Can You Take Benadryl (Diphenhydramine) With Oxycodone?

Answer

In general, it is not recommended to combine Benadryl (diphenhydramine) and oxycodone, especially if oxycodone is a new medication for you.

Increased Risk Of Side Effects

Oxycodone, by itself, can cause respiratory depression as well as depression of the CNS (Central Nervous System). Combining Benadryl (diphenhydramine), a sedating first-generation antihistamine, can enhance these effects.

There have been reports of significant drops in blood pressure, excess sedation as well as respiratory depression with the combination. Additionally, you certainly do not want to mix Benadryl (diphenhydramine), oxycodone, and alcohol together.

Having said all this, the combination of Benadryl (diphenhydramine) and oxycodone can be used in some situations.

Chronic use of oxycodone leads to tolerance to its effects.

Typically, once your level of tolerance to the depressant effects of oxycodone are appropriately assessed, your doctor may recommend combining Benadryl (diphenhydramine) for certain indications, such as insomnia. Your doctor may adjust the dose of one of the medications to get the best response in a safe way.

Final Words

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