Drug & supplement interaction

Arabinoxylan + Canagliflozin

Canagliflozin brand name: Invokana.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Arabinoxylan has a moderate interaction with Canagliflozin. Evidence from human research suggests that an arabinoxylan-rich fiber can reduce postprandial glucose levels.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceB
What do Severity, Likelihood & Evidence mean?
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Interaction report

Arabinoxylan and Canagliflozin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Canagliflozin

Canagliflozin falls under ANTIDIABETES DRUGS — the group Arabinoxylan interacts with.

Evidence from human research suggests that an arabinoxylan-rich fiber can reduce postprandial glucose levels. Theoretically, arabinoxylan might have additive effects with antidiabetes drugs and increase the risk of hypoglycemia. Monitor blood glucose levels closely. Dose adjustments might be necessary. Some antidiabetes drugs include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), and others.
Severity Moderate Likelihood Possible Evidence B

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version: arabinoxylan is a fiber that can gently lower your blood sugar after meals by slowing digestion. Canagliflozin (Invokana) also lowers blood sugar, but in a totally different way, by helping your kidneys flush extra sugar out in your urine. So this isn't a chemical clash. It's just two things nudging your sugar in the same direction at once, which could add up.

On its own, canagliflozin rarely causes low blood sugar, so the risk here is modest. Still, if you stack the fiber on top, watch for shakiness, sweating, dizziness, or feeling lightheaded, especially if you also take insulin or a sulfonylurea. The evidence is fairly early, so don't panic. Just keep an eye on your numbers and check with your pharmacist or doctor before adding it.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Lu ZX, Walker KZ, Muir JG, Mascara T, O'Dea K. Arabinoxylan fiber, a byproduct of wheat flour processing, reduces the postprandial glucose response in normoglycemic subjects. Am J Clin Nutr 2000;71(5):1123-1128.
  2. Lu ZX, Walker KZ, Muir JG, O'Dea K. Arabinoxylan fibre improves metabolic control in people with Type II diabetes. Eur J Clin Nutr 2004;58(4):621-8. PubMed
  3. Garcia AL, Otto B, Reich SC, et al. Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance. Eur J Clin Nutr 2007;61(3):334-41. PubMed
  4. Garcia AL, Steiniger J, Reich SC, et al. Arabinoxylan fibre consumption improved glucose metabolism, but did not affect serum adipokines in subjects with impaired glucose tolerance. Horm Metab Res 2006;38(11):761-766. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Arabinoxylan Also Interacts With Other Medications

Arabinoxylan has 85 moderate known drug interactions in our database — the Canagliflozin one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Canagliflozin)
Taking anything else?

Check Another of Your Medications Against Arabinoxylan

Covers the 2,830 medications we’ve checked against Arabinoxylan. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Canagliflozin

This page covers Arabinoxylan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Canagliflozin page lists 256 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 215 moderate · 39 minor.

From our pharmacist’s overview on the Canagliflozin page

“Canagliflozin (Invokana) lowers blood sugar, and that is precisely why this list deserves genuine care. Nearly every ingredient on it works on glucose one way or another: most can push it too low when stacked with the drug, while a few, niacin among them, raise it and work against the medicine.”

Reviewed by 2 · Jul 18, 2026

Open the Canagliflozin interaction page

One more smart check

Taking Arabinoxylan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Arabinoxylan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Arabinoxylan. Your product may carry other ingredients that interact with Canagliflozin too, on top of Arabinoxylan — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Arabinoxylan and Canagliflozin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Arabinoxylan
Top half

#674 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Canagliflozin
Steady interest

#1,913 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Arabinoxylan

What is Arabinoxylan?

Arabinoxylan
  • Blood sugar support
  • Digestive and gut health (prebiotic)
  • Cholesterol and triglyceride support
  • Immune support
  • Metabolic syndrome

Arabinoxylan is a type of dietary fiber found in cereal grains that acts as a prebiotic and may modestly affect blood sugar and blood fats. The evidence for most uses is early and limited, so it should not replace proven treatments. If you are considering it, talk with your pharmacist or doctor first.

Read the full Arabinoxylan monograph & all interactions
Medication

About Canagliflozin

What Is Canagliflozin Used For?

Brand name: Invokana

Invokana (canagliflozin) is used alongside diet and exercise to improve blood sugar control in adults and children aged 10 and older with type 2 diabetes. It is not for type 1 diabetes.

In adults with type 2 diabetes, Invokana is also used to lower the risk of heart attack, stroke, and cardiovascular death in those with established cardiovascular disease, and to reduce the risk of serious kidney complications — including end-stage kidney disease, cardiovascular death, and hospitalization for heart failure — in those with diabetic kidney disease and high levels of protein in the urine.

See full Canagliflozin drug information
Keep checking

Other Drugs & Arabinoxylan

Browse every other medication we’ve checked against Arabinoxylan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Arabinoxylan page.

No interaction 2,744 drugs checked — show the list

We also checked Arabinoxylan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Arabinoxylan list.

See the full Arabinoxylan interactions page
See every supplement checked against Canagliflozin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Arabinoxylan monograph › Uses, safety, and every drug interaction in one place Canagliflozin supplement interactions › Every supplement checked against Canagliflozin, ranked by severity Canagliflozin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Arabinoxylan and Canagliflozin Together: Common Questions

Can you take Arabinoxylan with Canagliflozin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Arabinoxylan and Canagliflozin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Canagliflozin and Arabinoxylan?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.