Drug & supplement interaction

Angelica Archangelica + Oxycodone Hydrochloride

Oxycodone Hydrochloride brand names: Xtampza ER, Roxybond.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Angelica Archangelica and Oxycodone Hydrochloride in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Oxycodone Hydrochloride states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Angelica Archangelica and Oxycodone Hydrochloride

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxycodone Hydrochloride and Angelica Archangelica in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Angelica Archangelica safety at a glance

Angelica Archangel... overall Use caution Often used in food amounts, but medicinal doses are not well studied and can cause skin sensitivity to sunlight.
Pregnancy Avoid Traditionally thought to affect the uterus and not well studied; best avoided in medicinal amounts.
Breastfeeding Avoid Not enough safety data, so avoid medicinal use while breastfeeding.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxycodone Hydrochloride and Angelica Archangelica? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Oxycodone Hydrochloride

Interactions in our licensed database are recorded against drug classes, not just single drug names. Oxycodone Hydrochloride is filed under 6 classifications — including narcotic drugs, cytochrome p450 2d6 (cyp2d6) substrates, cns depressants. Angelica Archangelica has documented interactions with 1 drug class — the most serious being photosensitizing drugs (moderate) — and none of Oxycodone Hydrochloride’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Angelica Archangelica Does Interact With Other Medications

Angelica Archangelica has 335 moderate known drug interactions in our database — Oxycodone Hydrochloride isn’t one of them. If you take anything else, check it against the full list below.

Moderate 335 No known interaction 2,495 (incl. Oxycodone Hydrochloride)
Taking anything else?

Check Another of Your Medications Against Angelica Archangelica

Covers the 2,830 medications we’ve checked against Angelica Archangelica. Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Angelica Archangelica and Oxycodone Hydrochloride May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do.

  • Constipation Additional detail

    Angelica Archangelica

    “Orally, Angelica archangelica has been reported to cause constipation in one out of 21 patients taking a specific Angelica archangelica leaf extract (SagaPro, SagaMedica).”

    Angelica Archangelica · Natural Medicines adverse-effect record, reported in constipation.

    1 source cited
    1. 92461. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed

    Oxycodone Hydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxycodone Hydrochloride. Read the label on DailyMed ›

  • A skin rash Additional detail

    Angelica Archangelica

    “Orally or topically, Angelica archangelica might cause photosensitivity reactions. Patients who take Angelica archangelica orally or apply it topically should be advised to avoid prolonged exposure to the sun. Some constituents of the leaves have a strong irritant effect on the skin and mucous membranes, referred to as "angelica dermatitis" (18).”

    Angelica Archangelica · Natural Medicines adverse-effect record, reported in dermatitis.

    2 sources cited
    1. 13406. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8. PubMed
    2. 18. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.

    Oxycodone Hydrochloride

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxycodone Hydrochloride. Read the label on DailyMed ›

Reported for Angelica Archangelica but not commonly for Oxycodone Hydrochloride: sun sensitivity.

Effects for Oxycodone Hydrochloride come from the ADVERSE REACTIONS section of its FDA label; effects for Angelica Archangelica come from the Natural Medicines adverse-effect record, quoted above. Where a percentage is shown, it is the share of 283,386 voluntary FDA FAERS reports for Oxycodone Hydrochloride that mention that effect — a reporting proportion, not an incidence rate and not evidence the drug caused it. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

How to take them

Some Oxycodone Hydrochloride Products Have a Food Rule — Angelica Archangelica Should Not Break It

At least one FDA label for a product containing Oxycodone Hydrochloride says to take it with food. If you take Angelica Archangelica on an empty stomach out of habit, keep them separate — and take Oxycodone Hydrochloride with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Oxycodone Hydrochloride products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 , 5.1 , 5.2 , 5.3 ) XTAMPZA ER is administered, twice daily, every 12 hours, and must be taken with food .

From the Dosage and Administration section of the FDA label we read for Oxycodone Hydrochloride — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

Everything else you take

See Every Supplement That Interacts With Oxycodone Hydrochloride

This page covers Angelica Archangelica only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxycodone Hydrochloride page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

Open the Oxycodone Hydrochloride interaction page

How much people look this up

Where Angelica Archangelica and Oxycodone Hydrochloride Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Angelica Archangelica
Steady interest

#1,254 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxycodone Hydrochloride
Steady interest

#1,893 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Angelica Archangelica reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Angelica Archangelica and Oxycodone Hydrochloride records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Angelica Archangelica

What is Angelica Archangelica?

