Drug & supplement interaction

Arabinoxylan + Methylene Blue

Methylene Blue brand names: Urolene Blue, Provayblue.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Arabinoxylan and Methylene Blue in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Arabinoxylan and Methylene Blue

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Methylene Blue and Arabinoxylan in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Arabinoxylan safety at a glance

Arabinoxylan overall Use caution Generally considered well tolerated as a food-derived fiber, but high-quality long-term safety data are limited.
Pregnancy Use caution Not enough reliable data on supplement use; stick to fiber from normal foods unless your provider advises otherwise.
Breastfeeding Use caution There is little safety information for supplements while breastfeeding, so caution is advised.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Methylene Blue and Arabinoxylan? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Methylene Blue

Interactions in our licensed database are recorded against drug classes, not just single drug names. Methylene Blue is filed under 3 classifications — serotonergic drugs, serotonergic drugs, oral drugs. Arabinoxylan has documented interactions with 1 drug class — the most serious being antidiabetes drugs (moderate) — and none of Methylene Blue’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Arabinoxylan Does Interact With Other Medications

Arabinoxylan has 86 moderate known drug interactions in our database — Methylene Blue isn’t one of them. If you take anything else, check it against the full list below.

Moderate 86 No known interaction 2,744 (incl. Methylene Blue)
Taking anything else?

Check Another of Your Medications Against Arabinoxylan

Covers the 2,830 medications we’ve checked against Arabinoxylan. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Arabinoxylan and Methylene Blue May Share a Side Effect

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Diarrhea Additional detail

    Arabinoxylan

    “Orally, arabinoxylan seems to be well tolerated. Some adverse effects reported in clinical trials include diarrhea, gas, bloating, and abdominal pain.”

    Arabinoxylan · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 25664. Grasten S, Liukkonen K-H, Chrevatidis A, et al. Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans. Nutrition Res 2003;23:1503-14. DOI
    2. 99677. François IE, Lescroart O, Veraverbeke WS, et al. Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over t
    3. 99680. Scarpellini E, Deloose E, Vos R, et al, The effect of arabinoxylooligosaccharides on gastric sensory-motor function and nutrient tolerance in man. Neurogastroenterol Motil. 2016 Aug;28(8):1194-203. PubMed

    “Orally, arabinoxylan can cause gastrointestinal adverse effects such as diarrhea, gas, bloating, and abdominal pain.”

    Arabinoxylan · Natural Medicines adverse-effect record, reported in diarrhea.

    3 sources cited
    1. 25664. Grasten S, Liukkonen K-H, Chrevatidis A, et al. Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans. Nutrition Res 2003;23:1503-14. DOI
    2. 99677. François IE, Lescroart O, Veraverbeke WS, et al. Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over t
    3. 99680. Scarpellini E, Deloose E, Vos R, et al, The effect of arabinoxylooligosaccharides on gastric sensory-motor function and nutrient tolerance in man. Neurogastroenterol Motil. 2016 Aug;28(8):1194-203. PubMed

    Methylene Blue

    Listed in the ADVERSE REACTIONS section of the FDA label for Methylene Blue. Read the label on DailyMed ›

Reported for Arabinoxylan but not commonly for Methylene Blue: stomach pain and bloating or gas.

Effects for Methylene Blue come from the ADVERSE REACTIONS section of its FDA label; effects for Arabinoxylan come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Everything else you take

See Every Supplement That Interacts With Methylene Blue

This page covers Arabinoxylan only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Methylene Blue page lists 38 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Lithium (major), 5-htp (moderate), Acetyl-l-carnitine (moderate) and Ayahuasca (moderate).

By severity: 2 major · 25 moderate · 11 minor.

From our pharmacist’s overview on the Methylene Blue page

“The pairing I would worry about first with methylene blue (Urolene Blue, Provayblue) is anything that raises serotonin, and lithium heads that group with a major rating. Methylene blue inhibits monoamine oxidase A, the enzyme that breaks serotonin down, so combining it with serotonin-boosting supplements can tip someone into serotonin…”

Reviewed by 2 · Jul 18, 2026

Open the Methylene Blue interaction page

One more smart check

Taking Arabinoxylan as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Arabinoxylan, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Arabinoxylan. Even though Arabinoxylan itself has no known interaction with Methylene Blue, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Arabinoxylan and Methylene Blue Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Arabinoxylan
Top half

#670 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Methylene Blue
Top 5%

#53 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Arabinoxylan reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Arabinoxylan and Methylene Blue records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Arabinoxylan

What is Arabinoxylan?

