Haronga Drug Interactions, Uses, Effectiveness, Safety & More
What is this page for?
First and foremost: how Haronga interacts with medications. The heart of this page is the interaction list — every drug Haronga is known to interact with, and how serious each one is.
But these pages have grown well beyond that into a full monograph — what Haronga is, what people use it for and how strong the evidence is, its safety and side effects, and answers to the questions we’re asked most — written and reviewed by the clinical staff at HelloPharmacist. It’s educational information from our licensed clinical databases, not medical advice, and we don’t sell or endorse products. Our editorial policy
Check Haronga against your medication
Add one medicationDrugs that interact with Haronga
0 medications have a known interaction with Haronga, graded by severity. Select any drug for the full evidence-based detail.
We don’t currently list any known drug interactions for Haronga. This doesn’t guarantee none exist — always confirm with your pharmacist before combining supplements with your medications.
What Severity, Likelihood & Evidence Mean
Severity — How Serious It Can Be
- Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
- Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
- Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
- No known interaction. Checked against our sources with nothing documented — not the same as proven safety.
Likelihood — How Well It’s Documented
- Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
- Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
- Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
- Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Where This Data Comes From
- Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
- Each drug listed above links to the full report for that exact Haronga combination — clinical detail, likelihood, evidence level, and citations.
- Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.
Haronga: Uses, Safety & Side Effects
Haronga (Harungana madagascariensis) is an African tree whose bark and leaves have been used traditionally and in some European products for indigestion and digestive complaints. Evidence for its benefits is very limited, and safety information is sparse, so it should be used with caution and under the guidance of a pharmacist or doctor.
- Scientific name
- Harungana madagascariensis
- Family
- Hypericaceae
- Part used
- Bark and leaves
- Common forms
- Capsules, tablets, dried bark, tea, liquid extracts
- Indigestion and dyspepsia
- Loss of appetite
- Digestive complaints
- Diarrhea (traditional use)
- Wound healing (traditional, topical)
Popular and traditional uses — not proof it works. See “Uses & effectiveness” below for the evidence.
Limited safety data exist, so use carefully and only when advised.
Insufficient reliable information available; avoid using.
Read the full pregnancy detailInsufficient reliable information available; avoid using.
Read the full breastfeeding detailPregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center). Safety guidance is general; always confirm with your pharmacist or doctor for your situation.
Overview
Haronga comes from Harungana madagascariensis, a tree that grows in tropical Africa, Madagascar, and parts of nearby islands. It belongs to the same plant family as St. John's wort. The bark and leaves are the parts most often used.
Traditionally, healers in Africa have used different parts of the plant for digestive problems, skin wounds, and other complaints. In Europe, extracts of Haronga have been included in some over-the-counter products marketed for mild digestive upset, such as indigestion and poor appetite.
How it works
Haronga contains a mix of plant compounds, including substances called anthranoids (such as hypericin-like pigments) and tannins. Some research suggests these may stimulate digestive secretions, including bile and stomach acid, which could in theory help with digestion.
Laboratory studies have also looked at possible antimicrobial and antioxidant effects of its extracts. It is important to understand that most of this work is based on test-tube or animal research, not large human studies, so we cannot be sure how it behaves in people.
Does Haronga work?
How to read these evidence grades
Natural Medicines’ 7-point scale. We show each rating’s label word-for-word.
For Haronga, current evidence isn’t strong enough to rate any specific use. The conditions it has been studied for are listed below.
Also studied for 1 condition — evidence insufficient to rate
Insufficient Reliable Evidence To Rate Aging skin
It is unclear if topical haronga is beneficial for reducing skin aging.
Source & disclaimer. Effectiveness ratings and evidence summaries are provided by Natural Medicines (Therapeutic Research Center) and shown as licensed. Where Natural Medicines hasn’t rated a use, HelloPharmacist’s pharmacists may add their own reviewed rating and evidence (each such entry is labeled). This is educational information, not medical advice — talk with your pharmacist or doctor before starting, stopping, or changing a supplement.
Safety & precautions
There is not much published safety information about Haronga, so a cautious approach is wise. People with liver problems, gallbladder disease, or bile duct blockages should be especially careful, since herbs that affect bile flow may not be suitable for them.
Because Haronga contains anthranoid compounds, prolonged or high-dose use could potentially cause digestive or other unwanted effects. Pregnant and breastfeeding people should avoid it because there is not enough information to consider it safe. It is also best avoided in children unless a healthcare provider advises otherwise. Always check with a pharmacist or doctor before starting Haronga, especially if you take other medicines or have a chronic condition.
Side effects
Reported side effects are not well documented, but digestive complaints such as stomach upset, cramping, or loose stools are possible, particularly at higher doses. Because the plant is related to St. John's wort and contains light-sensitive pigments, increased sensitivity to sunlight is a theoretical concern.
Allergic reactions are always possible with any plant product. Stop using Haronga and seek medical care if you notice rash, swelling, trouble breathing, or other signs of a serious reaction.
Dosing
There is no well-established standardized dose for Haronga. Amounts vary between products and traditional preparations.
If you use a commercial product, follow the directions on the label and do not exceed the recommended amount. Because reliable dosing guidance is lacking, it is best to check with a pharmacist or doctor before using it, and to avoid long-term use without professional advice.
Haronga & Pregnancy
Haronga & Breastfeeding
© 2026 Therapeutic Research Center
Pregnancy & lactation ratings: Natural Medicines, Therapeutic Research Center
References & further reading
The 2 sources that drive our Haronga monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing.
- Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
- Herbs at a Glance — NIH National Center for Complementary and Integrative Health Source
This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.
Haronga: Common Questions
What is Haronga used for, and does it work?
Does Haronga interact with prescription medications?
How are Haronga interactions rated?
Is it safe to take Haronga with my medications?
Where does this Haronga interaction information come from?
What is Haronga used for?
Is Haronga safe to take?
Can I take Haronga while pregnant or breastfeeding?
Does Haronga have side effects?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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