Drug & supplement interaction

Dimethylhexylamine (dmha) + Orphenadrine

Orphenadrine brand names: Norflex, Disipal, Banflex, Flexoject, Flexon, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Oct 4, 2026
The bottom line No known interaction

We found no known interaction between Dimethylhexylamine (dmha) and Orphenadrine in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Dimethylhexylamine (dmha) and Orphenadrine

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Orphenadrine and Dimethylhexylamine (dmha) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Dimethylhexylamine (dmha) safety at a glance

Dimethylhexylamine... overall Avoid DMHA is an unapproved stimulant with serious safety concerns and is best avoided.
Pregnancy Avoid Avoid during pregnancy; no safety data and it is a potent stimulant.
Breastfeeding Avoid Avoid while breastfeeding; no safety data and it may pass into breast milk.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Orphenadrine and Dimethylhexylamine (dmha)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Orphenadrine

Interactions in our licensed database are recorded against drug classes, not just single drug names. Orphenadrine is filed under 3 classifications — skeletal muscle relaxants, cytochrome p450 2b6 (cyp2b6) substrates, oral drugs. Dimethylhexylamine (dmha) has documented interactions with 1 drug class — the most serious being stimulant drugs (moderate) — and none of Orphenadrine’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Dimethylhexylamine (dmha) Does Interact With Other Medications

Dimethylhexylamine (dmha) has 172 moderate known drug interactions in our database — Orphenadrine isn’t one of them. If you take anything else, check it against the full list below.

Moderate 172 No known interaction 2,658 (incl. Orphenadrine)
Taking anything else?

Check Another of Your Medications Against Dimethylhexylamine (dmha)

Covers the 2,830 medications we’ve checked against Dimethylhexylamine (dmha). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Dimethylhexylamine (dmha) and Orphenadrine May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • A fast or pounding heartbeat Additional detail

    Dimethylhexylamine (dmha)

    “Theoretically, DMHA might be associated with an increased risk for hypertension, tachycardia, and cardiovascular events, as have been reported with a structurally similar stimulant, dimethylamylamine (DMAA).”

    Dimethylhexylamine (dmha) · Natural Medicines adverse-effect record, reported in hypertension.

    3 sources cited
    1. 17906. McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
    2. 17907. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
    3. 17908. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.

    Orphenadrine

    Listed in the ADVERSE REACTIONS section of the FDA label for Orphenadrine. Read the label on DailyMed ›

Reported for Dimethylhexylamine (dmha) but not commonly for Orphenadrine: raised blood pressure.

Effects for Orphenadrine come from the ADVERSE REACTIONS section of its FDA label; effects for Dimethylhexylamine (dmha) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

From our Q&A

Questions About Dimethylhexylamine (dmha) or Orphenadrine

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Dimethylhexylamine (dmha) or Orphenadrine, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Orphenadrine

This page covers Dimethylhexylamine (dmha) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Orphenadrine page lists 35 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Procaine (major), Adrafinil (moderate), African Wild Potato (moderate) and Artichoke (moderate).

By severity: 2 major · 22 moderate · 11 minor.

Open the Orphenadrine interaction page

One more smart check

Taking Dimethylhexylamine (dmha) as Part of a Dietary Supplement Product? Check It for Interactions

We hold 72 real supplement products containing Dimethylhexylamine (dmha), each one broken down to its full ingredient list — and combination products often carry several ingredients besides Dimethylhexylamine (dmha). Even though Dimethylhexylamine (dmha) itself has no known interaction with Orphenadrine, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Dimethylhexylamine (dmha) and Orphenadrine Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Dimethylhexylamine (dmha)
Top half

#539 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Orphenadrine
Steady interest

#2,731 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Dimethylhexylamine (dmha) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified October 4, 2026. The Dimethylhexylamine (dmha) and Orphenadrine records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Dimethylhexylamine (dmha)

What is Dimethylhexylamine (dmha)?

  • Pre-workout energy
  • Fat loss and weight management
  • Athletic performance
  • Appetite suppression
  • Focus and stimulation

DMHA (dimethylhexylamine, also called octodrine) is a synthetic stimulant added to some pre-workout and weight-loss supplements, often falsely labeled as a natural plant extract. It has not been shown to be safe as a dietary supplement, has been flagged by the FDA as an unapproved and potentially dangerous ingredient, and is best avoided. Talk to a pharmacist or doctor before using any product that contains it.

