Metolazone

Metolazone, is used to reduce the swelling and fluid retention caused by heart failure or kidney disease. It also is used alone or with other medications to treat high blood pressure. Metolazone is in a class of medications called diuretics ('water pills'). It causes the kidneys to reduce the amount of water and salt in the body by increasing the amount of urine.

Metolazone comes as a tablet to take by mouth. It is usually taken once a day. Take metolazone at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take metolazone exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Your doctor will probably start you on a low dose of metolazone and gradually increase your dose, depending on your response to this medication.

Metolazone controls high blood pressure but does not cure it. Continue to take metolazone even if you feel well. Do not stop taking metolazone without talking to your doctor.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Before taking metolazone,

• tell your doctor and pharmacist if you are allergic to metolazone, sulfa drugs, thiazides, any other medications, or any of the ingredients in metolazone tablets. Ask your pharmacist for a list of the ingredients.

• tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: anticoagulants ('blood thinners') such as warfarin (Coumadin); aspirin and other nonsteroidal anti-inflammatory medications (NSAIDs) such as ibuprofen (Advil, Motrin) and naproxen (Aleve, Naprosyn); corticotropin; digoxin (Lanoxin); furosemide (Lasix); insulin or other medications for diabetes; lithium (Eskalith, Lithobid); medications for asthma and colds; medications for pain or seizures; methenamine (Hiprex, Urex); other medications for high blood pressure; sedatives; oral steroids such as dexamethasone (Decadron, Dexone), methylprednisolone (Medrol), and prednisone (Deltasone); tranquilizers; and vitamin D. Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

• tell your doctor if you have kidney or liver failure. Your doctor will probably tell you not to take metolazone.

• tell your doctor if you have or have ever had diabetes, gout, systemic lupus erythematosus (SLE, a chronic inflammatory condition), or parathyroid, heart, kidney, or liver disease.

• tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking metolazone, call your doctor.

• if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking metolazone.

• you should know that metolazone may make you dizzy or drowsy. Do not drive a car or operate machinery until you know how this medication affects you.

• ask your doctor about the safe use of alcoholic beverages while you are taking metolazone. Alcohol can make the side effects from metolazone worse.

• plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Metolazone may make your skin sensitive to sunlight.

• you should know that metolazone may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking metolazone. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.

Follow your doctor's directions. they may include a daily exercise program and a low-sodium or low-salt diet, potassium supplements, and increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet.

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

• Metolazone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:

  • dizziness

  • weakness

  • restlessness

  • headache

  • muscle cramps

  • joint pain or swelling

  • constipation

  • diarrhea

• Some side effects can be serious. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment:

  • dry mouth, dark urine, decreased sweating, dry skin, and other signs of dehydration

  • chest pain

  • rapid, irregular, or pounding heartbeats

  • hives

  • rash

  • itching

  • blistering or peeling skin

  • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs

  • hoarseness

  • difficulty swallowing or breathing

  • sore throat with fever

  • unusual bleeding or bruising

  • upset stomach

  • extreme tiredness

  • loss of appetite

  • pain in the upper right part of the stomach

  • yellowing of the skin or eyes

  • flu-like symptoms

• Metolazone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

• If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administration's (FDA) MedWatch Adverse Event Reporting program online (http://www.fda.gov/Safety/MedWatch) or by phone (1-800-332-1088).

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from light, excess heat and moisture (not in the bathroom).

Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA's Safe Disposal of Medicines website (http://goo.gl/c4Rm4p) for more information if you do not have access to a take-back program.

It is important to keep all medication out of sight and reach of children as many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location – one that is up and away and out of their sight and reach. http://www.upandaway.org

In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at https://www.poisonhelp.org/help. If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at 911.

Symptoms of overdose may include the following:

• dizziness

• drowsiness

• fainting

• slow or difficult breathing

• upset stomach

• coma

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your body's response to metolazone.

Before having any laboratory test, tell your doctor and the laboratory personnel that you are taking metolazone.

