Drug & supplement interaction

Lutein + Oxycodone

Oxycodone brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, and others.

No Known Interaction
Medically reviewed by · Updated July 2026 · Pair last verified Sep 20, 2026
The bottom line No known interaction

We found no known interaction between Lutein and Oxycodone in our sources. Absence of a documented interaction is not the same as proven safety, and does not guarantee one does not exist. Do not start, stop, or change a medication or supplement based on this page; confirm with your pharmacist or doctor first. Additionally, although there is no interaction, the label for Oxycodone states a food rule worth keeping to.

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Interaction report

Lutein and Oxycodone

We checked these two against our interaction database. Here is what we found.

No Known Interaction Found

We did not find a documented interaction between Oxycodone and Lutein in our sources. This does not guarantee that the combination is completely free of risk — there is often limited research on supplements and herbal products, especially around drug interactions.

Worth understanding: our licensed dataset holds no drug-interaction record for Lutein at all — not against Oxycodone, and not against any other medication we track. This verdict therefore rests on the absence of any recorded data, not on research that looked at this combination and found nothing. We cannot rule an interaction out.

If you decide to take both, the practical routine is simple: add one new thing at a time and note the date you started it. If the combination is going to disagree with you, it usually shows in the first days to a couple of weeks — and a start date turns “I’ve been feeling off” into something a pharmacist can actually work with. Do not stop a prescribed medicine on your own.

Always talk with your pharmacist or doctor before making changes to your medications or supplements, particularly if you take several medications or have an ongoing health condition.

Lutein safety at a glance

Lutein overall Generally safe Lutein from foods and typical supplement doses is generally considered safe for most adults.
Pregnancy Likely Safe When used orally and appropriately in amounts found in foods. The high end of dietary lutein intake ranges from 6.9-11.7 mg/day. Read the full pregnancy detail
Breastfeeding Likely Safe When used orally and appropriately in amounts found in foods. The high end of dietary lutein intake ranges from 6.9-11.7 mg/day. Read the full breastfeeding detail

Pregnancy & breastfeeding ratings are from Natural Medicines (Therapeutic Research Center) — the full detail is in the Special populations card below. Safety guidance is general; always confirm with your pharmacist or doctor for your situation.

Still wondering about combining Oxycodone and Lutein? Ask Dr. Brian Staiger, PharmD, BCPS directly ›
What to actually watch for

What Oxycodone’s Own FDA Label Lists

This is not an interaction — none of it involves Lutein. These are the most notable effects listed in the ADVERSE REACTIONS section of Oxycodone’s own FDA label, for the medication by itself. Knowing the drug’s own list makes it easier to work out the likely cause if something new turns up while you take both. 10 of them are worth acting on rather than waiting out — marked below.

  • Dependence or withdrawal symptoms Worth acting on
  • Serotonin syndrome Worth acting on
  • Thoughts of self-harm Worth acting on
  • A bowel blockage Worth acting on
  • Pain or burning when passing urine Worth acting on
  • Memory problems Worth acting on
  • Dehydration Worth acting on
  • Trouble swallowing Worth acting on
  • Trouble passing urine Worth acting on
  • Low sodium Worth acting on

Showing the 10 most notable of 66 label-listed effects — ranked by how unusual each one is across medicines generally, with serious effects weighted up.

From the ADVERSE REACTIONS section of the FDA label for Oxycodone. Read the label on DailyMed › Lutein’s licensed record lists no adverse effects our clinical vocabulary could match, so there is no Lutein side to compare — that is a limit of the record, not a statement that Lutein has no side effects.

Special populations

Lutein in Pregnancy & Breastfeeding

Pregnancy And Lactation Likely Safe

When used orally and appropriately in amounts found in foods. The high end of dietary lutein intake ranges from 6.9-11.7 mg/day.

DISCLAIMER: This tool is intended for informational purposes only, and should not be interpreted as specific medical advice. Patients should consult with a qualified healthcare provider before making decisions about therapies and/or health conditions.© 2026 Therapeutic Research Center

How to take them

Some Oxycodone Products Have a Food Rule — Lutein Should Not Break It

At least one FDA label for a product containing Oxycodone says to take it with food. If you take Lutein on an empty stomach out of habit, keep them separate — and take Oxycodone with a meal where the label says to.

This may not be true of your version. Food instructions belong to the product, not the ingredient: two Oxycodone products can carry different directions, and extended-release forms often differ from immediate-release ones. The label we read is quoted below — check the directions on your own box or bottle, or ask your pharmacist, for how to take the exact product you were given.

( 2.2 , 5.1 , 5.2 , 5.3 ) XTAMPZA ER is administered, twice daily, every 12 hours, and must be taken with food .

From the Dosage and Administration section of the FDA label we read for Oxycodone — where that label names a specific product, the instruction is that product's. Read the label on DailyMed ›

A food rule is not an interaction — it is about how much of the medicine you absorb. The directions that came with your own product, and your pharmacist, outrank anything on this page.

From our Q&A

Questions About Lutein or Oxycodone

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Lutein or Oxycodone, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Oxycodone

This page covers Lutein only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Oxycodone page lists 145 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 114 moderate · 23 minor.

