Metolazone

Generic name: Pronounced as (me tol' a zone)
Brand names
  • Mykrox®
  • Zaroxolyn®
Click on drug name to hear pronunciation

Medical Content Reviewed By HelloPharmacist Staff

Last Revised - 06/15/2017

Metolazone, is used to reduce the swelling and fluid retention caused by heart failure or kidney disease. It also is used alone or with other medications to treat high blood pressure. Metolazone is in a class of medications called diuretics ('water pills'). It causes the kidneys to reduce the amount of water and salt in the body by increasing the amount of urine.

Metolazone comes as a tablet to take by mouth. It is usually taken once a day. Take metolazone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metolazone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of metolazone and gradually increase your dose, depending on your response to this medication.

Metolazone controls high blood pressure but does not cure it. Continue to take metolazone even if you feel well. Do not stop taking metolazone without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking metolazone,

  • tell your doctor and pharmacist if you are allergic to metolazone, sulfa drugs, thiazides, any other medications, or any of the ingredients in metolazone tablets. Ask your pharmacist for a list of the ingredients.

  • tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); corticotropin; digoxin (Lanoxin); furosemide (Lasix); insulin or other medications for diabetes; lithium (Eskalith, Lithobid); medications for asthma and colds; medications for pain or seizures; methenamine (Hiprex, Urex); other medications for high blood pressure; sedatives; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); tranquilizers; and vitamin D. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

  • tell your doctor if you have kidney or liver failure. Your doctor will probably tell you not to take metolazone.

  • tell your doctor if you have or have ever had diabetes, gout, systemic lupus erythematosus (SLE, a chronic inflammatory condition), or parathyroid, heart, kidney, or liver disease.

  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking metolazone, call your doctor.

  • if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking metolazone.

  • you should know that metolazone may make you dizzy or drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

  • ask your doctor about the safe use of alcoholic beverages while you are taking metolazone. Alcohol can make the side effects from metolazone worse.

  • plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Metolazone may make your skin sensitive to sunlight.

  • you should know that metolazone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking metolazone. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Follow your doctor's directions. they may include a daily exercise program and a low-sodium or low-salt diet, potassium supplements, and increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

  • Metolazone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

    • dizziness

    • weakness

    • restlessness

    • headache

    • muscle cramps

    • joint pain or swelling

    • constipation

    • diarrhea

  • Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

    • dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration

    • chest pain

    • rapid, irregular, or pounding heartbeats

    • hives

    • rash

    • itching

    • blistering or peeling skin

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

    • hoarseness

    • difficulty swallowing or breathing

    • sore throat with fever

    • unusual bleeding or bruising

    • upset stomach

    • extreme tiredness

    • loss of appetite

    • pain in the upper right part of the stomach

    • yellowing of the skin or eyes

    • flu-like symptoms

  • Metolazone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

  • If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

  • dizziness

  • drowsiness

  • fainting

  • slow or difficult breathing

  • upset stomach

  • coma

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to metolazone.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking metolazone.