Learn the brand name of your medication. Do not switch brands without talking to your doctor or pharmacist, as different brands of metolazone may work differently in the body.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Drug	Interaction
Repaglinide	Repaglinide The therapeutic efficacy of Repaglinide can be decreased when used in combination with Metolazone.
Insulin Glargine (rDNA origin) Injection	Insulin Glargine (rDNA origin) Injection The therapeutic efficacy of Insulin glargine can be decreased when used in combination with Metolazone.
Bisacodyl	Bisacodyl The risk or severity of adverse effects can be increased when Metolazone is combined with Bisacodyl.
Calcium Carbonate	Calcium Carbonate Metolazone may decrease the excretion rate of Calcium carbonate which could result in a higher serum level.
Candesartan	Candesartan Metolazone may increase the hypotensive activities of Candesartan.
Cilostazol	Cilostazol Metolazone may increase the excretion rate of Cilostazol which could result in a lower serum level and potentially a reduction in efficacy.
Diphenoxylate	Diphenoxylate The therapeutic efficacy of Metolazone can be decreased when used in combination with Diphenoxylate.
Estrogen and Progestin (Oral Contraceptives)	Estrogen and Progestin (Oral Contraceptives) Conjugated estrogens may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Fenofibrate	Fenofibrate Metolazone may increase the excretion rate of Fenofibrate which could result in a lower serum level and potentially a reduction in efficacy.
Guanfacine	Guanfacine Metolazone may increase the excretion rate of Guanfacine which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Hydroxide	Magnesium Hydroxide Metolazone may increase the excretion rate of Magnesium hydroxide which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Oxide	Magnesium Oxide The risk or severity of adverse effects can be increased when Metolazone is combined with Magnesium oxide.
Methylergonovine	Methylergonovine Methylergometrine may decrease the antihypertensive activities of Metolazone.
Miglitol	Miglitol The therapeutic efficacy of Miglitol can be decreased when used in combination with Metolazone.
Mycophenolate	Mycophenolate Metolazone may increase the excretion rate of Mycophenolic acid which could result in a lower serum level and potentially a reduction in efficacy.
Naratriptan	Naratriptan Naratriptan may decrease the antihypertensive activities of Metolazone.
Olsalazine	Olsalazine The therapeutic efficacy of Metolazone can be decreased when used in combination with Olsalazine.
Paregoric	Paregoric The therapeutic efficacy of Metolazone can be decreased when used in combination with Morphine.
Penbutolol	Penbutolol Metolazone may increase the hypotensive activities of Acebutolol.
Pentazocine	Pentazocine The therapeutic efficacy of Metolazone can be decreased when used in combination with Pentazocine.
Polyethylene glycol-electrolyte solution (PEG-ES)	Polyethylene glycol-electrolyte solution (PEG-ES) The risk or severity of adverse effects can be increased when Metolazone is combined with Polyethylene glycol.
Potassium	Potassium Potassium may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Prednisone	Prednisone Prednisone may increase the hypokalemic activities of Metolazone.
Psyllium	Psyllium The risk or severity of adverse effects can be increased when Metolazone is combined with Plantago seed.
Ranitidine	Ranitidine Metolazone may increase the excretion rate of Ranitidine which could result in a lower serum level and potentially a reduction in efficacy.
Reserpine	Reserpine Reserpine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Rizatriptan	Rizatriptan Metolazone may increase the excretion rate of Rizatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Sumatriptan	Sumatriptan Metolazone may increase the excretion rate of Sumatriptan which could result in a lower serum level and potentially a reduction in efficacy.
Tacrolimus	Tacrolimus Tacrolimus may decrease the excretion rate of Metolazone which could result in a higher serum level.
Tizanidine	Tizanidine The risk or severity of adverse effects can be increased when Tizanidine is combined with Metolazone.
Triamcinolone	Triamcinolone Triamcinolone may increase the hypokalemic activities of Metolazone.
Zolmitriptan	Zolmitriptan Zolmitriptan may decrease the antihypertensive activities of Metolazone.
Ampicillin Injection	Ampicillin Injection Ampicillin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Doxycycline Injection	Doxycycline Injection Doxycycline may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Fluconazole Injection	Fluconazole Injection Fluconazole may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Foscarnet Injection	Foscarnet Injection Foscarnet may decrease the excretion rate of Metolazone which could result in a higher serum level.
Hydromorphone Injection	Hydromorphone Injection Hydromorphone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Levofloxacin Injection	Levofloxacin Injection Metolazone may increase the excretion rate of Levofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Meperidine Injection	Meperidine Injection Meperidine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Methylprednisolone Injection	Methylprednisolone Injection Methylprednisolone may increase the hypokalemic activities of Metolazone.
Metoclopramide Injection	Metoclopramide Injection Metolazone may increase the excretion rate of Metoclopramide which could result in a lower serum level and potentially a reduction in efficacy.
Morphine Injection	Morphine Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Morphine.
Pamidronate Injection	Pamidronate Injection Pamidronic acid may decrease the excretion rate of Metolazone which could result in a higher serum level.
Vancomycin Injection	Vancomycin Injection Metolazone may decrease the excretion rate of Vancomycin which could result in a higher serum level.
Altretamine	Altretamine Amphetamine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Cefuroxime	Cefuroxime Cefuroxime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cyclosporine	Cyclosporine The risk or severity of renal failure can be increased when Metolazone is combined with Cyclosporine.
Torsemide	Torsemide Torasemide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Olanzapine	Olanzapine The serum concentration of Metolazone can be increased when it is combined with Olanzapine.
Dofetilide	Dofetilide The risk or severity of QTc prolongation can be increased when Metolazone is combined with Dofetilide.
Eprosartan	Eprosartan Metolazone may increase the hypotensive activities of Eprosartan.
Meloxicam	Meloxicam The therapeutic efficacy of Metolazone can be decreased when used in combination with Meloxicam.
Oxcarbazepine	Oxcarbazepine The risk or severity of hyponatremia can be increased when Metolazone is combined with Oxcarbazepine.
Pantoprazole	Pantoprazole Pantoprazole may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Sevelamer	Sevelamer Sevelamer can cause a decrease in the absorption of Metolazone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Telmisartan	Telmisartan Metolazone may increase the hypotensive activities of Telmisartan.
Temozolomide	Temozolomide Metolazone may increase the excretion rate of Temozolomide which could result in a lower serum level and potentially a reduction in efficacy.
Zaleplon	Zaleplon Metolazone may increase the excretion rate of Zaleplon which could result in a lower serum level and potentially a reduction in efficacy.
Desloratadine	Desloratadine The serum concentration of Metolazone can be increased when it is combined with Desloratadine.
Linezolid	Linezolid Linezolid may increase the hypotensive activities of Metolazone.
Trimipramine	Trimipramine Trimipramine may decrease the antihypertensive activities of Metolazone.
Glycopyrrolate	Glycopyrrolate The serum concentration of Metolazone can be increased when it is combined with Glycopyrronium.
Perindopril	Perindopril The risk or severity of hypotension can be increased when Metolazone is combined with Perindopril.
Tenofovir	Tenofovir Tenofovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Choline Magnesium Trisalicylate	Choline Magnesium Trisalicylate The therapeutic efficacy of Metolazone can be decreased when used in combination with Choline magnesium trisalicylate.
Dutasteride	Dutasteride Dutasteride may decrease the antihypertensive activities of Metolazone.
Epinephrine Injection	Epinephrine Injection The risk or severity of Cardiac Arrhythmia can be increased when Epinephrine is combined with Metolazone.
Eplerenone	Eplerenone Metolazone may increase the excretion rate of Eplerenone which could result in a lower serum level and potentially a reduction in efficacy.
Escitalopram	Escitalopram The risk or severity of hyponatremia can be increased when Escitalopram is combined with Metolazone.
Olmesartan	Olmesartan Olmesartan may increase the hypotensive activities of Metolazone.
Zonisamide	Zonisamide Metolazone may increase the excretion rate of Zonisamide which could result in a lower serum level and potentially a reduction in efficacy.
Aripiprazole	Aripiprazole The risk or severity of hypotension can be increased when Aripiprazole is combined with Metolazone.
Atomoxetine	Atomoxetine Atomoxetine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Dexmethylphenidate	Dexmethylphenidate Dexmethylphenidate may decrease the antihypertensive activities of Metolazone.
Atazanavir	Atazanavir Atazanavir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Almotriptan	Almotriptan Metolazone may increase the excretion rate of Almotriptan which could result in a lower serum level and potentially a reduction in efficacy.
