Medication interaction hub

What Supplements Interact with Propoxyphene?

Propoxyphene brand names: Darvon, Prophene-65, Margesic, Davon, Darvon N. Every interaction below applies to the brands too.

172 Interactions 8 Major 141 Moderate 23 Minor
Curated & coded by · Clinical Pharmacist · Updated September 22, 2026

Drug–supplement interaction data sourced from Natural Medicines Pro, the licensed clinical database from TRC Healthcare / Therapeutic Research, with additional analysis by the HelloPharmacist Pharmacist Team. Our sources · Editorial policy

What is this page for?

One answer, for one medication: what supplements and herbal products interact with Propoxyphene? Every vitamin, herb, and supplement ingredient we’ve checked against it is on this page, ranked by severity, each linking to the full report for that exact pair.

This page covers supplement interactions only — to check Propoxyphene against your other medications, use the drug–drug interaction checker. Educational information from our licensed clinical databases, not medical advice. Our editorial policy

HelloPharmacist Bottom Line
Our Pharmacist Explains
What is this? The interaction data in the HelloPharmacist supplement database is licensed from Natural Medicines Pro by TRC Healthcare (Therapeutic Research). HelloPharmacist pharmacists often add our own analysis and context on top of that licensed data — such as this Bottom Line summary and the notes on individual interaction pages — and any such commentary is noted as ours.

Propoxyphene (Darvon) is an opioid painkiller, and the biggest hazard among the 172 supplement interactions on file is anything else that slows the brain and breathing. Seventy-eight of these ingredients pile on that sedation, alcohol and kava among the worst rated, and with an opioid the combination can push breathing dangerously low. Eight entries rate major, and those deserve your attention before any of the rest.

The risk does not stop at sedation. Thirty-eight ingredients can strain the liver, adding to a drug your liver already has to process, and about sixty involve a shared liver enzyme that can shift levels of the drug or the supplement. Activated charcoal works the opposite way, soaking up an oral dose before it absorbs, so keep the two well apart. The remaining 141 moderate and 23 minor entries are manageable, but while you are on an opioid, anything sedating needs a hard look first.

— , Clinical Pharmacist · July 18, 2026

Major 8 Moderate 141 Minor 23 No known interaction 1,280

This box checks one ingredient at a time (like turmeric or magnesium). Taking a supplement product with a whole label of ingredients? Search the product instead — we check every ingredient on it ↓

Most Viewed Ingredient Interactions

Propoxyphene: Top Interactions at a Glance

The Propoxyphene supplement & herbal interactions people checked most in the last 24 hours, colored by severity. Tap any ingredient to open the full report for that pair.

Showing the 12 highest-ranked of 172 interacting ingredients — plus 1,280 more checked with no known interaction. See the complete ranked list.

Start here

The Most-Checked Propoxyphene Combinations Today

The Propoxyphene + supplement pages people viewed most in the last 24 hours (resets at midnight). Open any card for the full report.

Moderate Likelihood Possible Grape + Propoxyphenei

Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.

Read the full interaction Moderate Likelihood Possible Hops + Propoxyphenei

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.

Read the full interaction Moderate Likelihood Possible Saigon Cinnamon + Propoxyphenei

Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Read the full interaction Moderate Likelihood Possible Rauvolfia Vomitoria + Propoxyphenei

Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.

Read the full interaction Moderate Likelihood Possible Ashwagandha + Propoxyphenei

Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Read the full interaction Moderate Likelihood Possible Niacin + Propoxyphenei

Theoretically, concomitant use of niacin and hepatotoxic drugs might increase the risk of hepatotoxicity.

Read the full interaction
The complete list

Every Supplement Checked Against Propoxyphene

All 1,452 ingredients in our database, ranked by severity — 172 with a Propoxyphene interaction on file and 1,280 with none found. Filter by severity or search any ingredient; hover the for what each ingredient is.

Looking for an interaction with a specific supplement product? Search products instead ↓

Straight answers

Can You Take It With Propoxyphene?

One-line answers, one card per combination — scroll through today’s 20 and tap any card for the full report. A different set rotates in daily until every combination has had its turn.

Can you take Grape with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, grape seed extract may increase the levels of CYP2D6 substrates.

Full Grape + Propoxyphene answer

Can you take Hops with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.

Full Hops + Propoxyphene answer

Can you take Saigon Cinnamon with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Saigon cinnamon might cause additive effects when used with hepatotoxic drugs.

Full Saigon Cinnamon + Propoxyphene answer

Can you take Rauvolfia Vomitoria with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking Rauvolfia vomitoria might cause additive sedative effects.

Full Rauvolfia Vomitoria + Propoxyphene answer

Can you take Ashwagandha with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, taking ashwagandha might increase the sedative effects of CNS depressants.

Full Ashwagandha + Propoxyphene answer

Can you take Shepherd's Purse with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use with drugs with sedative properties may cause additive effects and side effects.

