Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

MacuHealth Ingredients & Drug Interactions

by MacuHealth

MacuHealth label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking MacuHealth against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

MacuHealth is a dietary supplement by MacuHealth with 3 active ingredients. Its ingredients are commonly taken for eye health, age-related macular degeneration, cataract prevention.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Zeaxanthin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against MacuHealth by MacuHealth

Ask about any prescription or over-the-counter medication and we check it for interactions with MacuHealth by MacuHealth — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of MacuHealth by MacuHealth

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

MacuHealth is a softgel with three active ingredients: lutein, zeaxanthin, and meso-zeaxanthin. These are carotenoids—naturally occurring yellow and orange plant pigments that concentrate in the macula, the part of your eye responsible for central vision.

They're also found in foods like leafy greens and egg yolks. The remaining ingredients are inactive (sunflower oil, gelatin, glycerin, and others) that help deliver and preserve the active compounds.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: macular health and visual performance.
  • We looked for evidence on: Age-related macular degeneration (AMD), Asthenopia (eye strain), Cataracts, Central serous retinopathy, Choroideremia, Diabetic retinopathy — and 4 related terms.
  • The strongest evidence on file: Lutein is rated "Possibly Effective" for Age-related macular degeneration (AMD) (Natural Medicines).
  • Also on file: Lutein is rated "Possibly Effective" for Cataracts.
  • Also on file: Zeaxanthin is rated "Possibly Effective" for Age-related macular degeneration (AMD).

Lutein is possibly effective for age-related macular degeneration (AMD) and cataracts. Zeaxanthin and meso-zeaxanthin are also possibly effective for AMD.

For other conditions—like cognitive decline, Alzheimer's disease, asthma, and cancer—the evidence isn't established in the data we hold. If you're considering this product for AMD or cataract prevention, talk with your eye doctor or pharmacist about whether the evidence fits your situation.

The evidence, ingredient by ingredient Lutein Zeaxanthin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lutein is generally well tolerated; studies haven't found adverse effects at daily doses up to 20 mg. Both zeaxanthin and meso-zeaxanthin are generally well tolerated at typical supplement doses.

Regarding pregnancy and breastfeeding, the data rates all three ingredients as likely safe. That said, the safety notes caution that supplement doses haven't been well studied in pregnancy and breastfeeding, so if you're pregnant or nursing, talk with your doctor or pharmacist before starting.

Side effects, ingredient by ingredient Lutein Zeaxanthin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Zeaxanthin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (medications that lower blood sugar), check this product with your pharmacist or use the search tool below. The zeaxanthin and meso-zeaxanthin in MacuHealth may theoretically increase the risk of low blood sugar when combined with these medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

MacuHealth is for anyone interested in supporting eye health, especially if you're concerned about age-related macular degeneration. If you take diabetes medications, check with your pharmacist first—the zeaxanthin and meso-zeaxanthin in this product may theoretically increase the risk of low blood sugar.

Pregnant or nursing mothers should discuss this supplement with their doctor to weigh what's known.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about MacuHealth, straight from the product label.

Brand MacuHealth
Net contents 90 Softgel(s)
Market status On market
Date entered into DSLD Mar 22, 2024
DSLD ID 310121
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for MacuHealth by MacuHealth, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel(s)
Maximum serving Sizes:
1 Softgel(s)
Servings per container
90
IngredientAmount% DV
Lutein10 mg--
Zeaxanthin2 mg--
Meso-Zeaxanthin10 mg--

Other ingredients: Sunflower Oil, Gelatin, Glycerin, Water, Purified, Annatto, Marigold Flower extract, yellow Beeswax, Tween 80, Soy Lecithin, Ascorbyl Palmitate, D-Alpha-Tocopherol Acetate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Clinically tested & gluten free

Clinically tested & gluten free

Now with micro-micelle technology

Created Tested Validated by science Boosts macular health Contrast sensitivity Visual performance

FDA Statement of Identity

Dietary Supplement

Precautions

Contains soy.

Suggested/Recommended/Usage/Directions

Directions: Take 1 softgel daily, preferably with a meal.