Eletriptan	Eletriptan Eletriptan may decrease the antihypertensive activities of Metolazone.
Polyethylene Glycol 3350	Polyethylene Glycol 3350 The risk or severity of adverse effects can be increased when Metolazone is combined with Polyethylene glycol.
Vardenafil	Vardenafil Vardenafil may increase the antihypertensive activities of Metolazone.
Alfuzosin	Alfuzosin Alfuzosin may increase the hypotensive activities of Metolazone.
Emtricitabine	Emtricitabine Metolazone may increase the excretion rate of Emtricitabine which could result in a lower serum level and potentially a reduction in efficacy.
Memantine	Memantine Metolazone may increase the excretion rate of Memantine which could result in a lower serum level and potentially a reduction in efficacy.
Tegaserod	Tegaserod The risk or severity of adverse effects can be increased when Metolazone is combined with Tegaserod.
Tadalafil	Tadalafil Tadalafil may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Frovatriptan	Frovatriptan Frovatriptan may decrease the antihypertensive activities of Metolazone.
Apomorphine Injection	Apomorphine Injection The risk or severity of adverse effects can be increased when Apomorphine is combined with Metolazone.
Protriptyline	Protriptyline Protriptyline may decrease the antihypertensive activities of Metolazone.
Duloxetine	Duloxetine The risk or severity of orthostatic hypotension and syncope can be increased when Metolazone is combined with Duloxetine.
Tinidazole	Tinidazole Metolazone may increase the excretion rate of Tinidazole which could result in a lower serum level and potentially a reduction in efficacy.
Trospium	Trospium The serum concentration of Metolazone can be increased when it is combined with Trospium.
Bosentan	Bosentan Metolazone may increase the hypotensive activities of Bosentan.
Cefditoren	Cefditoren Metolazone may increase the excretion rate of Cefdinir which could result in a lower serum level and potentially a reduction in efficacy.
Cyanocobalamin Injection	Cyanocobalamin Injection Hydroxocobalamin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Eszopiclone	Eszopiclone Eszopiclone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Ganciclovir	Ganciclovir Metolazone may increase the excretion rate of Ganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Insulin Aspart (rDNA Origin) Injection	Insulin Aspart (rDNA Origin) Injection The therapeutic efficacy of Insulin aspart can be decreased when used in combination with Metolazone.
Ribavirin	Ribavirin Metolazone may increase the excretion rate of Ribavirin which could result in a lower serum level and potentially a reduction in efficacy.
Solifenacin	Solifenacin The serum concentration of Metolazone can be increased when it is combined with Solifenacin.
Valganciclovir	Valganciclovir Metolazone may increase the excretion rate of Valganciclovir which could result in a lower serum level and potentially a reduction in efficacy.
Adefovir	Adefovir Adefovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Dextroamphetamine	Dextroamphetamine Amphetamine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Pramlintide Injection	Pramlintide Injection The therapeutic efficacy of Pramlintide can be decreased when used in combination with Metolazone.
Exenatide Injection	Exenatide Injection The therapeutic efficacy of Exenatide can be decreased when used in combination with Metolazone.
Isocarboxazid	Isocarboxazid Isocarboxazid may increase the hypotensive activities of Metolazone.
Ramelteon	Ramelteon Metolazone may increase the excretion rate of Ramelteon which could result in a lower serum level and potentially a reduction in efficacy.
Darifenacin	Darifenacin The serum concentration of Metolazone can be increased when it is combined with Darifenacin.
Fentanyl	Fentanyl Fentanyl may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Pregabalin	Pregabalin Pregabalin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Phenylephrine	Phenylephrine Phenylephrine may decrease the antihypertensive activities of Metolazone.
Insulin Detemir (rDNA Origin) Injection	Insulin Detemir (rDNA Origin) Injection The therapeutic efficacy of Insulin detemir can be decreased when used in combination with Metolazone.
Ranolazine	Ranolazine Ranolazine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Rasagiline	Rasagiline Rasagiline may increase the hypotensive activities of Metolazone.
Sitagliptin	Sitagliptin The therapeutic efficacy of Sitagliptin can be decreased when used in combination with Metolazone.
Varenicline	Varenicline Metolazone may increase the excretion rate of Varenicline which could result in a lower serum level and potentially a reduction in efficacy.
Albuterol	Albuterol Metolazone may increase the excretion rate of Salbutamol which could result in a lower serum level and potentially a reduction in efficacy.
Paliperidone	Paliperidone Metolazone may increase the excretion rate of Paliperidone which could result in a lower serum level and potentially a reduction in efficacy.
Clofarabine Injection	Clofarabine Injection Metolazone may increase the excretion rate of Clofarabine which could result in a lower serum level and potentially a reduction in efficacy.
Insulin Glulisine (rDNA origin) Injection	Insulin Glulisine (rDNA origin) Injection The therapeutic efficacy of Insulin glulisine can be decreased when used in combination with Metolazone.
Lubiprostone	Lubiprostone Metolazone may increase the excretion rate of Lubiprostone which could result in a lower serum level and potentially a reduction in efficacy.
Rituximab Injection	Rituximab Injection Metolazone may increase the hypotensive activities of Rituximab.
Aliskiren	Aliskiren Metolazone may increase the hypotensive activities of Aliskiren.
Pemetrexed Injection	Pemetrexed Injection Metolazone may decrease the excretion rate of Pemetrexed which could result in a higher serum level.
Lisdexamfetamine	Lisdexamfetamine Lisdexamfetamine may decrease the antihypertensive activities of Metolazone.
Nabilone	Nabilone The risk or severity of adverse effects can be increased when Nabilone is combined with Metolazone.
Sorafenib	Sorafenib Sorafenib may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Sunitinib	Sunitinib The therapeutic efficacy of Sunitinib can be decreased when used in combination with Metolazone.
Levocetirizine	Levocetirizine Metolazone may increase the excretion rate of Levocetirizine which could result in a lower serum level and potentially a reduction in efficacy.
Pegaptanib Injection	Pegaptanib Injection Metolazone may increase the excretion rate of Pegaptanib which could result in a lower serum level and potentially a reduction in efficacy.
Azacitidine Injection	Azacitidine Injection Metolazone may increase the excretion rate of Azacitidine which could result in a lower serum level and potentially a reduction in efficacy.
Paclitaxel (with polyoxyethylated castor oil) Injection	Paclitaxel (with polyoxyethylated castor oil) Injection The risk or severity of adverse effects can be increased when Metolazone is combined with Castor oil.
Lenalidomide	Lenalidomide Lenalidomide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Toremifene	Toremifene The risk or severity of hypercalcemia can be increased when Metolazone is combined with Toremifene.
Budesonide	Budesonide Budesonide may increase the hypokalemic activities of Metolazone.
Desmopressin	Desmopressin Desmopressin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Doripenem Injection	Doripenem Injection Metolazone may increase the excretion rate of Doripenem which could result in a lower serum level and potentially a reduction in efficacy.
Arsenic Trioxide Injection	Arsenic Trioxide Injection Metolazone may increase the excretion rate of Arsenic trioxide which could result in a lower serum level and potentially a reduction in efficacy.
Desvenlafaxine	Desvenlafaxine The risk or severity of hyponatremia can be increased when Desvenlafaxine is combined with Metolazone.
Cevimeline	Cevimeline Cevimeline may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Nebivolol	Nebivolol Metolazone may increase the hypotensive activities of Nebivolol.
Tretinoin	Tretinoin The risk or severity of adverse effects can be increased when Tretinoin is combined with Metolazone.
Certolizumab Injection	Certolizumab Injection Metolazone may increase the excretion rate of Certolizumab pegol which could result in a lower serum level and potentially a reduction in efficacy.
Daptomycin Injection	Daptomycin Injection Daptomycin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Methylnaltrexone Injection	Methylnaltrexone Injection Metolazone may increase the excretion rate of Methylnaltrexone which could result in a lower serum level and potentially a reduction in efficacy.
Midazolam	Midazolam Metolazone may increase the excretion rate of Midazolam which could result in a lower serum level and potentially a reduction in efficacy.
Naltrexone Injection	Naltrexone Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Naltrexone.
Dexrazoxane Injection	Dexrazoxane Injection Dexrazoxane may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Milnacipran	Milnacipran The risk or severity of hyponatremia can be increased when Milnacipran is combined with Metolazone.
Plerixafor Injection	Plerixafor Injection Metolazone may increase the excretion rate of Plerixafor which could result in a lower serum level and potentially a reduction in efficacy.
Sodium Phosphate	Sodium Phosphate Metolazone may increase the nephrotoxic activities of Sodium phosphate, monobasic.
Fesoterodine	Fesoterodine Metolazone may increase the excretion rate of Fesoterodine which could result in a lower serum level and potentially a reduction in efficacy.
