Drug & supplement interaction

Zeaxanthin + Empagliflozin

Empagliflozin brand name: Jardiance.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Zeaxanthin has a moderate interaction with Empagliflozin. Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Zeaxanthin and Empagliflozin

Here is the interaction we found between these two, with the evidence behind it.

Moderate

ANTIDIABETES DRUGS

Why this applies to Empagliflozin

Empagliflozin falls under ANTIDIABETES DRUGS — the group Zeaxanthin interacts with.

Theoretically, taking zeaxanthin with antidiabetes drugs might increase the risk of hypoglycemia.
In an animal diabetic model, zeaxanthin has hypoglycemic effects. However, population research has found that increasing intake of dietary zeaxanthin plus lutein does not decrease the risk of developing type 2 diabetes.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the honest picture with zeaxanthin and your Jardiance (empagliflozin). The concern is purely theoretical: in one animal study, zeaxanthin seemed to lower blood sugar a bit on its own. If that effect carried over to people, stacking it on top of empagliflozin could in theory push your blood sugar lower than intended, with symptoms like shakiness, sweating, dizziness, or feeling lightheaded.

That said, real-world studies in people found that getting more zeaxanthin (and lutein) in the diet did not change diabetes risk, so this is weak evidence at best. Empagliflozin by itself rarely causes true lows unless you also take insulin or a sulfonylurea. I wouldn't lose sleep over it, but it's worth a quick mention to your pharmacist or doctor, and keep an eye on your blood sugar readings.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Montonen J, Knekt P, Jarvinen R, Reunanen A. Dietary antioxidant intake and risk of type 2 diabetes. Diabetes Care 2004;27:362-6. PubMed
  2. Leermakers ET, Darweesh SK, Baena CP, et al. The effects of lutein on cardiometabolic health across the life course: a systematic review and meta-analysis. Am J Clin Nutr 2016;103(2):481-94. PubMed
  3. Kou L, Du M, Zhang C, Dai Z, Li X, Zhang B. The Hypoglycemic, Hypolipidemic, and Anti-Diabetic Nephritic Activities of Zeaxanthin in Diet-Streptozotocin-Induced Diabetic Sprague Dawley Rats. Appl Biochem Biotechnol 2017;182(3):944-955. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Zeaxanthin Also Interacts With Other Medications

Zeaxanthin has 85 moderate known drug interactions in our database — the Empagliflozin one above is one of them. If you take anything else, check it against the full list below.

Moderate 85 No known interaction 2,745 (incl. Empagliflozin)
Taking anything else?

Check Another of Your Medications Against Zeaxanthin

Covers the 2,830 medications we’ve checked against Zeaxanthin. Pick one to open its full report.

From our Q&A

Questions About Zeaxanthin or Empagliflozin

These are real questions from readers, answered by the pharmacists at HelloPharmacist — written by a person, not generated from a database. Each one covers Zeaxanthin or Empagliflozin, not necessarily both, but if one is close to what you were about to ask it will usually go further than a database entry can:

Not quite your question? Ask our pharmacists directly — it is free, there is no account required, and answers usually come back within 24 hours.

Everything else you take

See Every Supplement That Interacts With Empagliflozin

This page covers Zeaxanthin only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Empagliflozin page lists 257 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: Activated Charcoal (major), Siberian Cocklebur (major), Acai (moderate), African Wild Potato (moderate) and Agaricus Mushroom (moderate).

By severity: 2 major · 216 moderate · 39 minor.

From our pharmacist’s overview on the Empagliflozin page

“Almost everything on this page can nudge blood sugar in someone taking empagliflozin (Jardiance) for type 2 diabetes, heart failure, or kidney protection, and two entries deserve genuine caution before anything else. Siberian cocklebur has caused severe low blood sugar in humans and should not be combined with any glucose-lowering medi…”

Reviewed by 2 · Jul 18, 2026

Open the Empagliflozin interaction page

One more smart check

Taking Zeaxanthin as Part of a Dietary Supplement Product? Check It for Interactions

We hold 3,239 real supplement products containing Zeaxanthin, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Zeaxanthin. Your product may carry other ingredients that interact with Empagliflozin too, on top of Zeaxanthin — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Zeaxanthin and Empagliflozin Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Zeaxanthin
Top 10%

#87 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Empagliflozin
Top half

#1,076 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Zeaxanthin

What is Zeaxanthin?

Zeaxanthin
  • Eye and macular health
  • Age-related macular degeneration (AMD)
  • Protection from blue light
  • General antioxidant support
  • Cataract risk reduction

Zeaxanthin is a carotenoid pigment that, along with lutein, concentrates in the macula of the eye and may help support long-term eye health. The strongest evidence relates to slowing progression of advanced age-related macular degeneration when combined with other nutrients, while many other uses remain unproven. It is generally well tolerated, but talk to your pharmacist or doctor before starting any supplement.

Read the full Zeaxanthin monograph & all interactions
Medication

About Empagliflozin

What Is Empagliflozin Used For?

Brand name: Jardiance

Jardiance (empagliflozin) tablets are approved for several important uses in adults. It reduces the risk of cardiovascular death and hospitalization in adults with heart failure. It also slows the progression of chronic kidney disease by reducing the risk of serious kidney decline, end-stage kidney disease, cardiovascular death, and hospitalization. In adults with type 2 diabetes and established cardiovascular disease, Jardiance reduces the risk of cardiovascular death.

Jardiance is also used — alongside diet and exercise — to improve blood sugar control in type 2 diabetes in adults and children aged 10 and older. It is not recommended for blood sugar control in type 1 diabetes (it may raise the risk of a dangerous condition called diabetic ketoacidosis) or in type 2 diabetes patients with severely reduced kidney function.

See full Empagliflozin drug information
Keep checking

Other Drugs & Zeaxanthin

Browse every other medication we’ve checked against Zeaxanthin — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
85Moderate
0Minor
2,744No known interaction
85 Moderate 2,744 No interaction
Moderate

85 interactions

Showing 60 of 85 moderate interactions — see all 85 on the Zeaxanthin page.

No interaction 2,744 drugs checked — show the list

We also checked Zeaxanthin against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,744 medications checked with no known interaction — see the full Zeaxanthin list.

See the full Zeaxanthin interactions page
See every supplement checked against Empagliflozin, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Zeaxanthin monograph › Uses, safety, and every drug interaction in one place Empagliflozin supplement interactions › Every supplement checked against Empagliflozin, ranked by severity Empagliflozin drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Zeaxanthin and Empagliflozin Together: Common Questions

Can you take Zeaxanthin with Empagliflozin?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Zeaxanthin and Empagliflozin interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Empagliflozin and Zeaxanthin?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.