Learn the brand name of your medication. Do not switch brands without talking to your doctor or pharmacist, as different brands of metolazone may work differently in the body.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug Interaction
Repaglinide Repaglinide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Metolazone.
Insulin Glargine (rDNA origin) Injection Insulin Glargine (rDNA origin) Injection The therapeutic efficacy of Insulin glargine can be decreased when used in combination with Metolazone.
Bisacodyl Bisacodyl The risk or severity of adverse effects can be increased when Metolazone is combined with Bisacodyl.
Calcium Carbonate Calcium Carbonate Metolazone may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Candesartan Candesartan Metolazone may increase the hypotensive activities of Candesartan.
Cilostazol Cilostazol Metolazone may increase the excretion rate of Cilostazol which could result in a lower serum level and potentially a reduction in efficacy.
Diphenoxylate Diphenoxylate The therapeutic efficacy of Metolazone can be decreased when used in combination with Diphenoxylate.
Estrogen and Progestin (Oral Contraceptives) Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Fenofibrate Fenofibrate Metolazone may increase the excretion rate of Fenofibrate which could result in a lower serum level and potentially a reduction in efficacy.
Guanfacine Guanfacine Metolazone may increase the excretion rate of Guanfacine which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Hydroxide Magnesium Hydroxide Metolazone may increase the excretion rate of Magnesium hydroxide which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Oxide Magnesium Oxide The risk or severity of adverse effects can be increased when Metolazone is combined with Magnesium oxide.
Methylergonovine Methylergonovine Methylergometrine may decrease the antihypertensive activities of Metolazone.
Miglitol Miglitol The therapeutic efficacy of Miglitol can be decreased when used in combination with Metolazone.
Mycophenolate Mycophenolate Metolazone may increase the excretion rate of Mycophenolic acid which could result in a lower serum level and potentially a reduction in efficacy.
Naratriptan Naratriptan Naratriptan may decrease the antihypertensive activities of Metolazone.
Olsalazine Olsalazine The therapeutic efficacy of Metolazone can be decreased when used in combination with Olsalazine.
Paregoric Paregoric The therapeutic efficacy of Metolazone can be decreased when used in combination with Morphine.
Penbutolol Penbutolol Metolazone may increase the hypotensive activities of Acebutolol.
Pentazocine Pentazocine The therapeutic efficacy of Metolazone can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES) Polyethylene glycol-electrolyte solution (PEG-ES) The risk or severity of adverse effects can be increased when Metolazone is combined with Polyethylene glycol.
Potassium Potassium Potassium may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone Prednisone Prednisone may increase the hypokalemic activities of Metolazone.
Psyllium Psyllium The risk or severity of adverse effects can be increased when Metolazone is combined with Plantago seed.
Ranitidine Ranitidine Metolazone may increase the excretion rate of Ranitidine which could result in a lower serum level and potentially a reduction in efficacy.
Reserpine Reserpine Reserpine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Rizatriptan Rizatriptan Metolazone may increase the excretion rate of Rizatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Sumatriptan Sumatriptan Metolazone may increase the excretion rate of Sumatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Tacrolimus Tacrolimus Tacrolimus may decrease the excretion rate of Metolazone which could result in a higher serum level.
Tizanidine Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Metolazone.
Triamcinolone Triamcinolone Triamcinolone may increase the hypokalemic activities of Metolazone.
Zolmitriptan Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Metolazone.
Ampicillin Injection Ampicillin Injection Ampicillin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Doxycycline Injection Doxycycline Injection Doxycycline may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Fluconazole Injection Fluconazole Injection Fluconazole may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Foscarnet Injection Foscarnet Injection Foscarnet may decrease the excretion rate of Metolazone which could result in a higher serum level.
Hydromorphone Injection Hydromorphone Injection Hydromorphone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Levofloxacin Injection Levofloxacin Injection Metolazone may increase the excretion rate of Levofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Meperidine Injection Meperidine Injection Meperidine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Methylprednisolone Injection Methylprednisolone Injection Methylprednisolone may increase the hypokalemic activities of Metolazone.
Metoclopramide Injection Metoclopramide Injection Metolazone may increase the excretion rate of Metoclopramide which could result in a lower serum level and potentially a reduction in efficacy.
Morphine Injection Morphine Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Morphine.
Pamidronate Injection Pamidronate Injection Pamidronic acid may decrease the excretion rate of Metolazone which could result in a higher serum level.
Vancomycin Injection Vancomycin Injection Metolazone may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine Altretamine Amphetamine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Cefuroxime Cefuroxime Cefuroxime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cyclosporine Cyclosporine The risk or severity of renal failure can be increased when Metolazone is combined with Cyclosporine.
Torsemide Torsemide Torasemide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine Olanzapine The serum concentration of Metolazone can be increased when it is combined with Olanzapine.
Dofetilide Dofetilide The risk or severity of QTc prolongation can be increased when Metolazone is combined with Dofetilide.
Eprosartan Eprosartan Metolazone may increase the hypotensive activities of Eprosartan.
Meloxicam Meloxicam The therapeutic efficacy of Metolazone can be decreased when used in combination with Meloxicam.
Oxcarbazepine Oxcarbazepine The risk or severity of hyponatremia can be increased when Metolazone is combined with Oxcarbazepine.
Pantoprazole Pantoprazole Pantoprazole may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Sevelamer Sevelamer Sevelamer can cause a decrease in the absorption of Metolazone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan Telmisartan Metolazone may increase the hypotensive activities of Telmisartan.
Temozolomide Temozolomide Metolazone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Zaleplon Zaleplon Metolazone may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Desloratadine Desloratadine The serum concentration of Metolazone can be increased when it is combined with Desloratadine.
Linezolid Linezolid Linezolid may increase the hypotensive activities of Metolazone.
Trimipramine Trimipramine Trimipramine may decrease the antihypertensive activities of Metolazone.
Glycopyrrolate Glycopyrrolate The serum concentration of Metolazone can be increased when it is combined with Glycopyrronium.
Perindopril Perindopril The risk or severity of hypotension can be increased when Metolazone is combined with Perindopril.
Tenofovir Tenofovir Tenofovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Choline Magnesium Trisalicylate Choline Magnesium Trisalicylate The therapeutic efficacy of Metolazone can be decreased when used in combination with Choline magnesium trisalicylate.
Dutasteride Dutasteride Dutasteride may decrease the antihypertensive activities of Metolazone.
Epinephrine Injection Epinephrine Injection The risk or severity of Cardiac Arrhythmia can be increased when Epinephrine is combined with Metolazone.
Eplerenone Eplerenone Metolazone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram Escitalopram The risk or severity of hyponatremia can be increased when Escitalopram is combined with Metolazone.
Olmesartan Olmesartan Olmesartan may increase the hypotensive activities of Metolazone.
Zonisamide Zonisamide Metolazone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Aripiprazole Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Metolazone.
Atomoxetine Atomoxetine Atomoxetine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Dexmethylphenidate Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Metolazone.
Atazanavir Atazanavir Atazanavir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Almotriptan Almotriptan Metolazone may increase the excretion rate of Almotriptan which could result in a lower serum level and potentially a reduction in efficacy.