From our pharmacist’s overview on the Oxycodone page

“Oxycodone is a potent opioid painkiller, and anything that deepens its sedation can slow breathing itself, which is why this list deserves genuine respect. Of the 145 supplement and herbal ingredients on record, eight rate major, and the biggest cluster by far, 78 ingredients, adds extra drowsiness on top of the opioid's own.”

Reviewed by 2 · Jul 18, 2026

Open the Oxycodone interaction page

One more smart check

Taking Lutein as Part of a Dietary Supplement Product? Check It for Interactions

We hold 6,588 real supplement products containing Lutein, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Lutein. Even though Lutein itself has no known interaction with Oxycodone, another ingredient on your label might. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Lutein and Oxycodone Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Lutein
Top 5%

#40 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Oxycodone
Top 10%

#225 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Where does our data come from?
  • Source: the Natural Medicines (TRC Healthcare) clinical database — the evidence-graded professional reference for herb & supplement interactions.
  • Citation library: 103,510 references behind our interaction content, 65,311 of them resolved to verified PubMed/DOI sources. See every Lutein reference on this page ↓
  • Freshness: we automatically re-check this combination every week — this pair was last verified September 20, 2026. The Lutein and Oxycodone records this page draws on were last updated July 10, 2026.
  • What “no known interaction” means: no documented interaction in the sources above — not a guarantee of safety. Supplements are studied far less than prescription drugs, so we say exactly what the evidence supports, and nothing more.
Data structure & sourcing designed and verified by .
Supplement

About Lutein

What is Lutein?

  • Eye health
  • Age-related macular degeneration
  • Cataract prevention
  • Reducing eye strain from screens
  • General antioxidant support

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular degeneration in certain people. For most other eye and health claims, the evidence is limited or mixed. It is generally well tolerated, but talk to your pharmacist or doctor before starting it, especially during pregnancy or breastfeeding.

Pigment extracted from plants such as marigold flowers (Tagetes erecta) and found in leafy greens · Capsules, softgels, tablets, combination eye-health supplements, gummies

An interaction check asks whether these two react with each other — it does not ask whether Lutein is a good idea for someone in your situation. Here is what our Lutein record says about it on its own.

Lutein: dosing

There is no single official dose of lutein for supplements. Amounts used in eye-health research have varied, and lutein is often combined with zeaxanthin in eye formulas.The best approach is to follow the directions on the product label and not take more than recommended.

From our Lutein monograph — the full record covers uses, side effects and every documented interaction.

Read the full Lutein monograph & all interactions
Medication

About Oxycodone

What Is Oxycodone Used For?

Brand names: OxyContin, Roxicodone, OxyIR, Percolone, Oxecta, OxyNeo

Oxycodone is prescribed for pain severe enough to need daily, long-term opioid treatment — pain that hasn't responded well to non-opioid medicines or shorter-acting options. The extended-release form is designed for continuous pain control, not for occasional or as-needed use.

It is approved for adults and, in certain cases, for opioid-tolerant children 11 years and older who are already on opioid therapy. Because of the serious risks involved, it is reserved for situations where other approaches have genuinely fallen short.

See full Oxycodone drug information
Keep checking

Other Drugs & Lutein

Browse every other medication we’ve checked against Lutein — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
0Moderate
0Minor
2,829No known interaction
2,829 No interaction
No interaction 2,829 drugs checked — show the list

We also checked Lutein against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,829 medications checked with no known interaction — see the full Lutein list.

See the full Lutein interactions page
See every supplement checked against Oxycodone, ranked by severity
Evidence & sources

Lutein References

The 2 references that drive our Lutein monograph and interaction data, from the evidence-graded Natural Medicines (TRC Healthcare) database. Citations with a link open the study on PubMed or the publisher’s site.

  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

Medication overviews come from MedlinePlus (NIH); supplement label data from the NIH Dietary Supplement Label Database. Content is written and reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

Pharmacist Counseling Corner

Taking Lutein and Oxycodone Together: Common Questions

Is it safe to take Lutein with Oxycodone?
We do not list a known interaction between Lutein and Oxycodone. That does not guarantee the combination is risk-free, so confirm with your pharmacist or doctor — especially if you take other medications or have a health condition.
Should I take Lutein and Oxycodone at the same time of day?
At least one FDA label for a product containing Oxycodone says to take it with food. If you take Lutein on an empty stomach out of habit, keep them separate and take Oxycodone with a meal where the label says to. Food instructions belong to the product rather than the ingredient — two Oxycodone products can differ — so check the directions on your own box. This is about absorption, not an interaction.
Does Oxycodone interact with any supplements?
Yes. Oxycodone has documented interactions with 145 supplements in our database — Lutein is not one of them. The Oxycodone interaction page linked on this page lists every one, ranked by severity.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Where next

Keep Exploring

Lutein monograph Uses, safety profile, and every drug interaction in one place Oxycodone drug information The full plain-English guide to this medication Oxycodone supplement interactions Every supplement checked against Oxycodone, ranked by severity Supplement interaction checker Check any supplement or product against your medications Browse medications A–Z Every drug we’ve checked against herbs & supplements References The 2 citations behind this page Ask a pharmacist Free, personal answer from our licensed team

Still Have a Question About Oxycodone and Lutein?

Our pharmacists answer your medication & supplement questions — free.

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.