Betaxolol	Betaxolol Betaxolol may increase the hypotensive activities of Metolazone.
Iloperidone	Iloperidone Iloperidone may decrease the antihypertensive activities of Metolazone.
Prasugrel	Prasugrel Metolazone may increase the excretion rate of Prasugrel which could result in a lower serum level and potentially a reduction in efficacy.
Tolvaptan (low blood sodium)	Tolvaptan (low blood sodium) Tolvaptan may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Dronedarone	Dronedarone Dronedarone may decrease the antihypertensive activities of Metolazone.
Pralatrexate Injection	Pralatrexate Injection Metolazone may increase the excretion rate of Pralatrexate which could result in a lower serum level and potentially a reduction in efficacy.
Palonosetron Injection	Palonosetron Injection Palonosetron may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Saxagliptin	Saxagliptin The therapeutic efficacy of Saxagliptin can be decreased when used in combination with Metolazone.
Telavancin Injection	Telavancin Injection Metolazone may increase the excretion rate of Telavancin which could result in a lower serum level and potentially a reduction in efficacy.
Tapentadol	Tapentadol The therapeutic efficacy of Metolazone can be decreased when used in combination with Tapentadol.
Topotecan	Topotecan Metolazone may increase the excretion rate of Topotecan which could result in a lower serum level and potentially a reduction in efficacy.
Asenapine	Asenapine Asenapine may decrease the antihypertensive activities of Metolazone.
Oxymorphone	Oxymorphone The therapeutic efficacy of Metolazone can be decreased when used in combination with Oxymorphone.
Liraglutide Injection	Liraglutide Injection The therapeutic efficacy of Liraglutide can be decreased when used in combination with Metolazone.
Dalfampridine	Dalfampridine Metolazone may increase the excretion rate of Dalfampridine which could result in a lower serum level and potentially a reduction in efficacy.
Ceftaroline Injection	Ceftaroline Injection Ceftaroline fosamil may decrease the excretion rate of Metolazone which could result in a higher serum level.
Lurasidone	Lurasidone Lurasidone may decrease the antihypertensive activities of Metolazone.
Acetaminophen Injection	Acetaminophen Injection Acetaminophen may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Vilazodone	Vilazodone Vilazodone may decrease the antihypertensive activities of Metolazone.
Ipilimumab Injection	Ipilimumab Injection Metolazone may increase the excretion rate of Ipilimumab which could result in a lower serum level and potentially a reduction in efficacy.
Denileukin Diftitox Injection	Denileukin Diftitox Injection Aldesleukin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Terbutaline Injection	Terbutaline Injection Metolazone may increase the excretion rate of Terbutaline which could result in a lower serum level and potentially a reduction in efficacy.
Azilsartan	Azilsartan The risk or severity of adverse effects can be increased when Azilsartan medoxomil is combined with Metolazone.
Roflumilast	Roflumilast Metolazone may increase the excretion rate of Roflumilast which could result in a lower serum level and potentially a reduction in efficacy.
Linagliptin	Linagliptin The therapeutic efficacy of Linagliptin can be decreased when used in combination with Metolazone.
Cyclophosphamide Injection	Cyclophosphamide Injection The risk or severity of granulocytopenia can be increased when Metolazone is combined with Cyclophosphamide.
Rivaroxaban	Rivaroxaban Metolazone may increase the excretion rate of Rivaroxaban which could result in a lower serum level and potentially a reduction in efficacy.
Ruxolitinib	Ruxolitinib Metolazone may increase the excretion rate of Ruxolitinib which could result in a lower serum level and potentially a reduction in efficacy.
Clobazam	Clobazam Clobazam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Deferiprone	Deferiprone Metolazone may increase the excretion rate of Deferiprone which could result in a lower serum level and potentially a reduction in efficacy.
Cabergoline	Cabergoline Cabergoline may decrease the antihypertensive activities of Metolazone.
Naloxone Injection	Naloxone Injection Metolazone may increase the excretion rate of Naloxone which could result in a lower serum level and potentially a reduction in efficacy.
Ambrisentan	Ambrisentan Metolazone may increase the hypotensive activities of Ambrisentan.
Fondaparinux Injection	Fondaparinux Injection Metolazone may increase the excretion rate of Fondaparinux which could result in a lower serum level and potentially a reduction in efficacy.
Iloprost	Iloprost Iloprost may increase the hypotensive activities of Metolazone.
Enzalutamide	Enzalutamide Metolazone may increase the excretion rate of Enzalutamide which could result in a lower serum level and potentially a reduction in efficacy.
Mirabegron	Mirabegron Metolazone may increase the excretion rate of Mirabegron which could result in a lower serum level and potentially a reduction in efficacy.
Corticotropin, Repository Injection	Corticotropin, Repository Injection Corticotropin may increase the hypokalemic activities of Metolazone.
Linaclotide	Linaclotide The risk or severity of adverse effects can be increased when Metolazone is combined with Linaclotide.
Lorcaserin	Lorcaserin The therapeutic efficacy of Mecasermin can be decreased when used in combination with Metolazone.
Teduglutide Injection	Teduglutide Injection Metolazone may increase the excretion rate of Teduglutide which could result in a lower serum level and potentially a reduction in efficacy.
Alogliptin	Alogliptin The therapeutic efficacy of Alogliptin can be decreased when used in combination with Metolazone.
Pomalidomide	Pomalidomide Metolazone may increase the excretion rate of Pomalidomide which could result in a lower serum level and potentially a reduction in efficacy.
Canagliflozin	Canagliflozin The therapeutic efficacy of Canagliflozin can be decreased when used in combination with Metolazone.
Methazolamide	Methazolamide Methazolamide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Trametinib	Trametinib Metolazone may increase the excretion rate of Trametinib which could result in a lower serum level and potentially a reduction in efficacy.
Levomilnacipran	Levomilnacipran The risk or severity of hyponatremia can be increased when Levomilnacipran is combined with Metolazone.
Ertapenem Injection	Ertapenem Injection Ertapenem may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Vortioxetine	Vortioxetine Metolazone may increase the excretion rate of Vortioxetine which could result in a lower serum level and potentially a reduction in efficacy.
Avanafil	Avanafil Avanafil may increase the antihypertensive activities of Metolazone.
Ketorolac Injection	Ketorolac Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Ketorolac.
Obinutuzumab Injection	Obinutuzumab Injection Metolazone may increase the hypotensive activities of Obinutuzumab.
Sofosbuvir	Sofosbuvir Metolazone may increase the excretion rate of Sofosbuvir which could result in a lower serum level and potentially a reduction in efficacy.
Dapagliflozin	Dapagliflozin The therapeutic efficacy of Dapagliflozin can be decreased when used in combination with Metolazone.
Apremilast	Apremilast Metolazone may increase the excretion rate of Apremilast which could result in a lower serum level and potentially a reduction in efficacy.
Droxidopa	Droxidopa The risk or severity of Cardiac Arrhythmia can be increased when Droxidopa is combined with Metolazone.
Albiglutide Injection	Albiglutide Injection The therapeutic efficacy of Albiglutide can be decreased when used in combination with Metolazone.
Testosterone Injection	Testosterone Injection Metolazone may increase the excretion rate of Testosterone which could result in a lower serum level and potentially a reduction in efficacy.
Empagliflozin	Empagliflozin Metolazone may increase the diuretic activities of Empagliflozin.
Hydrocodone	Hydrocodone The therapeutic efficacy of Metolazone can be decreased when used in combination with Hydrocodone.
Dulaglutide Injection	Dulaglutide Injection The therapeutic efficacy of Dulaglutide can be decreased when used in combination with Metolazone.
Edoxaban	Edoxaban Metolazone may increase the excretion rate of Edoxaban which could result in a lower serum level and potentially a reduction in efficacy.
Methamphetamine	Methamphetamine Metolazone may increase the excretion rate of Metamfetamine which could result in a lower serum level and potentially a reduction in efficacy.
Tasimelteon	Tasimelteon Metolazone may increase the excretion rate of Tasimelteon which could result in a lower serum level and potentially a reduction in efficacy.
Riociguat	Riociguat Metolazone may increase the hypotensive activities of Riociguat.
Risperidone Injection	Risperidone Injection Metolazone may increase the hypotensive activities of Risperidone.
Insulin Human Inhalation	Insulin Human Inhalation The therapeutic efficacy of Insulin human can be decreased when used in combination with Metolazone.
Dinutuximab Injection	Dinutuximab Injection The risk or severity of adverse effects can be increased when Dinutuximab is combined with Metolazone.
Haloperidol Injection	Haloperidol Injection Haloperidol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Ivabradine	Ivabradine The risk or severity of Cardiac Arrhythmia can be increased when Metolazone is combined with Ivabradine.
Amiloride	Amiloride Amiloride may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Macitentan	Macitentan Metolazone may increase the excretion rate of Macitentan which could result in a lower serum level and potentially a reduction in efficacy.