Arabinoxylan
  • Blood sugar support
  • Digestive and gut health (prebiotic)
  • Cholesterol and triglyceride support
  • Immune support
  • Metabolic syndrome

Arabinoxylan is a type of dietary fiber found in cereal grains that acts as a prebiotic and may modestly affect blood sugar and blood fats. The evidence for most uses is early and limited, so it should not replace proven treatments. If you are considering it, talk with your pharmacist or doctor first.

Fiber extracted from the cell walls of cereal grains (such as wheat bran, rice bran, corn, rye, oat, and barley) · Powder, capsules, and a modified rice-bran product known as MGN-3 (Biobran)

An interaction check asks whether these two react with each other — it does not ask whether Arabinoxylan is a good idea for someone in your situation. Here is what our Arabinoxylan record says about it on its own.

Arabinoxylan: dosing

There is no official or standardized dose of arabinoxylan, and amounts used in studies have varied widely depending on the product and the goal.The best approach is to follow the directions on the specific product label and to start low and increase slowly to limit gas and bloating.

From our Arabinoxylan monograph — the full record covers uses, side effects and every documented interaction.

Read the full Arabinoxylan monograph & all interactions
Keep checking

Other Drugs & Arabinoxylan

Browse every other medication we’ve checked against Arabinoxylan — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
86Moderate
0Minor
2,743No known interaction
86 Moderate 2,743 No interaction
Moderate

86 interactions

Showing 60 of 86 moderate interactions — see all 86 on the Arabinoxylan page.

No interaction 2,743 drugs checked — show the list

We also checked Arabinoxylan against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,743 medications checked with no known interaction — see the full Arabinoxylan list.

See the full Arabinoxylan interactions page
See every supplement checked against Methylene Blue, ranked by severity
Evidence & sources

Arabinoxylan References

The 8 references that drive our Arabinoxylan monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Grasten S, Liukkonen K-H, Chrevatidis A, et al. Effects of wheat pentosan and inulin on the metabolic activity of fecal microbiota and on bowel function in healthy humans. Nutrition Res 2003;23:1503-14. DOI
  2. Lu ZX, Walker KZ, Muir JG, Mascara T, O'Dea K. Arabinoxylan fiber, a byproduct of wheat flour processing, reduces the postprandial glucose response in normoglycemic subjects. Am J Clin Nutr 2000;71(5):1123-1128.
  3. Lu ZX, Walker KZ, Muir JG, O'Dea K. Arabinoxylan fibre improves metabolic control in people with Type II diabetes. Eur J Clin Nutr 2004;58(4):621-8. PubMed
  4. Garcia AL, Otto B, Reich SC, et al. Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance. Eur J Clin Nutr 2007;61(3):334-41. PubMed
  5. Garcia AL, Steiniger J, Reich SC, et al. Arabinoxylan fibre consumption improved glucose metabolism, but did not affect serum adipokines in subjects with impaired glucose tolerance. Horm Metab Res 2006;38(11):761-766. PubMed
  6. François IE, Lescroart O, Veraverbeke WS, et al. Effects of a wheat bran extract containing arabinoxylan oligosaccharides on gastrointestinal health parameters in healthy adult human volunteers: a double-blind, randomised, placebo-controlled, cross-over t
  7. Schioldan AG, Gregersen S, Hald S, et al. Effects of a diet rich in arabinoxylan and resistant starch compared with a diet rich in refined carbohydrates on postprandial metabolism and features of the metabolic syndrome. Eur J Nutr. 2018 Mar;57(2):795-807. PubMed
  8. Scarpellini E, Deloose E, Vos R, et al, The effect of arabinoxylooligosaccharides on gastric sensory-motor function and nutrient tolerance in man. Neurogastroenterol Motil. 2016 Aug;28(8):1194-203. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Arabinoxylan and Methylene Blue Together: Common Questions

Is it safe to take Arabinoxylan with Methylene Blue?
We do not list a known interaction between Arabinoxylan and Methylene Blue. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Arabinoxylan and Methylene Blue have any of the same side effects?
Yes — our sources link each of them separately to one of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
How was the Arabinoxylan and Methylene Blue combination checked?
Interactions in our licensed database are recorded against drug classes. Methylene Blue is filed under 3 classifications, and Arabinoxylan has documented interactions with 1 drug class — none of Methylene Blue's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Arabinoxylan interact with any other medications?
Yes. Arabinoxylan has 86 documented drug interactions in our database — Methylene Blue is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Methylene Blue interact with any supplements?
Yes. Methylene Blue has documented interactions with 38 supplements in our database — Arabinoxylan is not one of them. The Methylene Blue interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Arabinoxylan monograph Uses, safety profile, and every drug interaction in one place Methylene Blue supplement interactions Every supplement checked against Methylene Blue, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 8 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Methylene Blue and Arabinoxylan?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.