Drug & supplement interaction

Galacto-oligosaccharides (gos) + Oxycodone

Oxycodone brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 13, 2026
The bottom line No known interaction

We found no known interaction between Galacto-oligosaccharides (gos) and Oxycodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Oxycodone states a food rule worth keeping to, and the two are separately associated with some of the same side effects, which would make a new symptom harder to attribute to one or the other.

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Interaction report

Galacto-oligosaccharides (gos) and Oxycodone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxycodone and Galacto-oligosaccharides (gos) in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Galacto-oligosaccharides (gos) safety at a glance

Galacto-oligosacch... overall Generally safe GOS is generally recognized as safe and well tolerated for most people in food amounts.
Pregnancy Likely Safe When consumed in amounts commonly found in foods. Read the full pregnancy detail
Breastfeeding Likely Safe When consumed in amounts commonly found in foods. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxycodone and Galacto-oligosaccharides (gos)? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
How we checked

Why No Interaction Is Listed for Oxycodone

Interactions in our licensed database are recorded against drug classes, not just single drug names. Oxycodone is filed under 6 classifications — including narcotic drugs, cytochrome p450 2d6 (cyp2d6) substrates, cns depressants. Galacto-oligosaccharides (gos) has documented interactions with 1 drug class — the most serious being immunosuppressants (moderate) — and none of Oxycodone’s classifications are among them.

Classification data comes from our licensed Natural Medicines dataset. A medication can belong to classes beyond those recorded there, so this describes how the check was run — it is not a safety guarantee.

Keep it in perspective

Galacto-oligosaccharides (gos) Does Interact With Other Medications

Galacto-oligosaccharides (gos) has 121 moderate known drug interactions in our database — Oxycodone isn’t one of them. If you take anything else, check it against the full list below.

Moderate 121 No known interaction 2,709 (incl. Oxycodone)
Taking anything else?

Check Another of Your Medications Against Galacto-oligosaccharides (gos)

Covers the 2,830 medications we’ve checked against Galacto-oligosaccharides (gos). Pick one to open its full report.

What to actually watch for

No Interaction Found — But Data Suggests Galacto-oligosaccharides (gos) and Oxycodone May Share Several of the Same Side Effects

This is not an interaction. Neither one changes how your body handles the other, and nothing here says they react together. What our sources do show is that each has separately been linked to the effects below — so taking both can make those effects more likely to turn up, and harder to pin on one or the other if they do. One of them is worth acting on rather than waiting out — marked below.

  • A severe allergic reaction Worth acting on Additional detail

    Galacto-oligosaccharides (gos)

    “Orally, GOS seem to be well tolerated in infants, children, and adults.

    Most Common Adverse Effects:

    Orally: Bloating, constipation, diarrhea, flatulence, and increased stool frequency.

    Serious Adverse Effects (Rare):

    Orally: Anaphylaxis in sensitive individuals.”

    Galacto-oligosaccharides (gos) · Natural Medicines adverse-effect record, reported in constipation.

    Oxycodone

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxycodone. Read the label on DailyMed ›

  • Bloating or gas / Constipation / Diarrhea Additional detail

    Galacto-oligosaccharides (gos)

    “Orally, galacto-oligosaccharides may cause bloating, flatulence, and increased stool frequency. Giving a formula supplemented with 4 grams/L of GOS and polydextrose (1:1 ratio) to infants has been associated with an increased incidence of gastrointestinal adverse effects, primarily constipation and diarrhea, in one clinical study. However, it is unclear if this was due to GOS, polydextrose, or the combination.”

    Galacto-oligosaccharides (gos) · Natural Medicines adverse-effect record, reported in constipation.

