Medication interaction hub

What Supplements Interact with Tolbutamide?

Tolbutamide brand name: Orinase. Every interaction below applies to the brands too.

305 Interactions 2 Major 255 Moderate 48 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Tolbutamide? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Tolbutamide against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

People take tolbutamide (Orinase) to lower blood sugar in type 2 diabetes, and diabetes is exactly the condition supplement shelves target, which is why this list runs to 305 ingredients and deserves real caution. Of those, 239 also push glucose around, most often downward, so combining them can drive sugar lower than intended. Two carry major ratings and matter most. Siberian cocklebur has caused severe hypoglycemia in people, and activated charcoal can soak up the drug in the gut before it gets absorbed.

Nearly everything else is moderate, 255 entries versus 48 minor. Some slow the enzyme that clears tolbutamide, which raises its levels, and about twenty add sun sensitivity. Even beer makes the list, since alcohol blunts the body's ability to recover from a low. Check glucose more often whenever a supplement joins the mix, and treat shakiness, sweating, or confusion as low blood sugar until proven otherwise.

— , Clinical Pharmacist · July 18, 2026

Major 2 Moderate 255 Minor 48 No known interaction 1,147

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Tolbutamide: Top Interactions at a Glance

The Tolbutamide supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 305 interacting ingredients — plus 1,147 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Tolbutamide Combinations Today

The Tolbutamide + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Damiana + Tolbutamidei

Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Possible Phaseolus Vulgaris + Tolbutamidei

Theoretically, Phaseolus vulgaris might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Terminalia Chebula + Tolbutamidei

Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypoglycemia.

Read the full interaction Moderate Likelihood Probable Salacia + Tolbutamidei

Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction Moderate Likelihood Possible Juniper + Tolbutamidei

Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.

Read the full interaction Moderate Likelihood Possible Kombucha + Tolbutamidei

Theoretically, kombucha might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Read the full interaction
The complete list

Every Supplement Checked Against Tolbutamide

All 1,452 ingredients in our database, ranked by severity — 305 with a Tolbutamide interaction on file and 1,147 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Tolbutamide?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Damiana with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking damiana with antidiabetes drugs might increase the risk of hypoglycemia.

Full Damiana + Tolbutamide answer

Can you take Phaseolus Vulgaris with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Phaseolus vulgaris might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Phaseolus Vulgaris + Tolbutamide answer

Can you take Terminalia Chebula with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of Terminalia chebula with antidiabetes drugs could affect blood sugar control and increase the risk of hypog...

Full Terminalia Chebula + Tolbutamide answer

Can you take Salacia with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Salacia might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Salacia + Tolbutamide answer

Can you take Juniper with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking juniper berry with antidiabetes medications might cause additive hypoglycemia.

Full Juniper + Tolbutamide answer

Can you take Bay Leaf with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Concomitant use of bay leaf with antidiabetes drugs might increase the risk of hypoglycemia.

Full Bay Leaf + Tolbutamide answer

Can you take Berberine with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, berberine might increase serum levels of drugs metabolized by CYP2C9.

Full Berberine + Tolbutamide answer

Can you take Bilberry with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Bilberry + Tolbutamide answer

Can you take Bishop's Weed with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Bishop's weed constituents seem to cause photosensitivity.

Full Bishop's Weed + Tolbutamide answer

Can you take Bitter Orange with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, bitter orange might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Bitter Orange + Tolbutamide answer

Can you take Black Mulberry with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black mulberry leaf might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Black Mulberry + Tolbutamide answer

Can you take Black Mustard with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black mustard seed might increase the risk of hypoglycemia when used with antidiabetes drugs.

Full Black Mustard + Tolbutamide answer

Can you take Black Pepper with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black pepper might increase the risk of hypoglycemia when taken with antidiabetes drugs.

Full Black Pepper + Tolbutamide answer

Can you take Black Seed with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, black seed might increase levels of drugs metabolized by CYP2C9.

