Drug & supplement interaction

Centaury + Oxycodone

Oxycodone brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, and others.

No Known Interaction
Medically reviewed by · Updated June 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Centaury and Oxycodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Oxycodone states a food rule worth keeping to.

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Interaction report

Centaury and Oxycodone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxycodone and Centaury in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Centaury at all — not against Oxycodone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Centaury safety at a glance

Centaury overall Use caution Generally used in small amounts as a digestive bitter, but high-quality safety data are limited.
Pregnancy Avoid Not enough safety information; avoid use during pregnancy.
Breastfeeding Avoid Safety while breastfeeding is unknown, so it is best avoided.

Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxycodone and Centaury? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Oxycodone’s Own FDA Label Lists

This is not an interaction — none of it involves Centaury. These are the most notable effects listed in the ADVERSE REACTIONS section of Oxycodone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • Serotonin syndrome Worth acting on
  • Thoughts of self-harm Worth acting on
  • A bowel blockage Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • Trouble passing urine Worth acting on
  • Low sodium Worth acting on

Showing the 10 most notable of 66 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Oxycodone. Read the label on DailyMed › Centaury’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Centaury side to compare — that is a limit of the record, not a statement that Centaury has no side effects.

How to take them

Some Oxycodone Products Have a Food Rule — Centaury Should Not Break It

At least one FDA label for a product containing Oxycodone says to take it with food. If you take Centaury on an empty stomach out of habit, keep them separate — and take Oxycodone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Oxycodone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 , 5.1 , 5.2 , 5.3 ) XTAMPZA ER is administered, twice daily, every 12 hours, and must be taken with food .

From the Dosage and Administration section of the FDA label we read for Oxycodone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Centaury or Oxycodone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Centaury or Oxycodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Oxycodone

This page covers Centaury only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxycodone page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 114 moderate · 23 minor.

From our pharmacist’s overview on the Oxycodone page

“Oxycodone is a potent opioid painkiller, and anything that deepens its sedation can slow breathing itself, which is why this list deserves genuine respect. Of the 145 supplement and herbal ingredients on record, eight rate major, and the biggest cluster by far, 78 ingredients, adds extra drowsiness on top of the opioid's own.”

Reviewed by 2 · Jul 18, 2026

Open the Oxycodone interaction page

One more smart check

Taking Centaury as Part of a Dietary Supplement Product? Check It for Interactions

We hold 67 real supplement products containing Centaury, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Centaury. Even though Centaury itself has no known interaction with Oxycodone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Centaury and Oxycodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Centaury
Top half

#682 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxycodone
Top 25%

#468 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Centaury reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Centaury and Oxycodone records this page draws on were last updated June 22, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Centaury

What is Centaury?

  • Poor appetite
  • Indigestion and bloating
  • Stimulating digestion (bitter tonic)
  • Mild fever (traditional)
  • Liver and gallbladder support (traditional)

Centaury is a bitter-tasting herb traditionally used to stimulate appetite and ease mild digestive complaints. Solid human studies are lacking, so its benefits remain largely unproven, and it is best used short-term with guidance from a pharmacist or doctor.

Centaurium erythraea · Gentianaceae · Aerial parts (flowering tops, leaves, and stems) · Tea (infusion), tincture, liquid extract, capsules, and as an ingredient in herbal bitters

An interaction check asks whether these two react with each other — it does not ask whether Centaury is a good idea for someone in your situation. Here is what our Centaury record says about it on its own.

Centaury: dosing

There is no officially established standard dose for centaury. Traditional use generally involves small amounts of the dried herb prepared as a tea or a few drops of tincture taken before meals.Because products differ widely in strength and form, the safest approach is to follow the directions on the product label and not exceed the recommended amount. It is meant for short-term, occasional use rather than long-term daily use.

From our Centaury monograph — the full record covers uses, side effects and every documented interaction.

Read the full Centaury monograph & all interactions
Medication

About Oxycodone

What Is Oxycodone Used For?

Brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, OxyNeo

Oxycodone is prescribed for pain severe enough to need daily, long-term opioid treatment — pain that hasn't responded well to non-opioid medicines or shorter-acting options. The extended-release form is designed for continuous pain control, not for occasional or as-needed use.

It is approved for adults and, in certain cases, for opioid-tolerant children 11 years and older who are already on opioid therapy. Because of the serious risks involved, it is reserved for situations where other approaches have genuinely fallen short.

See full Oxycodone drug information
Keep checking

Other Drugs & Centaury

Browse every other medication we’ve checked against Centaury — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Centaury against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Centaury list.

See the full Centaury interactions page
See every supplement checked against Oxycodone, ranked by severity
Evidence & sources

Centaury References

The 1 references that drive our Centaury monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Martynyuk L, Martynyuk L, Ruzhitska O, Martynyuk O. Effect of the herbal combination Canephron N on diabetic nephropathy in patients with diabetes mellitus: results of a comparative cohort study. J Altern Complement Med. 2014;20(6):472-478. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Centaury and Oxycodone Together: Common Questions

Is it safe to take Centaury with Oxycodone?
We do not list a known interaction between Centaury and Oxycodone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Centaury and Oxycodone at the same time of day?
At least one FDA label for a product containing Oxycodone says to take it with food. If you take Centaury on an empty stomach out of habit, keep them separate and take Oxycodone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Oxycodone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Oxycodone interact with any supplements?
Yes. Oxycodone has documented interactions with 145 supplements in our database — Centaury is not one of them. The Oxycodone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Centaury monograph Uses, safety profile, and every drug interaction in one place Oxycodone drug information The full plain-English guide to this medication Oxycodone supplement interactions Every supplement checked against Oxycodone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 1 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxycodone and Centaury?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.