Flibanserin	Flibanserin Flibanserin may decrease the antihypertensive activities of Metolazone.
Prednisolone	Prednisolone Prednisolone may increase the hypokalemic activities of Metolazone.
Brexpiprazole	Brexpiprazole Brexpiprazole may decrease the antihypertensive activities of Metolazone.
Ziprasidone Injection	Ziprasidone Injection Ziprasidone may increase the antihypertensive activities of Metolazone.
Cariprazine	Cariprazine Cariprazine may decrease the antihypertensive activities of Metolazone.
Penicillin G Procaine Injection	Penicillin G Procaine Injection Metolazone may increase the excretion rate of Procaine benzylpenicillin which could result in a lower serum level and potentially a reduction in efficacy.
Eluxadoline	Eluxadoline The therapeutic efficacy of Metolazone can be decreased when used in combination with Eluxadoline.
Insulin Degludec (rDNA Origin) Injection	Insulin Degludec (rDNA Origin) Injection The therapeutic efficacy of Insulin degludec can be decreased when used in combination with Metolazone.
Ixazomib	Ixazomib Metolazone may increase the excretion rate of Ixazomib which could result in a lower serum level and potentially a reduction in efficacy.
Lesinurad	Lesinurad Metolazone may increase the excretion rate of Lesinurad which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Liposomal Injection	Amphotericin B Liposomal Injection Amphotericin B may decrease the excretion rate of Metolazone which could result in a higher serum level.
Dexamethasone Injection	Dexamethasone Injection Dexamethasone may increase the hypokalemic activities of Metolazone.
Brivaracetam Injection	Brivaracetam Injection Metolazone may increase the excretion rate of Brivaracetam which could result in a lower serum level and potentially a reduction in efficacy.
Midodrine	Midodrine Midodrine may decrease the antihypertensive activities of Metolazone.
Selexipag	Selexipag Metolazone may increase the hypotensive activities of Selexipag.
Diphenhydramine Injection	Diphenhydramine Injection The serum concentration of Metolazone can be increased when it is combined with Diphenhydramine.
Calcifediol	Calcifediol The risk or severity of hypokalemia can be increased when Calcifediol is combined with Metolazone.
Ergocalciferol	Ergocalciferol The risk or severity of hypokalemia can be increased when Ergocalciferol is combined with Metolazone.
Doxercalciferol	Doxercalciferol The risk or severity of hypokalemia can be increased when Doxercalciferol is combined with Metolazone.
Furosemide Injection	Furosemide Injection Metolazone may increase the excretion rate of Furosemide which could result in a lower serum level and potentially a reduction in efficacy.
Lixisenatide Injection	Lixisenatide Injection The therapeutic efficacy of Lixisenatide can be decreased when used in combination with Metolazone.
Doxepin (Insomnia)	Doxepin (Insomnia) Doxepin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Plecanatide	Plecanatide The risk or severity of adverse effects can be increased when Metolazone is combined with Plecanatide.
Deutetrabenazine	Deutetrabenazine Metolazone may increase the excretion rate of Deutetrabenazine which could result in a lower serum level and potentially a reduction in efficacy.
Valbenazine	Valbenazine Metolazone may increase the excretion rate of Valbenazine which could result in a lower serum level and potentially a reduction in efficacy.
Deflazacort	Deflazacort Deflazacort may increase the hypokalemic activities of Metolazone.
Safinamide	Safinamide Safinamide may increase the hypotensive activities of Metolazone.
Naldemedine	Naldemedine Metolazone may increase the excretion rate of Naldemedine which could result in a lower serum level and potentially a reduction in efficacy.
Benznidazole	Benznidazole Metolazone may increase the excretion rate of Benznidazole which could result in a lower serum level and potentially a reduction in efficacy.
Delafloxacin	Delafloxacin Metolazone may increase the excretion rate of Delafloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Semaglutide Injection	Semaglutide Injection The therapeutic efficacy of Semaglutide can be decreased when used in combination with Metolazone.
Ertugliflozin	Ertugliflozin The therapeutic efficacy of Ertugliflozin can be decreased when used in combination with Metolazone.
Buprenorphine Injection	Buprenorphine Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Buprenorphine.
Apalutamide	Apalutamide Metolazone may increase the excretion rate of Apalutamide which could result in a lower serum level and potentially a reduction in efficacy.
Fostamatinib	Fostamatinib Fostamatinib may increase the antihypertensive activities of Metolazone.
Baricitinib	Baricitinib Metolazone may increase the excretion rate of Baricitinib which could result in a lower serum level and potentially a reduction in efficacy.
Lofexidine	Lofexidine Metolazone may increase the excretion rate of Lofexidine which could result in a lower serum level and potentially a reduction in efficacy.
Plazomicin Injection	Plazomicin Injection Metolazone may decrease the excretion rate of Plazomicin which could result in a higher serum level.
Cannabidiol	Cannabidiol Cannabidiol may decrease the antihypertensive activities of Metolazone.
Stiripentol	Stiripentol Metolazone may increase the excretion rate of Stiripentol which could result in a lower serum level and potentially a reduction in efficacy.
Paclitaxel (with albumin) Injection	Paclitaxel (with albumin) Injection The risk or severity of adverse effects can be increased when Paclitaxel is combined with Metolazone.
Prucalopride	Prucalopride Metolazone may increase the excretion rate of Prucalopride which could result in a lower serum level and potentially a reduction in efficacy.
Magnesium Citrate	Magnesium Citrate The risk or severity of adverse effects can be increased when Metolazone is combined with Magnesium citrate.
Siponimod	Siponimod Siponimod may decrease the antihypertensive activities of Metolazone.
Acyclovir Ophthalmic	Acyclovir Ophthalmic Acyclovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Solriamfetol	Solriamfetol Metolazone may increase the excretion rate of Solriamfetol which could result in a lower serum level and potentially a reduction in efficacy.
Pitolisant	Pitolisant Metolazone may increase the excretion rate of Pitolisant which could result in a lower serum level and potentially a reduction in efficacy.
Calcium Acetate	Calcium Acetate Metolazone may decrease the excretion rate of Calcium acetate which could result in a higher serum level.
Selpercatinib	Selpercatinib Selpercatinib may decrease the antihypertensive activities of Metolazone.
Naxitamab-gqgk Injection	Naxitamab-gqgk Injection Naxitamab may decrease the antihypertensive activities of Metolazone.
Progestin-Only (drospirenone) Oral Contraceptives	Progestin-Only (drospirenone) Oral Contraceptives Drospirenone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Viloxazine	Viloxazine Metolazone may increase the excretion rate of Viloxazine which could result in a lower serum level and potentially a reduction in efficacy.
Tobramycin Injection	Tobramycin Injection Tobramycin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Fenoprofen	Fenoprofen The therapeutic efficacy of Metolazone can be decreased when used in combination with Fenoprofen.
Indomethacin	Indomethacin Indomethacin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Mefenamic Acid	Mefenamic Acid The therapeutic efficacy of Metolazone can be decreased when used in combination with Mefenamic acid.
Naproxen	Naproxen The therapeutic efficacy of Metolazone can be decreased when used in combination with Naproxen.
Tolmetin	Tolmetin The therapeutic efficacy of Metolazone can be decreased when used in combination with Tolmetin.
Sulindac	Sulindac The therapeutic efficacy of Metolazone can be decreased when used in combination with Sulindac.
Trazodone	Trazodone The risk or severity of hyponatremia can be increased when Trazodone is combined with Metolazone.
Isotretinoin	Isotretinoin Metolazone may increase the excretion rate of Isotretinoin which could result in a lower serum level and potentially a reduction in efficacy.
Sucralfate	Sucralfate Sucralfate may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Floxuridine	Floxuridine Floxuridine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Phenobarbital	Phenobarbital The risk or severity of hypotension and orthostatic hypotension can be increased when Phenobarbital is combined with Metolazone.
Metaxalone	Metaxalone Metolazone may increase the excretion rate of Metaxalone which could result in a lower serum level and potentially a reduction in efficacy.
Methotrexate Injection	Methotrexate Injection The risk or severity of adverse effects can be increased when Metolazone is combined with Methotrexate.
Levorphanol	Levorphanol The therapeutic efficacy of Metolazone can be decreased when used in combination with Levorphanol.
Primidone	Primidone The risk or severity of hypotension and orthostatic hypotension can be increased when Primidone is combined with Metolazone.
Diethylpropion	Diethylpropion Diethylpropion may decrease the antihypertensive activities of Metolazone.
Chlorpromazine	Chlorpromazine Chlorpromazine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Diazepam	Diazepam Metolazone may increase the excretion rate of Diazepam which could result in a lower serum level and potentially a reduction in efficacy.
Oxazepam	Oxazepam Metolazone may increase the excretion rate of Oxazepam which could result in a lower serum level and potentially a reduction in efficacy.
