Drug & supplement interaction

California Poppy + Tolbutamide

Tolbutamide brand name: Orinase.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between California Poppy and Tolbutamide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

California Poppy and Tolbutamide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Tolbutamide and California Poppy in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

California Poppy safety at a glance

California Poppy overall Use caution Generally considered mild for short-term use, but human safety data are limited.
Pregnancy Avoid Not enough safety data; best avoided during pregnancy.
Breastfeeding Avoid Not enough safety data; best avoided while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Tolbutamide and California Poppy? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Tolbutamide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Tolbutamide is filed under 5 classifications — including antidiabetes drugs, cytochrome p450 2c9 (cyp2c9) substrates, photosensitizing drugs. California Poppy has documented interactions with 1 drug class — the most serious being cns depressants (moderate) — and none of Tolbutamide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

California Poppy Does Interact With Other Medications

California Poppy has 248 moderate known drug interactions in our database — Tolbutamide isn’t one of them. If you take anything else, check it against the full list below.

Moderate 248 No known interaction 2,582 (incl. Tolbutamide)
Taking anything else?

Check Another of Your Medications Against California Poppy

Covers the 2,830 medications we’ve checked against California Poppy. Pick one to open its full report.

What to actually watch for

What California Poppy Itself Has Been Linked To

This is not an interaction — nothing below involves Tolbutamide. It is the side-effect record for California Poppy on its own, from the licensed Natural Medicines monograph. If something new turns up after you add California Poppy, this list is the first place to look.

  • Joint or muscle stiffness Additional detail

    “There is currently a limited amount of information available about the adverse effects of California poppy.

    Most Common Adverse Effects:

    Orally: When used in combination with hawthorn and magnesium, California poppy has been reported to cause muscular stiffness, morning fatigue, and nausea. It is not clear if these effects are from California poppy, the other ingredients, or the combination.”

    California Poppy · Natural Medicines adverse-effect record, reported in fatigue.

  • Tiredness Additional detail

    “Orally, when used in combination with hawthorn and magnesium, California poppy has been reported to cause morning fatigue. It is not clear if this effect is from California poppy, the other ingredients, or the combination.”

    California Poppy · Natural Medicines adverse-effect record, reported in fatigue.

    1 source cited
    1. 12583. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
  • Nausea Additional detail

    “Orally, when used in combination with hawthorn and magnesium, California poppy has been reported to cause nausea. It is not clear if this effect is from California poppy, the other ingredients, or the combination.”

    California Poppy · Natural Medicines adverse-effect record, reported in nausea and vomiting.

    1 source cited
    1. 12583. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate

Everything above comes from the Natural Medicines adverse-effect record for California Poppy — expand a row for the licensed statement it rests on. We haven’t matched Tolbutamide to its FDA label in our system yet, so we can’t compare its own side-effect list here — the leaflet that comes with your prescription is the authoritative list for Tolbutamide.

Everything else you take

See Every Supplement That Interacts With Tolbutamide

This page covers California Poppy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Tolbutamide page lists 305 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 255 moderate · 48 minor.

From our pharmacist’s overview on the Tolbutamide page

“People take tolbutamide (Orinase) to lower blood sugar in type 2 diabetes, and diabetes is exactly the condition supplement shelves target, which is why this list runs to 305 ingredients and deserves real caution. Of those, 239 also push glucose around, most often downward, so combining them can drive sugar lower than intended.”

Reviewed by 2 · Jul 18, 2026

Open the Tolbutamide interaction page

One more smart check

Taking California Poppy as Part of a Dietary Supplement Product? Check It for Interactions

We hold 345 real supplement products containing California Poppy, each one broken down to its full ingredient list — and combination products often carry several ingredients besides California Poppy. Even though California Poppy itself has no known interaction with Tolbutamide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where California Poppy and Tolbutamide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement California Poppy
Top 25%

#310 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Tolbutamide
Steady interest

#2,321 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every California Poppy reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The California Poppy and Tolbutamide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About California Poppy

What is California Poppy?

California Poppy
  • Anxiety and stress
  • Trouble sleeping (insomnia)
  • Mild aches and pains
  • Restlessness or nervous tension
  • Bedwetting in children (traditional use)

California poppy is a traditional herbal remedy used mainly for anxiety and sleep problems, often combined with other calming herbs. Human research is very limited, so its true benefits are not well proven. It is generally considered mild, but should be avoided during pregnancy and breastfeeding and used with caution by anyone taking sedating medicines.