Full Shepherd's Purse + Propoxyphene answer

Can you take Shiitake Mushroom with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, shiitake mushroom might decrease levels of drugs metabolized by CYP2D6.

Full Shiitake Mushroom + Propoxyphene answer

Can you take Skullcap with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, skullcap can have additive effects when used with other CNS depressants.

Full Skullcap + Propoxyphene answer

Can you take Slippery Elm with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, slippery elm may slow the absorption and reduce serum levels of oral drugs.

Full Slippery Elm + Propoxyphene answer

Can you take Spearmint with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, spearmint might alter the sedative effects of CNS depressants.

Full Spearmint + Propoxyphene answer

Can you take Sweet Annie with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive adverse hepatotoxic effects.

Full Sweet Annie + Propoxyphene answer

Can you take Sweet Clover with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use of sweet clover with hepatoxic drugs might increase the risk of hepatotoxicity.

Full Sweet Clover + Propoxyphene answer

Can you take Tarragon with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Evidence from animal research suggests that tarragon essential oil can cause sedation and motor impairment when administered intraperitoneal...

Full Tarragon + Propoxyphene answer

Can you take Terminalia with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, use of Terminalia arjuna may increase the levels and clinical effects of CYP2D6 substrates.

Full Terminalia + Propoxyphene answer

Can you take Testolone with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, concomitant use might have additive hepatotoxic effects.

Full Testolone + Propoxyphene answer

Can you take Theacrine with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, theacrine might alter the effects of CNS depressants.

Full Theacrine + Propoxyphene answer

Can you take Thuja with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Thuja products can contains significant amounts of thujone, a neurotoxin.

Full Thuja + Propoxyphene answer

Can you take Tianeptine with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Tianeptine has sedative effects; high doses may have additive effects with other CNS depressants.

Full Tianeptine + Propoxyphene answer

Can you take Tinospora Cordifolia with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, Tinospora cordifolia might increase levels of drugs metabolized by CYP2D6.

Full Tinospora Cordifolia + Propoxyphene answer

Can you take Tragacanth with Propoxyphene?

Moderate Possibly, but carefully — this moderate-rated combination may need monitoring, a dose adjustment, or separated timing. Theoretically, tragacanth might alter absorption of oral drugs.

Full Tragacanth + Propoxyphene answer
Read the list like a pharmacist

What Severity, Likelihood & Evidence Mean

Severity — How Serious It Can Be

  • Major. Clinically significant; generally best avoided, or used only under direct professional supervision.
  • Moderate. May need monitoring, a dose adjustment, or separating the times you take each one.
  • Minor. Generally not clinically significant, but still worth noting and mentioning to your pharmacist.
  • No known interaction. Checked against our sources with nothing documented — not the same as proven safety.

Likelihood — How Well It’s Documented

  • Likely. Well-controlled human studies have demonstrated the likely existence of this interaction
  • Probable. Interaction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • Possible. Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists
  • Unlikely. Interaction has been demonstrated in animal or in lab research but has been shown not to occur in humans.

Where This Data Comes From

  • Interaction records are evidence-graded and sourced from the Natural Medicines database (TRC Healthcare), the same reference used by pharmacists and hospitals.
  • Each entry links to a full report with the clinical detail, likelihood, evidence level, and citations for that exact combination.
  • Content is reviewed by licensed HelloPharmacist pharmacists — see our data sources and editorial standards.

How Does Our Interaction Checker Work?

Behind every verdict on this page is a category system. Our source database doesn’t document supplement interactions drug-by-drug — it documents them against groups of medications that behave the same way (for example, “drugs processed by the CYP3A4 liver enzyme” or “blood-thinning medications”).

So the check works in three steps: (1) Propoxyphene is classified into the pharmacology categories it belongs to, (2) every supplement interaction documented against any of those categories is inherited by Propoxyphene, and (3) each ingredient keeps its own severity, likelihood, and evidence grades from the underlying record. That’s why one supplement can carry several records for one drug — it may interact through more than one category.

Propoxyphene sits in 7 interaction categories. Open any one to see what the group means:

Cns Depressants 78 ingredients

Central-nervous-system depressants. Sedating supplements can intensify drowsiness and slowed reactions when combined.

78 of the supplement ingredients on this page reach Propoxyphene through this category.

Cytochrome P450 2D6 (Cyp2D6) Substrates 60 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

60 of the supplement ingredients on this page reach Propoxyphene through this category.

Hepatotoxic Drugs 38 ingredients

Medications with known liver considerations. Supplements that can stress the liver add to the load.

38 of the supplement ingredients on this page reach Propoxyphene through this category.

Oral Drugs 17 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

17 of the supplement ingredients on this page reach Propoxyphene through this category.

Seizure Threshold Lowering Drugs 6 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

6 of the supplement ingredients on this page reach Propoxyphene through this category.