    6 sources cited
    1. 26706. Teuri U, Korpela R. Galacto-oligosaccharides relieve constipation in elderly people. Ann Nutr Metab 1998;42(6):319-327. PubMed
    2. 26709. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. PubMed
    3. 26724. Ito M, Deguchi Y, Matsumoto K, et al. Influence of galactooligosaccharides on the human fecal microflora. J Nutr Sci Vitaminol (Tokyo) 1993;39(6):635-640. PubMed
    4. 99217. Morel FB, Dai Q, Ni J, Thomas D, Parnet P, Fança-Berthon P. a-Galacto-oligosaccharides dose-dependently reduce appetite and decrease inflammation in overweight adults. J Nutr. 2015;145(9):2052-9. PubMed
    5. 99222. Bisceglia M, Indrio F, Riezzo G, Poerio V, Corapi U, Raimondi F. The effect of prebiotics in the management of neonatal hyperbilirubinaemia. Acta Paediatr. 2009;98(10):1579-81. PubMed
    6. 106527. Colombo J, Carlson SE, Algarín C, et al. Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a randomized controlled trial. Pediatr Res 2021;89(5):1222-31. PubMed

    Oxycodone

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxycodone. Read the label on DailyMed ›

  • A skin rash Additional detail

    Galacto-oligosaccharides (gos)

    “Orally, giving a formula supplemented with 4 grams/L of GOS and polydextrose (1:1 ratio) to infants has been associated with an increased incidence of atopic dermatitis in one clinical study. However, most other clinical research in infants at risk of atopy shows that GOS-containing formula may actually reduce the risk of developing atopic dermatitis.”

    Galacto-oligosaccharides (gos) · Natural Medicines adverse-effect record, reported in atopic disease.

    4 sources cited
    1. 26709. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. PubMed
    2. 26707. Kukkonen K, Savilahti E, Haahtela T, et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2007;119(1):192-198. PubMed
    3. 26708. Moro G, Arslanoglu S, Stahl B, et al. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child 2006;91(10):814-819. PubMed
    4. 99223. Arslanoglu S, Moro GE, Schmitt J, Tandoi L, Rizzardi S, Boehm G. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr. 2008;138(6 PubMed

    Oxycodone

    Listed in the ADVERSE REACTIONS section of the FDA label for Oxycodone. Read the label on DailyMed ›

Effects for Oxycodone come from the ADVERSE REACTIONS section of its FDA label; effects for Galacto-oligosaccharides (gos) come from the Natural Medicines adverse-effect record, quoted above. Wording is matched across sources by our own clinical vocabulary, so treat this as a prompt to pay attention, not a diagnosis.

Special populations

Galacto-oligosaccharides (gos) in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When consumed in amounts commonly found in foods.

Pregnancy And Lactation Possibly Safe

When used orally. GOS have been safely used in clinical research in doses of about 4.5 grams daily from week 25 of pregnancy until delivery.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Oxycodone Products Have a Food Rule — Galacto-oligosaccharides (gos) Should Not Break It

At least one FDA label for a product containing Oxycodone says to take it with food. If you take Galacto-oligosaccharides (gos) on an empty stomach out of habit, keep them separate — and take Oxycodone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Oxycodone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 , 5.1 , 5.2 , 5.3 ) XTAMPZA ER is administered, twice daily, every 12 hours, and must be taken with food .

From the Dosage and Administration section of the FDA label we read for Oxycodone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Galacto-oligosaccharides (gos) or Oxycodone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Galacto-oligosaccharides (gos) or Oxycodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Oxycodone

This page covers Galacto-oligosaccharides (gos) only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxycodone page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 114 moderate · 23 minor.

From our pharmacist’s overview on the Oxycodone page

“Oxycodone is a potent opioid painkiller, and anything that deepens its sedation can slow breathing itself, which is why this list deserves genuine respect. Of the 145 supplement and herbal ingredients on record, eight rate major, and the biggest cluster by far, 78 ingredients, adds extra drowsiness on top of the opioid's own.”