Formula

Triple carotenoid formula

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

MacuHealth by MacuHealth label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

MacuHealth label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in MacuHealth by MacuHealth

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container90 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lutein

No known
interactions
10 mg per serving

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help...

Lutein monograph & interactions

Zeaxanthin

Interacts with
86 drugs
2 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Zeaxanthin monograph & interactions

Meso-Zeaxanthin

Interacts with
86 drugs
10 mg per serving

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The stron...

Meso-Zeaxanthin monograph & interactions

Other (inactive) ingredients: Sunflower Oil, Gelatin, Glycerin, Water, Purified, Annatto, Marigold Flower extract, Yellow Beeswax, Tween 80, Soy Lecithin, Ascorbyl Palmitate, D-Alpha-Tocopherol Acetate. These complete the product’s ingredient list but are not active constituents.

Interaction report

MacuHealth by MacuHealth Drug Interactions

Want to check YOUR meds against MacuHealth?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Zeaxanthin 86

Individual Drug Interactions

The ingredients in MacuHealth interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in MacuHealth interact with drugs. Each result below shows which ingredient is responsible. Zeaxanthin

Each ingredient & the kinds of drugs it affects

For each ingredient in MacuHealth with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Zeaxanthin1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.

Likelihood Possible Evidence D
Zeaxanthin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for MacuHealth, from the product label.

MacuHealth

See all MacuHealth products
Name
MacuHealth
Pharmacist Counseling Corner

MacuHealth by MacuHealth: Common Questions

Does MacuHealth by MacuHealth interact with any medications?
Yes. Based on its ingredients, MacuHealth has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
MacuHealth contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are lutein and zeaxanthin, and why are they in this product?
They're carotenoids—plant pigments that naturally collect in your eye's macula, which controls your central vision. Lutein and both forms of zeaxanthin are thought to protect the eye from age-related wear. You also get them from leafy greens and eggs.
Does MacuHealth actually work for macular degeneration?
The evidence rates all three ingredients as possibly effective for age-related macular degeneration. That means there's some promise, but it's not definitive. Talk with your eye doctor about whether this fits your eye health plan.
Can I take MacuHealth if I'm pregnant or breastfeeding?
The data rates all three ingredients as likely safe in pregnancy and breastfeeding. However, supplement doses haven't been heavily studied in these situations, so talk with your doctor or pharmacist to decide what's best for you personally.
Are there side effects I should know about?
Lutein is generally well tolerated, with no adverse effects reported at doses up to 20 mg daily. Zeaxanthin and meso-zeaxanthin are also generally well tolerated at typical supplement amounts.
I take diabetes medicine. Is MacuHealth safe for me?
That's a question for your pharmacist. Zeaxanthin and meso-zeaxanthin may theoretically increase low blood sugar risk with diabetes drugs. Use the interaction checker on this page with your exact medications, or call your pharmacist before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

MacuHealth label
Go deeper

The Full Monographs Behind MacuHealth’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lutein

Lutein is a plant-based antioxidant pigment that concentrates in the eye, and the best evidence suggests it (often combined with zeaxanthin) may help slow progression of age-related macular...

Read the full Lutein monograph → Herb & supplement monograph

Zeaxanthin

Interacts with 86 drugs

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progres...

Read the full Zeaxanthin monograph →
Sources

Sources & How We Checked

MacuHealth's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lutein 2 references
  1. Brown L, Rimm EB, Seddon JM, et al. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am J Clin Nutr 1999;70:517-24. PubMed
  2. Chasan-Taber L, Willett WC, Seddon JM, et al. A prospective study of carotenoid and vitamin A intakes and risk of cataract extraction in US women. Am J Clin Nutr 1999;70:509-16. PubMed

See these in context on the Lutein monograph →

Zeaxanthin 4 references
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed
  4. Xu X, Zhao X, Berde Y, Low YL, Kuchan MJ. Milk and Plasma Lutein and Zeaxanthin Concentrations in Chinese Breast-Feeding Mother-Infant Dyads With Healthy Maternal Fruit and Vegetable Intake. J Am Coll Nutr 2019;38(2):179-184. PubMed

See these in context on the Zeaxanthin monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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