Herb & supplement monograph

Haronga Drug Interactions, Uses, Effectiveness, Safety & More

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Interaction report

Drugs that interact with Haronga

0 medications have a known interaction with Haronga, graded by severity. Select any drug for the full evidence-based detail.

We don’t currently list any known drug interactions for Haronga. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.

Read The List Like a Pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each drug listed above links to the full report for that exact Haronga combination — clinical detail, likelihood, evidence level, and citations.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Monograph

Haronga: Uses, Safety & Side Effects

The bottom line

Haronga (Harungana madagascariensis) is an African tree whose bark and leaves have been used traditionally and in some European products for indigestion and digestive complaints. Evidence for its benefits is very limited, and safety information is sparse, so it should be used with caution and under the guidance of a pharmacist or doctor.

Scientific name
Harungana madagascariensis
Family
Hypericaceae
Part used
Bark and leaves
Common forms
Capsules, tablets, dried bark, tea, liquid extracts
People commonly use it for
  • Indigestion and dyspepsia
  • Loss of appetite
  • Digestive complaints
  • Diarrhea (traditional use)
  • Wound healing (traditional, topical)

Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.

Safety at a glance
OverallUse caution

Limited safety data exist, so use carefully and only when advised.

PregnancyInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full pregnancy detail
BreastfeedingInsufficient reliable information

Insufficient reliable information available; avoid using.

Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

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Overview

Haronga comes from Harungana madagascariensis, a tree that grows in tropical Africa, Madagascar, and parts of nearby islands. It belongs to the same plant family as St. John's wort. The bark and leaves are the parts most often used.

Traditionally, healers in Africa have used different parts of the plant for digestive problems, skin wounds, and other complaints. In Europe, extracts of Haronga have been included in some over-the-counter products marketed for mild digestive upset, such as indigestion and poor appetite.

How it works

Haronga contains a mix of plant compounds, including substances called anthranoids (such as hypericin-like pigments) and tannins. Some research suggests these may stimulate digestive secretions, including bile and stomach acid, which could in theory help with digestion.

Laboratory studies have also looked at possible antimicrobial and antioxidant effects of its extracts. It is important to understand that most of this work is based on test-tube or animal research, not large human studies, so we cannot be sure how it behaves in people.

Effectiveness

Does Haronga work?

Evidence overview · 1 use evaluated
1 Insufficient evidence
How to read these evidence grades

Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.

1EffectiveStrong, consistent evidence it works.
2Likely EffectiveGood evidence, though not yet conclusive.
3Possibly EffectiveSome evidence suggests a benefit.
4Possibly IneffectiveSome evidence it may not help.
5Likely IneffectiveFairly strong evidence it doesn’t help.
6IneffectiveStrong evidence it doesn’t work.
7Insufficient Reliable Evidence to RateToo little research to say either way.

For Haronga, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.

Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aging skin
Rating & evidence shown verbatim from Natural Medicines

It is unclear if topical haronga is beneficial for reducing skin aging.

Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.

Safety & precautions

There is not much published safety information about Haronga, so a cautious approach is wise. People with liver problems, gallbladder disease, or bile duct blockages should be especially careful, since herbs that affect bile flow may not be suitable for them.

Because Haronga contains anthranoid compounds, prolonged or high-dose use could potentially cause digestive or other unwanted effects. Pregnant and breastfeeding people should avoid it because there is not enough information to consider it safe. It is also best avoided in children unless a healthcare provider advises otherwise. Always check with a pharmacist or doctor before starting Haronga, especially if you take other medicines or have a chronic condition.

Side effects

Reported side effects are not well documented, but digestive complaints such as stomach upset, cramping, or loose stools are possible, particularly at higher doses. Because the plant is related to St. John's wort and contains light-sensitive pigments, increased sensitivity to sunlight is a theoretical concern.

Allergic reactions are always possible with any plant product. Stop using Haronga and seek medical care if you notice rash, swelling, trouble breathing, or other signs of a serious reaction.

Dosing

There is no well-established standardized dose for Haronga. Amounts vary between products and traditional preparations.

If you use a commercial product, follow the directions on the label and do not exceed the recommended amount. Because reliable dosing guidance is lacking, it is best to check with a pharmacist or doctor before using it, and to avoid long-term use without professional advice.

Pregnancy & Breastfeeding

Haronga & Pregnancy

Insufficient reliable information

Insufficient reliable information available; avoid using.

Haronga & Breastfeeding

Insufficient reliable information

Insufficient reliable information available; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.

© 2026 Therapeutic Research Center

Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center

References & further reading

The 2 sources that drive our Haronga monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.

  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
Keep reading

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.

Pharmacist Counseling Corner

Haronga: Common Questions

What is Haronga used for, and does it work?
People use Haronga for a range of reasons, but according to the Natural Medicines database the current clinical evidence is insufficient to confirm it works for the specific conditions it has been studied for. See the graded list on this page, and talk to your pharmacist or doctor before relying on it for any condition.
Does Haronga interact with prescription medications?
We do not currently list any known drug interactions for Haronga. This does not guarantee that none exist, so always confirm with your pharmacist before combining it with your medications.
How are Haronga interactions rated?
Each interaction is graded major, moderate, or minor based on how clinically significant it is and the strength of the evidence behind it. Major interactions are the most serious and are best avoided, or used only under close professional supervision.
Is it safe to take Haronga with my medications?
It depends on the specific medication. Some combinations are fine, while others call for monitoring, timing changes, or should be avoided. Check your exact drug above and confirm with your pharmacist or doctor before starting, stopping, or changing anything.
Where does this Haronga interaction information come from?
Our interaction data is built on the Natural Medicines database — an evidence-graded reference for vitamins, herbs, and supplements — and is reviewed by licensed HelloPharmacist pharmacists, who may add clinical context.
What is Haronga used for?
It is mainly used in traditional and some over-the-counter products for digestive complaints like indigestion and loss of appetite. Evidence that it works is limited.
Is Haronga safe to take?
Safety data are limited, so it should be used cautiously and ideally under the guidance of a pharmacist or doctor, especially if you have liver or gallbladder problems.
Can I take Haronga while pregnant or breastfeeding?
No. There is not enough information to consider it safe, so it is best avoided during pregnancy and breastfeeding.
Does Haronga have side effects?
Possible side effects include stomach upset and loose stools, and allergic reactions can occur. Stop using it and seek care if you have a serious reaction.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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