Reviewed by 2 · Jul 18, 2026

Open the Oxycodone interaction page

How much people look this up

Where Galacto-oligosaccharides (gos) and Oxycodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Galacto-oligosaccharides (gos)
Steady interest

#1,450 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxycodone
Top half

#1,172 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Galacto-oligosaccharides (gos) reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 13, 2026. The Galacto-oligosaccharides (gos) and Oxycodone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Galacto-oligosaccharides (gos)

What is Galacto-oligosaccharides (gos)?

  • Prebiotic to support gut bacteria
  • Constipation
  • Digestive health
  • Immune support
  • Infant gut health

Galacto-oligosaccharides (GOS) are a type of prebiotic fiber that feed the helpful bacteria in your gut. They are generally well tolerated and may help with digestive regularity and gut balance, though they can cause gas and bloating, especially at higher doses. Evidence is promising but still limited for many uses, so talk with your pharmacist or doctor before starting.

Carbohydrate derived from lactose (milk sugar) · Powder, capsules, chewable tablets, added to foods, infant formula, and functional drinks

An interaction check asks whether these two react with each other — it does not ask whether Galacto-oligosaccharides (gos) is a good idea for someone in your situation. Here is what our Galacto-oligosaccharides (gos) record says about it on its own.

Galacto-oligosaccharides (gos): dosing

There is no single official or standardized dose for GOS. Studies have used a range of amounts, and the right dose can vary from person to person.A common, practical approach is to start with a small amount and slowly increase it over days or weeks.

From our Galacto-oligosaccharides (gos) monograph — the full record covers uses, side effects and every documented interaction.

Read the full Galacto-oligosaccharides (gos) monograph & all interactions
Medication

About Oxycodone

What Is Oxycodone Used For?

Brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, OxyNeo

Oxycodone is prescribed for pain severe enough to need daily, long-term opioid treatment — pain that hasn't responded well to non-opioid medicines or shorter-acting options. The extended-release form is designed for continuous pain control, not for occasional or as-needed use.

It is approved for adults and, in certain cases, for opioid-tolerant children 11 years and older who are already on opioid therapy. Because of the serious risks involved, it is reserved for situations where other approaches have genuinely fallen short.

See full Oxycodone drug information
Keep checking

Other Drugs & Galacto-oligosaccharides (gos)

Browse every other medication we’ve checked against Galacto-oligosaccharides (gos) — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
121Moderate
0Minor
2,708No known interaction
121 Moderate 2,708 No interaction
Moderate

121 interactions

Showing 60 of 121 moderate interactions — see all 121 on the Galacto-oligosaccharides (gos) page.

No interaction 2,708 drugs checked — show the list

We also checked Galacto-oligosaccharides (gos) against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,708 medications checked with no known interaction — see the full Galacto-oligosaccharides (gos) list.

See the full Galacto-oligosaccharides (gos) interactions page
See every supplement checked against Oxycodone, ranked by severity
Evidence & sources