Eletriptan Eletriptan Eletriptan may decrease the antihypertensive activities of Metolazone.
Polyethylene Glycol 3350 Polyethylene Glycol 3350 The risk or severity of adverse effects can be increased when Metolazone is combined with Polyethylene glycol.
Vardenafil Vardenafil Vardenafil may increase the antihypertensive activities of Metolazone.
Alfuzosin Alfuzosin Alfuzosin may increase the hypotensive activities of Metolazone.
Emtricitabine Emtricitabine Metolazone may increase the excretion rate of Emtricitabine which could result in a lower serum level and potentially a reduction in efficacy.
Memantine Memantine Metolazone may increase the excretion rate of Memantine which could result in a lower serum level and potentially a reduction in efficacy.
Tegaserod Tegaserod The risk or severity of adverse effects can be increased when Metolazone is combined with Tegaserod.
Tadalafil Tadalafil Tadalafil may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Frovatriptan Frovatriptan Frovatriptan may decrease the antihypertensive activities of Metolazone.
Apomorphine Injection Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Metolazone.
Protriptyline Protriptyline Protriptyline may decrease the antihypertensive activities of Metolazone.
Duloxetine Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Metolazone is combined with Duloxetine.
Tinidazole Tinidazole Metolazone may increase the excretion rate of Tinidazole which could result in a lower serum level and potentially a reduction in efficacy.
Trospium Trospium The serum concentration of Metolazone can be increased when it is combined with Trospium.
Bosentan Bosentan Metolazone may increase the hypotensive activities of Bosentan.
Cefditoren Cefditoren Metolazone may increase the excretion rate of Cefdinir which could result in a lower serum level and potentially a reduction in efficacy.
Cyanocobalamin Injection Cyanocobalamin Injection Hydroxocobalamin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Eszopiclone Eszopiclone Eszopiclone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Ganciclovir Ganciclovir Metolazone may increase the excretion rate of Ganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Insulin Aspart (rDNA Origin) Injection Insulin Aspart (rDNA Origin) Injection The therapeutic efficacy of Insulin aspart can be decreased when used in combination with Metolazone.
Ribavirin Ribavirin Metolazone may increase the excretion rate of Ribavirin which could result in a lower serum level and potentially a reduction in efficacy.
Solifenacin Solifenacin The serum concentration of Metolazone can be increased when it is combined with Solifenacin.
Valganciclovir Valganciclovir Metolazone may increase the excretion rate of Valganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Adefovir Adefovir Adefovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Dextroamphetamine Dextroamphetamine Amphetamine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Pramlintide Injection Pramlintide Injection The therapeutic efficacy of Pramlintide can be decreased when used in combination with Metolazone.
Exenatide Injection Exenatide Injection The therapeutic efficacy of Exenatide can be decreased when used in combination with Metolazone.
Isocarboxazid Isocarboxazid Isocarboxazid may increase the hypotensive activities of Metolazone.
Ramelteon Ramelteon Metolazone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Darifenacin Darifenacin The serum concentration of Metolazone can be increased when it is combined with Darifenacin.
Fentanyl Fentanyl Fentanyl may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Pregabalin Pregabalin Pregabalin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Phenylephrine Phenylephrine Phenylephrine may decrease the antihypertensive activities of Metolazone.
Insulin Detemir (rDNA Origin) Injection Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be decreased when used in combination with Metolazone.
Ranolazine Ranolazine Ranolazine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Rasagiline Rasagiline Rasagiline may increase the hypotensive activities of Metolazone.
Sitagliptin Sitagliptin The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Metolazone.
Varenicline Varenicline Metolazone may increase the excretion rate of Varenicline which could result in a lower serum level and potentially a reduction in efficacy.
Albuterol Albuterol Metolazone may increase the excretion rate of Salbutamol which could result in a lower serum level and potentially a reduction in efficacy.
Paliperidone Paliperidone Metolazone may increase the excretion rate of Paliperidone which could result in a lower serum level and potentially a reduction in efficacy.
Clofarabine Injection Clofarabine Injection Metolazone may increase the excretion rate of Clofarabine which could result in a lower serum level and potentially a reduction in efficacy.
Insulin Glulisine (rDNA origin) Injection Insulin Glulisine (rDNA origin) Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Metolazone.
Lubiprostone Lubiprostone Metolazone may increase the excretion rate of Lubiprostone which could result in a lower serum level and potentially a reduction in efficacy.
Rituximab Injection Rituximab Injection Metolazone may increase the hypotensive activities of Rituximab.
Aliskiren Aliskiren Metolazone may increase the hypotensive activities of Aliskiren.
Pemetrexed Injection Pemetrexed Injection Metolazone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Metolazone.
Nabilone Nabilone The risk or severity of adverse effects can be increased when Nabilone is combined with Metolazone.
Sorafenib Sorafenib Sorafenib may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Sunitinib Sunitinib The therapeutic efficacy of Sunitinib can be decreased when used in combination with Metolazone.
Levocetirizine Levocetirizine Metolazone may increase the excretion rate of Levocetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Pegaptanib Injection Pegaptanib Injection Metolazone may increase the excretion rate of Pegaptanib which could result in a lower serum level and potentially a reduction in efficacy.
Azacitidine Injection Azacitidine Injection Metolazone may increase the excretion rate of Azacitidine which could result in a lower serum level and potentially a reduction in efficacy.
Paclitaxel (with polyoxyethylated castor oil) Injection Paclitaxel (with polyoxyethylated castor oil) Injection The risk or severity of adverse effects can be increased when Metolazone is combined with Castor oil.
Lenalidomide Lenalidomide Lenalidomide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Toremifene Toremifene The risk or severity of hypercalcemia can be increased when Metolazone is combined with Toremifene.
Budesonide Budesonide Budesonide may increase the hypokalemic activities of Metolazone.
Desmopressin Desmopressin Desmopressin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Doripenem Injection Doripenem Injection Metolazone may increase the excretion rate of Doripenem which could result in a lower serum level and potentially a reduction in efficacy.
Arsenic Trioxide Injection Arsenic Trioxide Injection Metolazone may increase the excretion rate of Arsenic trioxide which could result in a lower serum level and potentially a reduction in efficacy.
Desvenlafaxine Desvenlafaxine The risk or severity of hyponatremia can be increased when Desvenlafaxine is combined with Metolazone.
Cevimeline Cevimeline Cevimeline may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Nebivolol Nebivolol Metolazone may increase the hypotensive activities of Nebivolol.
Tretinoin Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Metolazone.
Certolizumab Injection Certolizumab Injection Metolazone may increase the excretion rate of Certolizumab pegol which could result in a lower serum level and potentially a reduction in efficacy.
Daptomycin Injection Daptomycin Injection Daptomycin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Methylnaltrexone Injection Methylnaltrexone Injection Metolazone may increase the excretion rate of Methylnaltrexone which could result in a lower serum level and potentially a reduction in efficacy.
Midazolam Midazolam Metolazone may increase the excretion rate of Midazolam which could result in a lower serum level and potentially a reduction in efficacy.
Naltrexone Injection Naltrexone Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Naltrexone.
Dexrazoxane Injection Dexrazoxane Injection Dexrazoxane may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Milnacipran Milnacipran The risk or severity of hyponatremia can be increased when Milnacipran is combined with Metolazone.
Plerixafor Injection Plerixafor Injection Metolazone may increase the excretion rate of Plerixafor which could result in a lower serum level and potentially a reduction in efficacy.
