Drug & supplement interaction

Corn Poppy + Propoxyphene

Propoxyphene brand names: Darvon, Prophene-65, Margesic, Davon.

Moderate Interaction
Medically reviewed by · Updated September 2026
The bottom line Moderate

Corn Poppy has a moderate interaction with Propoxyphene. Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.

Read the full interaction report
SeverityModerate
LikelihoodPossible
EvidenceD
What do Severity, Likelihood & Evidence mean?
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Interaction report

Corn Poppy and Propoxyphene

Here is the interaction we found between these two, with the evidence behind it.

Moderate

CNS DEPRESSANTS

Why this applies to Propoxyphene

Propoxyphene falls under CNS DEPRESSANTS — the group Corn Poppy interacts with.

Theoretically, concomitant use of corn poppy with CNS depressants might increase the risk of sedation.
Animal research suggests that corn poppy leaf extract has sedative effects.
Severity Moderate Likelihood Possible Evidence D

Interaction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.

Dr. Brian Staiger, PharmD, BCPS
Dr. Brian Staiger explains PharmD, Clinical Pharmacist

Here's the simple version. Propoxyphene is an opioid pain reliever, so it already tends to make people feel drowsy, foggy, or slowed down. Corn poppy has been studied mostly in animals, where its leaf extract seemed to have a mild calming, sleepy effect. The worry is that stacking the two could add up and leave you more sedated than expected.

To be honest, this is a theoretical concern based on lab and animal work, not strong human studies, so I wouldn't lose sleep over it. Still, propoxyphene is a serious medicine, and feeling extra drowsy or having slowed breathing is something to take seriously. Please check with your pharmacist or doctor before combining them, and don't change how you take your medication on your own.

Contact Dr. Brian directly if you have additional questions on this interaction
References
  1. Soulimani, R., Younos, C., Jarmouni-Idrissi, S., Bousta, D., Khalouki, F., and Laila, A. Behavioral and pharmaco-toxicological study of Papaver rhoeas L. in mice. J Ethnopharmacol 3-3-2001;74(3):265-274. PubMed

What These Ratings Mean

Every interaction above is graded three ways — here’s the key to each label.

Severity how clinically significant the interaction is
Major

Clinically significant. Avoid the combination, or use only under close professional supervision.

Moderate

Usually worth avoiding or managing — may need monitoring, a dose change, or timing apart.

Minor

Generally not serious. Be aware of it and mention it to your pharmacist.

Likelihood how strong the evidence is that the interaction actually happens in people
  • LikelyWell-controlled human studies have demonstrated the likely existence of this interaction.
  • ProbableInteraction has not been documented in well-controlled studies, however, the interaction has been demonstrated in some small human studies or in controlled animal studies in conjunction with multiple case reports.
  • PossibleInteraction has been documented in animal or in lab research, or the interaction has been documented in humans but is limited to case reports or conflicting clinical research exists.
  • UnlikelyInteraction has been demonstrated in animal or in lab research but has been shown not to occur in humans.
Evidence the quality of the studies behind the rating (graded A–D)
  • AHigh-quality meta-analysis (quantitative systematic review).
  • BCase-control study.
  • CConsensus.
  • DAnecdotal evidence.

These ratings are for information only. Never start, stop, or otherwise change your therapy before speaking with your provider.

Keep it in perspective

Corn Poppy Also Interacts With Other Medications

Corn Poppy has 247 moderate known drug interactions in our database — the Propoxyphene one above is one of them. If you take anything else, check it against the full list below.

Moderate 247 No known interaction 2,583 (incl. Propoxyphene)
Taking anything else?

Check Another of Your Medications Against Corn Poppy

Covers the 2,830 medications we’ve checked against Corn Poppy. Pick one to open its full report.

Everything else you take

See Every Supplement That Interacts With Propoxyphene

This page covers Corn Poppy only. If you take other supplements — a multivitamin, a sleep aid, something for joints — the Propoxyphene page lists 172 supplements it has a documented interaction with, worst first, each one explained.

The most serious there right now: 1,4-butanediol (major), Activated Charcoal (major), Beer (major), Gamma-hydroxybutyrate (ghb) (major) and Kava (major).

By severity: 8 major · 141 moderate · 23 minor.

From our pharmacist’s overview on the Propoxyphene page

“Propoxyphene (Darvon) is an opioid painkiller, and the biggest hazard among the 172 supplement interactions on file is anything else that slows the brain and breathing. Seventy-eight of these ingredients pile on that sedation, alcohol and kava among the worst rated, and with an opioid the combination can push breathing dangerously low.”