Eschscholzia californica · Papaveraceae · Above-ground parts (flowers, leaves, stems) and roots · Tea, tincture, liquid extract, capsules, dried herb

An interaction check asks whether these two react with each other — it does not ask whether California Poppy is a good idea for someone in your situation. Here is what our California Poppy record says about it on its own.

California Poppy: dosing

There is no official, standardized dose for California poppy. Products vary widely in strength, and it is often part of herbal blends. The best approach is to follow the directions on the product label and not exceed the recommended amount.It is commonly taken in the evening when used for sleep, but timing and amount should be guided by the product and your own response.

From our California Poppy monograph — the full record covers uses, side effects and every documented interaction.

Read the full California Poppy monograph & all interactions
Medication

About Tolbutamide

What Is Tolbutamide Used For?

Brand name: Orinase

  • Tolbutamide is used along with diet and exercise, and sometimes with other medications, to treat type 2 diabetes (condition in which the body does not use insulin normally and, therefore, cannot control the amount of sugar in the blood). Tolbutamide is in a class of medications called sulfonylureas. Tolbutamide lowers blood sugar by causing the pancreas to produce insulin (a natural substance that is needed to break down sugar in the body) and helping the body use insulin efficiently. This medication will only help lower blood sugar in people whose bodies produce insulin naturally. Tolbutamide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and, therefore, cannot control the amount of sugar in the blood) or diabetic ketoacidosis (a serious condition that may occur if high blood sugar is not treated).

  • Over time, people who have diabetes and high blood sugar can develop serious or life-threatening complications, including heart disease, stroke, kidney problems, nerve damage, and eye problems. Taking medication(s), making lifestyle changes (e.g., diet, exercise, quitting smoking), and regularly checking your blood sugar may help to manage your diabetes and improve your health. This therapy may also decrease your chances of having a heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage (numb, cold legs or feet; decreased sexual ability in men and women), eye problems, including changes or loss of vision, or gum disease. Your doctor and other healthcare providers will talk to you about the best way to manage your diabetes.

See full Tolbutamide drug information Tolbutamide NDC codes and packages
Keep checking

Other Drugs & California Poppy

Browse every other medication we’ve checked against California Poppy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
248Moderate
0Minor
2,581No known interaction
248 Moderate 2,581 No interaction
Moderate

248 interactions

Showing 60 of 248 moderate interactions — see all 248 on the California Poppy page.

No interaction 2,581 drugs checked — show the list

We also checked California Poppy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,581 medications checked with no known interaction — see the full California Poppy list.

See the full California Poppy interactions page
See every supplement checked against Tolbutamide, ranked by severity
Evidence & sources

California Poppy References

The 3 references that drive our California Poppy monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate
  2. Paul LD, Springer D, Staack RF, et al. Cytochrome P450 isoenzymes involved in rat liver microsomal metabolism of californine and protopine. Eur J Pharmacol 2004;485:69-79. PubMed
  3. Paul LD, Maurer HH. Studies on the metabolism and toxicological detection of the Eschscholtzia californica alkaloids californine and protopine in urine using gas chromatography-mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2003;789:43-5

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking California Poppy and Tolbutamide Together: Common Questions

Is it safe to take California Poppy with Tolbutamide?
We do not list a known interaction between California Poppy and Tolbutamide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the California Poppy and Tolbutamide combination checked?
Interactions in our licensed database are recorded against drug classes. Tolbutamide is filed under 5 classifications, and California Poppy has documented interactions with 1 drug class — none of Tolbutamide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does California Poppy interact with any other medications?
Yes. California Poppy has 248 documented drug interactions in our database — Tolbutamide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Tolbutamide interact with any supplements?
Yes. Tolbutamide has documented interactions with 305 supplements in our database — California Poppy is not one of them. The Tolbutamide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

California Poppy monograph Uses, safety profile, and every drug interaction in one place Tolbutamide drug information The full plain-English guide to this medication Tolbutamide supplement interactions Every supplement checked against Tolbutamide, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Tolbutamide and California Poppy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.