Sodium Phosphate Sodium Phosphate Metolazone may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Fesoterodine Fesoterodine Metolazone may increase the excretion rate of Fesoterodine which could result in a lower serum level and potentially a reduction in efficacy.
Betaxolol Betaxolol Betaxolol may increase the hypotensive activities of Metolazone.
Iloperidone Iloperidone Iloperidone may decrease the antihypertensive activities of Metolazone.
Prasugrel Prasugrel Metolazone may increase the excretion rate of Prasugrel which could result in a lower serum level and potentially a reduction in efficacy.
Tolvaptan (low blood sodium) Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone Dronedarone Dronedarone may decrease the antihypertensive activities of Metolazone.
Pralatrexate Injection Pralatrexate Injection Metolazone may increase the excretion rate of Pralatrexate which could result in a lower serum level and potentially a reduction in efficacy.
Palonosetron Injection Palonosetron Injection Palonosetron may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Saxagliptin Saxagliptin The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Metolazone.
Telavancin Injection Telavancin Injection Metolazone may increase the excretion rate of Telavancin which could result in a lower serum level and potentially a reduction in efficacy.
Tapentadol Tapentadol The therapeutic efficacy of Metolazone can be decreased when used in combination with Tapentadol.
Topotecan Topotecan Metolazone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Asenapine Asenapine Asenapine may decrease the antihypertensive activities of Metolazone.
Oxymorphone Oxymorphone The therapeutic efficacy of Metolazone can be decreased when used in combination with Oxymorphone.
Liraglutide Injection Liraglutide Injection The therapeutic efficacy of Liraglutide can be decreased when used in combination with Metolazone.
Dalfampridine Dalfampridine Metolazone may increase the excretion rate of Dalfampridine which could result in a lower serum level and potentially a reduction in efficacy.
Ceftaroline Injection Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Metolazone which could result in a higher serum level.
Lurasidone Lurasidone Lurasidone may decrease the antihypertensive activities of Metolazone.
Acetaminophen Injection Acetaminophen Injection Acetaminophen may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Vilazodone Vilazodone Vilazodone may decrease the antihypertensive activities of Metolazone.
Ipilimumab Injection Ipilimumab Injection Metolazone may increase the excretion rate of Ipilimumab which could result in a lower serum level and potentially a reduction in efficacy.
Denileukin Diftitox Injection Denileukin Diftitox Injection Aldesleukin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Terbutaline Injection Terbutaline Injection Metolazone may increase the excretion rate of Terbutaline which could result in a lower serum level and potentially a reduction in efficacy.
Azilsartan Azilsartan The risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Metolazone.
Roflumilast Roflumilast Metolazone may increase the excretion rate of Roflumilast which could result in a lower serum level and potentially a reduction in efficacy.
Linagliptin Linagliptin The therapeutic efficacy of Linagliptin can be decreased when used in combination with Metolazone.
Cyclophosphamide Injection Cyclophosphamide Injection The risk or severity of granulocytopenia can be increased when Metolazone is combined with Cyclophosphamide.
Rivaroxaban Rivaroxaban Metolazone may increase the excretion rate of Rivaroxaban which could result in a lower serum level and potentially a reduction in efficacy.
Ruxolitinib Ruxolitinib Metolazone may increase the excretion rate of Ruxolitinib which could result in a lower serum level and potentially a reduction in efficacy.
Clobazam Clobazam Clobazam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Deferiprone Deferiprone Metolazone may increase the excretion rate of Deferiprone which could result in a lower serum level and potentially a reduction in efficacy.
Cabergoline Cabergoline Cabergoline may decrease the antihypertensive activities of Metolazone.
Naloxone Injection Naloxone Injection Metolazone may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Ambrisentan Ambrisentan Metolazone may increase the hypotensive activities of Ambrisentan.
Fondaparinux Injection Fondaparinux Injection Metolazone may increase the excretion rate of Fondaparinux which could result in a lower serum level and potentially a reduction in efficacy.
Iloprost Iloprost Iloprost may increase the hypotensive activities of Metolazone.
Enzalutamide Enzalutamide Metolazone may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy.
Mirabegron Mirabegron Metolazone may increase the excretion rate of Mirabegron which could result in a lower serum level and potentially a reduction in efficacy.
Corticotropin, Repository Injection Corticotropin, Repository Injection Corticotropin may increase the hypokalemic activities of Metolazone.
Linaclotide Linaclotide The risk or severity of adverse effects can be increased when Metolazone is combined with Linaclotide.
Lorcaserin Lorcaserin The therapeutic efficacy of Mecasermin can be decreased when used in combination with Metolazone.
Teduglutide Injection Teduglutide Injection Metolazone may increase the excretion rate of Teduglutide which could result in a lower serum level and potentially a reduction in efficacy.
Alogliptin Alogliptin The therapeutic efficacy of Alogliptin can be decreased when used in combination with Metolazone.
Pomalidomide Pomalidomide Metolazone may increase the excretion rate of Pomalidomide which could result in a lower serum level and potentially a reduction in efficacy.
Canagliflozin Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Metolazone.
Methazolamide Methazolamide Methazolamide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib Trametinib Metolazone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Levomilnacipran Levomilnacipran The risk or severity of hyponatremia can be increased when Levomilnacipran is combined with Metolazone.
Ertapenem Injection Ertapenem Injection Ertapenem may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Vortioxetine Vortioxetine Metolazone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Avanafil Avanafil Avanafil may increase the antihypertensive activities of Metolazone.
Ketorolac Injection Ketorolac Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Ketorolac.
Obinutuzumab Injection Obinutuzumab Injection Metolazone may increase the hypotensive activities of Obinutuzumab.
Sofosbuvir Sofosbuvir Metolazone may increase the excretion rate of Sofosbuvir which could result in a lower serum level and potentially a reduction in efficacy.
Dapagliflozin Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Metolazone.
Apremilast Apremilast Metolazone may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Droxidopa Droxidopa The risk or severity of Cardiac Arrhythmia can be increased when Droxidopa is combined with Metolazone.
Albiglutide Injection Albiglutide Injection The therapeutic efficacy of Albiglutide can be decreased when used in combination with Metolazone.
Testosterone Injection Testosterone Injection Metolazone may increase the excretion rate of Testosterone which could result in a lower serum level and potentially a reduction in efficacy.
Empagliflozin Empagliflozin Metolazone may increase the diuretic activities of Empagliflozin.
Hydrocodone Hydrocodone The therapeutic efficacy of Metolazone can be decreased when used in combination with Hydrocodone.
Dulaglutide Injection Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Metolazone.
Edoxaban Edoxaban Metolazone may increase the excretion rate of Edoxaban which could result in a lower serum level and potentially a reduction in efficacy.
Methamphetamine Methamphetamine Metolazone may increase the excretion rate of Metamfetamine which could result in a lower serum level and potentially a reduction in efficacy.
Tasimelteon Tasimelteon Metolazone may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Riociguat Riociguat Metolazone may increase the hypotensive activities of Riociguat.
Risperidone Injection Risperidone Injection Metolazone may increase the hypotensive activities of Risperidone.
Insulin Human Inhalation Insulin Human Inhalation The therapeutic efficacy of Insulin human can be decreased when used in combination with Metolazone.
Dinutuximab Injection Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Metolazone.
Haloperidol Injection Haloperidol Injection Haloperidol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Ivabradine Ivabradine The risk or severity of Cardiac Arrhythmia can be increased when Metolazone is combined with Ivabradine.