Flurazepam	Flurazepam Metolazone may increase the excretion rate of Flurazepam which could result in a lower serum level and potentially a reduction in efficacy.
Clorazepate	Clorazepate Metolazone may increase the excretion rate of Clorazepic acid which could result in a lower serum level and potentially a reduction in efficacy.
Lorazepam	Lorazepam Lorazepam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Phenoxybenzamine	Phenoxybenzamine Metolazone may decrease the antihypertensive activities of Phenoxybenzamine.
Carmustine	Carmustine Carmustine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Amantadine	Amantadine Metolazone may increase the excretion rate of Amantadine which could result in a lower serum level and potentially a reduction in efficacy.
Codeine	Codeine Codeine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Bromocriptine	Bromocriptine The therapeutic efficacy of Bromocriptine can be decreased when used in combination with Metolazone.
Metaproterenol	Metaproterenol Orciprenaline may increase the hypokalemic activities of Metolazone.
Tranylcypromine	Tranylcypromine Tranylcypromine may increase the hypotensive activities of Metolazone.
Phenelzine	Phenelzine Phenelzine may increase the hypotensive activities of Metolazone.
Procarbazine	Procarbazine Procarbazine may increase the hypotensive activities of Metolazone.
Ergoloid Mesylates	Ergoloid Mesylates Ergoloid mesylate may decrease the antihypertensive activities of Metolazone.
Tetracycline	Tetracycline Metolazone may increase the excretion rate of Tetracycline which could result in a lower serum level and potentially a reduction in efficacy.
Thioridazine	Thioridazine Thioridazine may decrease the antihypertensive activities of Metolazone.
Trifluoperazine	Trifluoperazine Trifluoperazine may decrease the antihypertensive activities of Metolazone.
Bleomycin	Bleomycin Bleomycin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Sulfadiazine	Sulfadiazine The therapeutic efficacy of Sulfadiazine can be decreased when used in combination with Metolazone.
Oxycodone	Oxycodone The therapeutic efficacy of Metolazone can be decreased when used in combination with Oxycodone.
Methadone	Methadone Methadone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Oxybutynin	Oxybutynin The serum concentration of Metolazone can be increased when it is combined with Oxybutynin.
Benztropine	Benztropine Benzatropine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Colestipol	Colestipol Colestipol can cause a decrease in the absorption of Metolazone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Maprotiline	Maprotiline Metolazone may increase the excretion rate of Maprotiline which could result in a lower serum level and potentially a reduction in efficacy.
Ibuprofen	Ibuprofen The therapeutic efficacy of Metolazone can be decreased when used in combination with Ibuprofen.
Trihexyphenidyl	Trihexyphenidyl The serum concentration of Metolazone can be increased when it is combined with Trihexyphenidyl.
Orphenadrine	Orphenadrine The serum concentration of Metolazone can be increased when it is combined with Orphenadrine.
Azathioprine	Azathioprine Metolazone may increase the excretion rate of Azathioprine which could result in a lower serum level and potentially a reduction in efficacy.
Phentermine	Phentermine Phentermine may decrease the antihypertensive activities of Metolazone.
Methylphenidate	Methylphenidate Methylphenidate may decrease the antihypertensive activities of Metolazone.
Amoxapine	Amoxapine The serum concentration of Metolazone can be increased when it is combined with Amoxapine.
Sulfasalazine	Sulfasalazine The therapeutic efficacy of Metolazone can be decreased when used in combination with Sulfasalazine.
Hydrocortisone	Hydrocortisone Hydrocortisone may increase the hypokalemic activities of Metolazone.
Phenazopyridine	Phenazopyridine Phenazopyridine may decrease the excretion rate of Metolazone which could result in a higher serum level.
Carbamazepine	Carbamazepine The risk or severity of adverse effects can be increased when Metolazone is combined with Carbamazepine.
Methyldopa	Methyldopa Metolazone may increase the excretion rate of Methyldopa which could result in a lower serum level and potentially a reduction in efficacy.
Clonidine	Clonidine The risk or severity of hypotension can be increased when Clonidine is combined with Metolazone.
Prazosin	Prazosin The risk or severity of hypotension can be increased when Prazosin is combined with Metolazone.
Hydralazine	Hydralazine Metolazone may increase the excretion rate of Hydralazine which could result in a lower serum level and potentially a reduction in efficacy.
Cimetidine	Cimetidine Cimetidine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Gentamicin Injection	Gentamicin Injection Gentamicin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Warfarin	Warfarin Metolazone may decrease the excretion rate of Warfarin which could result in a higher serum level.
Clonazepam	Clonazepam Metolazone may increase the excretion rate of Clonazepam which could result in a lower serum level and potentially a reduction in efficacy.
Promethazine	Promethazine Metolazone may increase the excretion rate of Promethazine which could result in a lower serum level and potentially a reduction in efficacy.
Meclofenamate	Meclofenamate The therapeutic efficacy of Metolazone can be decreased when used in combination with Meclofenamic acid.
Nitrofurantoin	Nitrofurantoin Metolazone may increase the excretion rate of Nitrofurantoin which could result in a lower serum level and potentially a reduction in efficacy.
Digoxin	Digoxin Metolazone may decrease the excretion rate of Digoxin which could result in a higher serum level.
Chloroquine	Chloroquine Metolazone may increase the excretion rate of Chloroquine which could result in a lower serum level and potentially a reduction in efficacy.
Quinine	Quinine The therapeutic efficacy of Quinine can be decreased when used in combination with Metolazone.
Calcitriol	Calcitriol The risk or severity of hypokalemia can be increased when Calcitriol is combined with Metolazone.
Triamterene	Triamterene Triamterene may decrease the excretion rate of Metolazone which could result in a higher serum level.
Lactulose	Lactulose The risk or severity of adverse effects can be increased when Metolazone is combined with Lactulose.
Chlorothiazide	Chlorothiazide The therapeutic efficacy of Chlorothiazide can be increased when used in combination with Metolazone.
Chlorthalidone	Chlorthalidone Chlorthalidone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Isosorbide	Isosorbide Isosorbide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Secobarbital	Secobarbital The risk or severity of hypotension and orthostatic hypotension can be increased when Secobarbital is combined with Metolazone.
Desipramine	Desipramine Desipramine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Amitriptyline	Amitriptyline Amitriptyline may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Imipramine	Imipramine Imipramine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Probenecid	Probenecid Metolazone may increase the excretion rate of Probenecid which could result in a lower serum level and potentially a reduction in efficacy.
Quinidine	Quinidine Metolazone may decrease the excretion rate of Quinidine which could result in a higher serum level.
Procainamide	Procainamide Metolazone may decrease the excretion rate of Procainamide which could result in a higher serum level.
Isoniazid	Isoniazid Metolazone may increase the excretion rate of Isoniazid which could result in a lower serum level and potentially a reduction in efficacy.
Pyrazinamide	Pyrazinamide Pyrazinamide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Disopyramide	Disopyramide The therapeutic efficacy of Disopyramide can be decreased when used in combination with Metolazone.
Butabarbital	Butabarbital Butabarbital may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Liothyronine	Liothyronine Liothyronine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Methimazole	Methimazole Metolazone may increase the excretion rate of Methimazole which could result in a lower serum level and potentially a reduction in efficacy.
Chlorpropamide	Chlorpropamide The therapeutic efficacy of Chlorpropamide can be decreased when used in combination with Metolazone.
Tolbutamide	Tolbutamide The therapeutic efficacy of Tolbutamide can be decreased when used in combination with Metolazone.
Tolazamide	Tolazamide The therapeutic efficacy of Tolazamide can be decreased when used in combination with Metolazone.
Dextromethorphan	Dextromethorphan The serum concentration of Metolazone can be increased when it is combined with Dextromethorphan.
Baclofen	Baclofen The risk or severity of adverse effects can be increased when Baclofen is combined with Metolazone.
Doxylamine	Doxylamine The serum concentration of Metolazone can be increased when it is combined with Doxylamine.
Cyproheptadine	Cyproheptadine The serum concentration of Metolazone can be increased when it is combined with Cyproheptadine.
Brompheniramine	Brompheniramine The serum concentration of Metolazone can be increased when it is combined with Brompheniramine.
Ethambutol	Ethambutol Ethambutol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Methyclothiazide	Methyclothiazide The therapeutic efficacy of Metolazone can be increased when used in combination with Methyclothiazide.
Hydrochlorothiazide	Hydrochlorothiazide The therapeutic efficacy of Metolazone can be increased when used in combination with Hydrochlorothiazide.
