glipizide deplete any nutrients?

Glipizide has 2 reported nutrient associations in the research literature — see the Glipizide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Glipizide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Glipizide.

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Pharmacist Counseling Corner

Glipizide & Supplements: Common Questions

What supplements interact with Glipizide?
Our database currently documents 307 ingredients with a known Glipizide interaction (2 major, 256 moderate, 49 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 307. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Glipizide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Glipizide?
Plenty of supplements coexist fine with Glipizide; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Glucotrol have the same supplement interactions as Glipizide?
Yes — Glucotrol, Glucotrol XL all contain Glipizide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Glipizide deplete any vitamins or nutrients?
It might — Glipizide has 2 reported nutrient-depletion associations in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Glipizide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Glipizide and my other medications?
This page covers Glipizide against supplements and herbal ingredients. Checking Glipizide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Glipizide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.