Amiloride Amiloride Amiloride may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan Macitentan Metolazone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Flibanserin Flibanserin Flibanserin may decrease the antihypertensive activities of Metolazone.
Prednisolone Prednisolone Prednisolone may increase the hypokalemic activities of Metolazone.
Brexpiprazole Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Metolazone.
Ziprasidone Injection Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Metolazone.
Cariprazine Cariprazine Cariprazine may decrease the antihypertensive activities of Metolazone.
Penicillin G Procaine Injection Penicillin G Procaine Injection Metolazone may increase the excretion rate of Procaine benzylpenicillin which could result in a lower serum level and potentially a reduction in efficacy.
Eluxadoline Eluxadoline The therapeutic efficacy of Metolazone can be decreased when used in combination with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Insulin degludec can be decreased when used in combination with Metolazone.
Ixazomib Ixazomib Metolazone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Lesinurad Lesinurad Metolazone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Liposomal Injection Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Metolazone which could result in a higher serum level.
Dexamethasone Injection Dexamethasone Injection Dexamethasone may increase the hypokalemic activities of Metolazone.
Brivaracetam Injection Brivaracetam Injection Metolazone may increase the excretion rate of Brivaracetam which could result in a lower serum level and potentially a reduction in efficacy.
Midodrine Midodrine Midodrine may decrease the antihypertensive activities of Metolazone.
Selexipag Selexipag Metolazone may increase the hypotensive activities of Selexipag.
Diphenhydramine Injection Diphenhydramine Injection The serum concentration of Metolazone can be increased when it is combined with Diphenhydramine.
Calcifediol Calcifediol The risk or severity of hypokalemia can be increased when Calcifediol is combined with Metolazone.
Ergocalciferol Ergocalciferol The risk or severity of hypokalemia can be increased when Ergocalciferol is combined with Metolazone.
Doxercalciferol Doxercalciferol The risk or severity of hypokalemia can be increased when Doxercalciferol is combined with Metolazone.
Furosemide Injection Furosemide Injection Metolazone may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Lixisenatide Injection Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Metolazone.
Doxepin (Insomnia) Doxepin (Insomnia) Doxepin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Plecanatide Plecanatide The risk or severity of adverse effects can be increased when Metolazone is combined with Plecanatide.
Deutetrabenazine Deutetrabenazine Metolazone may increase the excretion rate of Deutetrabenazine which could result in a lower serum level and potentially a reduction in efficacy.
Valbenazine Valbenazine Metolazone may increase the excretion rate of Valbenazine which could result in a lower serum level and potentially a reduction in efficacy.
Deflazacort Deflazacort Deflazacort may increase the hypokalemic activities of Metolazone.
Safinamide Safinamide Safinamide may increase the hypotensive activities of Metolazone.
Naldemedine Naldemedine Metolazone may increase the excretion rate of Naldemedine which could result in a lower serum level and potentially a reduction in efficacy.
Benznidazole Benznidazole Metolazone may increase the excretion rate of Benznidazole which could result in a lower serum level and potentially a reduction in efficacy.
Delafloxacin Delafloxacin Metolazone may increase the excretion rate of Delafloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Semaglutide Injection Semaglutide Injection The therapeutic efficacy of Semaglutide can be decreased when used in combination with Metolazone.
Ertugliflozin Ertugliflozin The therapeutic efficacy of Ertugliflozin can be decreased when used in combination with Metolazone.
Buprenorphine Injection Buprenorphine Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Buprenorphine.
Apalutamide Apalutamide Metolazone may increase the excretion rate of Apalutamide which could result in a lower serum level and potentially a reduction in efficacy.
Fostamatinib Fostamatinib Fostamatinib may increase the antihypertensive activities of Metolazone.
Baricitinib Baricitinib Metolazone may increase the excretion rate of Baricitinib which could result in a lower serum level and potentially a reduction in efficacy.
Lofexidine Lofexidine Metolazone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Plazomicin Injection Plazomicin Injection Metolazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol Cannabidiol Cannabidiol may decrease the antihypertensive activities of Metolazone.
Stiripentol Stiripentol Metolazone may increase the excretion rate of Stiripentol which could result in a lower serum level and potentially a reduction in efficacy.
Paclitaxel (with albumin) Injection Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Paclitaxel is combined with Metolazone.
Prucalopride Prucalopride Metolazone may increase the excretion rate of Prucalopride which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Citrate Magnesium Citrate The risk or severity of adverse effects can be increased when Metolazone is combined with Magnesium citrate.
Siponimod Siponimod Siponimod may decrease the antihypertensive activities of Metolazone.
Acyclovir Ophthalmic Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Solriamfetol Solriamfetol Metolazone may increase the excretion rate of Solriamfetol which could result in a lower serum level and potentially a reduction in efficacy.
Pitolisant Pitolisant Metolazone may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Calcium Acetate Calcium Acetate Metolazone may decrease the excretion rate of Calcium acetate which could result in a higher serum level.
Selpercatinib Selpercatinib Selpercatinib may decrease the antihypertensive activities of Metolazone.
Naxitamab-gqgk Injection Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Metolazone.
Progestin-Only (drospirenone) Oral Contraceptives Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine Viloxazine Metolazone may increase the excretion rate of Viloxazine which could result in a lower serum level and potentially a reduction in efficacy.
Tobramycin Injection Tobramycin Injection Tobramycin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Fenoprofen Fenoprofen The therapeutic efficacy of Metolazone can be decreased when used in combination with Fenoprofen.
Indomethacin Indomethacin Indomethacin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Mefenamic Acid Mefenamic Acid The therapeutic efficacy of Metolazone can be decreased when used in combination with Mefenamic acid.
Naproxen Naproxen The therapeutic efficacy of Metolazone can be decreased when used in combination with Naproxen.
Tolmetin Tolmetin The therapeutic efficacy of Metolazone can be decreased when used in combination with Tolmetin.
Sulindac Sulindac The therapeutic efficacy of Metolazone can be decreased when used in combination with Sulindac.
Trazodone Trazodone The risk or severity of hyponatremia can be increased when Trazodone is combined with Metolazone.
Isotretinoin Isotretinoin Metolazone may increase the excretion rate of Isotretinoin which could result in a lower serum level and potentially a reduction in efficacy.
Sucralfate Sucralfate Sucralfate may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Floxuridine Floxuridine Floxuridine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Phenobarbital Phenobarbital The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Metolazone.
Metaxalone Metaxalone Metolazone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Methotrexate Injection Methotrexate Injection The risk or severity of adverse effects can be increased when Metolazone is combined with Methotrexate.
Levorphanol Levorphanol The therapeutic efficacy of Metolazone can be decreased when used in combination with Levorphanol.
Primidone Primidone The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Metolazone.
Diethylpropion Diethylpropion Diethylpropion may decrease the antihypertensive activities of Metolazone.
Chlorpromazine Chlorpromazine Chlorpromazine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Diazepam Diazepam Metolazone may increase the excretion rate of Diazepam which could result in a lower serum level and potentially a reduction in efficacy.
Oxazepam Oxazepam Metolazone may increase the excretion rate of Oxazepam which could result in a lower serum level and potentially a reduction in efficacy.
Flurazepam Flurazepam Metolazone may increase the excretion rate of Flurazepam which could result in a lower serum level and potentially a reduction in efficacy.
Clorazepate Clorazepate Metolazone may increase the excretion rate of Clorazepic acid which could result in a lower serum level and potentially a reduction in efficacy.
