Drug & supplement interaction

Albizia Julibrissin + Oxycodone

Oxycodone brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, and others.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Albizia Julibrissin has a moderate interaction with Oxycodone. Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mice.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
Know someone taking this? Share
Facebook Post Reddit Email
On this page
Interaction report

Albizia Julibrissin and Oxycodone

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Oxycodone

Oxycodone falls under CNS DEPRESSANTS — the group Albizia Julibrissin interacts with.

Animal research suggests that certain constituents from Albizia julibrissin flowers can potentiate pentobarbital-induced sleeping time in mice. Theoretically, Albizia julibrissin might enhance the therapeutic and adverse effects of CNS depressants.
Some CNS depressants include pentobarbital (Nembutal), phenobarbital (Luminal), secobarbital (Seconal), clonazepam (Klonopin), lorazepam (Ativan), zolpidem (Ambien), and others.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the gist: Oxycodone is a strong opioid pain reliever that already slows down the brain and nervous system, causing drowsiness, slowed breathing, and relaxation. Albizia julibrissin is traditionally used to calm the mind and help with sleep, so the worry is that pairing the two could pile on those sedating effects. In animal studies, compounds from Albizia flowers made an anesthetic-type drug knock mice out longer, which is why it's grouped as something that may add to the effect of CNS depressants like oxycodone.

Now, to keep this honest: this is theoretical, based on lab and animal data, not human studies, so it's not a strong, proven interaction. Still, with oxycodone the stakes are higher, so signs like extra sleepiness, foggy thinking, or slowed breathing matter. Please check with your pharmacist or doctor before combining them.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Kang, T. H., Jeong, S. J., Kim, N. Y., Higuchi, R., and Kim, Y. C. Sedative activity of two flavonol glycosides isolated from the flowers of Albizzia julibrissin Durazz. J Ethnopharmacol 2000;71(1-2):321-323. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Albizia Julibrissin Also Interacts With Other Medications

Albizia Julibrissin has 247 moderate known drug interactions in our database — the Oxycodone one above is one of them. If you take anything else, check it against the full list below.

Moderate 247 No known interaction 2,583 (incl. Oxycodone)
Taking anything else?

Check Another of Your Medications Against Albizia Julibrissin

Covers the 2,830 medications we’ve checked against Albizia Julibrissin. Pick one to open its full report.

From our Q&A

Questions About Albizia Julibrissin or Oxycodone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Albizia Julibrissin or Oxycodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Oxycodone

This page covers Albizia Julibrissin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxycodone page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 114 moderate · 23 minor.

From our pharmacist’s overview on the Oxycodone page

“Oxycodone is a potent opioid painkiller, and anything that deepens its sedation can slow breathing itself, which is why this list deserves genuine respect. Of the 145 supplement and herbal ingredients on record, eight rate major, and the biggest cluster by far, 78 ingredients, adds extra drowsiness on top of the opioid's own.”

Reviewed by 2 · Jul 18, 2026

Open the Oxycodone interaction page

One more smart check

Taking Albizia Julibrissin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 124 real supplement products containing Albizia Julibrissin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Albizia Julibrissin. Your product may carry other ingredients that interact with Oxycodone too, on top of Albizia Julibrissin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Albizia Julibrissin and Oxycodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Albizia Julibrissin
Top half

#546 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxycodone
Top half

#1,059 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Albizia Julibrissin

What is Albizia Julibrissin?

Albizia Julibrissin
  • Anxiety and stress
  • Low mood or mild depression
  • Sleep trouble (insomnia)
  • Irritability
  • Traditional support for swelling or injuries

Albizia julibrissin (Persian silk tree, He Huan) is a plant used in traditional Chinese medicine, mainly the flower and bark, for calming the mind, lifting mood, and easing sleep problems. Human evidence is very limited, so its benefits are not well proven. Talk with your pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Albizia Julibrissin monograph & all interactions
Medication

About Oxycodone

What Is Oxycodone Used For?

Brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, OxyNeo

Oxycodone is prescribed for pain severe enough to need daily, long-term opioid treatment — pain that hasn't responded well to non-opioid medicines or shorter-acting options. The extended-release form is designed for continuous pain control, not for occasional or as-needed use.

It is approved for adults and, in certain cases, for opioid-tolerant children 11 years and older who are already on opioid therapy. Because of the serious risks involved, it is reserved for situations where other approaches have genuinely fallen short.

See full Oxycodone drug information
Keep checking

Other Drugs & Albizia Julibrissin

Browse every other medication we’ve checked against Albizia Julibrissin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
247Moderate
0Minor
2,582No known interaction
247 Moderate 2,582 No interaction
Moderate

247 interactions

Showing 60 of 247 moderate interactions — see all 247 on the Albizia Julibrissin page.

No interaction 2,582 drugs checked — show the list

We also checked Albizia Julibrissin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,582 medications checked with no known interaction — see the full Albizia Julibrissin list.

See the full Albizia Julibrissin interactions page
See every supplement checked against Oxycodone, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Albizia Julibrissin monograph › Uses, safety, and every drug interaction in one place Oxycodone supplement interactions › Every supplement checked against Oxycodone, ranked by severity Oxycodone drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Albizia Julibrissin and Oxycodone Together: Common Questions

Can you take Albizia Julibrissin with Oxycodone?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Albizia Julibrissin and Oxycodone interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Oxycodone and Albizia Julibrissin?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.