Chlorzoxazone	Chlorzoxazone Chlorzoxazone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Pyridoxine	Pyridoxine Pyridoxine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Folic Acid	Folic Acid Folic acid may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Propranolol (Cardiovascular)	Propranolol (Cardiovascular) Metolazone may increase the excretion rate of Propranolol which could result in a lower serum level and potentially a reduction in efficacy.
Minoxidil	Minoxidil Minoxidil may increase the hypotensive activities of Metolazone.
Pseudoephedrine	Pseudoephedrine Pseudoephedrine may decrease the antihypertensive activities of Metolazone.
Nortriptyline	Nortriptyline The serum concentration of Metolazone can be increased when it is combined with Nortriptyline.
Spironolactone	Spironolactone Spironolactone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Amphotericin B Injection	Amphotericin B Injection Amphotericin B may decrease the excretion rate of Metolazone which could result in a higher serum level.
Phytonadione	Phytonadione Metolazone may increase the excretion rate of Phylloquinone which could result in a lower serum level and potentially a reduction in efficacy.
Amikacin Injection	Amikacin Injection Amikacin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Nadolol	Nadolol Metolazone may increase the excretion rate of Nadolol which could result in a lower serum level and potentially a reduction in efficacy.
Butorphanol Injection	Butorphanol Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Butorphanol.
Nalbuphine Injection	Nalbuphine Injection The therapeutic efficacy of Metolazone can be decreased when used in combination with Nalbuphine.
Cholestyramine Resin	Cholestyramine Resin Cholestyramine can cause a decrease in the absorption of Metolazone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Allopurinol	Allopurinol The risk of a hypersensitivity reaction to Allopurinol is increased when it is combined with Metolazone.
Flavoxate	Flavoxate Metolazone may increase the excretion rate of Flavoxate which could result in a lower serum level and potentially a reduction in efficacy.
Papaverine	Papaverine The risk or severity of adverse effects can be increased when Papaverine is combined with Metolazone.
Colchicine	Colchicine Metolazone may increase the excretion rate of Colchicine which could result in a lower serum level and potentially a reduction in efficacy.
Cefaclor	Cefaclor Cefaclor may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefadroxil	Cefadroxil Cefadroxil may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefazolin Injection	Cefazolin Injection Cefazolin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cephalexin	Cephalexin Cephalexin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefoxitin Injection	Cefoxitin Injection Cefoxitin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Dacarbazine	Dacarbazine Metolazone may increase the excretion rate of Dacarbazine which could result in a lower serum level and potentially a reduction in efficacy.
Acetazolamide	Acetazolamide Acetazolamide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Cefotaxime Injection	Cefotaxime Injection Cefotaxime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Calcitonin Salmon Injection	Calcitonin Salmon Injection Salmon calcitonin may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Pyrantel	Pyrantel Metolazone may increase the excretion rate of Pyrantel which could result in a lower serum level and potentially a reduction in efficacy.
Captopril	Captopril The risk or severity of hypotension can be increased when Metolazone is combined with Captopril.
Dipyridamole	Dipyridamole Dipyridamole may increase the antihypertensive activities of Metolazone.
Isoxsuprine	Isoxsuprine Isoxsuprine may decrease the antihypertensive activities of Metolazone.
Ethacrynic Acid	Ethacrynic Acid Etacrynic acid may decrease the excretion rate of Metolazone which could result in a higher serum level.
Colistimethate Injection	Colistimethate Injection Colistimethate may decrease the excretion rate of Metolazone which could result in a higher serum level.
Metoprolol	Metoprolol Metoprolol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Aspirin	Aspirin Acetylsalicylic acid may decrease the excretion rate of Metolazone which could result in a higher serum level.
Salsalate	Salsalate The therapeutic efficacy of Metolazone can be decreased when used in combination with Salsalate.
Alprazolam	Alprazolam Alprazolam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Temazepam	Temazepam Temazepam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Triazolam	Triazolam Metolazone may increase the excretion rate of Triazolam which could result in a lower serum level and potentially a reduction in efficacy.
Dicyclomine	Dicyclomine Metolazone may increase the excretion rate of Dicyclomine which could result in a lower serum level and potentially a reduction in efficacy.
Hyoscyamine	Hyoscyamine The serum concentration of Metolazone can be increased when it is combined with Hyoscyamine.
Propantheline	Propantheline Metolazone may increase the excretion rate of Propantheline which could result in a lower serum level and potentially a reduction in efficacy.
Trimethoprim	Trimethoprim Trimethoprim may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Diltiazem	Diltiazem Diltiazem may increase the hypotensive activities of Metolazone.
Nifedipine	Nifedipine Metolazone may increase the excretion rate of Nifedipine which could result in a lower serum level and potentially a reduction in efficacy.
Timolol	Timolol Timolol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Verapamil	Verapamil Metolazone may increase the excretion rate of Verapamil which could result in a lower serum level and potentially a reduction in efficacy.
Atenolol	Atenolol Atenolol may increase the hypotensive activities of Metolazone.
Pindolol	Pindolol Metolazone may increase the excretion rate of Pindolol which could result in a lower serum level and potentially a reduction in efficacy.
Cisplatin Injection	Cisplatin Injection Metolazone may decrease the excretion rate of Cisplatin which could result in a higher serum level.
Diflunisal	Diflunisal The therapeutic efficacy of Metolazone can be decreased when used in combination with Diflunisal.
Piroxicam	Piroxicam The therapeutic efficacy of Metolazone can be decreased when used in combination with Piroxicam.
Bumetanide	Bumetanide Metolazone may increase the excretion rate of Bumetanide which could result in a lower serum level and potentially a reduction in efficacy.
Glyburide	Glyburide The therapeutic efficacy of Glyburide can be decreased when used in combination with Metolazone.
Glipizide	Glipizide The therapeutic efficacy of Glipizide can be decreased when used in combination with Metolazone.
Indapamide	Indapamide The therapeutic efficacy of Indapamide can be increased when used in combination with Metolazone.
Amoxicillin	Amoxicillin Metolazone may increase the excretion rate of Amoxicillin which could result in a lower serum level and potentially a reduction in efficacy.
Oxacillin Injection	Oxacillin Injection Metolazone may increase the excretion rate of Oxacillin which could result in a lower serum level and potentially a reduction in efficacy.
Pentoxifylline	Pentoxifylline Pentoxifylline may increase the hypotensive activities of Metolazone.
Pentamidine Injection	Pentamidine Injection The therapeutic efficacy of Pentamidine can be decreased when used in combination with Metolazone.
Ceftriaxone Injection	Ceftriaxone Injection Ceftriaxone may decrease the excretion rate of Metolazone which could result in a higher serum level.
Labetalol	Labetalol Metolazone may increase the excretion rate of Labetalol which could result in a lower serum level and potentially a reduction in efficacy.
Auranofin	Auranofin Metolazone may increase the excretion rate of Auranofin which could result in a lower serum level and potentially a reduction in efficacy.
Leuprolide Injection	Leuprolide Injection Leuprolide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Gemfibrozil	Gemfibrozil Metolazone may increase the excretion rate of Gemfibrozil which could result in a lower serum level and potentially a reduction in efficacy.
Guanabenz	Guanabenz Metolazone may decrease the antihypertensive activities of Guanabenz.
Dipivefrin Ophthalmic	Dipivefrin Ophthalmic Adefovir dipivoxil may decrease the excretion rate of Metolazone which could result in a higher serum level.
Ceftazidime Injection	Ceftazidime Injection Ceftazidime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Ketoprofen	Ketoprofen The risk or severity of adverse effects can be increased when Ketoprofen is combined with Metolazone.
Cefotetan Injection	Cefotetan Injection Cefotetan may decrease the excretion rate of Metolazone which could result in a higher serum level.
Enalapril	Enalapril The risk or severity of hypotension can be increased when Metolazone is combined with Enalapril.
Flurbiprofen	Flurbiprofen The therapeutic efficacy of Metolazone can be decreased when used in combination with Flurbiprofen.
Amiodarone	Amiodarone The risk or severity of adverse effects can be increased when Amiodarone is combined with Metolazone.
Aztreonam Injection	Aztreonam Injection Aztreonam may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Buspirone	Buspirone Buspirone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Ciprofloxacin	Ciprofloxacin Metolazone may increase the excretion rate of Ciprofloxacin which could result in a lower serum level and potentially a reduction in efficacy.
Mesalamine	Mesalamine The therapeutic efficacy of Metolazone can be decreased when used in combination with Mesalazine.
Diclofenac	Diclofenac The therapeutic efficacy of Metolazone can be decreased when used in combination with Diclofenac.
