Medication interaction hub

What Supplements Interact with Oxycodone?

Oxycodone brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, and others. Every interaction below applies to the brands too.

145 Interactions 8 Major 114 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated September 23, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Oxycodone? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Oxycodone against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Oxycodone is a potent opioid painkiller, and anything that deepens its sedation can slow breathing itself, which is why this list deserves genuine respect. Of the 145 supplement and herbal ingredients on record, eight rate major, and the biggest cluster by far, 78 ingredients, adds extra drowsiness on top of the opioid's own. Alcohol is the most familiar offender there. St. John's wort earns its major rating differently, speeding oxycodone's breakdown until the pain relief weakens.

Most of the rest sit at moderate, 114 entries, with 23 rated minor. Many of those change how much oxycodone circulates rather than what it does. Grapefruit juice can raise blood levels, while a few bulky fibers and absorbent products can cut how much of any swallowed pill gets in. A small handful may lower the seizure threshold. With a drug where oversedation is the emergency, the eight majors are the ones to know cold.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 114 Minor 23 No known interaction 1,307

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Oxycodone: Top Interactions at a Glance

The Oxycodone supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 145 interacting ingredients — plus 1,307 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Oxycodone Combinations Today

The Oxycodone + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Kratom + Oxycodonei

Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.

Read the full interaction Moderate Likelihood Possible Cannabis + Oxycodonei

Theoretically, cannabis might have additive effects if used with other CNS depressants.

Read the full interaction Moderate Likelihood Probable Grapefruit + Oxycodonei

Grapefruit juice can increase blood levels of oxycodone, potentially increasing the effects and adverse effects of oxycodone.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Oxycodonei

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Read the full interaction Minor Likelihood Unlikely Baikal Skullcap + Oxycodonei

Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative properties.

Read the full interaction Minor Likelihood Possible Rhodiola + Oxycodonei

Theoretically, rhodiola might increase the risk of adverse effects when taken with CNS depressants.

Read the full interaction
The complete list

Every Supplement Checked Against Oxycodone

All 1,452 ingredients in our database, ranked by severity — 145 with a Oxycodone interaction on file and 1,307 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Oxycodone?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Kratom with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might increase the risk for adverse CNS depressant effects.

Full Kratom + Oxycodone answer

Can you take Cannabis with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, cannabis might have additive effects if used with other CNS depressants.

Full Cannabis + Oxycodone answer

Can you take Grapefruit with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Grapefruit juice can increase blood levels of oxycodone, potentially increasing the effects and adverse effects of oxycodone.

Full Grapefruit + Oxycodone answer

Can you take Ashwagandha with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Oxycodone answer

Can you take Baikal Skullcap with Oxycodone?

Minor Usually — this is a minor-rated interaction, generally not clinically significant but worth mentioning to your pharmacist. Theoretically, Baikal skullcap might cause additive therapeutic and adverse effects when used concomitantly with drugs with sedative propert...

Full Baikal Skullcap + Oxycodone answer

Can you take German Chamomile with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, German chamomile might have additive effects when used with CNS depressants.

Full German Chamomile + Oxycodone answer

Can you take Ginkgo with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ginkgo with drugs that lower the seizure threshold might increase the risk for convulsions.

Full Ginkgo + Oxycodone answer

Can you take Goji with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, goji berry might inhibit CYP2D6 and reduce metabolism of CYP2D6 substrates.

Full Goji + Oxycodone answer

Can you take Gotu Kola with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking gotu kola might increase the sedative effects of CNS depressants.

Full Gotu Kola + Oxycodone answer

Can you take Grape with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.

Full Grape + Oxycodone answer

Can you take Greater Celandine with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Research in vitro shows that chelidonine, a constituent of greater celandine, inhibits cytochrome P450 2D6 (CYP2D6) enzyme activity.

Full Greater Celandine + Oxycodone answer

Can you take Griffonia Simplicifolia with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Griffonia simplicifolia seed extract with CNS depressants might increase the risk of additive CNS depression.

Full Griffonia Simplicifolia + Oxycodone answer

Can you take Guar Gum with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Guar gum might reduce the absorption of some oral drugs, potentially decreasing their effectiveness.

Full Guar Gum + Oxycodone answer

Can you take Guarumo with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. In an animal study, an aqueous extract of guarumo depressed the central nervous system, inducing significant motor incoordination and muscle...

Full Guarumo + Oxycodone answer

Can you take Gum Arabic with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, gum arabic can alter the absorption of oral drugs due to its fiber content.

Full Gum Arabic + Oxycodone answer

Can you take Hesperidin with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with CNS depressants may cause additive sedative effects.

Full Hesperidin + Oxycodone answer

Can you take Higenamine with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, higenamine might increase the levels and clinical effects of drugs metabolized by CYP2D6.

Full Higenamine + Oxycodone answer

Can you take Hops with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.

Full Hops + Oxycodone answer

Can you take Indian Snakeroot with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Indian snakeroot might cause additive sedative effects.

Full Indian Snakeroot + Oxycodone answer

Can you take Jackfruit with Oxycodone?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, jackfruit seeds might cause additive sedation when taken with CNS depressants.

Full Jackfruit + Oxycodone answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Oxycodone is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Oxycodone, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Oxycodone sits in 6 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Oxycodone through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Oxycodone through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Oxycodone through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Oxycodone through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Oxycodone through this category.

Oxycodone (Oxycontin) 2 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

2 of the supplement ingredients on this page reach Oxycodone through this category.

About Oxycodone

Oxycodone is an opioid pain reliever used to treat moderate to severe pain.

Generic name: Oxycodone  ·  Brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, OxyNeo, Roxybond, Xtampza ER.

See the full Oxycodone drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Oxycodone

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Oxycodone.

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Pharmacist Counseling Corner

Oxycodone & Supplements: Common Questions

What supplements interact with Oxycodone?
Our database currently documents 145 ingredients with a known Oxycodone interaction (8 major, 114 moderate, 23 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 145. The highest-ranked right now: Beer, Wine, 1,4-butanediol.
Which Oxycodone supplement interactions are the most serious?
Focus on the major group: Beer, Wine, 1,4-butanediol, Activated Charcoal and Gamma-hydroxybutyrate (ghb), among others. A major rating means the combination can be clinically significant, not that harm is guaranteed — but it's exactly the kind of thing to run past your pharmacist before your next dose, not after. Jump to the ranked list.
Can I take vitamins or supplements while on Oxycodone?
Plenty of supplements coexist fine with Oxycodone; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like OxyContin have the same supplement interactions as Oxycodone?
Yes — OxyContin, Roxicodone, OxyIR, Percolone, Oxecta and other brands all contain Oxycodone, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Oxycodone and my other medications?
This page covers Oxycodone against supplements and herbal ingredients. Checking Oxycodone against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Oxycodone drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 23, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.