Full Black Seed + Tolbutamide answer

Can you take Blood Irradiation Therapy with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary clinical research and one case report suggest that blood irradiation therapy may lower blood glucose levels.

Full Blood Irradiation Therapy + Tolbutamide answer

Can you take Blue Cohosh with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. There is some concern that blue cohosh might increase blood glucose levels.

Full Blue Cohosh + Tolbutamide answer

Can you take Blue-green Algae with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking blue-green algae with antidiabetes drugs might increase the risk of hypoglycemia.

Full Blue-green Algae + Tolbutamide answer

Can you take Boswellia Serrata with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.

Full Boswellia Serrata + Tolbutamide answer

Can you take Brewer's Yeast with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.

Full Brewer's Yeast + Tolbutamide answer

Can you take Brickellia with Tolbutamide?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Preliminary research in animal models shows that brickellia and its constituents have hypoglycemic effects.

Full Brickellia + Tolbutamide answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Tolbutamide is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Tolbutamide, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Tolbutamide sits in 5 interaction categories. Open any one to see what the group means:

Antidiabetes Drugs 239 ingredients

Blood-sugar-lowering medications. Supplements that also lower glucose can push blood sugar too low when combined.

239 of the supplement ingredients on this page reach Tolbutamide through this category.

Cytochrome P450 2C9 (Cyp2C9) Substrates 64 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

64 of the supplement ingredients on this page reach Tolbutamide through this category.

Photosensitizing Drugs 20 ingredients

Medications that make skin more sun-sensitive. Supplements with the same property can compound it.

20 of the supplement ingredients on this page reach Tolbutamide through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Tolbutamide through this category.

Tolbutamide (Orinase) 4 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

4 of the supplement ingredients on this page reach Tolbutamide through this category.

About Tolbutamide

Tolbutamide is a prescription medication also sold under the brand name Orinase. Because supplements and herbal products can change how medications work — or how strongly — every ingredient on this page has been checked against it in our interaction database.

Generic name: Tolbutamide  ·  Brand name: Orinase.

See the full Tolbutamide drug information

Related: does Tolbutamide deplete any nutrients?

Tolbutamide has 1 reported nutrient association in the research literature — see the Tolbutamide nutrient depletion report.

Check a real product

Take a Supplement Product? Check the Whole Bottle Against Tolbutamide

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Tolbutamide.

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Pharmacist Counseling Corner

Tolbutamide & Supplements: Common Questions

What supplements interact with Tolbutamide?
More than you might expect — 305 in total, though they are far from equal: 2 are rated major, 255 moderate, and 48 minor. The ranked list on this page puts the ones that genuinely matter first, and every entry opens a full report on that exact pair. The highest-ranked right now: Siberian Cocklebur, Activated Charcoal, American Ginseng.
Which Tolbutamide supplement interactions are the most serious?
Focus on the major group: Siberian Cocklebur and Activated Charcoal. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Tolbutamide?
Usually yes — most people on Tolbutamide can take most supplements. The catch is the exceptions, and they aren't always the exotic ones (St. John's Wort trips up more prescriptions than almost anything sold next to it). Look up each ingredient you actually take in the list above, and treat "no known interaction" as a green-ish light, not a guarantee. Try the label scanner or the interaction checker.
Do brands like Orinase have the same supplement interactions as Tolbutamide?
Yes — Orinase all contain Tolbutamide, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
Does Tolbutamide deplete any vitamins or nutrients?
It might — Tolbutamide has 1 reported nutrient-depletion association in the research literature, which is a different question from interactions: instead of a supplement changing the drug, the drug may lower a nutrient over time. See the Tolbutamide nutrient depletion report for the specifics and what to discuss with your pharmacist.
What about Tolbutamide and my other medications?
This page covers Tolbutamide against supplements and herbal ingredients. Checking Tolbutamide against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Tolbutamide drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.