Lorazepam Lorazepam Lorazepam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Phenoxybenzamine Phenoxybenzamine Metolazone may decrease the antihypertensive activities of Phenoxybenzamine.
Carmustine Carmustine Carmustine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Amantadine Amantadine Metolazone may increase the excretion rate of Amantadine which could result in a lower serum level and potentially a reduction in efficacy.
Codeine Codeine Codeine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Bromocriptine Bromocriptine The therapeutic efficacy of Bromocriptine can be decreased when used in combination with Metolazone.
Metaproterenol Metaproterenol Orciprenaline may increase the hypokalemic activities of Metolazone.
Tranylcypromine Tranylcypromine Tranylcypromine may increase the hypotensive activities of Metolazone.
Phenelzine Phenelzine Phenelzine may increase the hypotensive activities of Metolazone.
Procarbazine Procarbazine Procarbazine may increase the hypotensive activities of Metolazone.
Ergoloid Mesylates Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Metolazone.
Tetracycline Tetracycline Metolazone may increase the excretion rate of Tetracycline which could result in a lower serum level and potentially a reduction in efficacy.
Thioridazine Thioridazine Thioridazine may decrease the antihypertensive activities of Metolazone.
Trifluoperazine Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Metolazone.
Bleomycin Bleomycin Bleomycin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Sulfadiazine Sulfadiazine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Metolazone.
Oxycodone Oxycodone The therapeutic efficacy of Metolazone can be decreased when used in combination with Oxycodone.
Methadone Methadone Methadone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Oxybutynin Oxybutynin The serum concentration of Metolazone can be increased when it is combined with Oxybutynin.
Benztropine Benztropine Benzatropine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Colestipol Colestipol Colestipol can cause a decrease in the absorption of Metolazone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline Maprotiline Metolazone may increase the excretion rate of Maprotiline which could result in a lower serum level and potentially a reduction in efficacy.
Ibuprofen Ibuprofen The therapeutic efficacy of Metolazone can be decreased when used in combination with Ibuprofen.
Trihexyphenidyl Trihexyphenidyl The serum concentration of Metolazone can be increased when it is combined with Trihexyphenidyl.
Orphenadrine Orphenadrine The serum concentration of Metolazone can be increased when it is combined with Orphenadrine.
Azathioprine Azathioprine Metolazone may increase the excretion rate of Azathioprine which could result in a lower serum level and potentially a reduction in efficacy.
Phentermine Phentermine Phentermine may decrease the antihypertensive activities of Metolazone.
Methylphenidate Methylphenidate Methylphenidate may decrease the antihypertensive activities of Metolazone.
Amoxapine Amoxapine The serum concentration of Metolazone can be increased when it is combined with Amoxapine.
Sulfasalazine Sulfasalazine The therapeutic efficacy of Metolazone can be decreased when used in combination with Sulfasalazine.
Hydrocortisone Hydrocortisone Hydrocortisone may increase the hypokalemic activities of Metolazone.
Phenazopyridine Phenazopyridine Phenazopyridine may decrease the excretion rate of Metolazone which could result in a higher serum level.
Carbamazepine Carbamazepine The risk or severity of adverse effects can be increased when Metolazone is combined with Carbamazepine.
Methyldopa Methyldopa Metolazone may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Clonidine Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Metolazone.
Prazosin Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Metolazone.
Hydralazine Hydralazine Metolazone may increase the excretion rate of Hydralazine which could result in a lower serum level and potentially a reduction in efficacy.
Cimetidine Cimetidine Cimetidine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Gentamicin Injection Gentamicin Injection Gentamicin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Warfarin Warfarin Metolazone may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam Clonazepam Metolazone may increase the excretion rate of Clonazepam which could result in a lower serum level and potentially a reduction in efficacy.
Promethazine Promethazine Metolazone may increase the excretion rate of Promethazine which could result in a lower serum level and potentially a reduction in efficacy.
Meclofenamate Meclofenamate The therapeutic efficacy of Metolazone can be decreased when used in combination with Meclofenamic acid.
Nitrofurantoin Nitrofurantoin Metolazone may increase the excretion rate of Nitrofurantoin which could result in a lower serum level and potentially a reduction in efficacy.
Digoxin Digoxin Metolazone may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine Chloroquine Metolazone may increase the excretion rate of Chloroquine which could result in a lower serum level and potentially a reduction in efficacy.
Quinine Quinine The therapeutic efficacy of Quinine can be decreased when used in combination with Metolazone.
Calcitriol Calcitriol The risk or severity of hypokalemia can be increased when Calcitriol is combined with Metolazone.
Triamterene Triamterene Triamterene may decrease the excretion rate of Metolazone which could result in a higher serum level.
Lactulose Lactulose The risk or severity of adverse effects can be increased when Metolazone is combined with Lactulose.
Chlorothiazide Chlorothiazide The therapeutic efficacy of Chlorothiazide can be increased when used in combination with Metolazone.
Chlorthalidone Chlorthalidone Chlorthalidone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide Isosorbide Isosorbide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital Secobarbital The risk or severity of hypotension and orthostatic hypotension can be increased when Secobarbital is combined with Metolazone.
Desipramine Desipramine Desipramine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Amitriptyline Amitriptyline Amitriptyline may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Imipramine Imipramine Imipramine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Probenecid Probenecid Metolazone may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Quinidine Quinidine Metolazone may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide Procainamide Metolazone may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid Isoniazid Metolazone may increase the excretion rate of Isoniazid which could result in a lower serum level and potentially a reduction in efficacy.
Pyrazinamide Pyrazinamide Pyrazinamide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Disopyramide Disopyramide The therapeutic efficacy of Disopyramide can be decreased when used in combination with Metolazone.
Butabarbital Butabarbital Butabarbital may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Liothyronine Liothyronine Liothyronine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole Methimazole Metolazone may increase the excretion rate of Methimazole which could result in a lower serum level and potentially a reduction in efficacy.
Chlorpropamide Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Metolazone.
Tolbutamide Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Metolazone.
Tolazamide Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Metolazone.
Dextromethorphan Dextromethorphan The serum concentration of Metolazone can be increased when it is combined with Dextromethorphan.
Baclofen Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Metolazone.
Doxylamine Doxylamine The serum concentration of Metolazone can be increased when it is combined with Doxylamine.
Cyproheptadine Cyproheptadine The serum concentration of Metolazone can be increased when it is combined with Cyproheptadine.
Brompheniramine Brompheniramine The serum concentration of Metolazone can be increased when it is combined with Brompheniramine.
Ethambutol Ethambutol Ethambutol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Methyclothiazide Methyclothiazide The therapeutic efficacy of Metolazone can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide Hydrochlorothiazide The therapeutic efficacy of Metolazone can be increased when used in combination with Hydrochlorothiazide.
Chlorzoxazone Chlorzoxazone Chlorzoxazone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Pyridoxine Pyridoxine Pyridoxine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Folic Acid Folic Acid Folic acid may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Propranolol (Cardiovascular) Propranolol (Cardiovascular) Metolazone may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.