Synthetic chemical compound (not from a plant) · Capsules, tablets, powders, pre-workout blends

An interaction check asks whether these two react with each other — it does not ask whether Dimethylhexylamine (dmha) is a good idea for someone in your situation. Here is what our Dimethylhexylamine (dmha) record says about it on its own.

Dimethylhexylamine (dmha): dosing

There is no established safe or standardized dose for DMHA, and we do not recommend taking it. Do not try to guess a dose or combine it with other stimulants such as caffeine.

From our Dimethylhexylamine (dmha) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Dimethylhexylamine (dmha) monograph & all interactions
Medication

About Orphenadrine

What Is Orphenadrine Used For?

Brand names: Norflex, Disipal, Banflex, Flexoject, Flexon, Norflex Injection

Orphenadrine citrate is used to ease discomfort from acute, painful musculoskeletal conditions — things like muscle pain and stiffness. It is always used as part of a broader treatment plan that includes rest and physical therapy, not as a stand-alone cure.

Both the extended-release tablet and the injection form are approved for this use. Neither form directly relaxes tight muscles — the relief it provides is thought to be related to its pain-relieving (analgesic) properties.

See full Orphenadrine drug information Orphenadrine Citrate NDC codes and packages
Keep checking

Other Drugs & Dimethylhexylamine (dmha)

Browse every other medication we’ve checked against Dimethylhexylamine (dmha) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
172Moderate
0Minor
2,657No known interaction
172 Moderate 2,657 No interaction
Moderate

172 interactions

Showing 60 of 172 moderate interactions — see all 172 on the Dimethylhexylamine (dmha) page.

No interaction 2,657 drugs checked — show the list

We also checked Dimethylhexylamine (dmha) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,657 medications checked with no known interaction — see the full Dimethylhexylamine (dmha) list.

See the full Dimethylhexylamine (dmha) interactions page
See every supplement checked against Orphenadrine, ranked by severity
Evidence & sources

Dimethylhexylamine (dmha) References

The 6 references that drive our Dimethylhexylamine (dmha) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. McCarthy C, Farney TM, Canale RE, et al. A finished dietary supplement stimulates lipolysis and metabolic rate in young men and women. Nutr Metab Insights 2012;5:23-31. PubMed
  2. McCarthy C, Canale RE, Alleman RJ, et al. Biochemical and anthropometric effects of a weight loss dietary supplement in health men and women. Nutr Metab Insights 2012;5:13-22.
  3. Farney TM, McCarthy C, Canale RE, et al. Hemodynamic and hematologic profile of health adults ingesting dietary supplements containing 1,3-dimethylamylamine and caffeine. Nutr Metab Insights 2012;5:1-12.
  4. Rasmussen N, Keizers PH. History full circle: 'novel' sympathomimetics in supplements. Drug Test Anal 2016;8(3-4):283-6. PubMed
  5. Monroe RR, Drell HJ. Oral use of stimulants obtained from inhalers. J Am Med Assoc 1947; 135(14):909-15. PubMed
  6. Fellows EJ. The pharmacology of 2-amino-6-methylheptane. J Pharmacol Exp Ther 1947;90(4):351-8. DOI

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Dimethylhexylamine (dmha) and Orphenadrine Together: Common Questions

Is it safe to take Dimethylhexylamine (dmha) with Orphenadrine?
We do not list a known interaction between Dimethylhexylamine (dmha) and Orphenadrine. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Dimethylhexylamine (dmha) and Orphenadrine have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Dimethylhexylamine (dmha) and Orphenadrine combination checked?
Interactions in our licensed database are recorded against drug classes. Orphenadrine is filed under 3 classifications, and Dimethylhexylamine (dmha) has documented interactions with 1 drug class — none of Orphenadrine's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Dimethylhexylamine (dmha) interact with any other medications?
Yes. Dimethylhexylamine (dmha) has 172 documented drug interactions in our database — Orphenadrine is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Orphenadrine interact with any supplements?
Yes. Orphenadrine has documented interactions with 35 supplements in our database — Dimethylhexylamine (dmha) is not one of them. The Orphenadrine interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Dimethylhexylamine (dmha) monograph Uses, safety profile, and every drug interaction in one place Orphenadrine drug information The full plain-English guide to this medication Orphenadrine supplement interactions Every supplement checked against Orphenadrine, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 6 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Orphenadrine and Dimethylhexylamine (dmha)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.