Narcotic Drugs 5 ingredients

A pharmacology grouping from our source database: medications in this group share a property that certain supplements are known to interact with, so an interaction documented for the group applies to every drug in it.

5 of the supplement ingredients on this page reach Propoxyphene through this category.

Cytochrome P450 2D6 (Cyp2D6) Inhibitors 3 ingredients

A drug-metabolism group: these medications are processed by the named liver enzyme (a cytochrome P450). Supplements that speed this enzyme up or slow it down can lower or raise the medication's levels in your body.

3 of the supplement ingredients on this page reach Propoxyphene through this category.

About Propoxyphene

A combination of butalbital, acetaminophen, and caffeine used to relieve tension headaches across multiple oral products.

Generic name: Propoxyphene  ·  Brand names: Darvon, Prophene-65, Margesic, Davon, Darvon N.

See the full Acetaminophen, Butalbital, and Caffeine drug information
Check a real product

Take a Supplement Product? Check the Whole Bottle Against Propoxyphene

Most supplements are combination products — and the interaction may come from an ingredient you didn’t buy it for. Search any product below (or scan its label) and we’ll check every ingredient on it against Propoxyphene.

Search a supplement product

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Grounded search over our product catalog — every verdict comes from our interaction database, never AI guesswork. How we use AI

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Products that contain Propoxyphene-interacting ingredients

Real supplements from the NIH label database that contain the top interacting ingredients on this page — each one is worth a full label check before combining with Propoxyphene.

Zi Sheng Teapills by Plum Flower contains Siberian Cocklebur Cold Away by Health Concerns contains Siberian Cocklebur Sugar Coated Bi Yan Pian by Plum Flower contains Siberian Cocklebur Pe Min Kan Wan by Plum Flower contains Siberian Cocklebur
Pharmacist Counseling Corner

Propoxyphene & Supplements: Common Questions

What supplements interact with Propoxyphene?
Our database currently documents 172 ingredients with a known Propoxyphene interaction (8 major, 141 moderate, 23 minor). The practical move: scan the major group first, then look up the exact supplements you take rather than reading all 172. The highest-ranked right now: Beer, Siberian Cocklebur, Wine.
Which Propoxyphene supplement interactions are the most serious?
The 8 major-rated combinations — led by Beer, Siberian Cocklebur, Wine, 1,4-butanediol and Activated Charcoal — deserve real caution: these are the ones generally best avoided, or used only with your prescriber watching. If you take any of them today, don't panic and don't stop anything abruptly — call your pharmacist first. Jump to the ranked list.
Can I take vitamins or supplements while on Propoxyphene?
Plenty of supplements coexist fine with Propoxyphene; a shorter list does not. Rather than memorizing it, check the specific ingredients on your labels — the ranked list above covers every one we've checked, and multi-ingredient products can be checked label-by-label with our scanner. Try the label scanner or the interaction checker.
Do brands like Darvon have the same supplement interactions as Propoxyphene?
Yes — Darvon, Prophene-65, Margesic, Davon, Darvon N all contain Propoxyphene, so everything on this page applies to them equally. Interactions belong to the active drug, never to the brand on the box; the same is true of generics.
Where do these interaction ratings come from?
Every rating comes from the Natural Medicines database — the same evidence-graded reference pharmacists and hospitals use — and each interaction carries three separate grades: severity (how bad it can be), likelihood (how well it's documented in studies and case reports), and an evidence level. Our pharmacists review the content; we never let an AI decide an interaction. See how to read the ratings and our editorial policy.
What about Propoxyphene and my other medications?
This page covers Propoxyphene against supplements and herbal ingredients. Checking Propoxyphene against your other prescription or OTC medications is a different tool — our drug interaction checker covers that side. Head to the drug–drug interaction checker, or read the full Acetaminophen, Butalbital, and Caffeine drug information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Sourcing

Where This Data Comes From — and Why You Can Trust It

🧪 Licensed clinical database

Every interaction verdict on this page comes from Natural Medicines Pro (TRC Healthcare / Therapeutic Research) — the same evidence-graded reference used by pharmacists and hospitals. We license this data directly; we do not scrape it, and no AI invents an interaction.

🧑‍⚕️ Pharmacist review

This page is curated and coded by , Clinical Pharmacist, with additional analysis by the HelloPharmacist Pharmacist Team. Editorial commentary is ours; the licensed interaction records are shown as sourced.

🔄 Kept current

Our interaction database refreshes on a weekly cycle, and this page re-checks the live database every time it’s rebuilt — what you see reflects the database as of September 22, 2026.

🔍 Full transparency

How every dataset on this site is sourced, licensed, and updated is documented publicly: our data sources · editorial policy · how we use AI.

Educational information, not medical advice. An interaction being on file does not mean it will happen to you — and absence of one is not proof of safety. Never start or stop a medication or supplement without talking to your pharmacist or doctor.