Minoxidil Minoxidil Minoxidil may increase the hypotensive activities of Metolazone.
Pseudoephedrine Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Metolazone.
Nortriptyline Nortriptyline The serum concentration of Metolazone can be increased when it is combined with Nortriptyline.
Spironolactone Spironolactone Spironolactone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection Amphotericin B Injection Amphotericin B may decrease the excretion rate of Metolazone which could result in a higher serum level.
Phytonadione Phytonadione Metolazone may increase the excretion rate of Phylloquinone which could result in a lower serum level and potentially a reduction in efficacy.
Amikacin Injection Amikacin Injection Amikacin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Nadolol Nadolol Metolazone may increase the excretion rate of Nadolol which could result in a lower serum level and potentially a reduction in efficacy.
Butorphanol Injection Butorphanol Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Butorphanol.
Nalbuphine Injection Nalbuphine Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Nalbuphine.
Cholestyramine Resin Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Metolazone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol Allopurinol The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Metolazone.
Flavoxate Flavoxate Metolazone may increase the excretion rate of Flavoxate which could result in a lower serum level and potentially a reduction in efficacy.
Papaverine Papaverine The risk or severity of adverse effects can be increased when Papaverine is combined with Metolazone.
Colchicine Colchicine Metolazone may increase the excretion rate of Colchicine which could result in a lower serum level and potentially a reduction in efficacy.
Cefaclor Cefaclor Cefaclor may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefadroxil Cefadroxil Cefadroxil may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefazolin Injection Cefazolin Injection Cefazolin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cephalexin Cephalexin Cephalexin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefoxitin Injection Cefoxitin Injection Cefoxitin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Dacarbazine Dacarbazine Metolazone may increase the excretion rate of Dacarbazine which could result in a lower serum level and potentially a reduction in efficacy.
Acetazolamide Acetazolamide Acetazolamide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection Cefotaxime Injection Cefotaxime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Calcitonin Salmon Injection Calcitonin Salmon Injection Salmon calcitonin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Pyrantel Pyrantel Metolazone may increase the excretion rate of Pyrantel which could result in a lower serum level and potentially a reduction in efficacy.
Captopril Captopril The risk or severity of hypotension can be increased when Metolazone is combined with Captopril.
Dipyridamole Dipyridamole Dipyridamole may increase the antihypertensive activities of Metolazone.
Isoxsuprine Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Metolazone.
Ethacrynic Acid Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Metolazone which could result in a higher serum level.
Colistimethate Injection Colistimethate Injection Colistimethate may decrease the excretion rate of Metolazone which could result in a higher serum level.
Metoprolol Metoprolol Metoprolol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Aspirin Aspirin Acetylsalicylic acid may decrease the excretion rate of Metolazone which could result in a higher serum level.
Salsalate Salsalate The therapeutic efficacy of Metolazone can be decreased when used in combination with Salsalate.
Alprazolam Alprazolam Alprazolam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Temazepam Temazepam Temazepam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam Triazolam Metolazone may increase the excretion rate of Triazolam which could result in a lower serum level and potentially a reduction in efficacy.
Dicyclomine Dicyclomine Metolazone may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy.
Hyoscyamine Hyoscyamine The serum concentration of Metolazone can be increased when it is combined with Hyoscyamine.
Propantheline Propantheline Metolazone may increase the excretion rate of Propantheline which could result in a lower serum level and potentially a reduction in efficacy.
Trimethoprim Trimethoprim Trimethoprim may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Diltiazem Diltiazem Diltiazem may increase the hypotensive activities of Metolazone.
Nifedipine Nifedipine Metolazone may increase the excretion rate of Nifedipine which could result in a lower serum level and potentially a reduction in efficacy.
Timolol Timolol Timolol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Verapamil Verapamil Metolazone may increase the excretion rate of Verapamil which could result in a lower serum level and potentially a reduction in efficacy.
Atenolol Atenolol Atenolol may increase the hypotensive activities of Metolazone.
Pindolol Pindolol Metolazone may increase the excretion rate of Pindolol which could result in a lower serum level and potentially a reduction in efficacy.
Cisplatin Injection Cisplatin Injection Metolazone may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal Diflunisal The therapeutic efficacy of Metolazone can be decreased when used in combination with Diflunisal.
Piroxicam Piroxicam The therapeutic efficacy of Metolazone can be decreased when used in combination with Piroxicam.
Bumetanide Bumetanide Metolazone may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Glyburide Glyburide The therapeutic efficacy of Glyburide can be decreased when used in combination with Metolazone.
Glipizide Glipizide The therapeutic efficacy of Glipizide can be decreased when used in combination with Metolazone.
Indapamide Indapamide The therapeutic efficacy of Indapamide can be increased when used in combination with Metolazone.
Amoxicillin Amoxicillin Metolazone may increase the excretion rate of Amoxicillin which could result in a lower serum level and potentially a reduction in efficacy.
Oxacillin Injection Oxacillin Injection Metolazone may increase the excretion rate of Oxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Pentoxifylline Pentoxifylline Pentoxifylline may increase the hypotensive activities of Metolazone.
Pentamidine Injection Pentamidine Injection The therapeutic efficacy of Pentamidine can be decreased when used in combination with Metolazone.
Ceftriaxone Injection Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Metolazone which could result in a higher serum level.
Labetalol Labetalol Metolazone may increase the excretion rate of Labetalol which could result in a lower serum level and potentially a reduction in efficacy.
Auranofin Auranofin Metolazone may increase the excretion rate of Auranofin which could result in a lower serum level and potentially a reduction in efficacy.
Leuprolide Injection Leuprolide Injection Leuprolide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Gemfibrozil Gemfibrozil Metolazone may increase the excretion rate of Gemfibrozil which could result in a lower serum level and potentially a reduction in efficacy.
Guanabenz Guanabenz Metolazone may decrease the antihypertensive activities of Guanabenz.
Dipivefrin Ophthalmic Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Metolazone which could result in a higher serum level.
Ceftazidime Injection Ceftazidime Injection Ceftazidime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Ketoprofen Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Metolazone.
Cefotetan Injection Cefotetan Injection Cefotetan may decrease the excretion rate of Metolazone which could result in a higher serum level.
Enalapril Enalapril The risk or severity of hypotension can be increased when Metolazone is combined with Enalapril.
Flurbiprofen Flurbiprofen The therapeutic efficacy of Metolazone can be decreased when used in combination with Flurbiprofen.
Amiodarone Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Metolazone.
Aztreonam Injection Aztreonam Injection Aztreonam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Buspirone Buspirone Buspirone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Ciprofloxacin Ciprofloxacin Metolazone may increase the excretion rate of Ciprofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Mesalamine Mesalamine The therapeutic efficacy of Metolazone can be decreased when used in combination with Mesalazine.
Diclofenac Diclofenac The therapeutic efficacy of Metolazone can be decreased when used in combination with Diclofenac.
Fluoxetine Fluoxetine The risk or severity of hyponatremia can be increased when Fluoxetine is combined with Metolazone.