Fluoxetine	Fluoxetine The risk or severity of hyponatremia can be increased when Fluoxetine is combined with Metolazone.
Nimodipine	Nimodipine Nimodipine may increase the hypotensive activities of Metolazone.
Clozapine	Clozapine Clozapine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Estazolam	Estazolam Metolazone may increase the excretion rate of Estazolam which could result in a lower serum level and potentially a reduction in efficacy.
Didanosine	Didanosine Metolazone may increase the excretion rate of Didanosine which could result in a lower serum level and potentially a reduction in efficacy.
Pentostatin Injection	Pentostatin Injection Metolazone may decrease the excretion rate of Pentostatin which could result in a higher serum level.
Benazepril	Benazepril The risk or severity of hypotension can be increased when Metolazone is combined with Benazepril.
Etodolac	Etodolac The therapeutic efficacy of Metolazone can be decreased when used in combination with Etodolac.
Felodipine	Felodipine Metolazone may increase the hypotensive activities of Felodipine.
Fosinopril	Fosinopril The risk or severity of hypotension can be increased when Metolazone is combined with Fosinopril.
Nabumetone	Nabumetone The therapeutic efficacy of Metolazone can be decreased when used in combination with Nabumetone.
Quinapril	Quinapril The risk or severity of hypotension can be increased when Metolazone is combined with Quinapril.
Ramipril	Ramipril The risk or severity of hypotension can be increased when Metolazone is combined with Ramipril.
Amlodipine	Amlodipine Amlodipine may increase the hypotensive activities of Metolazone.
Lisinopril	Lisinopril The risk or severity of hypotension can be increased when Metolazone is combined with Lisinopril.
Oxaprozin	Oxaprozin The therapeutic efficacy of Metolazone can be decreased when used in combination with Oxaprozin.
Sotalol	Sotalol The risk or severity of adverse effects can be increased when Sotalol is combined with Metolazone.
Bisoprolol	Bisoprolol Metolazone may increase the excretion rate of Bisoprolol which could result in a lower serum level and potentially a reduction in efficacy.
Doxazosin	Doxazosin Metolazone may increase the hypotensive activities of Doxazosin.
Terazosin	Terazosin Metolazone may increase the hypotensive activities of Terazosin.
Isradipine	Isradipine Isradipine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Venlafaxine	Venlafaxine Venlafaxine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Fluvoxamine	Fluvoxamine The risk or severity of hyponatremia can be increased when Fluvoxamine is combined with Metolazone.
Nefazodone	Nefazodone The risk or severity of hyponatremia can be increased when Nefazodone is combined with Metolazone.
Lamotrigine	Lamotrigine Metolazone may increase the excretion rate of Lamotrigine which could result in a lower serum level and potentially a reduction in efficacy.
Losartan	Losartan Metolazone may increase the hypotensive activities of Losartan.
Valacyclovir	Valacyclovir Valaciclovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Tramadol	Tramadol Tramadol may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Carboplatin Injection	Carboplatin Injection Carboplatin may decrease the excretion rate of Metolazone which could result in a higher serum level.
Moexipril	Moexipril The risk or severity of hypotension can be increased when Metolazone is combined with Moexipril.
Ifosfamide Injection	Ifosfamide Injection Metolazone may increase the excretion rate of Ifosfamide which could result in a lower serum level and potentially a reduction in efficacy.
Nicardipine	Nicardipine Metolazone may increase the hypotensive activities of Nicardipine.
Bupropion	Bupropion Metolazone may increase the excretion rate of Bupropion which could result in a lower serum level and potentially a reduction in efficacy.
Ticlopidine	Ticlopidine Ticlopidine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Metformin	Metformin The therapeutic efficacy of Metformin can be decreased when used in combination with Metolazone.
Nisoldipine	Nisoldipine Nisoldipine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Lamivudine	Lamivudine Metolazone may increase the excretion rate of Lamivudine which could result in a lower serum level and potentially a reduction in efficacy.
Amifostine Injection	Amifostine Injection Metolazone may increase the hypotensive activities of Amifostine.
Acarbose	Acarbose The therapeutic efficacy of Acarbose can be decreased when used in combination with Metolazone.
Glimepiride	Glimepiride The therapeutic efficacy of Glimepiride can be decreased when used in combination with Metolazone.
Gemcitabine Injection	Gemcitabine Injection Gemcitabine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Cidofovir Injection	Cidofovir Injection Cidofovir may decrease the excretion rate of Metolazone which could result in a higher serum level.
Meropenem Injection	Meropenem Injection Metolazone may increase the excretion rate of Meropenem which could result in a lower serum level and potentially a reduction in efficacy.
Clomipramine	Clomipramine Clomipramine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Fosfomycin	Fosfomycin Metolazone may increase the excretion rate of Fosfomycin which could result in a lower serum level and potentially a reduction in efficacy.
Mirtazapine	Mirtazapine Mirtazapine may decrease the antihypertensive activities of Metolazone.
Trandolapril	Trandolapril The risk or severity of hypotension can be increased when Metolazone is combined with Trandolapril.
Topiramate	Topiramate The risk or severity of hypokalemia can be increased when Metolazone is combined with Topiramate.
Valsartan	Valsartan Valsartan may increase the hypotensive activities of Metolazone.
Insulin Lispro Injection	Insulin Lispro Injection The therapeutic efficacy of Insulin lispro can be decreased when used in combination with Metolazone.
Pramipexole	Pramipexole Pramipexole may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Carvedilol	Carvedilol Metolazone may increase the hypotensive activities of Carvedilol.
Nilutamide	Nilutamide Metolazone may increase the excretion rate of Nilutamide which could result in a lower serum level and potentially a reduction in efficacy.
Flutamide	Flutamide Flutamide may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Selegiline	Selegiline Selegiline may increase the hypotensive activities of Metolazone.
Sertraline	Sertraline The risk or severity of hyponatremia can be increased when Sertraline is combined with Metolazone.
Propafenone	Propafenone Propafenone may decrease the antihypertensive activities of Metolazone.
Irbesartan	Irbesartan Metolazone may increase the hypotensive activities of Irbesartan.
Tamsulosin	Tamsulosin Metolazone may increase the excretion rate of Tamsulosin which could result in a lower serum level and potentially a reduction in efficacy.
Ropinirole	Ropinirole The risk or severity of adverse effects can be increased when Ropinirole is combined with Metolazone.
Finasteride	Finasteride Finasteride may decrease the antihypertensive activities of Metolazone.
Quetiapine	Quetiapine Metolazone may increase the hypotensive activities of Quetiapine.
Cefepime Injection	Cefepime Injection Cefepime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefprozil	Cefprozil Cefprozil may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cefpodoxime	Cefpodoxime Cefpodoxime may decrease the excretion rate of Metolazone which could result in a higher serum level.
Cetirizine	Cetirizine Cetirizine may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Paroxetine	Paroxetine The risk or severity of hyponatremia can be increased when Paroxetine is combined with Metolazone.
Tolcapone	Tolcapone Tolcapone may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Citalopram	Citalopram The risk or severity of hyponatremia can be increased when Citalopram is combined with Metolazone.
Capecitabine	Capecitabine Metolazone may increase the excretion rate of Capecitabine which could result in a lower serum level and potentially a reduction in efficacy.
Abacavir	Abacavir Metolazone may increase the excretion rate of Abacavir which could result in a lower serum level and potentially a reduction in efficacy.
Sildenafil	Sildenafil Sildenafil may increase the antihypertensive activities of Metolazone.
Pioglitazone	Pioglitazone The therapeutic efficacy of Pioglitazone can be decreased when used in combination with Metolazone.
Celecoxib	Celecoxib The therapeutic efficacy of Metolazone can be decreased when used in combination with Celecoxib.
Rosiglitazone	Rosiglitazone The therapeutic efficacy of Rosiglitazone can be decreased when used in combination with Metolazone.
Tolterodine	Tolterodine Metolazone may increase the excretion rate of Tolterodine which could result in a lower serum level and potentially a reduction in efficacy.
Thalidomide	Thalidomide The risk or severity of adverse effects can be increased when Thalidomide is combined with Metolazone.
Oseltamivir	Oseltamivir Oseltamivir may increase the excretion rate of Metolazone which could result in a lower serum level and potentially a reduction in efficacy.
Colesevelam	Colesevelam Colesevelam can cause a decrease in the absorption of Metolazone resulting in a reduced serum concentration and potentially a decrease in efficacy.
Balsalazide	Balsalazide The therapeutic efficacy of Metolazone can be decreased when used in combination with Balsalazide.
Nateglinide	Nateglinide The therapeutic efficacy of Nateglinide can be decreased when used in combination with Metolazone.
Rabeprazole	Rabeprazole Metolazone may increase the excretion rate of Rabeprazole which could result in a lower serum level and potentially a reduction in efficacy.