Angelica Archangelica
  • Digestive upset and gas
  • Loss of appetite
  • Anxiety and restlessness
  • Mild respiratory complaints
  • Flavoring in foods and drinks

Angelica archangelica is a tall aromatic herb used traditionally for digestive complaints, poor appetite, and to flavor foods and liqueurs. Solid human evidence for its health benefits is limited, and its skin-sensitizing furanocoumarins mean caution is warranted. Pregnant and breastfeeding people should avoid it, and anyone considering it should check with a pharmacist or doctor first.

Angelica archangelica · Apiaceae (Umbelliferae) · Root, seeds (fruit), leaves, and essential oil · Tea, dried root, tincture, capsules, essential oil, and as a flavoring in liqueurs

An interaction check asks whether these two react with each other — it does not ask whether Angelica Archangelica is a good idea for someone in your situation. Here is what our Angelica Archangelica record says about it on its own.

Angelica Archangelica: dosing

There is no well-established standardized dose for Angelica archangelica. Traditional preparations include teas made from the dried root or seeds, tinctures, and capsules, but the amount of active compounds can vary widely between products.Because reliable dosing guidelines are lacking, the safest approach is to follow the directions on the product label and not exceed them. Avoid combining it with strong sun exposure or tanning.

From our Angelica Archangelica monograph — the full record covers uses, side effects and every documented interaction.

Read the full Angelica Archangelica monograph & all interactions
Medication

About Oxycodone Hydrochloride

Most-Reported Side Effects for Oxycodone Hydrochloride

From FAERS, the FDA’s public side-effect reporting system (283,386 reports, all brands). Reports are voluntary and are not proof the drug caused the effect.

Drug dependence 101,882 reports
Overdose 56,283 reports
Emotional distress 49,398 reports
Drug withdrawal syndrome 37,426 reports
Dependence 20,302 reports
Keep checking

Other Drugs & Angelica Archangelica

Browse every other medication we’ve checked against Angelica Archangelica — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
335Moderate
0Minor
2,494No known interaction
335 Moderate 2,494 No interaction
Moderate

335 interactions

Showing 60 of 335 moderate interactions — see all 335 on the Angelica Archangelica page.

No interaction 2,494 drugs checked — show the list

We also checked Angelica Archangelica against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,494 medications checked with no known interaction — see the full Angelica Archangelica list.

See the full Angelica Archangelica interactions page
See every supplement checked against Oxycodone Hydrochloride, ranked by severity
Evidence & sources

Angelica Archangelica References

The 3 references that drive our Angelica Archangelica monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  2. Ojala T, Vuorela P, Kiviranta J, et al. A bioassay using Artemia salina for detecting phototoxicity of plant coumarins. Planta Med 1999;65:715-8. PubMed
  3. Sigurdsson S, Geirsson G, Gudmundsdottir H, Egilsdottir PB, Gudbjarnason S. A parallel, randomized, double-blind, placebo-controlled study to investigate the effect of SagaPro on nocturia in men. Scand J Urol. 2013;47(1):26-32. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Angelica Archangelica and Oxycodone Hydrochloride Together: Common Questions

Is it safe to take Angelica Archangelica with Oxycodone Hydrochloride?
We do not list a known interaction between Angelica Archangelica and Oxycodone Hydrochloride. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Angelica Archangelica and Oxycodone Hydrochloride have any of the same side effects?
Yes — our sources link each of them separately to 2 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Angelica Archangelica and Oxycodone Hydrochloride at the same time of day?
At least one FDA label for a product containing Oxycodone Hydrochloride says to take it with food. If you take Angelica Archangelica on an empty stomach out of habit, keep them separate and take Oxycodone Hydrochloride with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Oxycodone Hydrochloride products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Angelica Archangelica and Oxycodone Hydrochloride combination checked?
Interactions in our licensed database are recorded against drug classes. Oxycodone Hydrochloride is filed under 6 classifications, and Angelica Archangelica has documented interactions with 1 drug class — none of Oxycodone Hydrochloride's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Angelica Archangelica interact with any other medications?
Yes. Angelica Archangelica has 335 documented drug interactions in our database — Oxycodone Hydrochloride is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Oxycodone Hydrochloride interact with any supplements?
Yes. Oxycodone Hydrochloride has documented interactions with 145 supplements in our database — Angelica Archangelica is not one of them. The Oxycodone Hydrochloride interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Angelica Archangelica monograph Uses, safety profile, and every drug interaction in one place Oxycodone Hydrochloride supplement interactions Every supplement checked against Oxycodone Hydrochloride, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 3 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxycodone Hydrochloride and Angelica Archangelica?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.