Drug & supplement interaction

Androstenetrione + Glipizide

Glipizide brand names: Glucotrol, Glucotrol XL.

No Known Interaction
The bottom line No known interaction

We found no known interaction between Androstenetrione and Glipizide in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first.

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Interaction report

Androstenetrione and Glipizide

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Glipizide and Androstenetrione in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Androstenetrione safety at a glance

Androstenetrione overall Use caution Limited safety data and hormone-related side effects make this a risky supplement.
Pregnancy Possibly Unsafe When used orally. There is no scientifically reliable information about using androstenetrione during pregnancy or lactation. Promoters indicate that it can inc... Read the full pregnancy detail
Breastfeeding Possibly Unsafe When used orally. There is no scientifically reliable information about using androstenetrione during pregnancy or lactation. Promoters indicate that it can inc... Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Glipizide and Androstenetrione? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Glipizide

Interactions in our licensed database are recorded against drug classes, not just single drug names. Glipizide is filed under 6 classifications — including sulfonylureas, antidiabetes drugs, cytochrome p450 2c9 (cyp2c9) substrates. Androstenetrione has documented interactions with 1 drug class — the most serious being androgens (minor) — and none of Glipizide’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Androstenetrione Does Interact With Other Medications

Androstenetrione has 9 minor known drug interactions in our database — Glipizide isn’t one of them. If you take anything else, check it against the full list below.

Taking anything else?

Check Another of Your Medications Against Androstenetrione

Covers the 2,830 medications we’ve checked against Androstenetrione. Pick one to open its full report.

What to actually watch for

What Androstenetrione Itself Has Been Linked To

This is not an interaction — nothing below involves Glipizide. It is the side-effect record for Androstenetrione on its own, from the licensed Natural Medicines monograph. If something new turns up after you add Androstenetrione, this list is the first place to look.

  • Breast tenderness / Acne Additional detail

    “There is no data regarding oral use of androstenetrione in humans. However, androstenetrione might increase testosterone levels. Theoretically, androstenetrione might cause testosterone-like side effects including spermatogenesis and infertility, acne, testicular atrophy, gynecomastia, behavioral changes, cardiovascular disease, and potentially increase the risk of pancreatic and prostate cancer.”

    Androstenetrione · Natural Medicines adverse-effect record, reported in acne.

Everything above comes from the Natural Medicines adverse-effect record for Androstenetrione — expand a row for the licensed statement it rests on. We read the ADVERSE REACTIONS section of Glipizide’s FDA label too, and the two lists don’t meaningfully overlap — which is why no Glipizide column appears here.

Special populations

Androstenetrione in Pregnancy & Breastfeeding

Pregnancy And Lactation Possibly Unsafe

When used orally. There is no scientifically reliable information about using androstenetrione during pregnancy or lactation. Promoters indicate that it can increase testosterone levels. If this is true, this product may not be safe due to the adverse effects associated with elevated testosterone levels; avoid using.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

From our Q&A

Questions About Androstenetrione or Glipizide

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Androstenetrione or Glipizide, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Glipizide

This page covers Androstenetrione only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Glipizide page lists 307 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), Adrafinil (moderate) and African Wild Potato (moderate).

By severity: 2 major · 256 moderate · 49 minor.

From our pharmacist’s overview on the Glipizide page

“Glipizide (Glucotrol, Glucotrol XL) lowers blood sugar by prompting the pancreas to release more insulin, and that same power is why I read its supplement list with real seriousness. Of the 307 ingredients on file, 239 also act on blood glucose, so stacking them can drive sugar dangerously low.”

Reviewed by 2 · Jul 18, 2026

Open the Glipizide interaction page

One more smart check

Taking Androstenetrione as Part of a Dietary Supplement Product? Check It for Interactions

We hold 2 real supplement products containing Androstenetrione, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Androstenetrione. Even though Androstenetrione itself has no known interaction with Glipizide, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Androstenetrione and Glipizide Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Androstenetrione
Steady interest

#1,113 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Glipizide
Top 25%

#600 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions. Androstenetrione is not yet covered by that licensed database, so its write-up cites publicly available medical sources directly (see the references below).
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Androstenetrione reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Androstenetrione and Glipizide records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Androstenetrione

What is Androstenetrione?

Androstenetrione
  • Boosting testosterone
  • Lowering estrogen
  • Bodybuilding and muscle building
  • Post-cycle support for steroid users
  • Athletic performance

Androstenetrione (6-OXO) is a synthetic compound marketed to raise testosterone by blocking the enzyme that turns testosterone into estrogen. Solid human evidence that it offers real benefits is lacking, and it can cause hormone-related side effects, so most people should avoid it and talk with a healthcare provider first.

Synthetic compound (not from a plant) · Capsules, tablets

An interaction check asks whether these two react with each other — it does not ask whether Androstenetrione is a good idea for someone in your situation. Here is what our Androstenetrione record says about it on its own.

Androstenetrione: dosing

There is no established, standardized dose for androstenetrione, and no dose has been proven safe and effective. Different products contain different amounts.Because of the hormone-related risks and weak evidence, we cannot recommend a specific amount.

From our Androstenetrione monograph — the full record covers uses, side effects and every documented interaction.

Read the full Androstenetrione monograph & all interactions
Medication

About Glipizide

What Is Glipizide Used For?

Brand names: Glucotrol, Glucotrol XL

Glipizide tablets and glipizide extended-release tablets are both used as an add-on to diet and exercise to improve blood sugar (glucose) control in adults with type 2 diabetes. It is not used for type 1 diabetes or diabetic ketoacidosis (a serious complication of uncontrolled blood sugar).

Most-Reported Side Effects for Glipizide

From FAERS, the FDA’s public side-effect reporting system (0 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Blood glucose increased 6,712 reports
Nausea 4,542 reports
Diarrhea 3,383 reports
Fatigue 3,045 reports
Weight decreased 2,832 reports
See full Glipizide drug information
Keep checking

Other Drugs & Androstenetrione

Browse every other medication we’ve checked against Androstenetrione — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
9Minor
2,820No known interaction
Minor

9 interactions

No interaction 2,820 drugs checked — show the list
Evidence & sources

Androstenetrione References

The 3 sources that drive our Androstenetrione monograph — publicly available pages from reputable medical and government organizations. Every link was verified to work before publishing. Androstenetrione is not covered by the licensed Natural Medicines interaction database, so its page cites these public sources directly.

  1. Dietary Supplements for Exercise and Athletic Performance — NIH Office of Dietary Supplements Source
  2. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  3. Herbs at a Glance — NIH NCCIH Source

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Androstenetrione and Glipizide Together: Common Questions

Is it safe to take Androstenetrione with Glipizide?
We do not list a known interaction between Androstenetrione and Glipizide. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
How was the Androstenetrione and Glipizide combination checked?
Interactions in our licensed database are recorded against drug classes. Glipizide is filed under 6 classifications, and Androstenetrione has documented interactions with 1 drug class — none of Glipizide's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Androstenetrione interact with any other medications?
Yes. Androstenetrione has 9 documented drug interactions in our database — Glipizide is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Glipizide interact with any supplements?
Yes. Glipizide has documented interactions with 307 supplements in our database — Androstenetrione is not one of them. The Glipizide interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Glipizide and Androstenetrione?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.