Drug & supplement interaction

Anhydrous Crystalline Maltose + Glipizide

Glipizide brand names: Glucotrol, Glucotrol XL.

Minor Interaction
Medically reviewed by · Updated February 2024
The bottom line Minor

Anhydrous Crystalline Maltose has a minor interaction with Glipizide. Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose).

Read the full interaction report
SeverityMinor
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Anhydrous Crystalline Maltose and Glipizide

Here is the interaction we found between these two, with the evidence behind it.

Minor

Antidiabetes Drugs

Why this applies to Glipizide

Glipizide falls under Antidiabetes Drugs — the group Anhydrous Crystalline Maltose interacts with.

Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose). While maltose itself does not necessarily interact directly with antidiabetic drugs, its digestion into glucose can lead to elevated blood sugar levels, which may impact the effectiveness of antidiabetic medications. In terms of effects on blood sugar, maltose may lead to a more rapid increase in blood sugar levels compared to sucrose, as it is directly converted into glucose. Individuals with diabetes should monitor their blood sugar levels closely when consuming foods or beverages containing maltose to maintain proper glucose control.
Severity Minor Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: glipizide works by lowering your blood sugar, and maltose is a sugar. When you slowly dissolve a maltose lozenge in your mouth, your body breaks it down into glucose, which can nudge your blood sugar upward. In theory, that could work against what glipizide is trying to do. The good news is this is a minor interaction, and the amount of sugar in a lozenge is small.

For most people this won't be a big deal, but since you have diabetes, it's worth keeping an eye on. If you start using these lozenges regularly, just check your blood sugar like you normally would and watch for higher-than-usual readings. Have a quick chat with your pharmacist or doctor first so they can help you fit it into your routine.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Anhydrous Crystalline Maltose Also Interacts With Other Medications

Anhydrous Crystalline Maltose has 85 minor known drug interactions in our database — the Glipizide one above is one of them. If you take anything else, check it against the full list below.

Minor 85 No known interaction 2,745 (incl. Glipizide)
Taking anything else?

Check Another of Your Medications Against Anhydrous Crystalline Maltose

Covers the 2,830 medications we’ve checked against Anhydrous Crystalline Maltose. Pick one to open its full report.

From our Q&A

Questions About Anhydrous Crystalline Maltose or Glipizide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Anhydrous Crystalline Maltose or Glipizide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Glipizide

This page covers Anhydrous Crystalline Maltose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glipizide page lists 307 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 256 moderate · 49 minor.

From our pharmacist’s overview on the Glipizide page

“Glipizide (Glucotrol, Glucotrol XL) lowers blood sugar by prompting the pancreas to release more insulin, and that same power is why I read its supplement list with real seriousness. Of the 307 ingredients on file, 239 also act on blood glucose, so stacking them can drive sugar dangerously low.”

Reviewed by 2 · Jul 18, 2026

Open the Glipizide interaction page

How much people look this up

Where Anhydrous Crystalline Maltose and Glipizide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Anhydrous Crystalline Maltose
Steady interest

#1,179 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glipizide
Top 25%

#372 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Anhydrous Crystalline Maltose

What is Anhydrous Crystalline Maltose?

Anhydrous Crystalline Maltose
  • Dry mouth (xerostomia)
  • Sjögren syndrome
  • Dry mouth from medications
  • Food stabilizer and texturizer

Anhydrous crystalline maltose is a starch-derived sugar (also called malt sugar) studied mainly as a slow-dissolving lozenge to ease dry mouth, including in people with Sjögren syndrome. Some studies suggest it may modestly improve saliva flow, but the overall evidence is limited. It appears generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have diabetes.

Read the full Anhydrous Crystalline Maltose monograph & all interactions
Medication

About Glipizide

What Is Glipizide Used For?

Brand names: Glucotrol, Glucotrol XL

Glipizide tablets and glipizide extended-release tablets are both used as an add-on to diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes. It is not used for type 1 diabetes or diabetic ketoacidosis (a serious complication of uncontrolled blood sugar).

See full Glipizide drug information
Keep checking

Other Drugs & Anhydrous Crystalline Maltose

Browse every other medication we’ve checked against Anhydrous Crystalline Maltose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
85Minor
2,744No known interaction
85 Minor 2,744 No interaction
Minor

85 interactions

Showing 60 of 85 minor interactions — see all 85 on the Anhydrous Crystalline Maltose page.

No interaction 2,744 drugs checked — show the list

We also checked Anhydrous Crystalline Maltose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Anhydrous Crystalline Maltose list.

See the full Anhydrous Crystalline Maltose interactions page
See every supplement checked against Glipizide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Anhydrous Crystalline Maltose monograph › Uses, safety, and every drug interaction in one place Glipizide supplement interactions › Every supplement checked against Glipizide, ranked by severity Glipizide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Anhydrous Crystalline Maltose and Glipizide Together: Common Questions

Can you take Anhydrous Crystalline Maltose with Glipizide?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Anhydrous Crystalline Maltose and Glipizide interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Glipizide and Anhydrous Crystalline Maltose?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.