Galacto-oligosaccharides (gos) References

The 12 references that drive our Galacto-oligosaccharides (gos) monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Teuri U, Korpela R. Galacto-oligosaccharides relieve constipation in elderly people. Ann Nutr Metab 1998;42(6):319-327. PubMed
  2. Kukkonen K, Savilahti E, Haahtela T, et al. Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 2007;119(1):192-198. PubMed
  3. Moro G, Arslanoglu S, Stahl B, et al. A mixture of prebiotic oligosaccharides reduces the incidence of atopic dermatitis during the first six months of age. Arch Dis Child 2006;91(10):814-819. PubMed
  4. Ziegler E, Vanderhoof JA, Petschow B, et al. Term infants fed formula supplemented with selected blends of prebiotics grow normally and have soft stools similar to those reported for breast-fed infants. J Pediatr Gastroenterol Nutr 2007;44(3):359-364. PubMed
  5. Bakker-Zierikzee AM, Tol EA, Kroes H, et al. Faecal sIgA secretion in infants fed on pre- or probiotic infant formula. Pediatr Allergy Immunol 2006;17(2):134-140. PubMed
  6. Shadid R, Haarman M, Knol J, et al. Effects of galactooligosaccharide and long-chain fructooligosaccharide supplementation during pregnancy on maternal and neonatal microbiota and immunity--a randomized, double-blind, placebo-controlled study. Am J Clin N PubMed
  7. Vos AP, Haarman M, Buco A, et al. A specific prebiotic oligosaccharide mixture stimulates delayed-type hypersensitivity in a murine influenza vaccination model. Int Immunopharmacol 2006;6(8):1277-1286. PubMed
  8. Ito M, Deguchi Y, Matsumoto K, et al. Influence of galactooligosaccharides on the human fecal microflora. J Nutr Sci Vitaminol (Tokyo) 1993;39(6):635-640. PubMed
  9. Morel FB, Dai Q, Ni J, Thomas D, Parnet P, Fança-Berthon P. a-Galacto-oligosaccharides dose-dependently reduce appetite and decrease inflammation in overweight adults. J Nutr. 2015;145(9):2052-9. PubMed
  10. Bisceglia M, Indrio F, Riezzo G, Poerio V, Corapi U, Raimondi F. The effect of prebiotics in the management of neonatal hyperbilirubinaemia. Acta Paediatr. 2009;98(10):1579-81. PubMed
  11. Arslanoglu S, Moro GE, Schmitt J, Tandoi L, Rizzardi S, Boehm G. Early dietary intervention with a mixture of prebiotic oligosaccharides reduces the incidence of allergic manifestations and infections during the first two years of life. J Nutr. 2008;138(6 PubMed
  12. Colombo J, Carlson SE, Algarín C, et al. Developmental effects on sleep-wake patterns in infants receiving a cow's milk-based infant formula with an added prebiotic blend: a randomized controlled trial. Pediatr Res 2021;89(5):1222-31. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Galacto-oligosaccharides (gos) and Oxycodone Together: Common Questions

Is it safe to take Galacto-oligosaccharides (gos) with Oxycodone?
We do not list a known interaction between Galacto-oligosaccharides (gos) and Oxycodone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Do Galacto-oligosaccharides (gos) and Oxycodone have any of the same side effects?
Yes — our sources link each of them separately to 5 of the same effects. That is not an interaction: neither changes how your body handles the other. It does mean that if one of those effects turns up, it can be harder to tell which one is behind it. They are listed on this page with the source behind each.
Should I take Galacto-oligosaccharides (gos) and Oxycodone at the same time of day?
At least one FDA label for a product containing Oxycodone says to take it with food. If you take Galacto-oligosaccharides (gos) on an empty stomach out of habit, keep them separate and take Oxycodone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Oxycodone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
How was the Galacto-oligosaccharides (gos) and Oxycodone combination checked?
Interactions in our licensed database are recorded against drug classes. Oxycodone is filed under 6 classifications, and Galacto-oligosaccharides (gos) has documented interactions with 1 drug class — none of Oxycodone's classifications are among them. A medication can belong to classes beyond those recorded in our dataset, so this describes how the check was run rather than guaranteeing safety.
Does Galacto-oligosaccharides (gos) interact with any other medications?
Yes. Galacto-oligosaccharides (gos) has 121 documented drug interactions in our database — Oxycodone is simply not one of them. If you take anything else, it is worth checking each one; they are all listed on this page.
Does Oxycodone interact with any supplements?
Yes. Oxycodone has documented interactions with 145 supplements in our database — Galacto-oligosaccharides (gos) is not one of them. The Oxycodone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Galacto-oligosaccharides (gos) monograph Uses, safety profile, and every drug interaction in one place Oxycodone drug information The full plain-English guide to this medication Oxycodone supplement interactions Every supplement checked against Oxycodone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 12 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxycodone and Galacto-oligosaccharides (gos)?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.