Drug & supplement interaction

Anhydrous Crystalline Maltose + Tolbutamide

Tolbutamide brand name: Orinase.

Minor Interaction
Medically reviewed by · Updated February 2024
The bottom line Minor

Anhydrous Crystalline Maltose has a minor interaction with Tolbutamide. Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose).

Read the full interaction report
SeverityMinor
LikelihoodProbable
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Anhydrous Crystalline Maltose and Tolbutamide

Here is the interaction we found between these two, with the evidence behind it.

Minor

Antidiabetes Drugs

Why this applies to Tolbutamide

Tolbutamide falls under Antidiabetes Drugs — the group Anhydrous Crystalline Maltose interacts with.

Maltose, a disaccharide composed of two glucose molecules, has the potential to affect blood sugar levels similarly to table sugar (sucrose). While maltose itself does not necessarily interact directly with antidiabetic drugs, its digestion into glucose can lead to elevated blood sugar levels, which may impact the effectiveness of antidiabetic medications. In terms of effects on blood sugar, maltose may lead to a more rapid increase in blood sugar levels compared to sucrose, as it is directly converted into glucose. Individuals with diabetes should monitor their blood sugar levels closely when consuming foods or beverages containing maltose to maintain proper glucose control.
Severity Minor Likelihood Probable Evidence B

Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports..

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: tolbutamide (Orinase) works by nudging your pancreas to release insulin so your blood sugar comes down. Maltose is just a sugar, two glucose units stuck together, and once it dissolves and gets swallowed your body breaks it into glucose quickly. So if you're using maltose lozenges through the day for dry mouth, that added sugar could push your blood sugar up a bit and work against what your tolbutamide is trying to do.

This is a minor concern, and a single lozenge isn't likely to undo your medicine. But if you use them often, keep an eye on your home glucose readings and let your pharmacist or doctor know. Sugar-free moisturizing options may be a smarter pick if blood sugar control is tricky for you.

Contact Dr. Brian directly if you have additional questions on this interaction

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Anhydrous Crystalline Maltose Also Interacts With Other Medications

Anhydrous Crystalline Maltose has 85 minor known drug interactions in our database — the Tolbutamide one above is one of them. If you take anything else, check it against the full list below.

Minor 85 No known interaction 2,745 (incl. Tolbutamide)
Taking anything else?

Check Another of Your Medications Against Anhydrous Crystalline Maltose

Covers the 2,830 medications we’ve checked against Anhydrous Crystalline Maltose. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Tolbutamide

This page covers Anhydrous Crystalline Maltose only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolbutamide page lists 305 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 255 moderate · 48 minor.

From our pharmacist’s overview on the Tolbutamide page

“People take tolbutamide (Orinase) to lower blood sugar in type 2 diabetes, and diabetes is exactly the condition supplement shelves target, which is why this list runs to 305 ingredients and deserves real caution. Of those, 239 also push glucose around, most often downward, so combining them can drive sugar lower than intended.”

Reviewed by 2 · Jul 18, 2026

Open the Tolbutamide interaction page

How much people look this up

Where Anhydrous Crystalline Maltose and Tolbutamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Anhydrous Crystalline Maltose
Steady interest

#880 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolbutamide
Steady interest

#1,697 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Anhydrous Crystalline Maltose

What is Anhydrous Crystalline Maltose?

Anhydrous Crystalline Maltose
  • Dry mouth (xerostomia)
  • Sjögren syndrome
  • Dry mouth from medications
  • Food stabilizer and texturizer

Anhydrous crystalline maltose is a starch-derived sugar (also called malt sugar) studied mainly as a slow-dissolving lozenge to ease dry mouth, including in people with Sjögren syndrome. Some studies suggest it may modestly improve saliva flow, but the overall evidence is limited. It appears generally well tolerated, but talk with your pharmacist or doctor before using it, especially if you have diabetes.

Read the full Anhydrous Crystalline Maltose monograph & all interactions
Medication

About Tolbutamide

What Is Tolbutamide Used For?

Brand name: Orinase

  • Tolbutamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolbutamide is in a class of medications called sulfonylureas. Tolbutamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Tolbutamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

See full Tolbutamide drug information
Keep checking

Other Drugs & Anhydrous Crystalline Maltose

Browse every other medication we’ve checked against Anhydrous Crystalline Maltose — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
85Minor
2,744No known interaction
85 Minor 2,744 No interaction
Minor

85 interactions

Showing 60 of 85 minor interactions — see all 85 on the Anhydrous Crystalline Maltose page.

No interaction 2,744 drugs checked — show the list

We also checked Anhydrous Crystalline Maltose against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Anhydrous Crystalline Maltose list.

See the full Anhydrous Crystalline Maltose interactions page
See every supplement checked against Tolbutamide, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Anhydrous Crystalline Maltose monograph › Uses, safety, and every drug interaction in one place Tolbutamide supplement interactions › Every supplement checked against Tolbutamide, ranked by severity Tolbutamide drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Anhydrous Crystalline Maltose and Tolbutamide Together: Common Questions

Can you take Anhydrous Crystalline Maltose with Tolbutamide?
There is only a minor interaction, which is usually not serious. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Anhydrous Crystalline Maltose and Tolbutamide interaction?
We rate it Minor. This interaction is generally not clinically significant, but it remains worth noting and discussing with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.