Canagliflozin

128 interactions 247 cited references

Also sold as: Invokana Invokana®

About Canagliflozin

Canagliflozin is used along with diet and exercise, and sometimes with other medications, to lower blood sugar levels in people with type 2 diabetes (condition in which blood sugar is too high because the body does not produce or use insulin normally). Canagliflozin is also used to reduce the risk of stroke, heart atta… Read the full Canagliflozin drug information page →

Medically reviewed by Dr. Brian Staiger, PharmD, BCPS · Updated Aug 9, 2026 · Editorial policy · Data sources

Sources: FDA prescribing information (Structured Product Labeling), the published literature cited in each entry, DDInter 2.0 (a major open-access drug-interaction database), and legacy DrugBank interaction data distributed by the NIH's RxNav service (decommissioned in 2024) — analyzed and reviewed by our pharmacist team. How we build this library →

Most serious with: Colchicine Posaconazole Levofloxacin Injection Ofloxacin Otic Repotrectinib Ranolazine

1 Contraindicated 78 Major 49 Moderate

All (128) Contraindicated (1) Major (78) Moderate (49)

Contraindicated

Canagliflozin Colchicine Colcrys Increased colchicine exposure and an increased risk of colchicine toxicity Details

Major

Canagliflozin Relugolix Orgovyx Increased relugolix exposure Details Canagliflozin Abiraterone Abirtega An increased risk of severe hypoglycemia Details Canagliflozin Abiraterone Acetate Abirtega An increased risk of severe hypoglycemia Details Canagliflozin Abiraterone Acetate, Micronized Abirtega An increased risk of severe hypoglycemia Details Canagliflozin Chloroquine Aralen® Hypoglycemia Details Canagliflozin Chlorothiazide Diuril An increased risk of hyperglycemia and an increased insulin requirement Details Canagliflozin Chlorthalidone Hemiclor An increased risk of hyperglycemia and an increased insulin requirement Details Canagliflozin Ciprofloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Canagliflozin Cyclosporine Atopica Increased cycloSPORINE exposure Details Canagliflozin Dabigatran Etexilate Increased dabigatran exposure and an increased risk of bleeding Details Canagliflozin Delafloxacin Baxdela Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Canagliflozin Digoxin Cardoxin® Increased digoxin exposure Details Canagliflozin Doxorubicin Adriamycin Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Canagliflozin Doxorubicin Hydrochloride Liposome Increased DOXOrubicin exposure and an increased risk of DOXOrubicin-related adverse reactions Details Canagliflozin Enoxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Canagliflozin Ensartinib Increased ensartinib exposure Details Canagliflozin Furosemide Disal An increased risk of hyperglycemia and an increased insulin requirement Details Canagliflozin Gatifloxacin Zymaxid Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Canagliflozin Gemifloxacin Factive Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Canagliflozin Grepafloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Canagliflozin Hydrochlorothiazide Inzirqo An increased risk of hyperglycemia and an increased insulin requirement Details Canagliflozin Hydroflumethiazide An increased risk of hyperglycemia and an increased insulin requirement Details Canagliflozin Hydroxychloroquine Plaquenil Enhanced hypoglycemic effect of antidiabetics and an increased risk of hypoglycemia Details Canagliflozin Indapamide An increased risk of hyperglycemia and an increased insulin requirement Details Canagliflozin Insulin Afrezza An increased risk of hypoglycemia Details Canagliflozin Insulin Aspart, Recombinant Fiasp An increased risk of hypoglycemia Details Canagliflozin Insulin Bovine An increased risk of hypoglycemia Details Canagliflozin Insulin Degludec Tresiba An increased risk of hypoglycemia Details Canagliflozin Insulin Detemir Levemir An increased risk of hypoglycemia Details Canagliflozin Insulin Glargine, Recombinant Basaglar An increased risk of hypoglycemia Details Canagliflozin Insulin Glulisine Apidra An increased risk of hypoglycemia Details Canagliflozin Insulin Icodec-Abae Awiqli An increased risk of hypoglycemia Details Canagliflozin Insulin Lispro, Recombinant Admelog An increased risk of hypoglycemia Details Canagliflozin Lanreotide Acetate An increased risk of hypoglycemia and impaired glucose regulation Details Canagliflozin Lefamulin Xenleta Increased lefamulin exposure and an increased risk of lefamulin-related adverse reactions Details Canagliflozin Levofloxacin Levaquin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Canagliflozin Lithium Reduced lithium exposure Details Canagliflozin Lomefloxacin Changes in blood glucose and increased risk of hypoglycemia or hyperglycemia Details Canagliflozin Loperamide Diamode Increased loperamide exposure and an increased risk of loperamide-related adverse effects Details

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Educational information only, not medical advice. Always confirm interactions with your pharmacist or prescriber before making any change to your medications.