Nimodipine Nimodipine Nimodipine may increase the hypotensive activities of Metolazone.
Clozapine Clozapine Clozapine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Estazolam Estazolam Metolazone may increase the excretion rate of Estazolam which could result in a lower serum level and potentially a reduction in efficacy.
Didanosine Didanosine Metolazone may increase the excretion rate of Didanosine which could result in a lower serum level and potentially a reduction in efficacy.
Pentostatin Injection Pentostatin Injection Metolazone may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril Benazepril The risk or severity of hypotension can be increased when Metolazone is combined with Benazepril.
Etodolac Etodolac The therapeutic efficacy of Metolazone can be decreased when used in combination with Etodolac.
Felodipine Felodipine Metolazone may increase the hypotensive activities of Felodipine.
Fosinopril Fosinopril The risk or severity of hypotension can be increased when Metolazone is combined with Fosinopril.
Nabumetone Nabumetone The therapeutic efficacy of Metolazone can be decreased when used in combination with Nabumetone.
Quinapril Quinapril The risk or severity of hypotension can be increased when Metolazone is combined with Quinapril.
Ramipril Ramipril The risk or severity of hypotension can be increased when Metolazone is combined with Ramipril.
Amlodipine Amlodipine Amlodipine may increase the hypotensive activities of Metolazone.
Lisinopril Lisinopril The risk or severity of hypotension can be increased when Metolazone is combined with Lisinopril.
Oxaprozin Oxaprozin The therapeutic efficacy of Metolazone can be decreased when used in combination with Oxaprozin.
Sotalol Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Metolazone.
Bisoprolol Bisoprolol Metolazone may increase the excretion rate of Bisoprolol which could result in a lower serum level and potentially a reduction in efficacy.
Doxazosin Doxazosin Metolazone may increase the hypotensive activities of Doxazosin.
Terazosin Terazosin Metolazone may increase the hypotensive activities of Terazosin.
Isradipine Isradipine Isradipine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Venlafaxine Venlafaxine Venlafaxine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Fluvoxamine Fluvoxamine The risk or severity of hyponatremia can be increased when Fluvoxamine is combined with Metolazone.
Nefazodone Nefazodone The risk or severity of hyponatremia can be increased when Nefazodone is combined with Metolazone.
Lamotrigine Lamotrigine Metolazone may increase the excretion rate of Lamotrigine which could result in a lower serum level and potentially a reduction in efficacy.
Losartan Losartan Metolazone may increase the hypotensive activities of Losartan.
Valacyclovir Valacyclovir Valaciclovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Tramadol Tramadol Tramadol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Carboplatin Injection Carboplatin Injection Carboplatin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Moexipril Moexipril The risk or severity of hypotension can be increased when Metolazone is combined with Moexipril.
Ifosfamide Injection Ifosfamide Injection Metolazone may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Nicardipine Nicardipine Metolazone may increase the hypotensive activities of Nicardipine.
Bupropion Bupropion Metolazone may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy.
Ticlopidine Ticlopidine Ticlopidine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Metformin Metformin The therapeutic efficacy of Metformin can be decreased when used in combination with Metolazone.
Nisoldipine Nisoldipine Nisoldipine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Lamivudine Lamivudine Metolazone may increase the excretion rate of Lamivudine which could result in a lower serum level and potentially a reduction in efficacy.
Amifostine Injection Amifostine Injection Metolazone may increase the hypotensive activities of Amifostine.
Acarbose Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Metolazone.
Glimepiride Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Metolazone.
Gemcitabine Injection Gemcitabine Injection Gemcitabine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Cidofovir Injection Cidofovir Injection Cidofovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Meropenem Injection Meropenem Injection Metolazone may increase the excretion rate of Meropenem which could result in a lower serum level and potentially a reduction in efficacy.
Clomipramine Clomipramine Clomipramine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Fosfomycin Fosfomycin Metolazone may increase the excretion rate of Fosfomycin which could result in a lower serum level and potentially a reduction in efficacy.
Mirtazapine Mirtazapine Mirtazapine may decrease the antihypertensive activities of Metolazone.
Trandolapril Trandolapril The risk or severity of hypotension can be increased when Metolazone is combined with Trandolapril.
Topiramate Topiramate The risk or severity of hypokalemia can be increased when Metolazone is combined with Topiramate.
Valsartan Valsartan Valsartan may increase the hypotensive activities of Metolazone.
Insulin Lispro Injection Insulin Lispro Injection The therapeutic efficacy of Insulin lispro can be decreased when used in combination with Metolazone.
Pramipexole Pramipexole Pramipexole may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Carvedilol Carvedilol Metolazone may increase the hypotensive activities of Carvedilol.
Nilutamide Nilutamide Metolazone may increase the excretion rate of Nilutamide which could result in a lower serum level and potentially a reduction in efficacy.
Flutamide Flutamide Flutamide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Selegiline Selegiline Selegiline may increase the hypotensive activities of Metolazone.
Sertraline Sertraline The risk or severity of hyponatremia can be increased when Sertraline is combined with Metolazone.
Propafenone Propafenone Propafenone may decrease the antihypertensive activities of Metolazone.
Irbesartan Irbesartan Metolazone may increase the hypotensive activities of Irbesartan.
Tamsulosin Tamsulosin Metolazone may increase the excretion rate of Tamsulosin which could result in a lower serum level and potentially a reduction in efficacy.
Ropinirole Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Metolazone.
Finasteride Finasteride Finasteride may decrease the antihypertensive activities of Metolazone.
Quetiapine Quetiapine Metolazone may increase the hypotensive activities of Quetiapine.
Cefepime Injection Cefepime Injection Cefepime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefprozil Cefprozil Cefprozil may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefpodoxime Cefpodoxime Cefpodoxime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cetirizine Cetirizine Cetirizine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Paroxetine Paroxetine The risk or severity of hyponatremia can be increased when Paroxetine is combined with Metolazone.
Tolcapone Tolcapone Tolcapone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Citalopram Citalopram The risk or severity of hyponatremia can be increased when Citalopram is combined with Metolazone.
Capecitabine Capecitabine Metolazone may increase the excretion rate of Capecitabine which could result in a lower serum level and potentially a reduction in efficacy.
Abacavir Abacavir Metolazone may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Sildenafil Sildenafil Sildenafil may increase the antihypertensive activities of Metolazone.
Pioglitazone Pioglitazone The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Metolazone.
Celecoxib Celecoxib The therapeutic efficacy of Metolazone can be decreased when used in combination with Celecoxib.
Rosiglitazone Rosiglitazone The therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Metolazone.
Tolterodine Tolterodine Metolazone may increase the excretion rate of Tolterodine which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Metolazone.
Oseltamivir Oseltamivir Oseltamivir may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Colesevelam Colesevelam Colesevelam can cause a decrease in the absorption of Metolazone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide Balsalazide The therapeutic efficacy of Metolazone can be decreased when used in combination with Balsalazide.
Nateglinide Nateglinide The therapeutic efficacy of Nateglinide can be decreased when used in combination with Metolazone.
Rabeprazole Rabeprazole Metolazone may increase the excretion rate of Rabeprazole which could result in a lower serum level and potentially a reduction in efficacy.

Content provided by: AHFS® Patient Medication Information™. © Copyright, 2021. The American Society of Health-System Pharmacists