Reviewed by 2 · Jul 18, 2026

Open the Propoxyphene interaction page

One more smart check

Taking Corn Poppy as Part of a Dietary Supplement Product? Check It for Interactions

We hold 1 real supplement products containing Corn Poppy, each one broken down to its full ingredient list — and combination products often carry several ingredients besides Corn Poppy. Your product may carry other ingredients that interact with Propoxyphene too, on top of Corn Poppy — and those would not show on this page. Find your product and we’ll check every ingredient on its label:

How much people look this up

Where Corn Poppy and Propoxyphene Sit Against Everything Else

Out of every supplement and medication people look up on HelloPharmacist, here is where these two land this week — and which way each has been moving.

Supplement Corn Poppy
Top half

#507 of 1,452 supplements looked up here in the last 7 days

29 days ago today
Medication Propoxyphene
Top 5%

#64 of 2,830 medications looked up here in the last 7 days

29 days ago today

Position among everything looked up on this site, not a measure of how commonly either one is used or how important it is. A supplement can climb this list because of a news story. It counts every request to the page, automated ones included, and nothing here identifies anyone.

Supplement

About Corn Poppy

What is Corn Poppy?

Corn Poppy
  • Cough and sore throat
  • Sleep and restlessness
  • Mild pain
  • Anxiety and nervousness
  • Digestive complaints

Corn poppy is a red-flowered plant traditionally used in teas and syrups for cough, sleep, and mild pain. Solid human research is very limited, so its benefits are not well proven, and unlike its relative the opium poppy, it contains only small amounts of weak alkaloids. Talk to a pharmacist or doctor before using it, and avoid it during pregnancy and breastfeeding.

Read the full Corn Poppy monograph & all interactions
Medication

About Acetaminophen, Butalbital, and Caffeine

What Is Acetaminophen, Butalbital, and Caffeine Used For?

Brand names: Darvon, Prophene-65, Margesic, Davon

This three-ingredient combination — butalbital, acetaminophen, and caffeine — is used to relieve the symptoms of tension headache (also called muscle contraction headache). All supported products, including tablets, capsules, and oral solution, share this same approved use.

It is worth knowing that evidence for using this combination to treat repeated, frequent tension headaches over time is limited. Because butalbital can be habit-forming, extended or repeated use is not recommended.

See full Acetaminophen, Butalbital, and Caffeine drug information
Keep checking

Other Drugs & Corn Poppy

Browse every other medication we’ve checked against Corn Poppy — both the ones with a known interaction and the ones without. Select any drug for the full detail.

0Major
247Moderate
0Minor
2,582No known interaction
247 Moderate 2,582 No interaction
Moderate

247 interactions

Showing 60 of 247 moderate interactions — see all 247 on the Corn Poppy page.

No interaction 2,582 drugs checked — show the list

We also checked Corn Poppy against these medications and found no known interaction in our sources. Open any page to confirm.

Showing the 60 most looked-up of 2,582 medications checked with no known interaction — see the full Corn Poppy list.

See the full Corn Poppy interactions page
See every supplement checked against Propoxyphene, ranked by severity
Sources

Sources & How We Checked

Interaction details are evidence-graded and sourced from the Natural Medicines database. The medication overview comes from MedlinePlus.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Corn Poppy monograph › Uses, safety, and every drug interaction in one place Propoxyphene supplement interactions › Every supplement checked against Propoxyphene, ranked by severity Acetaminophen, Butalbital, and Caffeine drug information › The full plain-English guide to this medication Supplement interaction checker › Check any supplement or product against your medications Browse medications A–Z › Every drug we've checked against herbs & supplements Ask a pharmacist › Free, personal answer from our licensed team
Pharmacist Counseling Corner

Taking Corn Poppy and Propoxyphene Together: Common Questions

Can you take Corn Poppy with Propoxyphene?
There is a moderate interaction, so it may be acceptable with monitoring or timing changes — but check with your pharmacist first. Read the full details on this page and confirm with your pharmacist before combining them.
How serious is the Corn Poppy and Propoxyphene interaction?
We rate it Moderate. This combination may require monitoring, a dose adjustment, or separating the times you take each one. Consult your pharmacist before using them together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Still Have a Question About Propoxyphene and Corn Poppy?

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This information is for education only and is not a substitute for professional medical advice. Always check with your pharmacist or doctor before starting, stopping, or combining supplements and medications.